MOJ proteomics & bioinformatics最新文献_第4页

A study of therapeutic effect of D-mannose on urinary infection caused by Escherichia coli d -甘露糖治疗大肠杆菌尿路感染的疗效研究

MOJ proteomics & bioinformatics Pub Date : 2018-05-25 DOI: 10.15406/mojpb.2018.07.00228

N. Taleb

引用次数: 1

A computational approach to identify microRNA (miRNA) based biomarker of Pharmacovariant from the regulation of disease pathology 一种从疾病病理调节中识别基于microRNA (miRNA)的药物变异生物标志物的计算方法

MOJ proteomics & bioinformatics Pub Date : 2018-05-15 DOI: 10.15406/mojpb.2018.07.00227

Harishch, er An, Aram

引用次数: 3

Evaluation the aggressive reaction of varicella in young adult immune system compared to children immune response 评价水痘在青少年免疫系统与儿童免疫系统中的侵袭性反应

MOJ proteomics & bioinformatics Pub Date : 2018-05-10 DOI: 10.15406/mojpb.2018.07.00226

Alaa A Elnour

引用次数: 2

DNA transformation–the law of the tetrad DNA转化——四分体法则

MOJ proteomics & bioinformatics Pub Date : 2018-05-10 DOI: 10.15406/mojpb.2018.07.00225

L. Gadbois

引用次数: 0

Biobanker as a true banker 作为一个真正的银行家

MOJ proteomics & bioinformatics Pub Date : 2018-04-30 DOI: 10.15406/mojpb.2018.07.00224

Youhe Gao

引用次数: 0

Analysis of heart rate variability based on quantitative approach 基于定量方法的心率变异性分析

MOJ proteomics & bioinformatics Pub Date : 2018-04-30 DOI: 10.15406/mojpb.2018.07.00223

H. Tun, Z. Naing, W. Moe, M. M. Latt

引用次数: 6

Science/education portraits II: Pre-tertiary and undergraduate research mentors should consider publication as project endpoint 科学/教育肖像II:大学预科和本科研究导师应考虑将出版作为项目终点

MOJ proteomics & bioinformatics Pub Date : 2018-04-26 DOI: 10.15406/mojpb.2018.07.00222

M. Ling

{"title":"Science/education portraits II: Pre-tertiary and undergraduate research mentors should consider publication as project endpoint","authors":"M. Ling","doi":"10.15406/mojpb.2018.07.00222","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00222","url":null,"abstract":"Research experience is an important component of science education due to its many benefits1–4 from the perspective of the student or mentee; including better understanding of research process,5 increased motivation6 and active learning,7 higher cumulative grade point averages,8 and a platform for developing analytical skills and a deeper understanding of theoretical principles9 and context.10 Besides the mentee, mentors had also reported substantial benefits,11,12 which has been supported by my own experiences.13 One of the mutually beneficial research outcomes is in the form of research publications. Although it can be challenging to quantify overall research productivity in terms of publications from graduate and undergraduate research separately, it can be generally safe to expect lower publication counts from undergraduate research compared to graduate research. A survey study by Morales et al.14 on 536 faculty members showed that 39% of undergraduate research students mentored in the preceding 5 years did not publish while a survey study by Hall et al.15 on 280 graduate students showed that 13.6% did not publish. It can then be plausible to conceive that pre-undergraduate/pre-tertiary research students are less likely to publish compared to undergraduate students. However, it had been shown that scholarly publications helps students / mentees in significant ways;14 including compete more successfully as applicants to graduate school,16 and more successful research careers.17","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77877174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can histone epigenetic profiling become an alternative treatment modality for colon cancer 组蛋白表观遗传分析能否成为结肠癌的一种替代治疗方式

MOJ proteomics & bioinformatics Pub Date : 2018-04-19 DOI: 10.15406/mojpb.2018.07.00221

