Minerva cardiology and angiology最新文献

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Prolonged atrial refractoriness to predict the onset of atrial fibrillation after transcatheter aortic valve implantation. 通过延长心房折返时间预测经导管主动脉瓣植入术后心房颤动的发生。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-11-13 DOI: 10.23736/S2724-5683.24.06605-5
Özcan Özdemir, Ersin Doğanözü, Onur Yildirim
{"title":"Prolonged atrial refractoriness to predict the onset of atrial fibrillation after transcatheter aortic valve implantation.","authors":"Özcan Özdemir, Ersin Doğanözü, Onur Yildirim","doi":"10.23736/S2724-5683.24.06605-5","DOIUrl":"10.23736/S2724-5683.24.06605-5","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common atrial arrhythmia after transcatheter aortic valve implantation (TAVI) and is associated with high mortality. Although some clinical and echocardiographic variables have been defined to predict new-onset atrial fibrillation (NOAF), electrophysiologic (EP) parameters have not been identified yet. We aimed to investigate the impact of atrial refractoriness on NOAF after TAVI.</p><p><strong>Methods: </strong>Seventy-nine consecutive patients who underwent TAVI were enrolled in this trial. All patients undergoing TAVI were screened for AF.</p><p><strong>Results: </strong>Fifteen (19%) had AF during the follow-up period. Patients with NOAF were older and had a higher BMI and STS. Left atrial diameter (LAD) was higher, left ventricular ejection fraction (LVEF) was lower, and preprocedural LVEDP was higher in patients with NOAF. As electrophysiologic (EP) parameters, atrial effective refractory periods (AERP) (in high right atrium [AERP<inf>HRA</inf>], in right posterolateral atrium [AERP<inf>RPL</inf>], and in distal coronary sinus [AERP<inf>DCS</inf>]) were lower, difference between atrial effective refractory periods (AERP<inf>DISP</inf>) and PA intervals were higher in patients with AF than those without AF. The only independent parameter that influenced the development of AF after TAVI was AERP<inf>DISP</inf>. The Receiver Operating Characteristic (ROC) analysis showed that an AERP<inf>DISP</inf>>46 msec significantly separated those with AF and those without AF with a sensitivity of 85% and a specificity of 97%.</p><p><strong>Conclusions: </strong>The current study demonstrates that the only independent variable predicting NOAF is AERPDISP. Therefore, increased AERPDISP values may help predict patients with high risk for NOAF and needing specific therapies.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"166-173"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echocardiographic assessment of patient hemodynamics in heart failure. 对心力衰竭患者血液动力学进行超声心动图评估。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-07-01 DOI: 10.23736/S2724-5683.24.06471-8
Federico Fortuni, Sara Morroni, Paolo Biagioli, Rinchyenkhand Myagmardorj, Caterina Viti, Stefano Sforna, Sara Moscatelli, Hoi W Wu, Giuseppe Ambrosio, Jeroen J Bax, Nina Ajmone Marsan, Erberto Carluccio
{"title":"Echocardiographic assessment of patient hemodynamics in heart failure.","authors":"Federico Fortuni, Sara Morroni, Paolo Biagioli, Rinchyenkhand Myagmardorj, Caterina Viti, Stefano Sforna, Sara Moscatelli, Hoi W Wu, Giuseppe Ambrosio, Jeroen J Bax, Nina Ajmone Marsan, Erberto Carluccio","doi":"10.23736/S2724-5683.24.06471-8","DOIUrl":"10.23736/S2724-5683.24.06471-8","url":null,"abstract":"<p><p>Heart failure (HF) is a clinical syndrome which is due to cardiac structural and/or functional abnormalities that result in elevated intra-cardiac pressures and/or inadequate cardiac output. Hemodynamic assessment in HF allows the identification and characterization of cardiac dysfunction, systemic and/or pulmonary congestion and the eventual impairment of systemic perfusion which are fundamental to phenotype HF, risk stratify HF patients and to guide their treatment. Patient hemodynamics can be characterized invasively with right heart catheterization but also non-invasively with the use of echocardiography and other non-invasive ultrasound tools. The aim of the present review is to summarize the main echocardiographic and ultrasound parameters to characterize the hemodynamics of patients with HF and help clinicians to make the most of these non-invasive tools to guide HF patient management.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"219-237"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for cardiovascular diseases: the focus on primary prevention. 心血管疾病的危险因素:重点放在初级预防上。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2023-11-16 DOI: 10.23736/S2724-5683.23.06360-3
