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Exploratory analysis on payment mechanisms to Community Mental Health Centers in Chile using mixed grounded theory. 运用混合基础理论对智利社区心理健康中心的支付机制进行探索性分析。
IF 1.2
Medwave Pub Date : 2024-06-04 DOI: 10.5867/medwave.2024.05.2920
Olga Toro-Devia, Rubén Alvarado, Mercedes Jeria, Denise Razzouk, Luis Salvador-Carulla
{"title":"Exploratory analysis on payment mechanisms to Community Mental Health Centers in Chile using mixed grounded theory.","authors":"Olga Toro-Devia, Rubén Alvarado, Mercedes Jeria, Denise Razzouk, Luis Salvador-Carulla","doi":"10.5867/medwave.2024.05.2920","DOIUrl":"https://doi.org/10.5867/medwave.2024.05.2920","url":null,"abstract":"<p><strong>Introduction: </strong>Research on psychiatric deinstitutionalization has neglected that reforms in this field are nested in a health system that has undergone financial reforms. This subordination could introduce incentives that are misaligned with new mental health policies. According to Chile's National Mental Health Plan, this would be the case in the Community Mental Health Centers (CMHC). The goal is to understand how the CMHCpayment mechanism is a potential incentive for community mental health.</p><p><strong>Methods: </strong>A mixed quantitative-qualitative convergent study using grounded theory. We collected administrative production data between 2010 and 2020. Following the payment mechanism theory, we interviewed 25 payers, providers, and user experts. We integrated the results through selective coding. This article presents the relevant results of mixed selective integration.</p><p><strong>Results: </strong>Seven payment mechanisms implemented heterogeneously in the country's CMHC are recognized. They respond to three schemes subject to rate limits and prospective public budget. They differ in the payment unit. They are associated with implementing the community mental health model negatively affecting users, the services provided, the human resources available, and the governance adopted. Governance, management, and payment unit conditions favoring the community mental health model are identified.</p><p><strong>Conclusions: </strong>A disjointed set of heterogeneously implemented payment schemes negatively affects the community mental health model. Formulating an explicit financing policy for mental health that is complementary to existing policies is necessary and possible.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International migration, food insecurity, and mental health: A scoping review protocol. 国际移民、粮食不安全与心理健康:范围界定审查协议。
IF 1.2
Medwave Pub Date : 2024-05-30 DOI: 10.5867/medwave.2024.04.2802
Alice Blukacz, Báltica Cabieses, Catalina Huerta, Amelia A Lake, Jo Smith, Emma L Giles, Faye Deane
{"title":"International migration, food insecurity, and mental health: A scoping review protocol.","authors":"Alice Blukacz, Báltica Cabieses, Catalina Huerta, Amelia A Lake, Jo Smith, Emma L Giles, Faye Deane","doi":"10.5867/medwave.2024.04.2802","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.2802","url":null,"abstract":"<p><strong>Introduction: </strong>Food insecurity is a global priority that has been found to negatively impact mental health, increasing the risk of mental disorders and severe mental illness. International migrants may face food insecurity throughout their migratory cycle due to a range of risk factors, such as poor transit conditions, precarious employment, financial pressure, discrimination, and lack of availability and access to culturally relevant food, among others. Although there are multiple reviews on migration, food insecurity, and health in general, no scoping review has been conducted on food insecurity among international migrants focusing on mental health.</p><p><strong>Objective: </strong>To investigate the available evidence on food insecurity and mental health among international migrants.</p><p><strong>Methods: </strong>A search of scientific literature in English, Spanish, French, Italian, and Portuguese published since 2013 will be performed in the Web of Science, PubMed, Medline, APA PsycArticles, Cinahl, and ASSIA databases, including grey literature available in Google Scholar. Two authors will independently review titles, abstracts, and full texts before extracting data from publications complying with the eligibility criteria. Extracted data will be descriptively mapped according to emerging thematic categories.</p><p><strong>Expected results: </strong>The review will contribute to identifying what is known about international migration, food insecurity, and mental health, gaps in the literature, opportunities for specific research subtopics, and how food insecurity and mental health can be linked in the existing literature.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological considerations in the study of perceived discrimination at work and its association with workers health and occupational outcomes: A scoping review. 工作中感知到的歧视及其与工人健康和职业结果的关系研究中的方法考虑:范围综述。
IF 1.2
Medwave Pub Date : 2024-05-22 DOI: 10.5867/medwave.2024.04.291