T. Pillai

{"title":"Can histone epigenetic profiling become an alternative treatment modality for colon cancer","authors":"T. Pillai","doi":"10.15406/mojpb.2018.07.00221","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00221","url":null,"abstract":"Colorectal cancer (CRC) is a formidable health problem worldwide. Almost 60% of cases are encountered in developed countries. In India, the annual incidence rates (AARs) for colon cancer in men are 4.4 per 100000. The AAR for colon cancer in women is 3.9per 100000 (GLOBO. CAN 2008). There were marked developments in the chemotherapy of CRC in the last decade. Eight new drugs were approved for chemotherapy. The survival has doubled compared to 5-fluorouracil alone. KRAS testing opened an era of personalised therapy. Though on an average there are 90 genes mutated per cancer, only less than 20 pathways will actually drive cancer development. The available therapy with combinations for CRC is very expensive coming to $300000 for 24 months. Early detection of tumors and improved therapy has lead to improvement in survival. With the administration of the adjuvant 5-fluorouracil, an improvement in survival of approximately 30%, with an additional 20% improvement with the addition of oxaliplatin in stage III colon cancer is reported. Family history of CRC contributes only 25% thus most commonly occurs sporadically, suggesting a contribution for shared genes and environment. About 5-% are from inherited mutations, while the remaining of the familial forms results from gene environment interactions.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80775805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The identification of urinary biomarkers for malaria in mouse model 疟疾小鼠模型尿液生物标志物的鉴定

MOJ proteomics & bioinformatics Pub Date : 2018-03-26 DOI: 10.15406/mojpb.2018.07.00219

Xundou Li, Weiwei Deng, Youhe Gao, Heng Wang

引用次数: 0

Structure-based drug designing methodology to elucidate the binding affinities of phyto-ligands of Annona muricata against oncogenic PirH2 以结构为基础的药物设计方法，阐明番荔枝植物配体对致癌性PirH2的结合亲和力

MOJ proteomics & bioinformatics Pub Date : 2018-03-15 DOI: 10.15406/mojpb.2018.07.00220

Nirav R. Shah, Harshvardhan Rao, S. Verma, P. PritamKumar

{"title":"Structure-based drug designing methodology to elucidate the binding affinities of phyto-ligands of Annona muricata against oncogenic PirH2","authors":"Nirav R. Shah, Harshvardhan Rao, S. Verma, P. PritamKumar","doi":"10.15406/mojpb.2018.07.00220","DOIUrl":"https://doi.org/10.15406/mojpb.2018.07.00220","url":null,"abstract":"Malignant neoplasm or cancer involves abnormal cell growth and by inchmeal it starts to proliferate over other parts of the body (http://www.who.int/mediacentre/factsheets/fs297/en/; http://www. cancer.gov/about-cancer/what-is-cancer). One of the latest worldwide incidences and mortality studies of 27 major cancers reveals lung cancer being the pre-eminent cause of cancer death (1.6 million) when compared to deaths caused by any other types of cancer (http:// globocan.iarc.fr/Pages/fact_sheets_cancer.aspx). With no absolute prevention and definitive cure, finding a treatment for cancer has become a prime concern (http://www.who.int/mediacentre/factsheets/ fs297/en/). This research paper focuses on finding a potential drug that could help in curing lung cancer and multiple other cancers as the drug targets cancer cells overexpressing PirH2; a protein discovered belonging to the family of ubiquitin protein ligase (http://www. yourgenome.org/facts/is-cancer-a-genetic-disease). Lung cancer is one of the major genetic diseases causing death1 and it is the most commonly diagnosed cancer in the world. Lung cancer can be broadly divided into three types: Non-Small cell Lung cancer, Small cell lung cancer and Lung Carcinoid tumor involving carcinomas. These tumors originate from epithelia of the trachea, bronchi or lungs, most common of them being squamous cell carcinoma, adenocarcinoma, and small cell carcinoma. Amongst the three types mentioned, the small cell lung cancer (SCLC) is known to be most malignant. Cancer cells are very sensitive to radiation and chemotherapy, chemotherapy being an essential component of the treatment of all patients with SCLC2 thus lung cancer bears emphasis in the following research.","PeriodicalId":18585,"journal":{"name":"MOJ proteomics & bioinformatics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87555422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1