Microorganisms最新文献

{"title":"Biodegradation of Polyvinyl Chloride by <i>Acinetobacter</i> sp. Isolated from Soil.","authors":"Shumao Chai, Jiahao Wang, Yiru Zhang, Zihan Zhang, Zihan Yang, Yitong Wei, Mingfu Niu","doi":"10.3390/microorganisms14102332","DOIUrl":"https://doi.org/10.3390/microorganisms14102332","url":null,"abstract":"<p><p>The excessive use of plastics has seriously damaged the environment. Biodegradation of plastics, especially polyvinyl chloride (PVC), by microorganisms has become a promising strategy for the remediation of environmental pollution. Plastic-contaminated soil is an important source for isolating microorganisms with plastic-degrading ability. In this study, a PVC-degrading strain, designated PVC-3-16, was isolated from farmland soil and identified as <i>Acinetobacter calcoaceticus</i>. After 60 days of incubation, a new characteristic functional group was detected on the surface of PVC powder by attenuated total reflection Fourier transform infrared spectroscopy. A putative catalase-peroxidase enzyme derived from the genome of PVC-3-16 was successfully expressed and purified. After treatment with the catalase-peroxidase, hydroxyl groups and cracks were detected on the surface of PVC films by attenuated total reflection Fourier transform infrared spectroscopy and scanning electron microscopy, respectively. The M_n, M_w, and M_z values of the PVC films decreased by 10.7%, 9.4%, and 5.7%, respectively, after treatment. The degradation product catalyzed by the catalase-peroxidase was identified as C₂₁H₄₄O. These findings indicate that PVC-3-16 is a promising strain that can be used for PVC biodegradation.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Scytonemin Biosynthesis in Engineered <i>Nostoc flagelliforme</i> with ScyR Overexpression and Cultivation Optimization.","authors":"Hao Xie, Yue Zhang, Xiaolong Yuan, Wanxia Xia, Xiang Gao","doi":"10.3390/microorganisms14102328","DOIUrl":"https://doi.org/10.3390/microorganisms14102328","url":null,"abstract":"<p><p>Scytonemin, a lipid-soluble indole-alkaloid pigment unique to cyanobacteria, is a bioactive small molecule with UV-shielding, antioxidant, and anti-inflammatory activities. <i>Nostoc flagelliforme</i> represents a promising strain for scytonemin biosynthesis, yet engineering to boost its yield remains challenging. Two genes encoding a histidine kinase (COO91_00772) and a response regulator (COO91_00771, ScyR) putatively constitute a two-component regulatory system governing the UV-induced biosynthesis of scytonemin. Here, we employed CRISPR/Cpf1 technology to achieve the insertion of an additional <i>ScyR</i> expression cassette into the <i>N. flagelliforme</i> genome and evaluated its effect on scytonemin yield. The engineered strain was designated Nf-psbA-ScyR, in which the <i>ScyR</i> gene was expressed under the P<i>psbA</i> promoter. This strain exhibited a markedly enhanced accumulation of scytonemin, reaching 4.6 mg g^-1 dry weight under UV-B radiation after 15-day cultivation with exogenous tryptophan supplementation, representing a 1.9-fold increase compared with the <i>MAAs</i>-deficient (Nf-MAAs-D) strain. Upon transition from indoor UV-B exposure to outdoor solar radiation, scytonemin production further increased to 5.4 mg g^-1 dry weight. These findings indicate that the ScyR regulator can highly promote scytonemin biosynthesis under UV induction, providing an engineering strategy for the exploitation of <i>N. flagelliforme</i>.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and Validation of Uric Acid-Lowering LAB from <i>Trachemys scripta elegans</i>.","authors":"Siyu Liu, Ping Shi, Yuansen Liu, Hafiz Umer Javed, Jiaming Huang, Chunxing Li, Yuhao Liao, Haitao Wang, Binyu Zhai, Rongping Bu","doi":"10.3390/microorganisms14102336","DOIUrl":"https://doi.org/10.3390/microorganisms14102336","url":null,"abstract":"<p><p>Hyperuricemia (HUA), a metabolic disorder characterized by elevated serum uric acid (UA) levels resulting from purine metabolism dysfunction, is closely associated with gout, hypertension, and cardiovascular diseases. Current pharmacological treatments are frequently associated with adverse effects, underscoring the need for safer alternatives. In this study, lactic acid bacteria (LAB) with UA-lowering potential were isolated from the intestine of <i>Trachemys scripta elegans</i> and screened through a multi-indicator approach combining UA degradation, purine metabolism, and xanthine oxidase (XOD) inhibition assays. Five candidate strains were identified, among which SL-5 exhibited the most outstanding performance, degrading 76.19% of UA, 96.62% of adenosine, 83.50% of guanosine, and 99.29% of hypoxanthine, while inhibiting XOD activity by 71.51%, demonstrating a dual capacity to both degrade purines and suppress UA synthesis. In vivo validation using a <i>C. elegans</i> hyperuricemia model confirmed that SL-5 reduced UA levels by 52.50%. Physiological characterization further revealed robust growth, high self-aggregation capacity (>80%), strong stress tolerance, and potent antioxidant activity. 