黄酮类化合物的天然存在和生物活性:合成策略和机制途径

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC
Shivangi Sharma, Pankaj Kumar Mishra, Shivendra Singh
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引用次数: 0

摘要

黄酮类化合物广泛分布于植物、谷物和蔬菜的各个部位。它们具有不同的酚类结构,这些类黄酮分子对改善生物的健康状况是已知的。如今,各种各样的药物、医药和化妆品材料都含有这些关键成分,即黄酮类化合物。黄酮类化合物可以调节必需酶的生物活性及其抗突变、抗炎、抗氧化和致癌等特性。黄酮类化合物目前的研究和开发模式有助于黄酮类化合物的鉴定、分离、表征和功能,以及它们在更好的生物活性方面的应用。在这篇文章中,我们讨论了不同种类的潜在生物活性黄酮的天然存在和结构框架。除此之外,本文还深入讨论了不同的合成策略及其制备不同类别黄酮类化合物的机理途径。由于类黄酮具有巨大的天然存在和生物活性,还需要更多的研究来进一步探索类黄酮对人类健康的有用性。研究此类黄酮类化合物的主要挑战是分子结构的多样性和生物利用度数据的匮乏。然而,这篇文章将有助于理解类黄酮的化学方面和几种潜在的生物活性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural Existence and Bioactivity of Flavonoids: Synthetic Strategies and Mechanistic Pathways
A class of chemicals known as flavonoids is widely distributed in various portions of plants, cereals, and vegetables. They have varied phenolic structures and these flavonoid molecules are known for the well-being improvement in living things. Today, a wide range of pharmaceutical, medicinal, & cosmetic materials possessed these key ingredients, known as flavonoids. Flavonoids can modulate the bioactivity of essential enzymes & their properties such as anti-mutagenic, anti-inflammatory, anti-oxidative, & anti-carcinogenic. The current patterns of flavonoid in research & development helps in the identification, isolation, characterization, & functions of flavonoids as well as their applications for better biological activities. In this article, we have discussed the natural existence and structural frameworks of the different classes of potential bioactive flavonoids. In addition to this, different synthetic strategies, and their mechanistic pathways for the preparation of different classes of flavonoids are also discussed thoroughly here. Owing to its tremendous natural existence and bioactivity, more research is still needed to further explore the usefulness of flavonoids for human wellness. The major challenge with the study of such flavonoids is the diversity of molecular structures & scarcity of data on their bioavailability. However, this article will be helpful for understanding the chemical aspect and several potential bioactivities of flavonoids
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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