Gonzalo Bravo, Alejandra Fuentes-García, M. Arriagada, H. Castellucci
{"title":"Methodological considerations in the study of perceived discrimination at work and its association with workers health and occupational outcomes: A scoping review.","authors":"Gonzalo Bravo, Alejandra Fuentes-García, M. Arriagada, H. Castellucci","doi":"10.5867/medwave.2024.04.291","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.291","url":null,"abstract":"Introduction\u0000Perceived workplace discrimination is a complex phenomenon involving unfair treatment in the workplace based on personal characteristics such as age, ethnicity, gender, or disability. The objective of this study is to explore the association of perceived workplace discrimination with health and occupational outcomes.\u0000\u0000\u0000Methods\u0000Following the PRISMA-ScR guidelines and the Joanna Briggs Institute methodology, a scoping review of articles published between 2000 and 2022 was conducted in databases such as Pubmed, Scopus, and PsyInfo. Inclusion criteria focused on studies exploring perceived workplace discrimination among workers, excluding those on patients, students, or the general population, and articles not written in English or Spanish.\u0000\u0000\u0000Results\u0000Of the 9,871 articles identified, 102 met the criteria and were analyzed. Research showed a progressive increase in the study of perceived workplace discrimination, with a majority of studies in North America and Europe and a predominance of cross-sectional designs. Most studies did not clearly define the concept of perceived workplace discrimination nor report the psychometric characteristics of the measurement instruments. A significant association was found between perceived discrimination and negative outcomes in workers' mental and physical health, as well as a negative impact on job satisfaction and an increase in absenteeism. Additionally, sociodemographic characteristics such as race/ethnicity, gender, and age influenced the perception of discrimination.\u0000\u0000\u0000Conclusions\u0000This review confirms that perceived workplace discrimination significantly impacts the health and job satisfaction of workers, with particular detriment in minorities and women. Despite an increase in research over the last two decades, there remains a lack of consistency in the definition and measurement of the phenomenon. Most studies have used cross-sectional designs, and there is a notable absence of research in the Latin American context.","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141112832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological considerations in the study of perceived discrimination at work and its association with workers health and occupational outcomes: A scoping review. 工作中感知到的歧视及其与工人健康和职业结果的关系研究中的方法考虑:范围综述。
IF 1.2
Medwave Pub Date : 2024-05-22 DOI: 10.5867/medwave.2024.04.2910
Gonzalo Bravo, Alejandra Fuentes-Garcia, María Arriagada, Héctor Castellucci
{"title":"Methodological considerations in the study of perceived discrimination at work and its association with workers health and occupational outcomes: A scoping review.","authors":"Gonzalo Bravo, Alejandra Fuentes-Garcia, María Arriagada, Héctor Castellucci","doi":"10.5867/medwave.2024.04.2910","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.2910","url":null,"abstract":"<p><strong>Introduction: </strong>Perceived workplace discrimination is a complex phenomenon involving unfair treatment in the workplace based on personal characteristics such as age, ethnicity, gender, or disability. The objective of this study is to explore the association of perceived workplace discrimination with health and occupational outcomes.</p><p><strong>Methods: </strong>Following the PRISMA-ScR guidelines and the Joanna Briggs Institute methodology, a scoping review of articles published between 2000 and 2022 was conducted in databases such as Pubmed, Scopus, and PsyInfo. Inclusion criteria focused on studies exploring perceived workplace discrimination among workers, excluding those on patients, students, or the general population, and articles not written in English or Spanish.</p><p><strong>Results: </strong>Of the 9,871 articles identified, 102 met the criteria and were analyzed. Research showed a progressive increase in the study of perceived workplace discrimination, with a majority of studies in North America and Europe and a predominance of cross-sectional designs. Most studies did not clearly define the concept of perceived workplace discrimination nor report the psychometric characteristics of the measurement instruments. A significant association was found between perceived discrimination and negative outcomes in workers' mental and physical health, as well as a negative impact on job satisfaction and an increase in absenteeism. Additionally, sociodemographic characteristics such as race/ethnicity, gender, and age influenced the perception of discrimination.</p><p><strong>Conclusions: </strong>This review confirms that perceived workplace discrimination significantly impacts the health and job satisfaction of workers, with particular detriment in minorities and women. Despite an increase in research over the last two decades, there remains a lack of consistency in the definition and measurement of the phenomenon. Most studies have used cross-sectional designs, and there is a notable absence of research in the Latin American context.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key factors in the choice of appropriate outcomes for clinical trials. 为临床试验选择适当结果的关键因素。
