Minerva medicaPub Date : 2024-06-01Epub Date: 2023-06-29DOI: 10.23736/S0026-4806.23.08746-3
Qing Xu, Mimi Sheng, Yaxiao Sun
{"title":"Cluster analysis of nursing effects on wound pain and healing of bedridden patients with pressure injuries.","authors":"Qing Xu, Mimi Sheng, Yaxiao Sun","doi":"10.23736/S0026-4806.23.08746-3","DOIUrl":"10.23736/S0026-4806.23.08746-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"411-412"},"PeriodicalIF":4.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-06-01Epub Date: 2020-06-12DOI: 10.23736/S0026-4806.20.06566-0
Dan Zhou, Jilan Wang, Suping Xu, Zengming Li, Dan Kou
{"title":"LINC00858 facilitates the malignant development of Wilms' Tumor by targeting miR-653-5p.","authors":"Dan Zhou, Jilan Wang, Suping Xu, Zengming Li, Dan Kou","doi":"10.23736/S0026-4806.20.06566-0","DOIUrl":"10.23736/S0026-4806.20.06566-0","url":null,"abstract":"<p><strong>Background: </strong>To uncover the clinical significance of LINC00858 in the development of Wilms' Tumor and the potential molecular mechanism.</p><p><strong>Methods: </strong>LINC00858 levels in Wilms' Tumor species and cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The clinical significance of LINC00858 in influencing pathological features and prognosis in patients with Wilms' Tumor was analyzed. Proliferative and migratory changes in Wilms' Tumor cells with LINC00858 knockdown were assessed. The downstream gene of LINC00858 was verified by luciferase assay, and its involvement in the development of Wilms' Tumor was further explored.</p><p><strong>Results: </strong>LINC00858 was highly expressed in Wilms' Tumor tissues and cell lines. High level of LINC00858 was correlated to high rate of lymphatic metastasis and poor prognosis in patients with Wilms' Tumor. Knockdown of LINC00858 suppressed proliferative and migratory potentials in HFWT and 17-94 cells. MiR-653-5p was targeted by LINC00858. It was lowly expressed in Wilms' Tumor tissues and negatively regulated by LINC00858. Knockdown of miR-653-5p partially abolished the regulatory effects of LINC00858 on proliferative and migratory potentials in Wilms' Tumor cells.</p><p><strong>Conclusions: </strong>LINC00858 is highly expressed in Wilms' Tumor species and correlated to lymphatic metastasis rate and overall survival in patients with Wilms' Tumor. Knockdown of LINC00858 suppresses Wilms' Tumor cells to proliferate and migrate via targeting miR-653-3p.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"277-283"},"PeriodicalIF":4.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38049163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-04-01Epub Date: 2023-05-11DOI: 10.23736/S0026-4806.23.08625-1
Yingjie Xu, Jing Zhu
{"title":"Imaging characteristics of left ventricular diastolic function in patients with dilated cardiomyopathy using three-dimensional speckle tracking imaging and MRI.","authors":"Yingjie Xu, Jing Zhu","doi":"10.23736/S0026-4806.23.08625-1","DOIUrl":"10.23736/S0026-4806.23.08625-1","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"254-255"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9443093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-04-01Epub Date: 2023-05-04DOI: 10.23736/S0026-4806.23.08616-0
Shuang Han, Yinhui Ji, Yaping Song, Shiqin Wang
{"title":"Clinical effect of Guizhi Fuling Pill combined with metformin on chronic pelvic inflammatory disease and its influence on inflammatory reaction in rats.","authors":"Shuang Han, Yinhui Ji, Yaping Song, Shiqin Wang","doi":"10.23736/S0026-4806.23.08616-0","DOIUrl":"10.23736/S0026-4806.23.08616-0","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"245-248"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09269-3
Xiaonan Wang, Shaofeng Sun, Dongsheng Yu, Hua Yu
{"title":"The improvement effect of acupuncture combined with massage on shoulder pain after stroke and its impact on limb function.","authors":"Xiaonan Wang, Shaofeng Sun, Dongsheng Yu, Hua Yu","doi":"10.23736/S0026-4806.24.09269-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09269-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"248 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09224-3
Jiaping Song, Yongcheng Xu, Tingting Wang, He Yu, He Dong
{"title":"The role of gut microbiota in host immune response mechanisms.","authors":"Jiaping Song, Yongcheng Xu, Tingting Wang, He Yu, He Dong","doi":"10.23736/S0026-4806.24.09224-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09224-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"131 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09044-X
A. Roveta, G. Pacileo, Mauro Cappelletti, Donatella Alesso, Alberto Bonissone, Lorenzo Fossati, Maria C Giaccari, Fabio Maccapani, Camillo Milano, Nicolò Parodi, Federico Torregiani, Francesca Ugo, Costanza Massarino, Luigi M Castello, A. Maconi
{"title":"How primary care research can be improved in clinical practice? An Italian case study.","authors":"A. Roveta, G. Pacileo, Mauro Cappelletti, Donatella Alesso, Alberto Bonissone, Lorenzo Fossati, Maria C Giaccari, Fabio Maccapani, Camillo Milano, Nicolò Parodi, Federico Torregiani, Francesca Ugo, Costanza Massarino, Luigi M Castello, A. Maconi","doi":"10.23736/S0026-4806.24.09044-X","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09044-X","url":null,"abstract":"BACKGROUND\u0000Primary care is considered essential for the sustainability of the Health System. Practice-Based Research Networks (PBRN) play a strategic role in translation of primary care research into practice. Research Capacity Building in primary care requires a improvement and development strategy and well-developed research infrastructures to support physicians.\u0000\u0000\u0000METHODS\u0000We used the system development methodology referring to the Lean Thinking to create and support a research team in primary and pediatric care. In particular a \"cascade\" deployment model and the X-Matrix, a framework used in management studies to support strategy definition and management process.\u0000\u0000\u0000RESULTS\u0000A research unit in primary and pediatric care has been created, by sharing vision, mission, core values, long-term strategies. The definition of a annual planning led to monitoring actions to guarantee the expected goals.\u0000\u0000\u0000CONCLUSIONS\u0000Lean methodology is useful to adapt to various managerial and operational contexts, including healthcare. In our case it allowed team members to spread the culture of research, its importance and role to improve the health of patients, thank to the organizational support of a hospital IR, the Research and Innovation Department.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"128 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}