Military Medical Research最新文献

{"title":"The national and provincial disease and indirect economic burden of high alcohol use in China from 1990 to 2023 with forecasting to 2050.","authors":"Yang Yang, Da-Chuang Zhou, Zhen-Ping Zhao, Ke-Jia Zhou, Di Zhang, Yu-Ting Xia, Peng Yin, Mai-Geng Zhou, Wen-Xi Tang","doi":"10.1016/j.mmr.2026.100043","DOIUrl":"10.1016/j.mmr.2026.100043","url":null,"abstract":"<p><strong>Background: </strong>High alcohol use, defined as consumption exceeding the theoretical minimum risk exposure level, poses a major public health challenge in China, yet comprehensive long-term estimates combining disease burden and indirect economic burdens are limited. This study quantified national and subnational trends in disease and indirect economic burdens attributable to high alcohol use in China from 1990 to 2023 and forecasted the high alcohol use-related indirect economic burden to 2050.</p><p><strong>Methods: </strong>Disease burden data were obtained from the Global Burden of Disease Study 2023. Economic parameters were sourced from the China Statistical Yearbook 2024, the Penn World Table, and the Seventh National Population Census. The indirect economic burden was estimated using a cost-of-illness model. The estimated annual percentage change (EAPC) was calculated to assess trends (1990-2023) in age-standardized mortality and DALY rates, as well as productivity losses due to premature death, morbidity, and total indirect economic burden. Spatial distributions of all-cause burden and the top six leading diseases (ranked by DALYs) were compared between 1990 and 2023. Sex and age-specific patterns were analyzed using absolute DALY numbers and indirect economic burden values. Finally, the Bayesian age-period-cohort model was used to forecast productivity losses due to premature death and morbidity, along with the total indirect economic burden to 2050.</p><p><strong>Results: </strong>National age-standardized mortality rate attributable to high alcohol use declined from 27.68/100,000 [95% uncertainty interval (UI) 13.17-48.69] in 1990 to 10.58/100,000 (95% UI 4.60-19.26) in 2023 (EAPC=-3.02%, 95% UI -4.15 to -1.85; <i>P</i><0.01), and the age-standardized DALY rate attributable to high alcohol use declined from 1012.53/100,000 (95% UI 567.90-1565.46) to 492.91/100,000 (95% UI 311.38-751.27) (EAPC=-2.26%, 95% UI -3.05 to -1.52; <i>P</i><0.01). Corresponding indirect economic burden as a percentage of Gross Domestic Product (GDP) decreased from 0.15% (95% UI 0.13-0.18) to 0.13% (95% UI 0.11-0.16) (EAPC=-0.47%, 95% UI -0.77 to -0.17; <i>P</i><0.01). High disease burden consistently clustered in Southwest and North China, while high economic burden mainly concentrated in East and Southwest, with notable regional mismatches. Burden was higher in males than in females, and the age profile of indirect economic loss shifted toward older working-age adults. Forecasts indicated that the overall indirect economic burden as a percentage of GDP reached a nadir around 2039 (EAPC=0.12%, 95% UI 0.10-0.14), before rising to 0.14% (95% UI 0.12-0.21) in 2050.</p><p><strong>Conclusions: </strong>From 1990 to 2023, age-standardized mortality and DALY rates attributable to high alcohol use declined substantially in China, and the indirect economic burden as a share of GDP decreased modestly, despite marked growth in absolute productivity loss. Su","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100043"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced CT-based deep learning radiomics for bladder cancer prognosis.","authors":"William C Cho","doi":"10.1016/j.mmr.2026.100065","DOIUrl":"10.1016/j.mmr.2026.100065","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100065"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of women's cancers in the group of twenty (G20) from 1990 to 2023: epidemiological trends and impact from fertility, quality of care, and survival.","authors":"Meng-Long Li, Rui-Shu Tang, Nan Wang, Jin-Lei Qi, Hui-Ming He, Meng-Ying Guan, Miao Li, Bing-Qing Wu, Yeerlin Asihaer, Sten H Vermund, Yi-Fei Hu","doi":"10.1016/j.mmr.2026.100026","DOIUrl":"10.1016/j.mmr.2026.100026","url":null,"abstract":"<p><strong>Background: </strong>Cancer in women represents a significant disease burden, posing challenges for prevention, treatment, and caregiving. This study aimed to analyze the epidemiological trends of the women's cancer burden and the main influencing factors in the group of twenty (G20) from 1990 to 2023.