Magdalena Wolska, Mariangela Peruzzi, Karol Kaziród-Wolski, Paweł Wróbel, Izabela Oleś, Janusz Sielski, Piotr Jankowski
{"title":"Risk factors for cardiovascular diseases: the focus on primary prevention.","authors":"Magdalena Wolska, Mariangela Peruzzi, Karol Kaziród-Wolski, Paweł Wróbel, Izabela Oleś, Janusz Sielski, Piotr Jankowski","doi":"10.23736/S2724-5683.23.06360-3","DOIUrl":"10.23736/S2724-5683.23.06360-3","url":null,"abstract":"<p><p>Views on the etiopathogenesis of atherosclerosis are subject to evolution. In addition to the classic well-known risk factors, new ones related to mental state, social life and environment are being discovered. Both acute and chronic stress stimulate inflammatory processes. Due to the change in lifestyle and eating habits, the accumulation of risk factors in childhood is an increasing problem. Knowledge of risk factors allows for effective primary prevention of cardiovascular diseases. The effectiveness of prevention increases when the activities cover the largest possible part of the society, and access to a doctor is easy. Therefore, government programs are being implemented offering patients easier access to diagnostics of cardiovascular diseases at the level of primary health care, which enables faster identification of people at the greatest cardiovascular risk. Easier access to primary care and a good doctor-patient relationship improve patient compliance. In this situation, the importance of the family doctor as a key link in the diagnosis, prevention and treatment of cardiovascular diseases is increasing.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"245-253"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of FOCUS-PDCA on reducing the incidence of complications after transradial intervention. FOCUS-PDCA 对降低经桡动脉介入术后并发症发生率的影响。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-10-08 DOI: 10.23736/S2724-5683.24.06544-X
Tong Zhou, Jing Liu, Shuangshuang Wang, Qian Zhang
{"title":"Impact of FOCUS-PDCA on reducing the incidence of complications after transradial intervention.","authors":"Tong Zhou, Jing Liu, Shuangshuang Wang, Qian Zhang","doi":"10.23736/S2724-5683.24.06544-X","DOIUrl":"10.23736/S2724-5683.24.06544-X","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the effect of the find, organize, clarify, understand, select-plan, do, check, act (FOCUS-PDCA) procedure on reducing the incidence of complications at the puncture site.</p><p><strong>Methods: </strong>Patients who underwent the transradial interventional therapy (TRI) were divided into control (N.=160) and FOCUS-PDCA (N.=158) groups. The postoperative complications at the puncture site was observed in the two groups, and the pain, bleeding, swelling and comfort of the two groups were compared and analyzed.</p><p><strong>Results: </strong>Two hours after surgery, the number of pain-free patients in the observation group was significantly higher than that in the control group (62.1% vs. 44.4%, P=0.014). The degree of swelling at 6 and 2 hours after TRI in observation group was significantly lower than that in control group (-0.08±0.23 vs. -0.00±0.17, P=0.001). No early radial artery occlusion was found in either group. The postoperative comfort score in observation group was significantly higher than that in control group (101.94±9.99 vs. 91.14±14.50, P<0.001).</p><p><strong>Conclusions: </strong>The FOCUS-PDCA approach may reduce the incidence of early pain and long-term swelling after TRI, improve patient comfort, and enhance the quality of specialist care. The results suggested that FOCUS-PDCA had the value of popularization and application.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"154-162"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miRNA-148a-3p targets to regulate the lipid metabolism gene SOCS3 to reduce myocardial ischemia/reperfusion injury. miRNA-148a-3p 靶向调节脂质代谢基因 SOCS3 以减轻心肌缺血再灌注损伤。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-11-13 DOI: 10.23736/S2724-5683.24.06578-5
Changgan Mo, Xiuge Tang, Ying Wei, Hui Han, Guangsuo Wei, Liyuan Wei, Xu Lin
