Journal of Diseases and Medicinal Plants最新文献

{"title":"Antimicrobial Properties of the Hydroethanolic Extract of Bauhinia rufescens L. and Euphorbia hirta L., Two Plants of the Traditional Chadian Pharmacopoeia","authors":"Emmanuel Issa, Adoum Fouda Abderrazzack, K. Anani, Ameyapoh Yaovi","doi":"10.11648/J.JDMP.20210702.11","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210702.11","url":null,"abstract":"Objective: To evaluate the antimicrobial properties of hydroethanol extracts of Bauhinia rufescens L. and Euphorbia hirta L. Methodology and results: The hydroethanol extracts of Bauhinia rufescens L. and Euphorbia hirta L.; two plants of the Chadian traditional pharmacopoeia used in the treatment of infantile diarrhoea and gastroenteritis in adults were submitted to in vitro tests in order to highlight their antibacterial and antifungal properties. The method of microdilution in liquid medium coupled with spreading on agar medium was used for the tests. The microbial strains used consisted of 13 hospital bacterial strains and 6 reference strains including a yeast strain of the Candida albicans ATCC 90028 species. The results obtained confirm the antimicrobial properties of Bauhinia rufescens L. and Euphorbia hirta L. because at 50 mg/ml, they inhibit 100% the growth of gram positive and Gram-negative bacilli tested. On the other hand, for Candida albicans ATCC 90028, it is only the extract of Euphorbia hirta that was active at 50 mg/ml. Conclusion: In view of these results, we can say that these plants have an antibacterial activity and that their use in traditional phytotherapy is justified.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130697277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar","authors":"G. Abizi, Ouattara-Soro Fatou Scherazade, Ernest Zougrou N’guessan, John Kouadio Kouakou, Emile Begbin Kouassi, S. Koffi, Jean-Jacques Kablan Kassi, A. Koné","doi":"10.11648/J.JDMP.20210701.14","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210701.14","url":null,"abstract":"Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129864194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Healing Methods: Focus on the Medicinal Plants Against Coronavirus (Covid-19) Infection","authors":"Yusuf-Babatunde Moruf Ademola, Quadri Jelili Akorede, Solaja Olatunde Odutola, Kuku Mukaila Akorede","doi":"10.11648/J.JDMP.20210701.12","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210701.12","url":null,"abstract":"Background: In African health care system, medicinal plants are major components and most assorted of all therapeutic systems. In major parts of rural Africa, traditional healers prescribing medicinal plants are the most easily accessible and affordable health resource available to the local community and at times the only therapy that subsists. Coronavirus diseases (COVID-19) is an acute virus (SARs-coV-2) which has caused a global pandemic. This paper aims to emphasize the importance of herbal medicine as a possible alternative and effective immune system booster against coronavirus disease in Ogun state, Nigeria. Materials and Methods: Ethnobotanical survey was carried out using 80 randomly selected respondents among the villagers, herbalists, herb sellers, traditional medical practitioners, students, community leaders, by oral interviews and semi-structured questionnaire. The data were analyzed using frequency counts and percentages. Results: A total of 81 plant species from 35 families which were mostly represented by Euphorbiaceae, Moraceae, Apocynaceae and Rubiaceae, and 61 botanicals were used singly while 21 other botanicals were combination of two or more plants in a single herbal preparations reported in the study area are used for management and alternative therapy against ailments such as fever, cough, body pain, flu, cold and shortness of breath that are associated to symptoms of covid-19. Conclusion: Herbal medicines provide an alternative therapy for boosting immunity system to help fight coronavirus. Traditional healers are still very relevant to African healthcare system.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"236 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122059588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats","authors":"J. Okafor, O. Erukainure, J. A. Ajiboye, Michael Obi Etoamaihe, I. Eboagwu, S. Adenekan","doi":"10.11648/J.JDMP.20200604.14","DOIUrl":"https://doi.org/10.11648/J.JDMP.20200604.14","url":null,"abstract":"Due to some undesirable secondary reaction of synthetic drugs, natural products and plants with medicinal properties are been exploited in controlling and treating many chronic diseases including diabetes. Oxidative stress has a major effects in diabetes and the difficulties associated with it including hepatotoxicity. Newbouldia laevis is a traditional medicinal plant known to possess antimicrobial, anticonvulsant, sedative, analgesic, anti-inflammatory and antidiarrheal