16S rDNA sequencing identified SL-5 as <i>Enterococcus hirae.</i> This study establishes an effective screening framework and provides a novel strain resource for the development of enzyme-based interventions against hyperuricemia.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver Nanoparticles Biosynthesized from <i>Metarhizium anisopliae</i> Crude Extract: Insecticidal Activity, Residual Efficacy, and Metabolic Responses in <i>Solenopsis invicta</i>.","authors":"Dongxu Wang, Canxia Wu, Wenzhe Li, Huaxin Cai, Jingyang Ni, Yinghua Tong","doi":"10.3390/microorganisms14102334","DOIUrl":"https://doi.org/10.3390/microorganisms14102334","url":null,"abstract":"<p><p>Green biosynthesis of silver nanoparticles using natural biological extracts represents a promising route to develop eco-friendly nanopesticides; nevertheless, many biogenic nanoformulations suffer from poor photostability and rapid loss of bioactivity under field sunlight exposure. In this study, silver nanoparticles (Des-AgNPs) were one-pot biosynthesized using crude fermentation extract from the entomopathogenic fungus <i>Metarhizium anisopliae</i> (Metschn.) Sorokīn, which served as both a reducing agent and a surface-capping ligand. <i>Solenopsis invicta</i> Buren was employed as a model pest to evaluate the physicochemical features, insecticidal potency, outdoor residual stability, and underlying metabolic toxic mechanism of the resulting nanomaterial. The synthesized Des-AgNPs exhibited high crystallinity, favorable dispersibility, and excellent colloidal stability. Laboratory bioassays demonstrated potent insecticidal activity against <i>S. invicta</i> workers, with a 5-day LC₅₀ of 174.74 mg/kg. Notably, outdoor exposure assays revealed that Des-AgNPs significantly outperformed the unformulated fungal crude extract in residual efficacy: Des-AgNPs retained high insecticidal activity after 96 h of environmental exposure, whereas the free crude extract underwent a pronounced decline in toxicity within 24 h. Untargeted LC-MS-based metabolomics was further applied to decipher the multi-target toxic responses triggered by Des-AgNPs. In total, 540 differential metabolites (321 upregulated, 183 downregulated) were identified. KEGG pathway enrichment revealed significant disruptions in glutathione metabolism, cytochrome P450-mediated xenobiotic detoxification, tyrosine/dopamine neurotransmitter metabolism, and ABC-transporter-driven efflux pathways. These metabolic perturbations reflected oxidative stress, impaired energy metabolism, compromised cell membrane integrity, disrupted neural transmission, and biomacromolecule damage in the model pest. Collectively, our results demonstrate that entomopathogenic-fungal-extract-capped silver nanoparticles can overcome the photodegradation drawback of free fungal bioactive metabolites. This mycosynthetic strategy provides a feasible framework for constructing stable, high-performance nanobiopesticides, and the workflow could be extended to other fungal extracts and target insect pests beyond the present model system.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil Microbiome Signatures Associated with Epidemiological Heterogeneity Across Natural Plague Foci in Inner Mongolia, China.","authors":"Yulong Wang, Jianyun Li, Xudong Yang, Fang Liu, Guangqian Pei, Mengnan Cui, Yan Guo, Yihua Jia, Shengju Zhang, Lili Bao, Yujun Cui, Yong Huang","doi":"10.3390/microorganisms14102329","DOIUrl":"https://doi.org/10.3390/microorganisms14102329","url":null,"abstract":"<p><p>Plague persistence relies on complex host-vector-environment interactions, yet the ecological contribution of soil microbiomes to natural foci remains poorly understood. We performed shotgun metagenomic sequencing of 143 soil samples across four distinct plague foci in Inner Mongolia, China, to characterize microbiome features associated with contrasting epidemiological states. Taxonomic, functional, and network analyses showed that the three active plague foci exhibited lower microbial diversity, simplified co-occurrence networks, and enrichment of specific taxa, particularly <i>Streptomyces</i>. Conversely, the quiescent <i>Marmota sibirica</i> focus harbored a more complex and interconnected microbial network with greater richness and exclusive detection of <i>Yersinia</i> bacteriophages, showing significant concordance with bacterial community structure. These patterns indicate distinct microbiome configurations associated with specific host and geographic settings, highlighting the need to disentangle host- and site-specific effects from broader epidemiological status. Compared with surface and deep soil, burrow-associated soil exhibited greater microbial differentiation and higher richness of bacteriophages, antimicrobial resistance genes, and virulence-associated genes, suggesting its potential as a sensitive environmental matrix for ecological monitoring. Overall, our findings identify distinct soil microbiome signatures-specifically taxonomic shifts, altered network complexity, exclusive <i>Yersinia</i> phage detection, and functional gene enrichment-associated with epidemiological heterogeneity across natural plague foci, providing a baseline for understanding ecological variation among endemic habitats.