Journal of Diseases and Medicinal Plants最新文献

{"title":"Anti-Anemic Potential of a Herbal Recipe Against Phenylhydrazine-Induced Anemia in Rats","authors":"Tatiana Kangah Mireille Kple, J. Akakpo-Akue, Konan Armand Marcelin Kouassi, S. Ouattara, Gbe Kouakou N’Dri Ange Konan, Diane Koulai, Larissa Adjoua Kouadio, Chiaye Claire Antoinette Yapo-Crezoit, Adou Koffi Mattieu Kra, Allico Joseph Djaman","doi":"10.11648/j.jdmp.20230902.12","DOIUrl":"https://doi.org/10.11648/j.jdmp.20230902.12","url":null,"abstract":"","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122962438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroprotective Activity and Potential Mechanism of the Stem Bark of <i>Boswellia dalzielii</i> on Gastric Ulcer in Rat","authors":"Gustave Lebeau Ndji Otto, A. Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, Amang André Perfusion, Désirée Sandrine Essama Mbida, Jean Pierre Kilekoung Mingoas, Ernestine Nkwengoua Zodengoumba, Tan Paul Vernyuy","doi":"10.11648/j.jdmp.20230902.11","DOIUrl":"https://doi.org/10.11648/j.jdmp.20230902.11","url":null,"abstract":"","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122533678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening, Antioxidant, Anti-Inflammatory and Antibacterial Studies on the Stem Bark Extracts of <i>Lannea microcarpa </i>Engl. & K. Krause","authors":"Barkoma Mohammed Bashir","doi":"10.11648/j.jdmp.20230901.13","DOIUrl":"https://doi.org/10.11648/j.jdmp.20230901.13","url":null,"abstract":": Medicinal Plants are Plants used for traditional medicines. Any part of the plant could be used as medicine. Medicinal plants have been discovered and used in traditional medicine practices since pre-historical times. A survey of traditional medicine man in Damaturu indicated that Lannia microcarpa is a plants used in the treatment of inflammation, wounds and cancer. The fresh samples (stem bark) of the plant was collected and successively extracted with n-hexane, ethyl acetate, methanol and water. Phytochemical constituents of Lannea microcarpa extracts revealed the presence of cardiac glycosides, flavonoids, saponins, phenols, tannins, alkaloids, sterols and terpenoids. The antioxidant potential was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, whereas membrane stabilization method was used to evaluate the anti-inflammatory potential of the extracts. The antibacterial potential of the plant extracts against four (4) wound pathogens: Salmonella typhi, Staphylococcus aureus, Escherichia coli and Strephtococcus pneumoneae, was evaluated using disc diffusion technician. The IC 50 values obtained for the Lannea microcarpa extracts indicated that the methanol and water extracts exhibited higher antioxidant activities than the standard ascorbic acid. The extracts were found effective in inhibiting the heat induced haemolysis. Diclofenac Sodium salt used as standard drug at 100µg/ml offered 90.66% protection a significant (p<0.05) protection against damaging effect of heat solution. The results showed that all extracts from the plant offered a significant (p<0.05) protection against the damaging effect of hypotonic solution, Diclofenac sodium (100µg/ml), the standard drug offered a significant (p<0.05) protection (57.52%). Lannea microcarpa extracts showed zone of inhibition only against Salmonella typhi and Strephtococcus pneumonea.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131459372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating <i>In Vivo</i> Model, Molecular Docking and Network Pharmacology to Determine the Mechanism of <i>Theobroma cacao</i> Seed in Treatment of Diarrheal","authors":"Maria Fernanda Marin, Jose Guillermo Mejía, Alberto Gabriel Flores, Ana Karla Cuchilla, Miguel Angel Moreno","doi":"10.11648/j.jdmp.20230901.12","DOIUrl":"https://doi.org/10.11648/j.jdmp.20230901.12","url":null,"abstract":"","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131352158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational Case Study on the Effectiveness of the Herbal Decoction Varanadi Kashaya in Managing Obesity of an Individual with Metabolic Disorders","authors":"Walpita Kankanamalage Anthoneen Ayesha Thilini Perera, Nambuhewage Dhammika Namal Jayawardhane","doi":"10.11648/j.jdmp.20230901.11","DOIUrl":"https://doi.org/10.11648/j.jdmp.20230901.11","url":null,"abstract":"","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122638210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Applications, Active Components and Mechanisms of Haemostatic Effects of Charred Chinese Medicines","authors":"Guo-hong Zhou, X. Shen, Zhendong Zhao, Renliang Yan, Pei-xin Huang, Ru-Qi Tan, Shuibo Liang, Yanting Zhi, Jiaqi Li","doi":"10.11648/J.JDMP.20210704.12","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210704.12","url":null,"abstract":"Charred traditional Chinese medicines have been used to stop bleeding since ancient times. To date, they are often applied to treat