properties. However, there is scanty information on its utilization in diabetes management. This investigation was carried out to determine the potentials of aqueous ethanolic extract of Newbouldia laevis leaves to protect hepatic tissues of rats from diabetes caused by oxidative stress and hapatocellular injury. Diabetic condition was effected in rats by single intraperitoneal injection of alloxan. Rats were slaughtered by cervical dislocation after administration of Newbouldia leave extracts at dose of 200 and 400 mg/kg bw for 21 days. Hepatic tissues were analysed for catalase, superoxide dismutase (SOD) and glutathione (GSH) activities, lipid peroxidation, lipid profile and protein content were also evaluated. Alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) which are hepatic biomarkers were analysed in the blood serum. Significant reduction (p<0.05) of GSH, catalase, and SOD activities were effected by diabetes induction, also rise in hepatic biomarkers and lipid peroxidation was observed. Treatment with extract at 200 mg/kg caused significant (p<0.05) increased activities of the studied antioxidant biomarkers and reduced lipid peroxidation. It also led to a reduced activity of hepatic biomarkers. These results shows antioxidant protective properties of N. laevis leaves against rise in oxidative stress and hepatocellular injury in diabetic rat’s hepatic tissues at lower dose, indicating that the extract may possess antioxidant activities in diabetics.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134109866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Antioxidant and Anti-inflammatory Effects of Balanites aegyptiaca (L) Del (Balanitaceae) Galls and Leaves","authors":"N. Meda, S. Guenné, Kaba Mariama Combassere-Cherif, A. Pârvu, Tiperciuc Brânduşa, A. Ouedraogo","doi":"10.11648/J.JDMP.20200604.13","DOIUrl":"https://doi.org/10.11648/J.JDMP.20200604.13","url":null,"abstract":"Balanites aegyptiaca (L.) Del. (Balanitaceae), a tropical plant is well known for its widespread uses in Burkina Faso traditional medicine. The present study aims to evaluate the anti-inflammatory effect of B. aegyptiaca trough the turpentine-induced inflammation. The aqueous acetone extracts of galls and leaves have been used to test the anti-inflammatory effects on adult male Wistar-Bratislava albino rats. Total leukocytes count was performed with an optical microscope (Olympus), using a Burcker-Turk counting-chamber. The nitric oxides synthesis (NOx), the total oxidative status (TOS) and total antioxidant response (TAR) of the serum were measured using a colorimetric assay. The results have showed that all the extracts reduced significantly (p<0.0001) the total leukocytes and total nitrites and nitrates levels in the rats serum. The oxidative stress evaluation showed that the treatment with any dose of B. aegyptiaca gall and leaf extracts was significantly decreased (p<0.0001) the total oxidative status. Moreover, these extracts have been prevented the Turpentine oil induced inflammation by increasing the total antioxidant response. TAR increasing did correlated to TOS decrease by comparison with the inflammation group. In general, an interesting anti-inflammatory effect was found in this study with the greatest activity found in the gall extracts. B. aegyptiaca could then be a potential source of natural antioxidants and anti-inflammatories.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128812953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Optimization of Extraction Technology of Anemonin from Pulsatilla chinensis and Its Inhibitory Effect on Alternaria panax","authors":"Xue Fang, Jinlei Liu, Lirui Yang, Xiang-guo Li","doi":"10.11648/J.JDMP.20190506.12","DOIUrl":"https://doi.org/10.11648/J.JDMP.20190506.12","url":null,"abstract":"Background: The main antibacterial component of Pulsatilla chinensis is anemonin, which has strong antibacterial effect, so it is studied. The Pulsatilla chinensis is one of the diseases that are difficult to solve in the growth of ginseng, but chemical control not only causes harm to the environment, but also has residues on ginseng itself. Pulsatilla is a good medicinal plant. It will have a certain effect on the prevention and treatment of ginseng disease, and it can do no residue, no harm to ginseng. Objective: This experiment can provide effective data support for the prevention and treatment of Pulsatilla chinensis. Method: In this experiment, Pulsatilla Chinensis was used as experimental materials to extract plant by reflux, ultrasonic extraction methods, the content of anemonin in each single factor experiment was determined by HPLC. According to the content, the response surface analysis method was used to find the best extraction process, and the mycelium growth rate method was further used to determine the antifungal effect of Alternaria panax. Results: The EC50 value of P. Chinensis extract to A. panax was methanol extract < acetone extract < ethanol extract in order from small to large; The optimum extraction conditions of anemonin, the effective component of P. Chinensis methanol extract, were as follows: methanol volume fraction 87%, extraction time 2 h, solid-liquid ratio 20 (V: m), the optimum extraction amount was 3.760 μg·g-1.