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bacillus pumilus</i> SG44 Reshapes the Microbiome and Alters Metamorphosis and Development of <i>Aurelia coerulea</i> Polyps.","authors":"Min Li, Xiangrui Guo, Manzoor Ahmad, Jiajing Yang, Jie Sun, Zirui Li, Hongyuan Lin, Yuting Zhang, Ye Zhao, Hao Sun, Yanying Zhang","doi":"10.3390/microorganisms14102338","DOIUrl":"https://doi.org/10.3390/microorganisms14102338","url":null,"abstract":"<p><p>Planula settlement and metamorphosis are critical transitions in the life cycle of the moon jellyfish <i>Aurelia coerulea</i>, and associated microorganisms can influence these processes. We developed a co-culture system combining the marine bacterium <i>Bacillus pumilus</i> SG44 with <i>A. coerulea</i> planula larvae and, using 16S rRNA gene high-throughput sequencing, examined how strain SG44 affects larval settlement and metamorphosis and the associated microbiota. Treatment with strain SG44 significantly elevated the settlement and metamorphosis rate of planulae, although the resulting polyps exhibited morphological deformities. Strain SG44 became established as the dominant population in both polyp tissues and the surrounding culture seawater. Strain SG44 significantly decreased the diversity of the polyp-associated microbial community and markedly reduced the relative abundance of <i>Neptuniibacter</i>, a reported beneficial taxon in jellyfish-associated microbiota, as well as other putatively beneficial genera, including <i>Halomonas</i> and <i>Sulfitobacter</i>. Co-occurrence network analysis revealed that the network of treatment with strain SG44 contracted in size while maintaining a comparably high average degree. These results indicate that strain SG44 affects the development of <i>A. coerulea</i> larvae, an effect that may be linked to shifts in the host-associated microbial community, although a causal relationship remains to be established, and provide a new perspective on microbe-host interactions during scyphozoan early development.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral Bacterial Profiles, Bacterial Co-Detection Patterns, and Molecular Alterations in Colorectal Cancer and Colorectal Polyps: A Vietnamese Cohort Study.","authors":"Vu Son Giang, Ho Van Son, Dao Tien Manh, Nguyen Thanh Tung, Nguyen Phuong Thao, Nguyen Thi Than, Nguyen Dang Tung, Tran Viet Hao, Le Duy Cuong","doi":"10.3390/microorganisms14102325","DOIUrl":"https://doi.org/10.3390/microorganisms14102325","url":null,"abstract":"<p><p>Intratumoral microbiota may contribute to colorectal cancer (CRC), but their relationships with bacterial co-occurrence, relative bacterial loads, and molecular alterations remain incompletely understood. This study characterized intratumoral bacterial profiles in CRC and colorectal polyps and examined their clinicopathological and molecular associations. A cross-sectional study included 149 patients with CRC and 109 patients with benign colorectal polyps. <i>F. nucleatum</i>, ETBF, <i>A. muciniphila</i>, and <i>eae</i>⁺<i>E. coli</i> were detected in formalin-fixed, paraffin-embedded tissues using multiplex real-time PCR, with relative bacterial loads quantified using the 2^-ΔCt method. <i>KRAS</i> and <i>BRAF</i> V600E mutations and <i>HSP110ΔE9</i> transcripts were assessed by real-time PCR/RT-qPCR. After multivariable adjustment for age, sex, tumor location, and the other bacterial species, ETBF and <i>eae</i>⁺<i>E. coli</i> were independently associated with CRC (adjusted ORs, 4.69 and 6.26, respectively; both <i>p</i> < 0.001). Relative loads of all four bacterial species were higher in CRC than in polyps (<i>p</i> < 0.001 for all comparisons). ETBF + <i>eae</i>⁺<i>E. coli</i> showed the strongest dual-species association with CRC (adjusted OR, 10.64; 95% CI, 4.49-25.24), while <i>F. nucleatum</i> + <i>A. muciniphila</i> + <i>eae</i>⁺<i>E. coli</i> showed the strongest triple-species association (adjusted OR, 21.56; 95% CI, 5.02-92.60). Increasing numbers of detected bacterial species were positively associated with CRC (<i>p</i> for trend < 0.001). CRC was characterized by higher relative bacterial loads and more interconnected bacterial co-colonization patterns than colorectal polyps. These findings support a community-level association between intratumoral bacterial profiles and CRC and warrant validation in larger multicenter longitudinal studies.