Minerva cardiology and angiology最新文献

{"title":"A retrospective comparative study of guiding catheters for elective percutaneous coronary interventions for simple circumflex lesions: active vs. passive support.","authors":"Yeliz Guler, Cevat Kirma","doi":"10.23736/S2724-5683.24.06731-0","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06731-0","url":null,"abstract":"<p><strong>Background: </strong>In percutaneous coronary interventions (PCI), the ability to anticipate procedural challenges and a comprehensive knowledge of specialized equipment are paramount. Among these, the choice of guide catheters is crucial. A retrospective analysis was conducted on patients who underwent elective PCI procedures targeting type A and B1 circumflex artery lesions.</p><p><strong>Methods: </strong>A total of 311 patients were categorized into two groups based on selection of guiding catheter: Group-1 used passive support catheters, whereas Group-2 employed standard Judkins catheters. We assessed the differences in procedural duration and characteristics, and contrast medium dosage between the two groups.</p><p><strong>Results: </strong>In the Group-2, the utilization of extra support wire (7.8% vs. 17.3%, P=0.023), repeated predilatation (6.8% vs. 15.4%, P=0.031), and guide catheter exchange (2.9% vs. 9.1%, P=0.044) was more prevalent. Additionally, in the Group-2, the amount of contrast agent used was higher (146±43 vs. 110±37, P<0.001) and the procedure duration was longer (35±16 vs. 25±8, P<0.001).</p><p><strong>Conclusions: </strong>In our study, when comparing the use of a Judkins catheter to a passive support catheter for type A/B1 circumflex artery lesions, the group utilizing the passive support catheter exhibited advantages in terms of procedure duration, usage of interventional materials, and contrast consumption. The choice of the guide catheter plays a pivotal role in performing PCI.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular mechanics assessment in amyloidosis patients: a systematic review and meta-analysis.","authors":"Andrea Sonaglioni, Priscilla Torretta, Gian L Nicolosi, Michele Lombardo","doi":"10.23736/S2724-5683.24.06683-3","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06683-3","url":null,"abstract":"<p><strong>Background: </strong>Over the last decade, a small number of studies have used speckle tracking echocardiography (STE) or cardiac magnetic resonance (CMR) for measuring left ventricular (LV) mechanics in patients with amyloidosis. This systematic review and meta-analysis aimed at assessing the overall influence of amyloidosis on LV global longitudinal strain (GLS) and regional longitudinal strain at basal (BLS), mid (MLS) and apical (ALS) level, respectively.</p><p><strong>Methods: </strong>All imaging studies assessing LV-GLS, LV-BLS, LV-MLS and LV-ALS in amyloidosis patients versus healthy controls, selected from PubMed and EMBASE databases, were included. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment of Case-Control Studies. Continuous data (LV-GLS, LV-BLS, LV-MLS and LV-ALS) were pooled as a standardized mean differences (SMDs) comparing amyloidosis group with healthy controls. The overall SMDs of LV-GLS, LV-BLS, LV-MLS and LV-ALS were calculated using the random-effect model.</p><p><strong>Results: </strong>The full-texts of 13 studies with 553 amyloidosis patients and 575 healthy controls were analyzed. STE (53.8%) and CMR (46.2%) studies were separately analyzed. Average LV-GLS magnitude was significantly impaired in amyloidosis patients vs. controls in both STE (13.8±3.9 vs. 19.8±2.7%) and CMR (12.3±4 vs. 17.9±3.5%) studies. The impairment of segmental strain detected in amyloidosis patients was prevalent at basal and mid level, with relative \"apical sparing.\" SMDs obtained for LV-GLS (SMD -1.80, 95% CI: -2.35, -1.24, P <0.001), LV-BLS (-1.98; 95% CI: -2.51, -1.45, P <0.001) and LV-MLS (-1.84; 95% CI: -2.46, -1.23, P <0.001) assessment were significantly larger than that obtained for LV-ALS (-0.72; 95% CI: -1.31, -0.13, P=0.02) measurement. Substantial heterogeneity was found among the studies assessing LV-GLS (I²=92.5%), LV-BLS (I²=91.4%), LV-MLS (I²=94.3%) and LV-ALS (I²=94.6%). Egger's test yielded a P value of 0.10, 0.20, 0.09 and 0.55 for LV-GLS, LV-BLS, LV-MLS and LV-ALS assessment respectively, indicating no publication bias. On meta-regression analysis, none of the moderators was significantly associated with effect modification for LV-GLS, LV-BLS, LV-MLS and LV-ALS (all P<0.05).</p><p><strong>Conclusions: </strong>Amyloidosis has a large negative effect on LV-GLS, primarily related to the deterioration of segmental longitudinal strain at the basal and mid level, with relative apical sparing.