Mini-reviews in Organic Chemistry最新文献_第3页

Functionalization of semi-conductive interfaces with cucurbit[n]urils 用葫芦[n]脲使半导电界面功能化

IF 2.3 4区化学

Mini-reviews in Organic Chemistry Pub Date : 2024-01-05 DOI: 10.2174/0118756298232086231203163938

Andisiwe Ngwekazi, Christopher Arendse, Priscilla Baker

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Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions 通过自由基级联反应构建香豆素或 2-喹啉酮化合物的最新进展

IF 2.3 4区化学

Mini-reviews in Organic Chemistry Pub Date : 2024-01-05 DOI: 10.2174/0118756298278048231205053801

Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan, Zhi-Wei Chen

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Meet the Editorial Advisory Board Member 与编辑顾问委员会成员会面

IF 2.3 4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-11-01 DOI: 10.2174/1570193x2007230331134915

I. Iavicoli

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Asciminib - ABL Kinase Inhibitor in the Treatment of Philadelphia Chromosome Positive Chronic Myeloid Leukemia: Chemistry and Pharmacology Perspectives 阿西米尼- ABL激酶抑制剂治疗费城染色体阳性慢性髓性白血病:化学和药理学观点

4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-10-17 DOI: 10.2174/0118756298270515231010062046

Umang Shah, Prachi Patel, Alkesh Patel, Dhruvi Gajjar, Mehul Patel, Nilay Solanki, Swayamprakash Patel, Ashish Patel, Rajesh Maheshwari

{"title":"Asciminib - ABL Kinase Inhibitor in the Treatment of Philadelphia Chromosome Positive Chronic Myeloid Leukemia: Chemistry and Pharmacology Perspectives","authors":"Umang Shah, Prachi Patel, Alkesh Patel, Dhruvi Gajjar, Mehul Patel, Nilay Solanki, Swayamprakash Patel, Ashish Patel, Rajesh Maheshwari","doi":"10.2174/0118756298270515231010062046","DOIUrl":"https://doi.org/10.2174/0118756298270515231010062046","url":null,"abstract":"Abstract: Asciminib, also known as ACP-196, is the FDA-approved low-molecular ABL kinase inhibitor. The ABL kinase is a non-receptor tyrosine kinase that helps in cell growth and survival and is a key player in the development of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). The BCR-ABL fusion protein, which is formed by chromosomal translocation in CML and Ph+ ALL, results in the constitutive activation of ABL kinase, leading to uncontrolled cell growth and proliferation. To have a high binding affinity for the active site of the enzyme, structural biology and computer-aided drug design (CADD) concepts were applied to the design of asciminib so that it could specifically target the ABL kinase enzyme. The drug was synthesized and characterized in a laboratory. In its pharmacological studies, it has shown that asciminib is a potent and selective inhibitor of ABL kinase. Phase I clinical trials assessed its safety and efficacy, revealing that it is effective against tumors while causing minimal discomfort to patients. In addition to this, it was able to induce apoptosis and a cytogenetic response as well as inhibit the proliferation of CML and Ph+ALL cells in patients with CML. As this trial gave a positive response, phase II and III trials were conducted. In that sense, asciminib has shown to be highly effective, with response rates of over 90% in patients with these diseases. The safety and efficacy of asciminib were also evaluated in combination with other drugs, such as tyrosine kinase inhibitors and immunomodulatory drugs, and the results were promising. Overall, the discovery and development of asciminib showed that by using the concepts of pharmacology and CADD, a drug with a 90% positive rate response can be developed with a high tolerance level and lower side effects","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136037795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xanthates and Dithiocarbamates: Synthesis, Characterization and Application in Flotation Processes 黄原酸盐和二硫代氨基甲酸盐:合成、表征及其在浮选中的应用

4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-10-10 DOI: 10.2174/0118756298267964231004113212

Nadezhda V. Vchislo, Ekaterina A. Verochkina, Igor B. Rozentsveig, Alexander E. Burdonov

{"title":"Xanthates and Dithiocarbamates: Synthesis, Characterization and Application in Flotation Processes","authors":"Nadezhda V. Vchislo, Ekaterina A. Verochkina, Igor B. Rozentsveig, Alexander E. Burdonov","doi":"10.2174/0118756298267964231004113212","DOIUrl":"https://doi.org/10.2174/0118756298267964231004113212","url":null,"abstract":"Abstract: It is known that flotation is the main method of extracting non-ferrous metals. The need of modern society for precious metals is constantly growing, and deposits of easily reversible ores are being depleted. Therefore, the improvement of the reagent regime and the search for new flotation reagents is an urgent task. We analyzed the literature data on the synthesis and use of common collectors such as xanthates and dithiocarbamates. Particular importance is given to recent progress in the functionalization of xanthates and dithiocarbamates, their selective characteristics and flotation mechanisms. Progress in the field of flotation can be made in the use of new effective reagents and their combinations, as well as in the modification of already known collectors. The generalization of the material in this review will help in the development of this area. The mini-review summarizes the syntheses of collectors such as xanthates and dithiocarbamates with the increased selective properties in the flotation process of non-ferrous metals. Furthermore, this review provides an analysis of the developments in these studies, especially highlighting recent progress in the functionalization of xanthates and dithiocarbamates, their selective characteristics and flotation mechanisms.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to a New Technique in Organic Synthesis: Recent Advances in Aqueous Reactions of Sparingly Soluble High-Melting Point Substrates Promoted by Granular Polytetrafluoroethylene 有机合成新技术简介:颗粒聚四氟乙烯促进高熔点稀溶底物的水反应研究进展