{"title":"miRNA-148a-3p targets to regulate the lipid metabolism gene SOCS3 to reduce myocardial ischemia/reperfusion injury.","authors":"Changgan Mo, Xiuge Tang, Ying Wei, Hui Han, Guangsuo Wei, Liyuan Wei, Xu Lin","doi":"10.23736/S2724-5683.24.06578-5","DOIUrl":"10.23736/S2724-5683.24.06578-5","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) is a major cause of death in cardiovascular patients. SOCS3's protective role in cardiac I/R-I is being explored, and miRNAs, particularly miRNA-148a-3p, are suspected to target SOCS3. To elucidate the role of miRNA-148a-3p targeting lipid metabolism gene SOCS3 in cardiac ischemia-reperfusion injury (I/R-I) in rats.</p><p><strong>Methods: </strong>Derived mRNA expression data GSE59867 from GEO, identified 558 lipid metabolism genes from KEGG and GSEA, and screened for differentially expressed genes in acute myocardial infarction (AMI). Predicted miRNA-148a-3p targeting SOCS3 using TargetScanHuman, validated binding via luciferase assay and 3'UTR mutation. Established a rat I/R-I model to assess miRNA-148a-3p and SOCS3 expression, and investigated SOCS3 regulation by miRNA-148a-3p overexpression. Analyzed expression of NF-κB p65, IL-1β, and TNF-α-related proteins, and evaluated cardiac hemodynamics post-SOCS3 regulation by miRNA-148a-3p.</p><p><strong>Results: </strong>In GSE59867, TSPO, SOCS3, LRP1, PLB1, CYP1B1, PPARG, ACSL1, and CYP27A1 were identified as differentially expressed lipid metabolism genes in AMI. The results of immune infiltration showed a close relationship between the differential lipid metabolism genes and the infiltration of immune cells such as macrophages and monocytes. The random forest algorithm identified SOCS3 as the key gene. The luciferase reporter gene demonstrated the participation of miRNA-148a-3p in the regulation of SOCS3 by binding to its 3'UTR. In vivo experiments revealed low expression of miRNA-148a-3p in myocardial I/R, while SOCS3 was highly expressed. Elevated miRNA-148a-3p expression led to a decrease in SOCS3, NF-κB p65, IL-1β, and TNF-α levels during cardiac I/R-I. Overexpression of miRNA-148a-3p enhanced the cardiac performance in rats experiencing cardiac I/R-I.</p><p><strong>Conclusions: </strong>Overexpression of miRNA-148a-3p regulates NF-κB signaling pathway by targeting lipid metabolism gene SOCS3, reduces inflammatory response, and then reduces cardiac I/R-I in rats.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"136-146"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian variation in patients with acute heart failure with preserved ejection fraction. 保留射血分数的急性心力衰竭患者的昼夜变化。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 DOI: 10.23736/S2724-5683.24.06665-1
Kenichi Matsushita, Kazumasa Harada, Takahiro Jimba, Takashi Kohno, Hiroki Nakano, Akito Shindo, Makoto Takei, Shun Kohsaka, Hideaki Yoshino, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
{"title":"Circadian variation in patients with acute heart failure with preserved ejection fraction.","authors":"Kenichi Matsushita, Kazumasa Harada, Takahiro Jimba, Takashi Kohno, Hiroki Nakano, Akito Shindo, Makoto Takei, Shun Kohsaka, Hideaki Yoshino, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama","doi":"10.23736/S2724-5683.24.06665-1","DOIUrl":"10.23736/S2724-5683.24.06665-1","url":null,"abstract":"<p><strong>Background: </strong>The circadian system influences the pathophysiology of many cardiovascular diseases; however, circadian variations in patients with heart failure with preserved ejection fraction (HFpEF) are unknown. Thus, this study aimed to compare the clinical characteristics and risk factors for in-hospital mortality between patients with daytime- versus nighttime-onset HFpEF.</p><p><strong>Methods: </strong>This multicenter retrospective study included 3875 consecutive patients with acute HFpEF. Daytime and nighttime periods were defined as 6:00-17:59 and 18:00-5:59, respectively. Potential prognostic factors for in-hospital mortality were selected using univariable analyses. Those with P values of <0.10 were used in multivariable logistic regression analyses with forward selection (likelihood ratios) to identify significant prognostic factors.</p><p><strong>Results: </strong>The incidence of daytime-onset HFpEF was significantly lower but the in-hospital mortality was significantly higher than that of nighttime-onset HFpEF. Independent prognostic factors for in-hospital mortality in patients with daytime-onset HFpEF were age (odds ratio [OR], 1.057) and systolic blood pressure (OR: 0.979). In contrast, age (OR: 1.067), coexisting atrial fibrillation/flutter (OR: 2.023), systolic blood pressure (OR: 0.989), estimated glomerular filtration rate (OR: 0.971), treatment with diuretics (OR: 0.282), and treatment with beta-blockers (OR: 0.514) were independent prognostic factors in patients with nighttime-onset HFpEF.