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-related efficacy and safety of sodium tanshinone II A sulfonate for the treatment of unstable angina pectoris: a meta-analysis.","authors":"Na Wang, Zeyuan Fan","doi":"10.23736/S2724-5683.24.06631-6","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06631-6","url":null,"abstract":"<p><strong>Introduction: </strong>Unstable angina pectoris (UAP), a prevalent form of angina pectoris, is caused by coronary artery stenosis, elevated blood viscosity, and atheromatous plaque that blocks blood vessels. A meta-analysis was conducted to evaluate the efficacy and safety of various injectable doses of sodium tanshinone II A sulfonate (STS) for UAP treatment.</p><p><strong>Evidence acquisition: </strong>The Web of Science, CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, and Embase databases were used to search for randomized controlled trials (RCTs) using STS until December 29^th, 2023. The selection of studies solely focused on conventional Western medicine (WM) and different STS dosages (40, 50, 60, or 80 mg/day) combined with WM. The risk of bias was evaluated using the Quality in Prognostic Studies (QUIPS) tool. The standardized mean difference (SMD) or risk ratio (RR) was used to develop the random-effects or fixed-effects model.</p><p><strong>Evidence synthesis: </strong>The study included 31 RCTs. The results of the meta-analysis showed that compared with WM alone, combination of WM and STS at 40 mg/day (RR: 1.15 [95% CI: 1.03, 1.29]; P=0.027) or 60 mg/day (RR: 1.20 [95% CI: 1.11, 1.30]; P=0.0005) increased electrocardiographic efficacy. Compared with WM alone, 40 mg/day of STS plus WM reduced plasma viscosity (SMD: -0.78 [95% CI: -1.60, 0.04]; P=0.056); whole blood low viscosity (SMD: -0.58 [95% CI: -0.95, -0.21]; P=0.015); CRP (SMD: -1.07 [95% CI: -2.10, -0.03]; P=0.047); and adverse events (SMD: -1.62 [95% CI: -3.55, 0.31]; P=0.069). In addition to 40 mg of STS, we found that 60 mg of STS plus WM reduced the incidence of adverse events (SMD: -1.01 [95% CI: -2.07, 0.04]; P=0.055).</p><p><strong>Conclusions: </strong>This meta-analysis indicated that the combination of STS on 40 mg/day with WM enhanced the safety and clinical efficacy of UAP therapy.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging ChatGPT in cardiogeriatrics.","authors":"Barbara Antonazzo, Vassilios S Vassiliou, Attilio Lauretti, Giuseppe Biondi-Zoccai","doi":"10.23736/S2724-5683.24.06808-X","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06808-X","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) into healthcare is transforming medical practice, and this holds true also for the prevention, diagnosis and treatment of cardiovascular disease in older patients. Large language models (LLMs) like ChatGPT (OpenAI, San Francisco, CA, USA) represent cutting edge AI tools which may offer significant potential to enhance patient care by improving communication, aiding in diagnosis, and assisting in treatment planning. In elderly patients, who often present with complex health profiles and multiple comorbidities, AI can prove particularly beneficial, and it can analyze extensive data to provide personalized, evidence-based recommendations. For instance, ChatGPT can support clinicians in managing polypharmacy by identifying potential drug interactions and suggesting optimal medication regimens, thereby reducing adverse effects. Additionally, AI tools can help overcome therapeutic inertia by prompting timely treatment adjustments, ensuring that elderly patients receive appropriate interventions. However, the successful implementation of AI in cardiogeriatrics requires robust technological infrastructures, a synergistic integration with electronic health records, and careful consideration of ethical and privacy concerns. Ongoing collaboration between technologists and healthcare professionals is essential to address these challenges and fully realize the benefits of AI in enhancing cardiovascular care for the elderly.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of sudden cardiac arrest.","authors":"Marinos Kosmopoulos, David G Benditt","doi":"10.23736/S2724-5683.24.06607-9","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06607-9","url":null,"abstract":"<p><p>Sudden cardiac arrest, and in particular sudden out-of-hospital cardiac arrest (OHCA) remains a major public health concern in which survival statistics, and in particular neurologically intact survival statistics, have remained largely unimproved over many decades. Overall survival remains approximately 10%, being somewhat better in victims receiving bystander cardiopulmonary resuscitation (CPR), and those who are found to have a shockable rhythm (i.e., VT or VF). CPR and defibrillation (especially public-access defibrillation) remain the essential immediate management tools. However, recent research has introduced several novel adjunctive interventions (e.g., mechanical compression-decompression devices, 'head-up' CPR methodology, portable extra-corporeal circulatory assistance [ECPR]) that will hopefully impact survival positively. In any case, it is apparent that no single resuscitative tool will be sufficient to markedly improve OHCA survival; the combined application of a multi-faceted strategy is needed. This might comprise bystander CPR, combined use of 'head-up' CPR along with impedance threshold valve [ITD] and active compression-decompression mechanical chest compression devices. Application of mobile ECPR devices as early as possible during resuscitation appears to improve outcomes albeit expensive and complex to deploy broadly. Employed together, these novel steps, offer the possibility of moving the survival needle in a positive direction.