Minerva medica最新文献_第10页

Role of available COVID-19 vaccines in reducing deaths and perspective for next generation vaccines and therapies to counter emerging viral variants: an update. 现有COVID-19疫苗在减少死亡方面的作用以及应对新出现病毒变体的下一代疫苗和疗法的展望:最新情况。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2023-06-09 DOI: 10.23736/S0026-4806.23.08509-9

Mohd Wahid, Arshad Jawed, Raju K Mandal, Mohammed Y Areeshi, Nahed A El-Shall, Ranjan K Mohapatra, Hardeep S Tuli, Kuldeep Dhama, Rinaldo Pellicano, Sharmila Fagoonee, Shafiul Haque

{"title":"Role of available COVID-19 vaccines in reducing deaths and perspective for next generation vaccines and therapies to counter emerging viral variants: an update.","authors":"Mohd Wahid, Arshad Jawed, Raju K Mandal, Mohammed Y Areeshi, Nahed A El-Shall, Ranjan K Mohapatra, Hardeep S Tuli, Kuldeep Dhama, Rinaldo Pellicano, Sharmila Fagoonee, Shafiul Haque","doi":"10.23736/S0026-4806.23.08509-9","DOIUrl":"10.23736/S0026-4806.23.08509-9","url":null,"abstract":"The COVID-19 disease wreaked havoc all over the world causing more than 6 million deaths out of over 519 million confirmed cases. It not only disturbed the human race health-wise but also caused huge economic losses and social disturbances. The utmost urgency to counter pandemic was to develop effective vaccines as well as treatments that could reduce the incidences of infection, hospitalization and deaths. The most known vaccines that could help in managing these parameters are Oxford-AstraZeneca (AZD1222), Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273) and Johnson & Johnson (Ad26.COV2.S). The effectiveness of AZD1222 vaccine in reducing deaths is 88% in the age group 40-59 years, touching 100% in the age group 16-44 years & 65-84 years. BNT162b2 vaccine also did well in reducing deaths due to COVID-19 (95% in the age group 40-49 years and 100% in the age group 16-44 years. Similarly, mRNA-1273 vaccine showed potential in reducing COVID-19 deaths with effectiveness ranging from 80.3 to 100% depending upon age group of the vaccinated individuals. Ad26.COV2.S vaccine was also 100% effective in reducing COVID-19 deaths. The SARS-CoV-2 emerging variants have emphasized the need of booster vaccine doses to enhance protective immunity in vaccinated individuals. Additionally, therapeutic effectiveness of Molnupiravir, Paxlovid and Evusheld are also providing resistance against the spread of COVID-19 disease as well as may be effective against emerging variants. This review highlights the progress in developing COVID-19 vaccines, their protective efficacies, advances being made to design more efficacious vaccines, and presents an overview on advancements in developing potent drugs and monoclonal antibodies for countering COVID-19 and emerging variants of SARS-CoV-2 including the most recently emerged and highly mutated Omicron variant.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"683-697"},"PeriodicalIF":4.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D intoxication: myth or reality. 维生素D中毒:神话还是现实?

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2023-07-18 DOI: 10.23736/S0026-4806.23.08795-5

Giuseppe Pellegrino, Velio Ascenti, Elio Desiderio, Gianpaolo Carrafiello

引用次数: 0

Predictive value and significance of Ki67 Index in sentinel lymph node metastasis of early invasive breast cancer. Ki67指数对早期浸润性乳腺癌前哨淋巴结转移的预测价值及意义。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2021-09-03 DOI: 10.23736/S0026-4806.21.07729-6

Chen Gao, Xiaorong Bai, Suisheng Yang, Xuanzhen Da, Xiaoqin Li, Shibo Wang, Xi Zhang

引用次数: 0

Analysis of clinical characteristics and detection of pathogens in patients with pulmonary tuberculosis complicated with fungal infection. 肺结核合并真菌感染的临床特点及病原菌检测分析。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2021-10-21 DOI: 10.23736/S0026-4806.21.07881-2

Shanshan Chen, Jiankui Ye, Yanli Wang, Xiaoli Tang, Weiping Xie

引用次数: 0

Elimination of infusion-related reactions after the switch of Herceptin® with Zercepac®. 赫赛汀与Zercepac切换后输注相关反应的消除。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2022-07-05 DOI: 10.23736/S0026-4806.22.08214-3