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil Nutrients Rather than Heavy Metals Dominate the Succession of Microbial Communities in Subtropical Coal Gangue Piles: A Case Study from a Successional Gradient in Southern China.","authors":"Hanchang Zhou, Tian Wang, Ziying Zhang, Yi Li, Quanquan Jia, Lin Yu, Xiaobao Kuang","doi":"10.3390/microorganisms14102322","DOIUrl":"https://doi.org/10.3390/microorganisms14102322","url":null,"abstract":"<p><p>The natural revegetation of coal gangue piles relies on microbial community succession, yet limiting factors in subtropical regions remain unclear, hindering the acceleration of natural revegetation. This study examined coal gangue tailings of varying successional ages in southern China to identify the factors that limits on microbial succession. Soil properties, microbial diversity, community structure, network complexity, and heavy metal fractions were analyzed across successional stages. Results show a progressive soil acidification anda shift from carbon/nitrogen limitation to phosphorus limitation as succession progresses. Bacterial richness peaked at middle stage and then declined, while fungal richness shows no significant difference among different stages. Bacterial community structure changed sharply in early successional stage while fungal structure in the mid-stages. The complexity of microbial cooccurance network initially decreased then increased. Heavy metals mostly accumulated in stable residual fractions during succession, which has only limited toxic effects. The nutrient limitation that shift from C/N to P was the dominant factor shaping core functional modules and community composition, though dissolved organic carbon and few heavy metal fractions were also the main driving factors of microbial network complexity. These findings indicate that microbial succession is constrained more by nutrient availability than by heavy metal toxicity, with early stages limited by C/N sources and later stages limited by phosphorus. This provides a basis for targeted management to accelerate natural recovery of coal gangue piles.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Simulated NH₄⁺/NO₃^- Inputs Reorganize Soil Microbial Communities and Modify N-Cycling Functional Potential in Temperate Forests.","authors":"Yunzhe Hu, Shulan Cheng, Huajun Fang, Mingzhu Lu","doi":"10.3390/microorganisms14102323","DOIUrl":"https://doi.org/10.3390/microorganisms14102323","url":null,"abstract":"<p><p>Forest soil nitrogen (N) turnover and nitrous oxide (N₂O) release are strongly influenced by atmospheric N deposition. Although the effects of individual inorganic N species on soil biogeochemistry are well documented, the consequences of changing their relative supply for N₂O formation and the underlying microbial pathways remain less clear. We therefore examined soil N₂O emissions, microbial communities, and N-transformation potential across a gradient of ammonium-to-nitrate (NH₄⁺/NO₃^-) inputs in a temperate forest soil from Northeast China. Seven treatments covering NH₄⁺/NO₃^- ratios from 1:5 to 5:1 were established. Soil physicochemical properties and N₂O emissions were measured, while microbial taxonomic profiles and N-cycling genes were characterized by metagenomic sequencing. Altering the composition of inorganic N reorganized the microbial community, including the relative representation of archaeal, bacterial, and eukaryotic groups. N₂O release was greatest when NH₄⁺ and NO₃^- were supplied in equal proportions, a pattern that may reflect a stronger contribution of nitrification-associated processes. Across the treatment gradient, the response of N₂O emissions to inorganic N composition was nonlinear. By contrast, the 1:2.5 NH₄⁺/NO₃^- treatment produced comparatively low N₂O emissions and contained a greater representation of genes associated with N₂O reduction, consistent with enhanced microbial potential for N₂O consumption. Under the more nitrate-dominated 1:5 treatment, genes involved in dissimilatory nitrate reduction to ammonium (DNRA) were enriched, indicating a shift in the potential routes of nitrate transformation. Metagenomic data further revealed marked variation in genes linked to nitrification, denitrification, and biological N fixation. In comparison with these compositional and functional responses, microbial diversity changed relatively little, possibly because overlapping functions were distributed among different taxa under contrasting N inputs. Overall, the findings show that the balance between ammonium and nitrate can affect forest-soil N₂O emissions by restructuring microbial assemblages and their potential to transform N. These responses emphasize the need to consider the composition, rather than only the amount, of N deposition when evaluating microbial regulation of ecosystem N cycling and greenhouse-gas release. Field studies are still needed to test the generality of these patterns and their relevance to N management.</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence as a Tool for Combating Antimicrobial Resistance.","authors":"Sergi Maicas, Jaume Segura-Garcia","doi":"10.3390/microorganisms14102319","DOIUrl":"https://doi.org/10.3390/microorganisms14102319","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) has evolved from a looming concern into a fully realized global emergency, reshaping clinical practice and public health faster than the adaption abilities of our traditional countermeasures [...].</p>","PeriodicalId":18667,"journal":{"name":"Microorganisms","volume":"14 10","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}