Minerva obstetrics and gynecology最新文献

To be or not to be: review on multidisciplinary management of agenesis of corpus callosum. 是活还是不活：胼胝体发育不全的多学科治疗综述。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-15 DOI: 10.23736/S2724-606X.24.05641-0

Carmen Aquino, Mariagrazia Marisei, Mario Tortora, Fabio Tortora, Emanuele Capasso, Daniela Surico, Francesco Briganti, Claudia Casella, Maurizio Guida

引用次数: 0

The predictive role of uterocervical angle in labor outcomes: a narrative review. 子宫颈角对分娩结果的预测作用：综述。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-10-29 DOI: 10.23736/S2724-606X.24.05572-6

Libera Troìa, Alessandro Libretti, Federica Savasta, Daniela Surico, Valentino Remorgida

{"title":"The predictive role of uterocervical angle in labor outcomes: a narrative review.","authors":"Libera Troìa, Alessandro Libretti, Federica Savasta, Daniela Surico, Valentino Remorgida","doi":"10.23736/S2724-606X.24.05572-6","DOIUrl":"10.23736/S2724-606X.24.05572-6","url":null,"abstract":"Introduction: Uterocervical angle (UCA) is the angle between the anterior or posterior uterine wall and the cervical canal, and it has become an unique ultrasonographic marker in the recent years. The predictive role of the UCA in spontaneous preterm births (sPTB) has been examined by numerous authors, however few data are available on UCA as predictor of labor outcome at term of pregnancy. Therefore, the purpose of this review is to evaluate the effectiveness of transvaginal ultrasound measurement of UCA at term, and its clinical implications in obstetrics' practice.Evidence acquisition: A literature search was conducted including all studies regarding the predictive role of ultrasonographic evaluation of the UCA on labor outcomes from 1990 to 2023.Evidence synthesis: A narrative synthesis was subsequently performed dividing studies that considered posterior and anterior UCA. Five studies were included for the anterior UCA, and ten for the posterior UCA. UCA was then evaluated as predictor of prolonged latent phase and predictor of the onset and mode of delivery.Conclusions: It is likely that the combination of multiple cervical parameters, rather than UCA assessment alone, together with clinical information, can achieve higher levels of accuracy in predicting delivery outcomes. Future prospective studies are needed to define with greater certainty the role of UCA as a useful screening tool before laboring, but, until then, the use of UCA as a screening test to predict labor outcome should remain investigational.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"119-127"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical factors predicting objective response to bevacizumab-based chemotherapies in advanced and recurrent epithelial ovarian cancer. 预测晚期和复发性上皮性卵巢癌患者对贝伐单抗化疗客观反应的临床因素。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-06-04 DOI: 10.23736/S2724-606X.24.05540-4

Nijat Khanmammadov, Izzet Dogan, Necla S Okay, Bayarmaa Khishigsuren, Abdulmunir Azizy, Pinar Saip, Khayal Gasimli, Adnan Aydiner

{"title":"Clinical factors predicting objective response to bevacizumab-based chemotherapies in advanced and recurrent epithelial ovarian cancer.","authors":"Nijat Khanmammadov, Izzet Dogan, Necla S Okay, Bayarmaa Khishigsuren, Abdulmunir Azizy, Pinar Saip, Khayal Gasimli, Adnan Aydiner","doi":"10.23736/S2724-606X.24.05540-4","DOIUrl":"10.23736/S2724-606X.24.05540-4","url":null,"abstract":"Background: Bevacizumab-based chemotherapies are commonly administered in the treatment of patients diagnosed with epithelial ovarian cancer (EOC). The primary aim of this study was to assess the factors that predict the objective response to bevacizumab-based therapies in cases of advanced and recurrent EOC.Methods: The retrospective data of 264 patients with EOC from the current study were collected between 2009 and 2022 at our clinic. Survival analyses were conducted utilizing the Kaplan-Meier method and the log-rank test. Binary logistic regression analysis was employed to assess the factors predicting the objective response.Results: A predominant subset of patients (83%) presented with serous adenocarcinoma, exhibiting a high-grade differentiation at 87%. The vast majority (80%) of the cohort experienced disease recurrence. Three-fourths of the cases received bevacizumab in combination with platinum-based doublet chemotherapy. In the multivariate analysis, clinical factors such as a disease recurrence (P=0.031), upfront tumor debulking surgery before bevacizumab (P=0.009), doublet chemotherapy (P=0.003), and the presence of malignant pleural effusion (P=0.024) emerged as significant determinants influencing the Objective Response Rate (ORR) in patients undergoing bevacizumab-based therapy. The ORR was 67.5% (N.=178), comprising 15.2% complete responses (N.=40) and 52.1% partial responses (N.=138). The median Progression-Free Survival (PFS) and Overall Survival (OS) were estimated at 10.2 months (95% CI, 8.60-11.9) and 20.1 months (95% CI, 16.0-24.2), respectively.Conclusions: The responses to bevacizumab-based chemotherapies could be predict by the presence of malignant pleural effusion, disease recurrence, upfront tumor debulking surgery and doublet regimen of chemotherapy.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"112-118"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A vaginal birth is a cost-reduction strategy for women with a low-lying placenta. 对于胎盘低置的妇女来说，阴道分娩是一种降低成本的策略。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-03-27 DOI: 10.23736/S2724-606X.24.05443-5