IF 1.2
Medwave Pub Date : 2024-05-15 DOI: 10.5867/medwave.2024.04.2790
Carlos Cabrera-Ubilla, Vicente Nuñez-Galleguillos, Javier Bracchiglione, Roberto Garnham, Ignacio Pérez
{"title":"Key factors in the choice of appropriate outcomes for clinical trials.","authors":"Carlos Cabrera-Ubilla, Vicente Nuñez-Galleguillos, Javier Bracchiglione, Roberto Garnham, Ignacio Pérez","doi":"10.5867/medwave.2024.04.2790","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.2790","url":null,"abstract":"<p><p>Health research is the foundation of medical knowledge and healthcare system recommendations. Therefore, choosing appropriate outcomes in studies of therapeutic interventions is a fundamental step in producing evidence and, subsequently, for decision-making. In this article, we propose three key factors for the choice of outcomes: the inclusion of patient-reported outcomes, since they focus on the patient's perception of their health status and quality of life; the consideration of clinically relevant outcomes, which are direct measurements of the patient's health status and, therefore, will be decisive in decision-making; and the use of core outcome sets, a tool that standardizes the measurement and interpretation of outcomes, facilitating the production and synthesis of appropriate evidence for the evidence ecosystem. The correct choice of outcomes will help health decision-makers and clinicians deliver appropriate patient-centered care and optimize the use of resources in healthcare and clinical research.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Daily compliance of the ABCDEF liberation bundle for patients in the intensive care unit: A retrospective descriptive study 重症监护室病人的捆绑治疗:回顾性描述研究。
IF 1.2
Medwave Pub Date : 2024-05-09 DOI: 10.5867/medwave.2024.04.2795
Felipe Muñoz-Muñoz, Jaime Leppe, Felipe González-Seguel, Ana Castro-Ávila
{"title":"Daily compliance of the ABCDEF liberation bundle for patients in the intensive care unit: A retrospective descriptive study","authors":"Felipe Muñoz-Muñoz, Jaime Leppe, Felipe González-Seguel, Ana Castro-Ávila","doi":"10.5867/medwave.2024.04.2795","DOIUrl":"10.5867/medwave.2024.04.2795","url":null,"abstract":"<p><strong>Introduction: </strong>Implementing the ABCDEF bundle has demonstrated improved outcomes in patients with critical illness. This study aims to describe the daily compliance of the ABCDEF bundle in a Chilean intensive care unit.</p><p><strong>Methods: </strong>Retrospective observational study of electronic clinical records of nursing, physiotherapy, and medical professionals who cared for patients over 18 years of age, admitted to an intensive care unit for at least 24 hours, with or without mechanical ventilation. Daily bundle compliance was determined by considering the daily records for each element: Assess pain (element A), both spontaneous awakening trials (element B1) and spontaneous breathing trials (element B2), choice of sedation (element C), delirium assessment (element D), early mobilization (element E), and family engagement (element F).</p><p><strong>Results: </strong>4165 registered bundle elements were obtained from nursing (47%), physiotherapy (44%), and physicians (7%), including 1134 patient/days (from 133 patients). Elements E and C showed 67 and 40% compliance, while D, A, and B2 showed 24, 14 and 11%, respectively. For B1 and F, 0% compliance was achieved. Compliance was higher in patients without mechanical ventilation for A and E, while it was similar for D.</p><p><strong>Conclusions: </strong>Early mobilization had the highest compliance, while spontaneous awakening trials and family engagement had absolute non-compliance. Future studies should explore the reasons for the different degrees of compliance per bundle element in clinical practice.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol for a systematic mapping review of surgical and pharmacological interventions for the treatment of trigeminal neuralgia. 关于治疗三叉神经痛的手术和药物干预措施的系统性绘图审查协议。
IF 1.2
Medwave Pub Date : 2024-05-08 DOI: 10.5867/medwave.2024.04.2759
Dominga Ladevig, Valentina Veloso, Camila Ávila-Oliver