</p><p><strong>Methods: </strong>Incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for breast, cervical, uterine, and ovarian cancers, as well as fertility rates for G20 and its 98 locations, were sourced from the Global Burden of Disease Study 2023. Age-standardized rates (ASRs), quality of care index (QCI), and 5-year relative survival of integrated women's cancers were calculated. Average annual percent changes (AAPCs) were used to determine the temporal trends by age and region. Decomposition analysis identified drivers of changes in case numbers, linear regression assessed the associations with DALY rate changes, and dominance analysis identified dominant predictors.</p><p><strong>Results: </strong>In 2023, the incidence, prevalence, mortality, and DALYs from women's cancers in G20 were 3.29 [95% uncertainty interval (UI) 2.60-4.14], 26.71 (95% UI 21.99-32.40), 1.16 (95% UI 0.91-1.45), and 36.58 million (95% UI 28.40-46.32), respectively, with ASRs of 87.63/100,000 (95% UI 65.12-115.85), 706.16/100,000 (95% UI 555.75-890.02), 30.03/100,000 (95% UI 22.10-39.58), and 994.79/100,000 (95% UI 728.43-1328.81). The QCI was 75.13 [95% confidence interval (CI) 73.67-76.59], and the 5-year relative survival was 65.74% (95% CI 65.53-65.95). From 1990 to 2023, there was a significant increase in incidence, prevalence, mortality, and DALYs in G20, primarily driven by population growth. Age-standardized incidence rate, QCI, and 5-year relative survival increased, while age-standardized mortality and DALY rates decreased. Changes in prevalence rates of breast cancer and cervical cancer for women aged 15-49 years were positively associated with changes in DALY rates of women's cancers, whereas changes in the total fertility rate were negatively associated. Dominance analysis confirmed these three factors consistently as dominant predictors between 1990 and 2023. Reducing the prevalence of breast and cervical cancers and increasing fertility among women aged 15-49 years could lower the overall DALY burden attributable to women's cancer.</p><p><strong>Conclusions: </strong>The incidence, prevalence, mortality, and DALYs of women's cancers in G20 have increased substantially from 1990 to 2023. Tailored prevention strategies should consider age and cancer type, emphasizing reproductive health for women of reproductive age.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100026"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better osteoarthritis care requires prevention and stratification.","authors":"David J Hunter, Benjamin G Faber, Kai Fu","doi":"10.1016/j.mmr.2026.100073","DOIUrl":"10.1016/j.mmr.2026.100073","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100073"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian clock and cancer.","authors":"Zhi-Hao Wei, Zi-Rui Dong, An-Shu Li, Qing-Yi Li, Jian Shi, Ke-Shan Wang, Xiao-Ping Zhang","doi":"10.1016/j.mmr.2026.100025","DOIUrl":"10.1016/j.mmr.2026.100025","url":null,"abstract":"<p><p>Circadian rhythms play a critical role in regulating physiological and behavioral processes, such as the sleep-wake cycle, hormone secretion, and metabolism. These rhythms are controlled by endogenous biological clocks, which are synchronized with environmental cues, primarily the light-dark cycle. Notably, disruption or reprogramming of circadian rhythms is closely associated with cancer initiation, progression, and treatment response. At the molecular level, the dysregulation of core clock genes can disturb normal cellular rhythms, leading to aberrant cell proliferation, impaired DNA repair, altered metabolism, and disrupted immune responses. This review systematically summarizes the pivotal roles and molecular mechanisms of circadian rhythms in tumor development, with a particular focus on strategies to modulate clock genes through behavioral interventions, pharmacological approaches, and gene-editing techniques, highlighting their potential as novel therapeutic strategies and clinical applications in cancer management.