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Predictive markers associated to fibrotic evolution in hypersensitivity pneumonitis: a single institution's analysis. 与超敏性肺炎纤维化演变相关的预测标志物：单一机构的分析。
IF 4.7 4区 医学
Minerva medica Pub Date : 2025-02-01 Epub Date: 2023-09-15 DOI: 10.23736/S0026-4806.23.08823-7
Francesco R Bertuccio, Valerio Partenope, Davide Piloni, Simone Montini, Nicola Baio, Chandra Bortolotto, Adele Valentini, Angelo G Corsico, Giulia M Stella
{"title":"Predictive markers associated to fibrotic evolution in hypersensitivity pneumonitis: a single institution's analysis.","authors":"Francesco R Bertuccio, Valerio Partenope, Davide Piloni, Simone Montini, Nicola Baio, Chandra Bortolotto, Adele Valentini, Angelo G Corsico, Giulia M Stella","doi":"10.23736/S0026-4806.23.08823-7","DOIUrl":"10.23736/S0026-4806.23.08823-7","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"79-81"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10592210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the effect of targeted nursing in patients with endocrine disorders and obesity. 对内分泌失调和肥胖症患者进行针对性护理的效果分析。
IF 4.7 4区 医学
Minerva medica Pub Date : 2025-02-01 Epub Date: 2020-07-28 DOI: 10.23736/S0026-4806.20.06844-5
Hong Xin, Hongxia Shao, Hongyan Deng
{"title":"Analysis of the effect of targeted nursing in patients with endocrine disorders and obesity.","authors":"Hong Xin, Hongxia Shao, Hongyan Deng","doi":"10.23736/S0026-4806.20.06844-5","DOIUrl":"10.23736/S0026-4806.20.06844-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"84-86"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38207329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed treatment with endostatin displays a protective role against pulmonary hypertension by targeting VEGF pathway. 通过靶向血管内皮生长因子通路，内司他丁延迟治疗对肺动脉高压具有保护作用。
IF 4.7 4区 医学
Minerva medica Pub Date : 2025-02-01 Epub Date: 2021-04-29 DOI: 10.23736/S0026-4806.21.07145-7
Shuai Huang, Nannan Li, Dong Yan
{"title":"Delayed treatment with endostatin displays a protective role against pulmonary hypertension by targeting VEGF pathway.","authors":"Shuai Huang, Nannan Li, Dong Yan","doi":"10.23736/S0026-4806.21.07145-7","DOIUrl":"10.23736/S0026-4806.21.07145-7","url":null,"abstract":"<p><strong>Background: </strong>Endostatin (ES) is an endogenous angiogenesis inhibitor. It is confirmed that ES has antitumor effects and plays a crucial part in regulating vascular smooth cells' proliferation. However, ES's effect on pulmonary hypertension (PH) is unclear. The aim of this study was to determine the effect of ES on PH's pathogenesis.</p><p><strong>Methods: </strong>PH was induced by pneumonectomy plus monocrotaline (MCT) injection, as indicated with significantly increased pulmonary arterial pressure and vascular wall thickness.</p><p><strong>Results: </strong>Immunohistochemical analysis showed that under physiological conditions, ES localized in endothelial cells (ECs) and spread to the muscular vascular layers in PH rats. ES was transfected into the lungs of rats intratracheally 2 weeks after MCT injection. Consequently, ES not only reduced elevated VEGF's expression but also reversed pulmonary artery remodeling. Eventually, ES improved elevated right ventricular (RV) mean pressure and RV hypertrophy.</p><p><strong>Conclusions: </strong>The administration of ES may be a new treatment for PH and PA remodeling, associating with the downregulation of VEGF production.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"13-21"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38919115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of pars plana vitrectomy combined with internal limiting membrane peeling for macular hollow retinal detachment. 玻璃体旁切除术联合内缘膜剥离治疗黄斑空洞性视网膜脱离的有效性和安全性。
IF 4.7 4区 医学
Minerva medica Pub Date : 2025-02-01 Epub Date: 2020-09-03 DOI: 10.23736/S0026-4806.20.06841-X
Jinwei Ren, Min Liu, Linlin Wang, Mingtao Zhao
{"title":"Efficacy and safety of pars plana vitrectomy combined with internal limiting membrane peeling for macular hollow retinal detachment.","authors":"Jinwei Ren, Min Liu, Linlin Wang, Mingtao Zhao","doi":"10.23736/S0026-4806.20.06841-X","DOIUrl":"10.23736/S0026-4806.20.06841-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"83-84"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38339859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose corticosteroids adjusted to oxygen requirement and monitoring of serum C-reactive protein to improve outcome of non-critically ill COVID-19 patients: the CocAA-CoLa Plus Study. 根据需氧量调整大剂量皮质类固醇并监测血清c反应蛋白以改善非危重症COVID-19患者的预后：可口可乐+研究
IF 4.7 4区 医学
Minerva medica Pub Date : 2025-02-01 Epub Date: 2023-05-11 DOI: 10.23736/S0026-4806.22.08326-4
Jean-Philippe Kevorkian, Claire Vandiedonck, Jean Laganier, Amanda Lopes, Ruxandra Burlacu, Florine Feron, Marie-Laure Chai X, Damien Sene, Jean-Pierre Riveline, Jean-François Gautier, Bruno Megarbane