</p><p><strong>Conclusions: </strong>The incidence of acute HFpEF exhibits circadian variations, and onset-related differences in clinical characteristics and prognostic factors for in-hospital mortality were identified. These findings may provide new insights for future research and guide individualized patient management strategies.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":"73 2","pages":"174-183"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of physical activity on left ventricular dimensions and function after myocardial infarction: a systematic review. 体育活动对心肌梗死后左心室尺寸和功能的影响:一项系统综述。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2023-10-23 DOI: 10.23736/S2724-5683.23.06356-1
Elisabetta Tonet, Alberto Boccadoro, Maria L Berloni, Veronica Amantea, Giovanni Grazzi, Gianni Mazzoni, Silvia Zagnoni, Andrea Raisi, Luca Canovi, Francesco Vitali, Rita Pavasini, Antonella Scala, Camilla Matese, Gabriele Guidi Colombi, Marco De Pietri, Giorgio Chiaranda, Gianluca Campo
{"title":"Effect of physical activity on left ventricular dimensions and function after myocardial infarction: a systematic review.","authors":"Elisabetta Tonet, Alberto Boccadoro, Maria L Berloni, Veronica Amantea, Giovanni Grazzi, Gianni Mazzoni, Silvia Zagnoni, Andrea Raisi, Luca Canovi, Francesco Vitali, Rita Pavasini, Antonella Scala, Camilla Matese, Gabriele Guidi Colombi, Marco De Pietri, Giorgio Chiaranda, Gianluca Campo","doi":"10.23736/S2724-5683.23.06356-1","DOIUrl":"10.23736/S2724-5683.23.06356-1","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary artery disease is the major pathophysiological driver of ventricular remodeling. A multimodal intervention is the key strategy to promote a positive left ventricular remodeling with improvement in volumes and ejection fraction, known as \"reverse remodeling.\" The aim of this review was to highlight the effect of physical activity (PA) on echocardiographic and cardiac magnetic resonance parameters of left ventricle in patients with myocardial infarction.</p><p><strong>Evidence acquisition: </strong>We performed a systematic review of the literature to summarize current evidence about the efficacy (in terms of improvement in chamber dimensions, ejection fraction, speckle tracking and diastolic function) of physical activity in patients with myocardial infarction, supported by echocardiographic or magnetic resonance data. Articles were searched in Pubmed, Cochrane Library and Biomed Central.</p><p><strong>Evidence synthesis: </strong>Only papers published in English and in peer-reviewed journals up to November 2022 were selected. After an initial evaluation, 1029 records were screened; the literature search identified 20 relevant articles. From this data, some PA protocols appeared to favor left ventricular reverse remodeling.</p><p><strong>Conclusions: </strong>PA provides beneficial effects on left ventricular parameters analyzed by echocardiography and cardiac magnetic resonance.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"238-244"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of serum miR-4429 discriminates chronic heart failure patients and regulates cardiomyocyte injury via modulating HAPLN1. 血清 miR-4429 的上调可鉴别慢性心力衰竭患者,并通过调节 HAPLN1 来调节心肌细胞损伤。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-09-16 DOI: 10.23736/S2724-5683.24.06596-7
He Sun, Yiming Yu, Xiao Ge, Lifang Cao, Feng Li, Jingjing Wu
{"title":"Upregulation of serum miR-4429 discriminates chronic heart failure patients and regulates cardiomyocyte injury via modulating HAPLN1.","authors":"He Sun, Yiming Yu, Xiao Ge, Lifang Cao, Feng Li, Jingjing Wu","doi":"10.23736/S2724-5683.24.06596-7","DOIUrl":"10.23736/S2724-5683.24.06596-7","url":null,"abstract":"<p><strong>Background: </strong>Chronic heart failure (CHF) is the outcome of various cardiac diseases. Due to the unobvious symptoms of early-stage CHF, the screening of CHF remains a challenging problem. This study focused on the dysregulated miR-4429 and evaluated its significance in the diagnosis and development of CHF, aiming to explore a novel biomarker for CHF.