purpura, metrorrhagia, upper gastrointestinal bleeding, postoperative hemorrhage of mixed hemorrhoids, and hemorrhoids bleeding. Conventional oral decoction is still a predominate application form. It is noteworthy that a new and original application form of charred herbs has occurred in the treatment of upper gastrointestinal bleeding. Different from the conventional oral decoction, the micron-sized rhei radix et rhizome carbonisatus was sprayed on the surface of the lesion through gastroscopy to stop upper gastrointestinal bleeding. Active tannins, calcium ions, flavonoids and anthraquinones play a role in a part of charred herbs to stop bleeding. The emergence or increase of active components may lead charred herbs to significantly better haemostatic effects than uncharred ones, especially the emergence of activated carbon and novel carbon dots. This underlines a big need to char herbs at first before their clinical use. It leads to a new issue how to char herbs properly for maximum active components, which is related to the quality control of charred herbs. Hence, the optimum charring methods should be explored in depth for different herbs in the future. Furthermore, modern research indicates the haemostatic mechanisms of charred herbs are related to their ability to activate coagulation pathways, enhance platelet systems and/or inhibit fibrinolysis systems.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128822499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> Anthelmintic Activity of <i>Tephrosia pedicellata</i> on Two Nematodes (<i>Haemonchus contortus, Caenorhaditis elegans</i>) and Its <i>In vivo</i> Toxicity on Rats","authors":"I. Haman, Ahmadou Adamou, Francis Nveikoueing, N. Njintang, D. Ndjonka","doi":"10.11648/J.JDMP.20210704.11","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210704.11","url":null,"abstract":"In Cameroon, the practice of traditional medicine in the treatment of intestinal helminthiasis is a reality and habits in the lives of traditional healers and breeders for various reasons related to their local life situations. In the valorization of medicinal plants in the treatment of digestive parasitosis as an alternative to synthetic anthelmintics, a study was carried out in order to verify their anthelmintic activity and the level of their toxicity. The present study was carried out to determine the in vitro anthelminthic activity of Tephrosia pedicellata extracts. Aqueous and hydroethanolic leaves extracts at different concentrations were tested against Haemonchus contortus development stages, mutant and wild type of free-living nematode Caenorhabditis elegans. The two plant extracts were then chemically screened and their toxicological profile was established using albino rats. Hydroethanolic extract was the most potent by killing Haemonchus contortus adults (LC50: 0.038 mg/mL after 24 hours), infesting larvae (LC50: 0.22 mg/mL after 48 hours) and inhibiting egg hatching (IC50: 0.76 mg/mL after 48 hours). The two plant extracts showed same activity on Caenorhabditis elegans levamisole non-sensitive (LC50: 0.26 mg/mL after 48 hours) and sensitive strains (LC50: 0.25 mg/mL after 48 hours), showing different mode of action to that of levamisole. Several plant chemicals were identified from both extracts, with higher content of polyphenol compounds (562.91 mg GAE/g DW), flavonoids (135.96 mg RE/g DW), condensed tannins (228.50 mg CE/g DW) and saponins (206.83 mg SE/g DW) obtained with the hydroethanolic extract. No toxic effect was observed during acute toxicity study. Moreover, apart from the significant increase of platelets and Aspartate transaminase (p=0.001) and the glomerular inflammation in the lungs at the dose of 1000 mg/kg, no harmful variation of haematological and biochemical parameters of rats were observed. The pattern of anthelmintic activity of these extracts on Caenorhabditis elegans and the non-toxic effect of hydroethanolic extract provide a way for new anthelminthic drug.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133391811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cistus × Incanus L. Pandalis Is Highly Effective Against Delta Variant of SARS-CoV-2 in Vitro","authors":"J. Traeder","doi":"10.11648/J.JDMP.20210703.13","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210703.13","url":null,"abstract":"Background: Recent studies have shown that a special extract from Cistus x incanus L. Pandalis (Cystus Pandalis® extract) has proven to be effective against SARS-CoV-2 in vitro and it is likely that the extract shows to be effective against other new variants of SARS-CoV-2 like the “Indian” Delta-Variety as well. Methods: In order to verify our claim, we examined how the extract Cystus Pandalis® inhibits the cytopathic action (CPE) of the Coronavirus in a cell model with human intestinal cells (Caco-2). We incubated viruses with the extract and mixed them with the cell cultures. Result: Cystus Pandalis® extract