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122929015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Characterisation of Endophytic Fungi Strains from Lantana camara Leaves Displaying Antifungal Activity Against Phytophthora colocasiae","authors":"Mbouobda Hermann Desiré, Muyang Rosaline Forsah, Djeuani Astride Carole, Djou Tchinda Ismael, Fotso","doi":"10.11648/J.JDMP.20190506.11","DOIUrl":"https://doi.org/10.11648/J.JDMP.20190506.11","url":null,"abstract":"Colocasiae esculenta is an important tropical tuber crop susceptible to attack by many diseases. The most devastative among these is Taro leaf blight cause by the pathogen Phytophthora colocasiae. The pathogen can cause rapid complete defoliation and crop destruction and under some circumstances, the disease can attack harvested corms and cause heavy losses during storage. Endophytes constitute an important source of bioactive secondary metabolites and enzymes. Based on their phytochemical properties, they can be used as a source of antifungal agent for the treatment of some infectious diseases. In order to evaluate the impact of endophytes on plant defence, in vitro evaluation of the growth effect of endophytic fungi against P. colocasiae was conducted in dual culture, after isolating and screening endophytic fungi from L. camara leaves for their production of some extracellular enzymes (amylases, lipases, laccases, protease and cellulose) and some secondary metabolites (tannins, saponins, phenols, cardiac glycoside) using standard procedures. In-vitro culture techniques with Potato Dextrose Agar (PDA) as culture medium were used to isolate endophytes from L. camara leaf tissues. Isolate identification was done using macroscopic and microscopic characteristics. These isolates were then tested in vitro to evaluate their morphological growth effect against P. colocasiae via the dual culture. Five endophytic fungi were isolated from Lantana camara leaves and coded L1, L2, L3, L4 and L5. The L2, L3 and L5 strains were filamentous and showed coenocytic hyphae which bore some structures’ called conidiosphores identified as Cladosporium sp. L1 strain was filamentous fungi having clamp connections hyphae (bridge-like growth) above hyphal septa and brown sclerotia. L4 strain showed very tiny interwoven and tightly parked mycelia. As enzyme activities, all the strains were found to produce amylase and not protease. L1, L3 and L4 were able to synthesis laccase while L5 produced cellulose and lipase. For the secondary metabolites, all the strains were able to produced tannins and cardiac glycoside but they did not synthesis saponins. L1, L2 and L4 strains were able to produced phenol. In dual culture, the growth of the pathogen decreased the growth rate of the endophytes. L2 strain grew normally by forming an arc around P. colocasiae growth while L3 and L5 strains induced the pathogen to grow on the opposite side of P. colocasiae. Concerning L1 and L4 strains, there were no effect. Based on the antifungal activities against P colocasiae, these strains L2 and L3 could be used for biological control of taro life blight.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126980124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Ethnomedicinal and Pharmacological Uses of Echinops kebericho Mesfin in Ethiopia","authors":"Gadisa Demie","doi":"10.11648/j.jdmp.20190505.12","DOIUrl":"https://doi.org/10.11648/j.jdmp.20190505.12","url":null,"abstract":"The genus Echinops is native to African countries, the Middle East, Europe, and Asia comprises 120 species. In Ethiopia, this genus is represented by well known endemic and critically endangered species Echinops kebericho Mesfin also known as “ Kebercho,” in Amharic language which has a long history of ethnomedicinal uses. Due to the popularity of species as a source of ethnomedicine, this species is severely over-harvested throughout their distributional ranges. This review documents fragmented information on traditional uses and pharmacological evidence of Echinops kebericho in Ethiopia. This review article was carried out by searching studies in PubMed, Google scholar and Google search up to August 2019. The search terms were “Echinops kebericho Mesfin”, “therapeutic” & “pharmacological”. Ethnomedicinal uses of Echinops kebericho Mesfin has been recorded from different regions of Ethiopia for 32 human and 2 livestock ailments. E. kebericho is used to treat evil eye, headache, cough, stomachache, febrile illness and malaria ailments. The extracts of E. kebericho, particularly those from root, exhibited a wide range of pharmacological effects including antihelminthic, antibacterial, antifungal, antidiarrheal, anti spasmolytic and antimalarial activities. These pharmacological studies have established a scientific basis for therapeutic uses of Echinops kebericho Mesfin. Although Ethiopian Echinops kebericho is widely used by traditional practitioners but, it is threatened due to over exploitation of root part. Therefore, E. kebericho need urgent conservation attention, micro propagation, effective documentation and further research.