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Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease. 针对性护理干预对老年冠心病患者负面精神状态和生活质量的影响。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06759-2
Xiwei Chen, Ying Tian, Jing Qin, Jing Liu
{"title":"Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease.","authors":"Xiwei Chen, Ying Tian, Jing Qin, Jing Liu","doi":"10.23736/S0026-4806.20.06759-2","DOIUrl":"10.23736/S0026-4806.20.06759-2","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"690-692"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis. 环状 RNA circFANCL 通过对 miR-337-3p/HMGB1 信号轴的作用推动胶质瘤的发展。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4806.20.06639-2
Tao Wang, Jia Zhou, Mengshi Wu, Wei Luo, Feng Liang
{"title":"Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis.","authors":"Tao Wang, Jia Zhou, Mengshi Wu, Wei Luo, Feng Liang","doi":"10.23736/S0026-4806.20.06639-2","DOIUrl":"10.23736/S0026-4806.20.06639-2","url":null,"abstract":"<p><strong>Background: </strong>Circular RNAs (circRNAs) are significant modulatory molecules in the developing process of glioma. Our study will emphasize on exploring the function of circRNA Fanconi anemia group L protein (circFANCL) and the specific mechanism in glioma.</p><p><strong>Methods: </strong>The quantitative real-time polymerase chain reaction (qRT-PCR) was implemented for detecting circFANCL, microRNA-337-3p (miR-337-3p) and high-mobility group box-1 (HMGB1). Cell proliferation analysis was assessed using cell counting kit-8 (CCK-8) and colony formation assays. Flow cytometry was applied to determine cell cycle and apoptosis. All protein detection was completed by western blot. Animal experiment was performed to investigate the role of circFANCL in vivo. Dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays were collectively conducted for analyzing the targeted combination.</p><p><strong>Results: </strong>CircFANCL was signally increased in glioma tissues and cells, and the up-regulated circFANCL could predict poor prognosis in clinical glioma patients. Down-regulated circFANCL induced the proliferation inhibition, cell cycle arrest and apoptosis promotion of glioma cells in vitro, and inhibited tumor growth in vivo. Regarding the mechanism, circFANCL served as a sponge of miR-337-3p that was a tumor suppressor in glioma and circFANCL targeted miR-337-3p to regulate HMGB1 that was a target gene of miR-337-3p. Furthermore, HMGB1 down-regulation was responsible for the repression of glioma progression caused by knockdown of circFANCL.</p><p><strong>Conclusions: </strong>Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"623-634"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38169261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference value of magnetic resonance imaging and echocardiography in the diagnosis of pulmonary hypertension at high altitude. 磁共振成像和超声心动图在高海拔地区肺动脉高压诊断中的参考价值。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-07-21 DOI: 10.23736/S0026-4806.20.06760-9
Caiying Pei, Qianqian Cui, Qinghua Zhao, Yilin Liu, Chunxia Wang, Lihua Jing
{"title":"Reference value of magnetic resonance imaging and echocardiography in the diagnosis of pulmonary hypertension at high altitude.","authors":"Caiying Pei, Qianqian Cui, Qinghua Zhao, Yilin Liu, Chunxia Wang, Lihua Jing","doi":"10.23736/S0026-4806.20.06760-9","DOIUrl":"10.23736/S0026-4806.20.06760-9","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"692-693"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38182379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge. COVID-19 存活者出院 2 年后仍有呼吸道症状的血小板促血栓形成活性。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2023-05-19 DOI: 10.23736/S0026-4806.23.08661-5
Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo
{"title":"Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge.","authors":"Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo","doi":"10.23736/S0026-4806.23.08661-5","DOIUrl":"10.23736/S0026-4806.23.08661-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"695-697"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the effect of improved emergency nursing process on the treatment of patients with acute chest pain. 分析改进急诊护理流程对急性胸痛患者治疗的影响。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06755-5
Jing Song, Jun Li, Xingzhen Wang, Li Liu
{"title":"Analysis of the effect of improved emergency nursing process on the treatment of patients with acute chest pain.","authors":"Jing Song, Jun Li, Xingzhen Wang, Li Liu","doi":"10.23736/S0026-4806.20.06755-5","DOIUrl":"10.23736/S0026-4806.20.06755-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"689-690"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoadjuvant therapy for HER2-positive and negative simultaneous bilateral primary breast cancer. HER2阳性和阴性同时存在的双侧原发性乳腺癌的新辅助治疗。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2022-07-05 DOI: 10.23736/S0026-4806.22.08238-6
Yan Mao, Haibo Wang