{"title":"Protocol for a systematic mapping review of surgical and pharmacological interventions for the treatment of trigeminal neuralgia.","authors":"Dominga Ladevig, Valentina Veloso, Camila Ávila-Oliver","doi":"10.5867/medwave.2024.04.2759","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.2759","url":null,"abstract":"<p><strong>Introduction: </strong>Trigeminal neuralgia is a painful neuropathic disorder characterized by sudden electric shock-like pain that significantly impacts patients' quality of life. Multiple treatment alternatives are available, including medical and surgical options but establishing the optimal course of action can be challenging. To enhance clinical decision-making for trigeminal neuralgia treatment, it is imperative to organize, describe and map the available systematic reviews and randomized trials. This will help identify the best treatment alternatives supported by evidence and acknowledge potential knowledge gaps where future research is needed.</p><p><strong>Objective: </strong>This systematic mapping review aims to provide up-to-date evidence on the different surgical and pharmacological treatment alternatives used for trigeminal neuralgia.</p><p><strong>Methods: </strong>A search will be systematically conducted on the Epistemonikos database to identify potentially eligible systematic reviews. Additionally, a search will be made in PubMed, CENTRAL, and EBSCO to identify randomized controlled trials assessing pharmacological and surgical treatment interventions for trigeminal neuralgia. Two independent reviewers will screen and select the studies. Data on the different treatment alternatives and reported outcomes in the included studies will be extracted using standardized forms. Following extraction, descriptive statistical methods will be used to analyze the data. The final output of this study will include an evidence map that will illustrate the connections between different treatments and their respective outcomes, providing a clear depiction of the evidence landscape.</p><p><strong>Expected results: </strong>This study expects to map, describe and assess the methodological quality of the available systematic reviews and trials on pharmacological interventions and neurosurgical procedures for treating trigeminal neuralgia. It will present the results in an evidence map that organizes the available evidence based on their different interventions and outcomes. This evidence map will serve as a visual tool to assist healthcare professionals and patients to understand evidence-based treatment options and their implications for managing this medical condition.</p><p><strong>Introducción: </strong>La neuralgia del trigémino es un trastorno neuropático doloroso caracterizado por un dolor súbito y agudo, similar a una descarga eléctrica, que impacta significativamente en la calidad de vida. Dada la variedad de tratamientos disponibles, médicos y quirúrgicos, es crucial organizar y mapear la evidencia proveniente de revisiones sistemáticas y ensayos clínicos para orientar las decisiones clínicas. Esto permite identificar tratamientos respaldados por evidencia y señalar áreas de investigación futura.</p><p><strong>Objetivo: </strong>El propósito de esta revisión sistemática de mapeo es proporcionar una visión actualizada de la evide","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Friedewald and Vujovic methods with the calculated LDL concentration in a biochemical auto-analyzer. 弗里德瓦尔德法和武约维奇法与生化自动分析仪计算出的低密度脂蛋白浓度的比较。
IF 1.2
Medwave Pub Date : 2024-05-06 DOI: 10.5867/medwave.2024.04.2775
Jaime Rosales-Rimache, Jeisson Apaza-Condori, Jhonatan Rabanal-Sanchez, Li Jari, Fernando Soncco-Llulluy
{"title":"Comparison of the Friedewald and Vujovic methods with the calculated LDL concentration in a biochemical auto-analyzer.","authors":"Jaime Rosales-Rimache, Jeisson Apaza-Condori, Jhonatan Rabanal-Sanchez, Li Jari, Fernando Soncco-Llulluy","doi":"10.5867/medwave.2024.04.2775","DOIUrl":"https://doi.org/10.5867/medwave.2024.04.2775","url":null,"abstract":"<p><strong>Objective: </strong>To compare the concentration of Low-Density Lipoprotein (LDL-c) obtained using the Friedewald formula with those obtained directly with the RAYTO CHEMRAY 120 autoanalyzer.</p><p><strong>Methods: </strong>Cross-sectional study. We evaluated outpatients with a medical request for a lipid profile study (total cholesterol, triglycerides, LDL, and HDL). The analyses were carried out in a RAYTO CHEMRAY 120 autoanalyzer under the principle of spectrophotometry. We obtained LDL-c using the Friedewald and Vujovic formulas.</p><p><strong>Results: </strong>We evaluated 199 individuals whose direct LDL concentration averages were measured by the RAYTO CHEMRAY 120 equipment. Those calculated by the Friedewald and Vujovic formulas were 129.97 ± 32.66, 119.28 ± 30.44, and 127.01 ± 32.01, respectively, and in all cases, significant differences (P < 0.001) were observed with the RAYTO analyzer. In both cases a low positive bias was found with the RAYTO analyzer.. The Passing-Bablok and Deming's regressions showed a linear correlation between both methods (Friedewald and Vujovic) with the LDL values obtained with the Rayto autoanalyzer.</p><p><strong>Conclusions: </strong>Our study found that the Friedewald and Vujovic methods are good predictors of LDL cholesterol levels and have a low level of bias. Therefore, they could be used as potential predictors.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with COPD: A cross-sectional study. IGF-1 和 IGF-2 基因型与慢性阻塞性肺病患者呼吸肌强度的关系:一项横断面研究。