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127195366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Colonic Pseudotumoral Form of Crohn’s Disease: About a Case at the Sourô Sanou University Hospital Center in Bobo-Dioulasso","authors":"Zouré Nogogna, Koura Mâli, S. Roland, Napon, Zongo Passolguewindé Delphine, Kamboulé Bébare Euloges, Ouattara Zanga Damien, Somda Kounpilélimé Sosthène, Coulibaly Aboubacar, S. Sandrine, Traoré Adama, S. Appolinaire","doi":"10.11648/J.JDMP.20190505.11","DOIUrl":"https://doi.org/10.11648/J.JDMP.20190505.11","url":null,"abstract":"Crohn's disease is a chronic inflammatory bowel disease (IBD) that can affect all segments of the digestive tract. For long time, it is a pathology considered to be uncommon among African blacks. It constitutes a heterogeneous group both in its etiopathogenesis and in its clinical and progressive presentation. The pseudotumoral form remains exceptional. We report a case of this form, observed in a 44-year-old patient. The pseudotumoral form of colonic Crohn's disease was diagnosed based on morphological, histological and progression criteria. This illustrates the need for multiple and repeated biopsies to eliminate malignant tumor, tuberculosis, intestinal parasitosis and other causes of digestive granulomatosis.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"154 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114002807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hypoglycaemic and Hypolipidemic Effects of Aqueous Extract of Alkanna strigosa in Alloxan Induced Diabetic Rats","authors":"K. Mansi, M. Abu-al-basal, T. Aburjai","doi":"10.11648/J.JDMP.20190504.11","DOIUrl":"https://doi.org/10.11648/J.JDMP.20190504.11","url":null,"abstract":"Many plants have been used for the treatment of diabetes mellitus in Jordanian system of medicine and in other ancient systems of the world. The present study is aimed to evaluate the potential mechanism of antidiabetic action of aqueous extract of Alkanna strigosa aerial part and its hypolipidemic effects in normal and alloxan-induced diabetic rats. This study was conducted on fifty experimental animals. Adult albino rats (Sprague- Dawely strain) weighing about 220 g each were used throughout the study. Fifty rats were randomly assigned to five experimental groups of 10 rats each: Group 1 - received normal saline (0.5 ml/kg), and serves as control. Group II - gavaged daily for thirty days with 1ml of the extract at doses of 400 mg/kg body wt and served as control. Group III - Untreated diabetic rats that received two doses of alloxan 150 mg/kg. Group IV – Treated diabetic rats for thirty consecutive days with 1 ml of the extract at a dose of 400 mg/kg body wt. Group V: Treated diabetic rats for thirty consecutive days with 14.2 mg/kg of metformin. Several hematological and biochemical parameters were assessed. It was found that the administration of aqueous extract of Alkanna strigosa produced significant reduction in blood glucose level in diabetic rats after thirty days of treatment. However, there was a significant (p < 0.05). Increase of insulin secretion. Also, the RBC and WBC count, PCV and neutrophil percentage decreased significantly (p < 0.05). This study indicated that the aqueous extract of Alkanna strigosa increased the RBC and WBC counts, PCV, ESR, and neutrophil percentage in diabetic rats. However, the WBC count of the extract - treated diabetic group was still lower than those of control values. Administration of the extract resulted in a significant reduction in the mean values of serum cholesterol, triglyceride, LDL-C, ESR, urea, uric acid, creatinine accompanied by an increase in the mean values of total protein, albumin, insulin, HDL-C, neutrophile count and PCV in diabetic rats. No significant changes in these parameters were found in the control group. Effects produced by this extract were closely similar to a standard antidiabetic drug, metformin. (p < 0.05) hypoglycemic effects in alloxan-induced diabetic rats, protection against body weight loss of diabetic animals and might alleviate diabetes-induced disturbances of some biochemical and hematological parameters. These results suggest that the oral administration of aqueous extract of the aerial part of Alkanna strigosa possesses antidiabetic and hypolipidemic effects in alloxan-induced diabetic rats.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133177964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}