A study of therapeutic effect of D-mannose on urinary infection caused by Escherichia coli

To demonstrate experimentally the efficiency of D-Mannose treatment on urinary tract infections caused by E. coli bacteria, several works have been published in this context. One study showed that D-Mannose was as effective as antibiotic prophylaxis to prevent recurrent urinary tract infections.3 In 1979, Aronson et al.4 demonstrated for the first time the ability of carbohydrates to protect animals against the urinary infections, co-administration of the reduced D-Mannose to 67% infection rate. The work of J. W. Janekta & S. J. Hultgren5 also demonstrated the efficiency of DMannose and say the glucid blocks the adhesion of E. coli to cells of the bladder; after drug administration by mice with chronic urinary tract infection, the bacteria levels fell much faster than in the second group of mice treated with antibiotic treatment. In another study,6 the urinary tract of the rats was inoculated with E. coli, in one day the level of bacteria in the urine of animals receiving D-Mannose is significantly lower.