has almost completely inhibited virus growth at concentrations greater than 100 μg/ml. The calculated IC50 (mean inhibitory concentration) for the \"Indian\" Delta variant was 101 µg/ml. Conclusion: Cistus x incanus L. Pandalis extract (Cystus Pandalis® extract) is capable of preventing cell cultures from being infected by SARS-CoV-2 in-vitro. Because of its high in-vitro potency against the new variants of SARS-CoV-2, it is more than ever reasonable to use Cystus Pandalis® prophylactically in order to decrease the virus load. The development of resistance to the extract is not likely. People tolerate the extract very well. No significant side effects have been detected. Phytopharmaceuticals extraxted from Cistus x incanus L. Pandalis are able to combat viral infections and can help contain future pandamics by being handed in advance profilactically.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114717295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extract from Cistus × Incanus L. Pandalis also Effective Against “British” Alpha (B.1.1.7) and “South African” Beta (B.1.351) SARS-CoV-2 Variants","authors":"J. Traeder","doi":"10.11648/J.JDMP.20210702.13","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210702.13","url":null,"abstract":"Background: In previous studies, a special extract from Cistus × incanus L. Pandalis (Cystus Pandalis® extract) has already proven to be effective against SARS-CoV-2 in vitro. We assume that an effect was also likely against the new SARS-CoV-2 variants, like the “British” alpha variant (B.1.1.7) as well as against the “South African” beta variant (B.1.351). Methods: To verify this, we investigated the inhibition of the cytopathic effect (CPE) of the coronaviruses by the Cystus Pandalis® extract in a cell model with human intestinal cells (Caco-2). We inoculated viral pre-treated cells with the herbal extract (A), and we mixed pre-treated viruses with the herbal extract in the cell cultures (B). Result: We observed an almost complete inhibition of virus growth by Cystus Pandalis® extract at concentrations of more than 100 μg/ml. The calculated IC50 (mean inhibitory concentration) for the “British” alpha variant (B.1.1.7) as well as for the “South African” beta variant (B.1.351) is below 50 μg/ml. There was no significant difference in the results in the two different ways of treatment. Conclusion: Extract from Cistus × incanus L. Pandalis (Cystus Pandalis® extract) can prevent in in-vitro cell cultures infections with SARS-CoV-2. Due to the high in vitro activity against the new variants, it also appears reasonable in the future to use Cystus Pandalis® as prophylaxis against infections with SARS-CoV-2. A development of resistance is unlikely. People tolerate the extract very well. It has no significant side effects.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121457838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Traditional Knowledge Associated with Medicinal Plants in North Achfer District, Amhara Region, North Ethiopia","authors":"Tensay Ayalw, Edeget Merawi","doi":"10.11648/J.JDMP.20210702.12","DOIUrl":"https://doi.org/10.11648/J.JDMP.20210702.12","url":null,"abstract":"The objective of the study was to document traditional knowledge on medicinal plants in north Achefer district. This study was conducted using semi-structured interviews using purposeful and random sampling methods. The collected data was analyzed using IBM SPSS statics 21software. A total of 65 informants 59 male and 6 female were interviewed from 5 kebele of north Achefer district. Among 65 informants only 12 (18.5%) individuals are traditional healers and the rest 53 (81.5%) persons were not traditional healers. A total of 74 medicinal plants were recorded for treating human and animal ailments through oral, dermal and nasal routs. From the collected medicinal plant species, 98% / of them were identified and the rest 2% / medicinal plant species were listed by their local name. Among 39 plant families the most frequently used plant species reported were Solanaceae 5 (7.4%) and Euphorbiaceae 5 (7.4%), Fabaceae 4 (5.9%) and the least Lamiaceae 3 (4.4%). In the study area medicinal plants affect by different factors, the main factors were human activity (69.2%) by cutting; agricultural explanation, cultivating introduced species and natural factors (20%) drought, erosion, hail and the rest (10.8%) of respondents were reported that factors affected medicinal plants in the area. North Achefer woreda is rich in indigenous knowledge associated with medicinal plant but the distribution and diversity of medicinal plants have been declined at alarming rate. So attention should given and use best conservation methods to protect species from loss.","PeriodicalId":186601,"journal":{"name":"Journal of Diseases and Medicinal Plants","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132961486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}