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Microbial Cell Factories最新文献

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Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae. 微生物组衍生的多酮和非核糖体肽的模块化生物合成：乳酸菌科的见解和机会。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-21 DOI: 10.1186/s12934-026-03008-8
Jelle Dillen, Tom Eilers, Caroline E M K Dricot, Matisse Van Hee, Dieter Vandenheuvel, Joleen Masschelein, Sarah Lebeer
{"title":"Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae.","authors":"Jelle Dillen, Tom Eilers, Caroline E M K Dricot, Matisse Van Hee, Dieter Vandenheuvel, Joleen Masschelein, Sarah Lebeer","doi":"10.1186/s12934-026-03008-8","DOIUrl":"https://doi.org/10.1186/s12934-026-03008-8","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endophytic fungi-assisted biological synthesis of zinc oxide nanoparticles using gamma-rays for promising antibacterial and antibiofilm potential against some gram-positive bacteria. 内生真菌辅助的氧化锌纳米粒子的生物合成利用伽马射线对一些革兰氏阳性细菌的抗菌和抗生物膜潜力。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-20 DOI: 10.1186/s12934-026-02993-0
Sobhy S Abdel-Fatah, Nasser H Mohammad, Gharieb S El-Sayyad
{"title":"Endophytic fungi-assisted biological synthesis of zinc oxide nanoparticles using gamma-rays for promising antibacterial and antibiofilm potential against some gram-positive bacteria.","authors":"Sobhy S Abdel-Fatah, Nasser H Mohammad, Gharieb S El-Sayyad","doi":"10.1186/s12934-026-02993-0","DOIUrl":"10.1186/s12934-026-02993-0","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploitation of actinomycetes from coastal ecosystems of İzmir Peninsula for antimicrobial activity via strain identification, untargeted metabolomics and drug combination studies. 通过菌株鉴定、非靶向代谢组学和药物联合研究，开发İzmir半岛沿海生态系统放线菌的抗菌活性。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-19 DOI: 10.1186/s12934-026-03003-z
Mustafa Ünver Kurt, Özge Can, Burçin Karakuzu, Göklem Üner, Ahmet Ceyhan Gören, Ataç Uzel, Erdal Bedir
{"title":"Exploitation of actinomycetes from coastal ecosystems of İzmir Peninsula for antimicrobial activity via strain identification, untargeted metabolomics and drug combination studies.","authors":"Mustafa Ünver Kurt, Özge Can, Burçin Karakuzu, Göklem Üner, Ahmet Ceyhan Gören, Ataç Uzel, Erdal Bedir","doi":"10.1186/s12934-026-03003-z","DOIUrl":"https://doi.org/10.1186/s12934-026-03003-z","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing methyltransferase-cofactor interactions for engineered microbial production of isotopically labelled SAM and SAH. 甲基转移酶-辅助因子相互作用在工程微生物生产中同位素标记的SAM和SAH的再利用。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-17 DOI: 10.1186/s12934-026-03010-0
Uliana V Bulgakova, Alexander Yu Rudenko, Inna L Karpenko, Vasilij G Vasil'ev, Petr V Sergiev, Olga A Dontsova, Vladimir I Polshakov, Sofia S Mariasina
{"title":"Repurposing methyltransferase-cofactor interactions for engineered microbial production of isotopically labelled SAM and SAH.","authors":"Uliana V Bulgakova, Alexander Yu Rudenko, Inna L Karpenko, Vasilij G Vasil'ev, Petr V Sergiev, Olga A Dontsova, Vladimir I Polshakov, Sofia S Mariasina","doi":"10.1186/s12934-026-03010-0","DOIUrl":"https://doi.org/10.1186/s12934-026-03010-0","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacillus thuringiensis as a factory producing parasporin toxins with promising anticancer properties: a review. 苏云金芽孢杆菌作为一种生产具有抗癌特性的副孢蛋白毒素的工厂：综述。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-17 DOI: 10.1186/s12934-026-02998-9
Natalia Musiuk, Wioleta Lewandowska, Aleksandra Rembiszewska, Izabela Święcicka
{"title":"Bacillus thuringiensis as a factory producing parasporin toxins with promising anticancer properties: a review.","authors":"Natalia Musiuk, Wioleta Lewandowska, Aleksandra Rembiszewska, Izabela Święcicka","doi":"10.1186/s12934-026-02998-9","DOIUrl":"https://doi.org/10.1186/s12934-026-02998-9","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel L-lysine α-oxidase from marine streptomyces: production, optimization and potent antibacterial activity against drug-resistant pathogens. 来自海洋链霉菌的新型l -赖氨酸α-氧化酶：生产、优化和对耐药病原体的有效抗菌活性。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-13 DOI: 10.1186/s12934-026-02992-1
Mohamed Abdelraof, Amany A Hassabo, Doaa Darwich, Mohamed M Abdel-Monsef
{"title":"Novel L-lysine α-oxidase from marine streptomyces: production, optimization and potent antibacterial activity against drug-resistant pathogens.","authors":"Mohamed Abdelraof, Amany A Hassabo, Doaa Darwich, Mohamed M Abdel-Monsef","doi":"10.1186/s12934-026-02992-1","DOIUrl":"10.1186/s12934-026-02992-1","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-copy plasmid engineering enhances recombinant protein and antimicrobial peptide production in Corynebacterium glutamicum. 高拷贝质粒工程提高谷氨酸棒状杆菌重组蛋白和抗菌肽的生产。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-13 DOI: 10.1186/s12934-026-03004-y