{"title":"Neoadjuvant therapy for HER2-positive and negative simultaneous bilateral primary breast cancer.","authors":"Yan Mao, Haibo Wang","doi":"10.23736/S0026-4806.22.08238-6","DOIUrl":"10.23736/S0026-4806.22.08238-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"697-698"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the effect of lower limb nursing on prevention of deep venous thrombosis in long-term bedridden patients. 下肢护理对长期卧床患者预防深静脉血栓形成的影响分析。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-10-01 Epub Date: 2020-07-20 DOI: 10.23736/S0026-4806.20.06681-1
Wenting Zou, Ying Li, Ziheng Xue
{"title":"Analysis of the effect of lower limb nursing on prevention of deep venous thrombosis in long-term bedridden patients.","authors":"Wenting Zou, Ying Li, Ziheng Xue","doi":"10.23736/S0026-4806.20.06681-1","DOIUrl":"10.23736/S0026-4806.20.06681-1","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"616-618"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of whole-course seamless link nursing model intervention on the treatment of acute coronary syndrome. 全程无缝链接护理模式干预对急性冠状动脉综合征治疗的影响。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-10-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06753-1
Lili Guo, Cuiling Mu, Ting Yang, Defen Yin
{"title":"Effect of whole-course seamless link nursing model intervention on the treatment of acute coronary syndrome.","authors":"Lili Guo, Cuiling Mu, Ting Yang, Defen Yin","doi":"10.23736/S0026-4806.20.06753-1","DOIUrl":"10.23736/S0026-4806.20.06753-1","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"619-621"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NF-κB signaling pathway promotes proliferation and inhibits apoptosis of childhood acute lymphoblastic leukemia cells via regulating CRIM1. NF-κB 信号通路通过调控 CRIM1 促进儿童急性淋巴细胞白血病细胞的增殖并抑制其凋亡。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-10-01 Epub Date: 2020-07-21 DOI: 10.23736/S0026-4806.20.06752-X
Honglei Shi, Bin Xu, Min Yang
{"title":"NF-κB signaling pathway promotes proliferation and inhibits apoptosis of childhood acute lymphoblastic leukemia cells via regulating CRIM1.","authors":"Honglei Shi, Bin Xu, Min Yang","doi":"10.23736/S0026-4806.20.06752-X","DOIUrl":"10.23736/S0026-4806.20.06752-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"618-619"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38182377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression and prognostic significance of Topo-II and c-erbB-2 in breast cancer. Topo-II和c-erbB-2在乳腺癌中的表达及其预后意义。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-08-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4806.20.06637-9
Hua Shao, Chuanbo Feng, Zhonglin Wang, Shuangjiu Zhu, Xinwen Zheng
{"title":"The expression and prognostic significance of Topo-II and c-erbB-2 in breast cancer.","authors":"Hua Shao, Chuanbo Feng, Zhonglin Wang, Shuangjiu Zhu, Xinwen Zheng","doi":"10.23736/S0026-4806.20.06637-9","DOIUrl":"10.23736/S0026-4806.20.06637-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the expression and prognostic significance of topoisomeraseII (Topo-II) and c-erbB-2.</p><p><strong>Methods: </strong>A total of 92 cases of patients with breast cancer who came to our hospital for treatment from November 2013 to January 2016 were included as the experimental group, and 90 healthy subjects who came to our hospital for physical examination during the same period were selected as the control group. ELISA was used to detect the expression levels of Topo-II and c-erbB-2 in serum of each group. The correlation among expression levels, degree of tumor differentiation and pathological types of Topo-II and c-erbB-2 in serum of patients with breast cancer were observed.</p><p><strong>Results: </strong>The expression levels of Topo-II and c-erbB-2 in the experimental group were higher than those in the control group (P<0.05). The expression levels of Topo-II and c-erbB-2 in serum of patients with different stages increased with the clinical stages. The survival rate of patients with different expression levels of Topo-II and c-erbB-2 was compared, it was found that the survival rate of the low-expression group (80.49%) was significantly higher than that of the high-expression group (50.98%). The ROC curve was used to analyze Topo-II and c-erbB-2, the result showed that the sensitivity, specificity and AUC of Topo-II in the diagnosis of breast cancer was 72.22%, 94.56% and 0.8641, respectively. The sensitivity, specificity, and AUC of c-erbB-2 in the diagnosis of breast cancer were 94.45%, 66.30% and 0.8379, respectively.</p><p><strong>Conclusions: </strong>In conclusion, Topo-II and c-erbB-2 are highly expressed in breast cancer and are closely related to breast cancer. Moreover, the detection of Topo-II and c-erbB-2 in serum can help diagnose gestational diabetes mellitus quickly and effectively.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"458-464"},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38169260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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