The identification of urinary biomarkers for malaria in mouse model

Abstract

Biomarkers is a measurable changes associated with a physiological and/or pathophysiological process. In order to maintain normal life activities, the blood is homeostatic and draining into urine is important way of keeping blood stable. Without homeostasis, urine is more likely to reflect changes in the body. In addition, urine can accumulate a variety of changes of the body, making it an ideal biological source for disease biomarker discovery.1,2 As reviewed in a recent paper, kinds of physiological changes can be reflected in urine, so it is expect that urine can be used to detect the changes in pathological and/or pharmacological process.3 Actually, urine can be more sensitive to physiological changes than blood,4 and some biomarkers behave even better in urine than in blood.5–7 Many urinary biomarkers have recently been identified for various types of diseases.8