</p><p><strong>Methods: </strong>A total of 103 CHF patients and 71 healthy individuals with matched clinicopathological features were enrolled. Serum miR-4429 levels were analyzed by PCR and its significance in discriminating CHF patients was evaluated by receiver operatinf curve (ROC). Cardiomyocyte was treated with H<inf>2</inf>O<inf>2</inf> to mimic cell injury during CHF, the regulatory effect and the underlying mechanism of miR-4429 was investigated by cell transfection and cell counting kit-8 assay.</p><p><strong>Results: </strong>miR-4429 was significantly upregulated in CHF patients (P< 0.0001), which sensitively and specifically discriminated CHF patients from healthy individuals (AUC=0.803, 95% CI=0.735-0.872). miR-4429 was closely associated with the decreased cardiac function of CHF patients (r>0.5, P<0.0001). H<inf>2</inf>O<inf>2</inf> induced increased miR-4429 and reduced HAPLN1 in cardiomyocytes (P<0.001). H<inf>2</inf>O<inf>2</inf>-treated cardiomyocytes showed inhibited proliferation and increased reactive oxygen species (ROS) levels, and silencing miR-4429 could alleviate cardiomyocyte injury caused by H<inf>2</inf>O<inf>2</inf> (P<0.0001). miR-4429 negatively regulated HAPLN1, and the knockdown of HAPLN1 could reverse the protective effect of silencing miR-4429 on cardiomyocyte injury (P<0.0001).</p><p><strong>Conclusions: </strong>The upregulation of miR-4429 served as a biomarker discriminating CHF patients and indicating severe disease conditions. Silencing miR-4429 could alleviate cardiomyocyte injury via negatively regulating HAPLN1.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"184-191"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future of factor XI inhibitors in cardiovascular practice. XI 因子抑制剂在心血管领域的应用前景。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-05-27 DOI: 10.23736/S2724-5683.23.06474-8
Antonio Greco, Nicola Ammirabile, Davide Landolina, Antonino Imbesi, Carmelo Raffo, Davide Capodanno
{"title":"Future of factor XI inhibitors in cardiovascular practice.","authors":"Antonio Greco, Nicola Ammirabile, Davide Landolina, Antonino Imbesi, Carmelo Raffo, Davide Capodanno","doi":"10.23736/S2724-5683.23.06474-8","DOIUrl":"10.23736/S2724-5683.23.06474-8","url":null,"abstract":"<p><p>Anticoagulation is indicated for treatment and prevention of arterial and venous thrombosis. Targeting different steps of the coagulation process, currently available anticoagulants entail an increased risk of bleeding, which detrimentally impacts on prognosis and hinders the administration of an effective antithrombotic regimen. Factor XI (FXI) inhibition has emerged as a strategy to uncouple prevention of thrombosis from bleeding. Indeed, while FXI is crucial for the amplification phase in pathological thrombosis, it is ancillary in physiological hemostasis. A comprehensive search in several scientific databases has been performed to identify relevant studies in the field. In addition, ongoing trials have been searched for in proper datasets to provide an updated and comprehensive assessment of the current state of investigations on FXI inhibition. Many compounds have been tested to inhibit FXI at different stages (i.e., synthesis, activation, or interactions with target molecules and coagulation factors). These include antisense oligonucleotides, monoclonal antibodies, small molecules, natural peptides and aptamers. In phase 2 studies, FXI inhibitors reduced thrombotic complications without any corresponding increase in bleeding. FXI inhibitors were noninferior and potentially superior to low-molecular-weight heparin in orthopedic surgery and reduced bleeding compared to apixaban in patients with atrial fibrillation. FXI inhibition is also under testing in other conditions, including end-stage renal disease, cancer, or noncardioembolic stroke. FXI inhibition represents a promising and rapidly emerging approach for a number of clinical indications. This article reviews the rationale, evidence, pharmacology, and future applications of FXI inhibition.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"201-218"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between sST2 and NT-proBNP levels and postoperative atrial fibrillation in patients having non-cardiac surgery. 非心脏手术患者的 sST2 和 NT-proBNP 水平与术后心房颤动的关系。
IF 1.4 4区 医学
Minerva cardiology and angiology Pub Date : 2025-04-01 Epub Date: 2024-11-13 DOI: 10.23736/S2724-5683.24.06649-3
Mustafa U Somuncu, Naile E Güdül, Uğur Köktürk, Bengü G Köksal, Fatih P Tatar, Ahmet Avci
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