4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-10-05 DOI: 10.2174/0118756298253318230929034500

Linlin Xing, Yong Zhang, Taixuan Jia, Chunbao Li

引用次数: 0

Photochemistry of Riboflavin: The Primary Transients 核黄素的光化学:初级瞬态

4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-09-13 DOI: 10.2174/1570193x21666230913092924

Igor V. Khudyakov

引用次数: 0

Synthetic Approaches and Reactions of 2-(Arylidene)benzo[b]thiophen-3(2H)one-1,1-dioxides 2-(芳基)苯并[b]噻吩-3(2H) 1- 1,1-二氧化物的合成方法及反应

4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-09-06 DOI: 10.2174/1570193x21666230906141749

RAJ KUMAR, Subrata Barick, Manvendra Kumar

{"title":"Synthetic Approaches and Reactions of 2-(Arylidene)benzo[b]thiophen-3(2H)one-1,1-dioxides","authors":"RAJ KUMAR, Subrata Barick, Manvendra Kumar","doi":"10.2174/1570193x21666230906141749","DOIUrl":"https://doi.org/10.2174/1570193x21666230906141749","url":null,"abstract":"Abstract: 2-(Arylidene)benzo[b]thiophen-3(2H)one 1,1-dioxides are oxidized form of thioaurones. Various methods have been reported for their synthesis, e.g., a) condensation of benzo[b]thiophen-3(2H)one 1,1-dioxides with aryl aldehydes under acidic or basic conditions, b) oxidation of thioaurones with hydrogen peroxide or sodium perborate tetrahydrate, c) from the catalytic reaction of iodonium ylides with (bis(trifluoroacetoxy)iodo) benzene in presence copper(II)acetoacetonate, d)by ring contraction of 1-thioflavones in the presence of ceric ammonium nitrate. The reports have shown addition reactions with p-thiocresol in the absence of any catalyst, conjugated addition product without hetero ring opening with Grignard reagent, forms corresponding oxime and hydrazone with hydroxyl amine and phenyl hydrazine, respectively, produces polycyclic compounds with enamines, shows contrasting behavior with NBS and gives addition products with organophosphorus compounds in both hydroxylic and non-hydroxylic solvents which depends on reaction medium. In the present mini-review, we have discussed the various synthetic strategies and reactions of 2-(arylidene)benzo[b]thiophen-3(2H)one 1,1-dioxides, along with their reported utilities.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135203931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Existence and Bioactivity of Flavonoids: Synthetic Strategies and Mechanistic Pathways 黄酮类化合物的天然存在和生物活性:合成策略和机制途径

IF 2.3 4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-09-01 DOI: 10.2174/1570193x21666230901110030

Shivangi Sharma, Pankaj Kumar Mishra, Shivendra Singh

{"title":"Natural Existence and Bioactivity of Flavonoids: Synthetic Strategies and Mechanistic Pathways","authors":"Shivangi Sharma, Pankaj Kumar Mishra, Shivendra Singh","doi":"10.2174/1570193x21666230901110030","DOIUrl":"https://doi.org/10.2174/1570193x21666230901110030","url":null,"abstract":"\u0000\u0000A class of chemicals known as flavonoids is widely distributed in various portions of plants, cereals, and vegetables. They have varied phenolic structures and these flavonoid molecules are known for the well-being improvement in living things. Today, a wide range of pharmaceutical, medicinal, & cosmetic materials possessed these key ingredients, known as flavonoids. Flavonoids can modulate the bioactivity of essential enzymes & their properties such as anti-mutagenic, anti-inflammatory, anti-oxidative, & anti-carcinogenic. The current patterns of flavonoid in research & development helps in the identification, isolation, characterization, & functions of flavonoids as well as their applications for better biological activities. In this article, we have discussed the natural existence and structural frameworks of the different classes of potential bioactive flavonoids. In addition to this, different synthetic strategies, and their mechanistic pathways for the preparation of different classes of flavonoids are also discussed thoroughly here. Owing to its tremendous natural existence and bioactivity, more research is still needed to further explore the usefulness of flavonoids for human wellness. The major challenge with the study of such flavonoids is the diversity of molecular structures & scarcity of data on their bioavailability. However, this article will be helpful for understanding the chemical aspect and several potential bioactivities of flavonoids\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46799465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Synthesis, Characterization, and Pharmacological Properties of Some Sydnone Derivatives 一些syd酮衍生物的合成、表征及药理性质的研究进展

IF 2.3 4区化学

Mini-reviews in Organic Chemistry Pub Date : 2023-08-31 DOI: 10.2174/1570193x21666230831153810

T. Khan, Ritu Yadav, A. K. Kesharwani, Karuna Chourasia

引用次数: 0