{"title":"High-dose corticosteroids adjusted to oxygen requirement and monitoring of serum C-reactive protein to improve outcome of non-critically ill COVID-19 patients: the CocAA-CoLa Plus Study.","authors":"Jean-Philippe Kevorkian, Claire Vandiedonck, Jean Laganier, Amanda Lopes, Ruxandra Burlacu, Florine Feron, Marie-Laure Chai X, Damien Sene, Jean-Pierre Riveline, Jean-François Gautier, Bruno Megarbane","doi":"10.23736/S0026-4806.22.08326-4","DOIUrl":"10.23736/S0026-4806.22.08326-4","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"75-79"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease. 针对性护理干预对老年冠心病患者负面精神状态和生活质量的影响。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06759-2
Xiwei Chen, Ying Tian, Jing Qin, Jing Liu
{"title":"Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease.","authors":"Xiwei Chen, Ying Tian, Jing Qin, Jing Liu","doi":"10.23736/S0026-4806.20.06759-2","DOIUrl":"10.23736/S0026-4806.20.06759-2","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"690-692"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis. 环状 RNA circFANCL 通过对 miR-337-3p/HMGB1 信号轴的作用推动胶质瘤的发展。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4806.20.06639-2
Tao Wang, Jia Zhou, Mengshi Wu, Wei Luo, Feng Liang
{"title":"Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis.","authors":"Tao Wang, Jia Zhou, Mengshi Wu, Wei Luo, Feng Liang","doi":"10.23736/S0026-4806.20.06639-2","DOIUrl":"10.23736/S0026-4806.20.06639-2","url":null,"abstract":"<p><strong>Background: </strong>Circular RNAs (circRNAs) are significant modulatory molecules in the developing process of glioma. Our study will emphasize on exploring the function of circRNA Fanconi anemia group L protein (circFANCL) and the specific mechanism in glioma.</p><p><strong>Methods: </strong>The quantitative real-time polymerase chain reaction (qRT-PCR) was implemented for detecting circFANCL, microRNA-337-3p (miR-337-3p) and high-mobility group box-1 (HMGB1). Cell proliferation analysis was assessed using cell counting kit-8 (CCK-8) and colony formation assays. Flow cytometry was applied to determine cell cycle and apoptosis. All protein detection was completed by western blot. Animal experiment was performed to investigate the role of circFANCL in vivo. Dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays were collectively conducted for analyzing the targeted combination.</p><p><strong>Results: </strong>CircFANCL was signally increased in glioma tissues and cells, and the up-regulated circFANCL could predict poor prognosis in clinical glioma patients. Down-regulated circFANCL induced the proliferation inhibition, cell cycle arrest and apoptosis promotion of glioma cells in vitro, and inhibited tumor growth in vivo. Regarding the mechanism, circFANCL served as a sponge of miR-337-3p that was a tumor suppressor in glioma and circFANCL targeted miR-337-3p to regulate HMGB1 that was a target gene of miR-337-3p. Furthermore, HMGB1 down-regulation was responsible for the repression of glioma progression caused by knockdown of circFANCL.</p><p><strong>Conclusions: </strong>Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"623-634"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38169261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference value of magnetic resonance imaging and echocardiography in the diagnosis of pulmonary hypertension at high altitude. 磁共振成像和超声心动图在高海拔地区肺动脉高压诊断中的参考价值。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-07-21 DOI: 10.23736/S0026-4806.20.06760-9
Caiying Pei, Qianqian Cui, Qinghua Zhao, Yilin Liu, Chunxia Wang, Lihua Jing
{"title":"Reference value of magnetic resonance imaging and echocardiography in the diagnosis of pulmonary hypertension at high altitude.","authors":"Caiying Pei, Qianqian Cui, Qinghua Zhao, Yilin Liu, Chunxia Wang, Lihua Jing","doi":"10.23736/S0026-4806.20.06760-9","DOIUrl":"10.23736/S0026-4806.20.06760-9","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"692-693"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38182379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge. COVID-19 存活者出院 2 年后仍有呼吸道症状的血小板促血栓形成活性。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2023-05-19 DOI: 10.23736/S0026-4806.23.08661-5
Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo
{"title":"Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge.","authors":"Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo","doi":"10.23736/S0026-4806.23.08661-5","DOIUrl":"10.23736/S0026-4806.23.08661-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"695-697"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the effect of improved emergency nursing process on the treatment of patients with acute chest pain. 分析改进急诊护理流程对急性胸痛患者治疗的影响。
IF 4.7 4区 医学
Minerva medica Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06755-5
Jing Song, Jun Li, Xingzhen Wang, Li Liu
{"title":"Analysis of the effect of improved emergency nursing process on the treatment of patients with acute chest pain.","authors":"Jing Song, Jun Li, Xingzhen Wang, Li Liu","doi":"10.23736/S0026-4806.20.06755-5","DOIUrl":"10.23736/S0026-4806.20.06755-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"689-690"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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