IF 1.2
Medwave Pub Date : 2024-04-30 DOI: 10.5867/medwave.2024.03.2783
Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst
{"title":"Association of IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with COPD: A cross-sectional study.","authors":"Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst","doi":"10.5867/medwave.2024.03.2783","DOIUrl":"https://doi.org/10.5867/medwave.2024.03.2783","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic obstructive pulmonary disease is a systemic disease characterized not only by respiratory symptoms but also by physical deconditioning and muscle weakness. One prominent manifestation of this disease is the decline in respiratory muscle strength. Previous studies have linked the genotypes of insulin-like growth factor 1 and 2 (IGF-1 and IGF-2) to muscle weakness in other populations without this disease. However, there is a notable knowledge gap regarding the biological mechanisms underlying respiratory muscle weakness, particularly the role of IGF-1 and IGF-2 genotypes in this pulmonary disease. Therefore, this study aimed to investigate, for the first time, the association between IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with chronic obstructive pulmonary disease. In addition, we analyzed the relationship between oxidative stress, chronic inflammation, and vitamin D with respiratory muscle strength.</p><p><strong>Methods: </strong>A cross sectional study with 61 individuals with chronic obstructive pulmonary disease. Polymerase chain reaction of gene polymorphisms IGF-1 (rs35767) and IGF-2 (rs3213221) was analyzed. Other variables, related to oxidative stress, inflammation and Vitamin D were dosed from peripheral blood. Maximal inspiratory and expiratory pressure were measured.</p><p><strong>Results: </strong>The genetic polymorphisms were associated with respiratory muscle strength ( 3.0 and 3.5; = 0.57). Specific genotypes of IGF-1 and IGF-2 presented lower maximal inspiratory and expiratory pressure (<0.05 for all). Oxidative stress, inflammatory biomarkers, and vitamin D were not associated with respiratory muscle strength.</p><p><strong>Conclusion: </strong>The polymorphisms of IGF-1 and IGF-2 displayed stronger correlations with respiratory muscle strength compared to blood biomarkers in patients with chronic obstructive pulmonary disease. Specific genotypes of IGF-1 and IGF-2 were associated with reduced respiratory muscle strength in this population.</p>","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic control in type 2 diabetic patients treated with empagliflozin: A case series. 使用恩格列净治疗 2 型糖尿病患者的代谢控制:病例系列。
IF 1.2
Medwave Pub Date : 2024-04-17 DOI: 10.5867/medwave.2024.03.2758
Wilfredo Navarrete, Pilar Durruty, Eileen Andrade, Rodrigo Orellana, María Georgina Ortiz, María Angélica Budini
{"title":"Metabolic control in type 2 diabetic patients treated with empagliflozin: A case series.","authors":"Wilfredo Navarrete, Pilar Durruty, Eileen Andrade, Rodrigo Orellana, María Georgina Ortiz, María Angélica Budini","doi":"10.5867/medwave.2024.03.2758","DOIUrl":"https://doi.org/10.5867/medwave.2024.03.2758","url":null,"abstract":"Background\u0000Type 2 diabetes mellitus is a highly prevalent disease and is associated with increased morbidity and mortality. Due to the low percentage of adequate glycemic control, new strategies for the treatment of type 2 diabetes mellitus have been sought, including sodium-glucose cotransporter type 2 inhibitorss.\u0000\u0000\u0000Objective\u0000To describe the evolution of patients with type 2 diabetes mellitus with insulin requirements treated with empagliflozin at the Peñaflor Hospital. The primary objective was to evaluate the efficacy of the medication regarding glycosylated hemoglobin A1c (HbA1c). The secondary objectives were: 1) achievement of HbA1c equal to or less than 7.5% according to survival analysis. 2) Change in glomerular filtration rate and urinary albumin excretion post treatment.\u0000\u0000\u0000Methods\u0000Review of clinical records of all patients treated with empagliflozin from November 2019 to June 2023. Average follow-up of 19 (16.3 to 40) months. To compare HbA1c values according to follow-up ranges, the paired T test or Wilcoxon test was used.\u0000\u0000\u0000Results\u0000We included 58 patients, 15 men and 43 women (74.1%), with an average age of 58.5 ± 9.2 years, ranging from 35 to 75 years. Baseline HbA1c of 10.3 ± 1.6% and 8.98% ± 2.2 in a follow-up of 18 to 24 months post-treatment, resulted in a decrease of 1.27% (p = 0.002; confidence interval 95%: 0.5 to 2.03). The most common adverse effect was urinary tract infection.\u0000\u0000\u0000Conclusions\u0000Patients with type 2 diabetes mellitus with insulin requirements treated with empagliflozin at the Peñaflor Hospital achieved better glycemic control with few adverse effects.","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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