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100025"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life expectancy of cancer patients in China.","authors":"Chang-Fa Xia, Jing Yang, Jin-Hui Zhou, Yong-Jie Xu, Wan-Qing Chen","doi":"10.1016/j.mmr.2026.100045","DOIUrl":"10.1016/j.mmr.2026.100045","url":null,"abstract":"<p><strong>Background: </strong>A cancer diagnosis is usually associated with a substantial loss of life years. However, few studies have quantified life expectancy (LE) and years of life lost (YLL) among cancer patients, particularly in China. This study aims to estimate LE and YLL by cancer type, sex, age at diagnosis, and attained age (i.e., the age a cancer survivor has reached at a given time) for cancer patients in China.</p><p><strong>Methods: </strong>This is a comparative assessment based on population-based cancer registration and death surveillance in China. Data on all-cause deaths, cancer cases, and relative survival in 2021 were obtained from publicly available reports released by the National Cancer Center and the Chinese Center for Disease Control and Prevention. Life tables for the general population were constructed using age-specific all-cause mortality rates, whereas relative survival rates and parameterized long-term excess hazard functions were used to construct life tables for cancer patients. We used the standard period life table method to estimate LE of both the general population and cancer patients, assuming that mortality probabilities remained constant over time. The YLL was the LE difference between cancer patients and the sex- and age-matched general population.</p><p><strong>Results: </strong>For cancer patients diagnosed at the median age of 64 years, the LE is 8.8 years [95% confidence interval (CI) 8.7-9.0], corresponding to a YLL of 9.2 years (95% CI 9.0-9.3). Male patients have an LE and YLL of 6.7 years (95% CI 6.6-6.8) and 9.8 years (95% CI 9.7-9.9), respectively, while females have 11.2 years (95% CI 11.1-11.4) and 8.4 years (95% CI 8.3-8.6). Thyroid cancer had the highest LE [31.9 years (95% CI 31.5-32.0)], while pancreatic cancer had the lowest [2.6 years (95% CI 2.4-2.8)]. Female patients had better LEs than males across 20 cancer types that affect both sexes. Younger patients experienced greater YLL, except in cases of thyroid cancer, oropharyngeal cancer, ovarian cancer, and male bladder cancer. LE gradually increased in patients who survived the first three years; thereafter, the decline depended on attained age, approaching that of the general population.</p><p><strong>Conclusions: </strong>LE of cancer patients in China varied by sex, cancer type, age at diagnosis, and attained age. Cancer patients, healthcare providers, and policymakers may incorporate these estimates into their decision-making.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100045"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.","authors":"Huan-Ran Hou, Ting-Ting Zhang, Ya-Wen Liu, Lin-Kun Cai, Yan Huang, Rui Wang, Hong-Yuan Wang, Jumatay Biekan, Peng-Gang Qiao, Zheng-Han Yang, Zhen-Chang Wang, Peng-Ling Ren, Peng-Fei Zhao","doi":"10.1016/j.mmr.2026.100048","DOIUrl":"10.1016/j.mmr.2026.100048","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Simulated microgravity, modeled by head-down tilt (HDT), induces cephalad fluid shifts that perturb intracranial hemodynamics and may affect cognitive function. However, the temporal adaptation of cerebral arterial blood flow (CaBF), both during simulated microgravity and throughout the recovery phase, remains incompletely understood.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this study, 38 healthy male participants underwent a 7-day -6° HDT protocol followed by a 5-day recovery phase. Four-dimensional flow magnetic resonance imaging (4D flow MRI) was performed at 8 time points [baseline, HDT 12 h, HDT 1 d, HDT 3 d, HDT 7 d, recovery (R) 1 d, R 3 d, and R 5 d] to quantify CaBF and total cerebral blood inflow (TCBI) in the basilar artery (BA), left and right internal carotid arteries (ICAL and ICAR), and left and right middle cerebral arteries (MCAL and MCAR). Systemic vitals and fasting cortisol/renin were collected, and a computerized reaching task assessed reaction time (RT), movement time (MT), and peak velocity (PV). Time effects were tested with repeated-measures