Chang'an Wang

引用次数: 0

Safety evaluation of celecoxib in patients with ulcerative colitis in remission stage with arthritis. 塞来昔布对关节炎缓解期溃疡性结肠炎患者的安全性评价。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2021-12-03 DOI: 10.23736/S0026-4806.21.07856-3

Jing Guo, Lu Li, Qingtao Ren

引用次数: 0

Stevens-Johnson Syndrome complicated by Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a child. 史蒂文斯-约翰逊综合征并发爱泼斯坦-巴尔病毒相关的噬血细胞淋巴组织细胞增多症1例

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2023-04-06 DOI: 10.23736/S0026-4806.23.08608-1

Qi Liu, Liya Chen, Suhua Li, Meijuan Shao, Lingling Zhou, Yiping Chen, Shaoyan Hu

引用次数: 0

Chronic hepatitis B infection and diabetes mellitus: a double liver trouble? 慢性乙型肝炎感染和糖尿病:双重肝病?

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2023-03-13 DOI: 10.23736/S0026-4806.23.08428-8

Fadi Abu Baker, Yana Davidov, Areil Israel, Ilan Green, Randa Taher, Ziv Ben Ari, Saif Abu Mouch

{"title":"Chronic hepatitis B infection and diabetes mellitus: a double liver trouble?","authors":"Fadi Abu Baker, Yana Davidov, Areil Israel, Ilan Green, Randa Taher, Ziv Ben Ari, Saif Abu Mouch","doi":"10.23736/S0026-4806.23.08428-8","DOIUrl":"10.23736/S0026-4806.23.08428-8","url":null,"abstract":"Background: Concomitant Diabetes mellitus (DM) is commonly recognized in patients with chronic hepatitis B (CHB) infection, although its impact on liver-related outcomes remains controversial. We aimed to evaluate the effect of DM on the course, management and outcome of patients with CHB.Methods: We performed a large retrospective cohort study utilizing the Leumit-Health-Service (LHS) database. We reviewed electronic reports of 692106 LHS members from different ethnicities and districts in Israel from 2000-2019 and included patients with CHB diagnosis based on ICD-9-CM codes and supportive serology results. These were divided into two cohorts of patients with CHB and DM (CHD-DM) (N.=252) and those with CHB without DM (N.=964). Clinical parameters, treatment figures and patients' outcomes were compared and multiple regression models and Cox regression analysis were performed to investigate the association between DM and cirrhosis/HCC risk in CHB patients.Results: CHD-DM patients were significantly older (49.2±10.9 vs. 37.9±14, P<0.001), and had higher rates of obesity (BMI>30) and NAFLD (47.2% vs. 23.1%, and 27% vs. 12.6%, P<0.001, respectively). Both groups had a predominance of inactive carrier (HBeAg negative infection) state, but the HBeAg seroconversion rate was significantly lower in the CHB-DM group (25% vs. 45.7%; P<0.01). Multivariable Cox regression analysis showed that DM was independently associated with increased cirrhosis risk (HR 2.63; P=0.002). Older age, advanced fibrosis and DM were associated with HCC, but DM did not reach significance (HR 1.4; P=0.12) possibly due to the small number of HCC cases.Conclusions: Concomitant DM in CHB patients was significantly and independently associated with cirrhosis and possibly with increased risk of HCC.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"658-666"},"PeriodicalIF":4.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9091348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can natural immunity partially replace vaccine against SARS-COV2 infection? A small single center study. 自然免疫能否部分取代针对SARS-COV2感染的疫苗?一个小的单中心研究。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2021-03-12 DOI: 10.23736/S0026-4806.21.07458-9

Graziella Bonetti, Gianpaolo Chitoni, Alessandra Bettinardi, Gianluca Borrelli, Gianfranco Fiordalisi, Antonio Marino, Annamaria Menolfi, Roberta Volpi, Filippo Manelli, Maria S Cotelli

引用次数: 0

Effect of early bedside rehabilitation intervention on limb function recovery in patients with stroke. 早期床边康复干预对脑卒中患者肢体功能恢复的影响。

IF 4.7 4区医学

Minerva medica Pub Date : 2023-10-01 Epub Date: 2021-12-03 DOI: 10.23736/S0026-4806.21.07902-7

Hua Li, Yong Liang, Chunmei Yang, Keru Zhang, Miao Tian, Bin Chen, Ji Xu

引用次数: 0