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis investigating gender differences in in-hospital, short-term and long-term outcomes among patients who underwent primary PCI.","authors":"Iva Patel, Pooja Vyas, Anand Shukla, Pratik Shah, Deepanshu Assudani, Khushboo Chauhan","doi":"10.23736/S2724-5683.24.06670-5","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06670-5","url":null,"abstract":"<p><strong>Introduction: </strong>To assess how gender disparities impact major adverse cardiovascular events during hospitalization, as well as in the short and long term, among patients with ST-elevation myocardial infarction who undergo primary PCI.</p><p><strong>Evidence acquisition: </strong>PubMed, Scopus and Cochrane database were searched for relevant studies. Studies were included if all comers with STEMI, reported gender specific patient characteristics, treatments and outcomes. Odds ratio and 95% confidence interval were calculated using random effect model.</p><p><strong>Evidence synthesis: </strong>A total of 23 studies were included for the pooled meta-analysis. Average age of female at presentation was 68.61±3.91 years while in male was 60.83±2.48 years. In unadjusted analysis, female patients were at higher risk for mortality (OR=1.98, 95% CI: 1.71-2.30, P<0.0001, I²=35%) at hospitalization, (OR=2.25, 95% CI=1.75-2.88, P≤0.00001) at short term and (OR=1.76, 95% CI: 1.41-2.21, P<0.000, I²=68%) at long term. The adjusted analysis of major adverse cardiovascular events for short term (OR=1.09, 95% CI: 0.91-1.31, P=0.37, I²=76%) and long term (OR=1.05, 95% CI: 0.98-1.12, P=0.17, I²=37%) were not found significant between both genders. However, it remained significant during hospitalization (OR=1.12, 95% CI: 1.03-1.22, I²=15%, Tau²=0.00).</p><p><strong>Conclusions: </strong>The findings of this comprehensive meta-analysis indicate higher major adverse cardiac events among women with STEMI who underwent PPCI. After adjusting for comorbidities, the difference between women and men showed insignificant at short term and long term but remained significant at in-hospital. Female patients exhibited a higher prevalence of cardiovascular risk factors than men. Implementing intensive cardiovascular risk reduction strategies in women may offer a pathway to address this gender disparity.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Dietary Inflammatory Index (DII) and sarcopenia in ischemic heart disease: an 1999-2004 NHANES study of 1088 US individuals.","authors":"Xiao-Yun Zheng, Yi Chen, Yan Gao, Mo Zhou, Wen-Zhuo Guan","doi":"10.23736/S2724-5683.24.06496-2","DOIUrl":"10.23736/S2724-5683.24.06496-2","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the relationship between DII and sarcopenia in individuals with ischemic heart disease (IHD).</p><p><strong>Methods: </strong>This was a retrospective study utilizing data of the National Health and Nutrition Examination Survey (NHANES) from 1999-2004. Adults aged ≥50 years diagnosed with IHD, having complete 24-hour dietary recall data, and dual energy X-ray absorptiometry (DEXA)-measured muscle mass were eligible for inclusion. Association between DII and sarcopenia, defined by reduced appendicular skeletal muscle mass, was determined by the logistic regression analyses.</p><p><strong>Results: </strong>Data of 1088 individuals were analyzed, with the mean age of 68.1±0.5 years. Significantly higher DII was observed in the sarcopenic group compared to the non-sarcopenic group (0.24 vs. -0.17, P=0.020). After adjusting for relevant confounders in the multivariable analysis, each unit increase in DII was significantly associated with higher odds of sarcopenia (adjusted odd ratio [aOR]=1.07, 95% confidence interval: 1.00-1.14, P value = 0.040). In stratified analyses, among patients with a Body Mass Index (BMI) ≥30 kg/m², both DII tertile 2 and tertile 3 were significantly associated with greater odds of sarcopenia (tertile 2 vs. tertile 1: aOR=2.85, 95% CI: 1.56-5.23, P=0.001; tertile 3 vs. tertile 1: aOR=3.11, 95% CI: 1.53-6.31, P=0.002), whereas no significant associations was observed among patients with a BMI<30 kg/m².</p><p><strong>Conclusions: </strong>This study has established a significant independent association between a higher DII and an increased risk of sarcopenia in US adults with IHD regardless of type of IHD. BMI appears as a moderating factor in this association.