analysis of variance (RM ANOVA) or the Friedman test. Predictors of ≥10% TCBI decrease during HDT and ≥10% TCBI increase during the recovery phase were assessed using logistic regression, and flow-behavior associations were examined using Spearman correlation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No significant vessel lumen area changes were found after post-hoc analysis, despite an overall difference observed in the MCAR (&lt;i&gt;χ&lt;/i&gt;²=17.40, &lt;i&gt;P=&lt;/i&gt;0.015). However, average blood flow significantly changed in the ICAL (&lt;i&gt;χ&lt;/i&gt;²=34.16, &lt;i&gt;P&lt;&lt;/i&gt;0.001), MCAL (&lt;i&gt;χ&lt;/i&gt;²=73.11, &lt;i&gt;P&lt;&lt;/i&gt;0.001), and MCAR (&lt;i&gt;χ&lt;/i&gt;²=49.02, &lt;i&gt;P&lt;&lt;/i&gt;0.001), while BA was stable (RM ANOVA &lt;i&gt;F&lt;/i&gt;=0.787, &lt;i&gt;P=&lt;/i&gt;0.599) and ICAR showed no significant pairwise effects despite an overall difference (&lt;i&gt;χ&lt;/i&gt;²=16.35, &lt;i&gt;P=&lt;/i&gt;0.022). TCBI progressively declined during HDT and rebounded rapidly at the onset of recovery (&lt;i&gt;P&lt;&lt;/i&gt;0.001). Logistic regression identified systolic blood pressure (SBP) as an independent predictor of a ≥10% TCBI reduction during HDT [&lt;i&gt;P=&lt;/i&gt;0.044, odds ratio (&lt;i&gt;OR&lt;/i&gt;)=3.004, 95% confidence interval (CI) 1.028-8.777], and baseline cortisol levels predicted significant TCBI decreases from baseline to HDT 7 d (&lt;i&gt;P=&lt;/i&gt;0.047, &lt;i&gt;OR&lt;/i&gt;=1.306, 95% CI 1.004-1.699). Cognitive-motor testing further revealed phase-dependent changes, with RT and MT generally shortening, most consistently in the no-beep condition, while PV remained stable with beep but increased without beep. Apart from an exploratory negative correlation between TCBI rebound and cued PV (&lt;i&gt;r&lt;/i&gt;=-0.360, &lt;i&gt;P=&lt;/i&gt;0.031), TCBI changes were largely decoupled from behavioral outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study demonstrates vessel-specific, lateralized adaptation of cerebral arterial inflow during 7 days of -6° HDT and 5 days of recovery, with anterior circulation more responsive to post","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100048"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of antimicrobial resistance in the WHO Southeast Asia and Western Pacific Regions, 1990-2021: a cross-country systematic analysis with forecasts to 2050.","authors":"Xiao-Ran Yu, Huan Wang, Jian Wang, Xin Yuan, Xiao-Ding Zhou, Qiu-Shui He, Igor Mokrousov, Lin Sun, Yan-Hui Dong, Zhi-Yong Zou","doi":"10.1016/j.mmr.2026.100002","DOIUrl":"10.1016/j.mmr.2026.100002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Antimicrobial resistance (AMR) constitutes a critical global health challenge with major implications for public health and economic stability, increasing infection- and sepsis-related mortality. Despite growing evidence on its contribution to disease burden, comprehensive assessments of long-term trends at the regional level remain limited in the World Health Organization (WHO) Southeast Asia Region (SEAR) and Western Pacific Region (WPR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We used data from the Global Research on Antimicrobial Resistance (GRAM) Project to evaluate sepsis- and AMR-related deaths and disability-adjusted life-years (DALYs) for 11 infectious syndromes, 22 pathogens, and 84 pathogen-drug combinations across 42 countries and territories in the WHO SEAR and WPR from 1990 to 2021. AMR burden was estimated under two counterfactual scenarios: deaths and DALYs attributable to AMR (representing the burden if drug-resistant infections were replaced by drug-susceptible infections), and deaths and DALYs associated with AMR (representing the burden if infections did not occur at all). We reported numbers, crude rates, and age-standardized rates, and generated forecasts of AMR burden to 2050 using an autoregressive integrated moving average model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In SEAR and WPR, there were 8.36×10&lt;sup&gt;6&lt;/sup&gt; [95% uncertainty interval (UI) 7.93-8.79] sepsis-related deaths in 1990, which decreased to 6.03×10&lt;sup&gt;6&lt;/sup&gt; (95% UI 5.68-6.39) in 2019 before increasing to 8.31×10&lt;sup&gt;6&lt;/sup&gt; (95% UI 