胸膜肺炎放线杆菌：流行病学、生物多样性、血清分型、毒力和实验室诊断的最新进展。

IF 1.8 4区医学 Q4 IMMUNOLOGY

Microbiology and Immunology Pub Date : 2025-10-12 DOI:10.1111/1348-0421.70017

Ho To, Joachim Frey, Marcelo Gottschalk, Katsuaki Sugiura, Shinya Nagai

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引用次数: 0

摘要

胸膜肺炎放线杆菌是猪胸膜肺炎的病原体，是一种高度传染性的呼吸道疾病。根据生长所需的NAD将其分为两种生物变种：生物变种1（依赖于NAD）和生物变种2（不依赖于NAD）。生物多样性1包括17个血清型（1-12和15-19），生物多样性2有8个血清型（2、4、7、9、11、13、14和17）。几种毒力因素是导致胸膜肺炎假单胞菌发病的原因，特别是Apx毒素、荚膜多糖、脂多糖和膜蛋白。本文就胸膜肺炎假单胞菌的生物变异、血清变异、流行病学、毒力因子、实验室诊断和疫苗等方面的研究进展进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Actinobacillus pleuropneumoniae: An Update on Epidemiology, Biovar, Serotyping, Virulence, and Laboratory Diagnosis.

Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious respiratory disease. It is classified into two biovars on the basis of NAD requirement for growth: biovar 1 (NAD-dependent) and biovar 2 (NAD-independent). Biovar 1 consists of 17 serovars (1-12 and 15-19) and biovar 2 has 8 serovars (2, 4, 7, 9, 11, 13, 14, and 17). Several virulence factors are responsible for the pathogenesis of A. pleuropneumoniae, particularly Apx toxins, capsular polysaccharides, lipopolysaccharides, and membrane proteins. In this review, the current knowledge of biovars, serovars, epidemiology, virulence factors of A. pleuropneumoniae as well as laboratory diagnosis and vaccines are summarized.

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.