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"65-72"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Medina Trifurcation Score: a new tool to predict outcomes of unprotected distal left main trifurcation percutaneous coronary intervention.","authors":"Andrea Marrone, Monica Verdoia, Alfonso Ielasi","doi":"10.23736/S2724-5683.24.06676-6","DOIUrl":"10.23736/S2724-5683.24.06676-6","url":null,"abstract":"","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"73-76"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial refractoriness early after transcatheter aortic valve implantation TAVI in patients with severe aortic stenosis and sinus rhythm.","authors":"Özcan Özdemir, Onur Yildirim","doi":"10.23736/S2724-5683.24.06540-2","DOIUrl":"10.23736/S2724-5683.24.06540-2","url":null,"abstract":"<p><strong>Background: </strong>Aortic valve stenosis (AS) is a common valvular heart disease, especially in the elderly, and is associated with a high prevalence of atrial fibrillation. Although the risk of atrial fibrillation is expected to decrease after the intervention, atrial fibrillation develops in many patients undergoing surgical or percutaneous transaortic valve implantation. We aimed to evaluate atrial refractoriness since it may play a key role in the occurrence of atrial fibrillation after transaortic valve implantation.</p><p><strong>Methods: </strong>Seventy-nine consecutive patients who underwent TAVI between October 2021 and May 2023 were enrolled in this trial. Sixty-seven patients underwent electrophysiology study before and after TAVI. We evaluated the changes in PA and AH intervals, as well as atrial effective refractory periods.</p><p><strong>Results: </strong>Besides the hemodynamic changes, atrial effective refractory periods increased, and atrial effective refractory period dispersion (39.8±21.6 vs. 31.1±18.0) decreased significantly after TAVI. The change in atrial effective refractory period dispersion after TAVI was correlated only with the changes in left ventricular end-diastolic pressure (r=0.77, P=0.001) and the changes in aortic gradient (r=0.4, P=0.001). The independent variables affecting the changes in atrial effective refractory period dispersion were basal pro-BNP levels, besides the changes in left ventricular end-diastolic pressure and aortic gradient after transaortic valve implantation.</p><p><strong>Conclusions: </strong>Our results show an acute improvement in atrial refractoriness after TAVI, though high atrial fibrillation rates are reported in the literature. The timing of aortic valve replacement is important, as irreversible maladaptive changes might have already developed by the time of intervention.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"113-119"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty in chronic heart failure: a multidimensional assessment of older patients undergoing cardiac rehabilitation.","authors":"Nicolò Granata, Martina Vigorè, Raffaella Vaninetti, Roberto Maestri, Roberta Borri, Angelo Caporotondi, Giancarlo Piaggi, Gioele Cremonese, Antonia Pierobon","doi":"10.23736/S2724-5683.24.06555-4","DOIUrl":"10.23736/S2724-5683.24.06555-4","url":null,"abstract":"<p><strong>Background: </strong>Chronic heart failure (CHF) is often associated with cognitive, psychological, and functional disorders. In addition, since patients suffering from this condition are often older adults, the presence of frailty could worsen the clinical situation.</p><p><strong>Methods: </strong>The present multicentric observational study aimed to investigate, through a multidimensional evaluation, the associations between clinical, functional, cognitive, psychological, and frailty variables of older (age ≥65) CHF inpatients undergoing cardiac rehabilitation and to identify the eventual independent predictors of the frailty status.</p><p><strong>Results: </strong>The study included 85 patients (mean age 73.88±5.84). The disease severity of the sample was moderate (left ventricular ejection fraction = 41.79±15.40). Among the patients, 32.94% had cognitive impairment, 12.94% and 14.11% reported moderate to severe anxious or depressive symptoms, respectively, and 34.12% were classified as frail (Clinical Frailty Scale [CFS] score ≥5). The CFS score showed a negative correlation with cognitive status (Addenbrooke's Cognitive Examination III [ACE III] [r=-0.48, P≤0.0001] and Frontal Assessment Battery [FAB] [r=-0.33, P=0.0001]) and functional status (Short Physical Performance Battery [SPPB] [r=-0.55, P≤0.0001] and Barthel Index [r=-0.52, P≤0.0001]), while showing a positive correlation with comorbidities (Cumulative Illness Rating Scale [CIRS] [r=0.40, P≤0.0001]). The stepwise regression analysis revealed that ACE III, SPPB, and CIRS were independent predictors of frailty status (CFS).</p><p><strong>Conclusions: </strong>Frailty is an important variable that should be considered since it is linked with most of the variables that play a role in the management and outcomes of older CHF patients and, thus, its evaluation should be integrated into the usual assessment in cardiac rehabilitation.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"120-128"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}