7.86-8.76) in 2021. The number of deaths associated with AMR ranged from 2,445,875 (95% UI 2,221,769-2,670,192) in 1990 to 2,358,190 (95% UI 2,173,521-2,545,190) in 2021, while deaths attributable to AMR ranged from 546,479 (95% UI 487,669-605,277) to 587,103 (95% UI 534,165-639,903) over the same period. From 1990 to 2021, deaths attributable to AMR decreased among people &lt;25 years, with a 76.1% [95% confidence interval (CI) 70.6-81.6] reduction occurring among children &lt;5 years, while those among adults aged ≥70 years more than doubled, increasing from 133,013 (95% UI 124,066-141,922) to 298,366 (95% UI 284,023-312,475). The largest increase in the number of deaths attributable to AMR was caused by methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt; [from 30,168 (95% UI 24,956-35,351) in 1990 to 66,946 (95% UI 57,544-76,479) in 2021]. In 2021, Kiribati had the highest age-standardized mortality rate (per 100,000 person-years) attributable to AMR [30.9 (95% UI 24.1-37.8)], whereas New Zealand had the lowest [3.2 (95% UI 2.6-3.8)] among the two regions. By 2050, the number of deaths associated with AMR is predicted to reach 3,875,753 (95% UI 1,502,402-9,998,297) in these two regions, of which 952,592 (95% UI 766,353-1,184,090) deaths are attributable to AMR.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study highlights the escalating burden of AMR in SEAR and WPR, emphasizing the urgent need for attention to this p","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100002"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13273464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary biomarkers in oral cancer diagnosis: advancing conventional treatment strategies.","authors":"Ankit Paul, Tarun Kumar Upadhyay, Adil Ali, Hemant Singh, Mohd Saeed, Farrukh Aqil","doi":"10.1016/j.mmr.2026.100018","DOIUrl":"10.1016/j.mmr.2026.100018","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) is a major global health challenge, with most cases being diagnosed at advanced stages. Traditional diagnostic methods are often invasive and costly, and can delay diagnosis. Saliva has emerged as a promising non-invasive source of biomarkers for OSCC detection. This highlights the need for accessible, non-invasive, and sensitive biomarkers for OSCC detection. This review critically evaluates the current status and future potential of salivary biomarkers in OSCC, with an emphasis on their diagnostic efficacy, sensitivity, specificity, clinical validation, and advantages over traditional serum- and plasma-based markers. Saliva is a promising liquid for biopsy due to its non-invasive collection and molecular richness. We summarize evidence on diverse salivary biomarkers, including microRNAs (miRNAs), proteins, metabolites, circulating tumor cells (CTCs), and circulating tumor DNA (ctDNA), highlighting their dysregulation in OSCC and diagnostic utility. Particular emphasis is placed on CTCs, ctDNA, and miRNAs, which demonstrate stability in saliva and potential for early detection. We further discuss advances in next-generation sequencing, mass spectrometry, and artificial intelligence/machine learning that enable the development of biomarker panels with improved diagnostic accuracy over single markers. Despite challenges such as sample heterogeneity and the lack of standardized protocols, salivary biomarkers hold strong potential to transform OSCC care by enabling earlier detection, guiding personalized therapies, and supporting non-invasive disease monitoring. However, achieving methodological standardization, validating biomarkers across diverse cohorts, and integrating them into clinical workflows are imperative before their routine application in practice.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100018"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders.","authors":"Li Li, Qi Han, Hao-Lei Bai, Qin Xiao, Xie He, Jia-Fei Chen, Zhi-Ming Zhen, Xue-Qin Luo, Yuan-Jing Zhang, Min-Min Lu, Xiao Wang, Shi-Yin Li, Jia-Xiang Xiong, Yun Wang, Zhi-An Hu, Xiao-Long Zhang, Yong Liu, Chao He","doi":"10.1016/j.mmr.2026.100035","DOIUrl":"10.1016/j.mmr.2026.100035","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"13 1","pages":"100035"},"PeriodicalIF":29.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}