Jens Christmann, Annalena Sommer, Peng Cao, Michael Kohlstedt, Oliver Goldbeck, Christian U Riedel, Judith Becker, Christoph Wittmann
{"title":"High-copy plasmid engineering enhances recombinant protein and antimicrobial peptide production in Corynebacterium glutamicum.","authors":"Jens Christmann, Annalena Sommer, Peng Cao, Michael Kohlstedt, Oliver Goldbeck, Christian U Riedel, Judith Becker, Christoph Wittmann","doi":"10.1186/s12934-026-03004-y","DOIUrl":"10.1186/s12934-026-03004-y","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From lab to law: emerging applications, potential benefits, evolving regulatory framework and challenges for engineered probiotics. 从实验室到法律：工程益生菌的新兴应用，潜在利益，不断发展的监管框架和挑战。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-13 DOI: 10.1186/s12934-026-02997-w
Francesco Di Pierro, Aswin Thacharodi, Muthiah Kumaraswami, Alexander Suvorov, Jure Zupet, Nicola Zerbinati
{"title":"From lab to law: emerging applications, potential benefits, evolving regulatory framework and challenges for engineered probiotics.","authors":"Francesco Di Pierro, Aswin Thacharodi, Muthiah Kumaraswami, Alexander Suvorov, Jure Zupet, Nicola Zerbinati","doi":"10.1186/s12934-026-02997-w","DOIUrl":"https://doi.org/10.1186/s12934-026-02997-w","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the biomass production conditions on survival of the probiotic yeast Saccharomyces cerevisiae var. boulardii in a laboratory model of the gastrointestinal tract. 生物质生产条件对实验室胃肠道模型中酿酒酵母菌博氏变种存活的影响
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-12 DOI: 10.1186/s12934-026-02999-8
Dorota A Rzechonek, Lisbeth Olsson
{"title":"Effect of the biomass production conditions on survival of the probiotic yeast Saccharomyces cerevisiae var. boulardii in a laboratory model of the gastrointestinal tract.","authors":"Dorota A Rzechonek, Lisbeth Olsson","doi":"10.1186/s12934-026-02999-8","DOIUrl":"10.1186/s12934-026-02999-8","url":null,"abstract":"","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptomics-guided identification of engineering targets for improving salt tolerance in Saccharomyces cerevisiae. 利用转录组学技术鉴定提高酿酒酵母耐盐性的工程靶点。
IF 4.9 2区 生物学
Microbial Cell Factories Pub Date : 2026-04-11 DOI: 10.1186/s12934-026-03005-x
Mao-Ting Li, Li Wang, Cai-Yun Xie, Min Gou, Yue-Qin Tang
{"title":"Transcriptomics-guided identification of engineering targets for improving salt tolerance in Saccharomyces cerevisiae.","authors":"Mao-Ting Li, Li Wang, Cai-Yun Xie, Min Gou, Yue-Qin Tang","doi":"10.1186/s12934-026-03005-x","DOIUrl":"https://doi.org/10.1186/s12934-026-03005-x","url":null,"abstract":"<p><strong>Background: </strong>High-salinity conditions frequently impair the fermentation performance of Saccharomyces cerevisiae in industrial processes involving high-osmolarity substrates. Identifying genetic determinants that enhance salt tolerance is therefore essential for the development of robust yeast cell factories. In this study, a comparative transcriptomic analysis was performed to investigate the transcriptional responses of a salt-tolerant strain, E-158, and its parental strain, KF-7, under 1.25 M NaCl stress, with the aim of identifying potential targets for strain engineering.</p><p><strong>Results: </strong>Comparative transcriptomic analysis revealed extensive transcriptional differences between E-158 and KF-7 under high-salt conditions, involving central carbon and nitrogen metabolism, peroxisome-associated oxidative stress responses, ion transport, cell wall-related processes, and sporulation-related pathways. Based on these profiles, two transcription factors (CUP9 and ZNF1) and three functional genes (DAL1, IDP2, and CTA1) were selected for functional validation. Overexpression or deletion of the transcription factors, as well as overexpression of the functional genes, was carried out in KF-7. Fermentation experiments under 1.25 M NaCl demonstrated that all engineered strains outperformed the parental strain. Among them, overexpression of CTA1 resulted in the greatest improvement, with glucose consumption and ethanol production increased by 35.04% and 45.66%, respectively, after 96 h of fermentation.</p><p><strong>Conclusions: </strong>This study demonstrates that comparative transcriptomics can serve as an effective strategy for identifying engineering targets associated with salt tolerance in S. cerevisiae. The evaluated genes provide potential targets for strain improvement and offer insights for the rational design of yeast cell factories suited for high-salinity biofuel and bioproduct fermentation processes.</p>","PeriodicalId":18582,"journal":{"name":"Microbial Cell Factories","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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