Elisabetta Colciago, Pietro Ferrara, Isadora Vaglio Tessitore, Lorenzo G Mantovani, Patrizia Vergani, Sara Ornaghi

{"title":"A vaginal birth is a cost-reduction strategy for women with a low-lying placenta.","authors":"Elisabetta Colciago, Pietro Ferrara, Isadora Vaglio Tessitore, Lorenzo G Mantovani, Patrizia Vergani, Sara Ornaghi","doi":"10.23736/S2724-606X.24.05443-5","DOIUrl":"10.23736/S2724-606X.24.05443-5","url":null,"abstract":"Background: Alongside health consequences, cesarean delivery (CD) has been associated with increased healthcare resource utilization (HCRU). A CD should be performed in case of placenta previa; in turn, the most appropriate mode of birth in women with a low-lying placenta (LLP) is still controversial. Since no previous data are available on the topic, the aim of this study was to evaluate the HCRU and economic impact on the Italian HC system of vaginal birth (VB) and CD in women with a LLP.Methods: This retrospective study used patient-level real-world data of a cohort of women with a LLP confirmed at 28-30 weeks. A cost-minimization analysis (CMA) was conducted to compare VB and CD. Since Diagnosis-Related-Group payment may not reflect the actual use of hospital resources, a micro-costing analysis (MCA) was performed to more comprehensively evaluate the economic impact of VB and CD.Results: The study included 86 women with a LLP at the third trimester scan, of which 49 (57%) had a VB and 37 (43%) underwent a CD. The CMA showed an economically marginal difference between VB and CD, especially when considering opportunity costs associated with the resources needed to look after women. However, the MCA identified charges for each VB being about half of those for each CD.Conclusions: The use of patient-level real-world data allowed to generate basic information to assess the value of available interventions in case of LLP. A VB should be promoted in women with LLP, avoiding further burden on the HC system's limited resources.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"85-92"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of labor in high-risk nulliparous women with unfavorable cervix. 对宫颈不佳的高危无子宫妇女进行引产。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-09-20 DOI: 10.23736/S2724-606X.24.05462-9

Valerio Carletti, Veronica Yacoub, Herbert C Valensise, Francesco Maneschi

{"title":"Induction of labor in high-risk nulliparous women with unfavorable cervix.","authors":"Valerio Carletti, Veronica Yacoub, Herbert C Valensise, Francesco Maneschi","doi":"10.23736/S2724-606X.24.05462-9","DOIUrl":"10.23736/S2724-606X.24.05462-9","url":null,"abstract":"Background: Inducing labor by ensuring a good maternal-fetal outcome is a challenge. The aim of the study was to evaluate the success rate, safeness, and time to delivery after the induction of labor (IOL), with the alternately first use of dinoprostone or Foley balloon, in high-risk pregnancy nulliparous women with unfavorable Bishop Score (BS).Methods: This is a retrospective study of high-risk nulliparous women who underwent the IOL, either with dinoprostone or the Foley balloon method. In the former case, if the labor has not started after dinoprostone removal, oxytocin infusion started. In Foley group, the BS was re-evaluated after Foley removal, and IOL continued with the use of dinoprostone (if BS<6) or oxytocin (if BS>6). Here, too, if no labor occurred after dinoprostone removal, Oxytocin was administered. Delivery mode, fetal and maternal complications were recorded. The time to delivery was tracked.Results: A total of 261 women were enrolled in the study. The CS rate was similar between groups (37.56% vs. 35.93%; P=0.81). Time to delivery was statistically lower in dinoprostone group (26.82h), as opposed to Foley (47.4h) (P<0.0001). Body Mass Index (BMI) of women who underwent Cesarean section (CS) was significantly higher than women who gave birth by vaginal delivery (VD), 26.80 vs. 27.40, P=0.012.Conclusions: IOL in high-risk pregnancy nulliparous women resulted in equal rate of CS between the two groups. Dinoprostone first use resulted in a shorter time to delivery, with no maternal-fetal side effects. There is then no need to prolong IOL and raise maternal stress, as this will not yield better outcomes.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"103-111"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barbed suture in laparoscopic myomectomy. 腹腔镜子宫肌瘤切除术中的带刺缝合。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-09-16 DOI: 10.23736/S2724-606X.24.05494-0

Federica Savasta, Alessandro Libretti, Livio Leo, Libera Troìa, Valentino Remorgida

{"title":"Barbed suture in laparoscopic myomectomy.","authors":"Federica Savasta, Alessandro Libretti, Livio Leo, Libera Troìa, Valentino Remorgida","doi":"10.23736/S2724-606X.24.05494-0","DOIUrl":"10.23736/S2724-606X.24.05494-0","url":null,"abstract":"Uterine myomas are the most common benign gynecological tumors among women of reproductive age. The laparoscopic approach, when feasible, is considered the most suitable and safe technique for intervention. Typically, uterine muscular wall defects are sutured with absorbable filaments. However, performing intra-corporeal knots during laparoscopic procedures demands significant surgical abilities and experience. While laparoscopic myomectomies are often recommended, they pose a high risk of hemorrhage. Barbed sutures may address the challenges of laparoscopic knotting due to their inherent barbs, leading to filament cohesion with tissues. This characteristic could potentially reduce the total operative time and blood loss during surgery. In consideration of the latest literature meta-analysis on the topic, published in 2018 and cited in the present work, six papers were included in this review, excluding case reports, reviews and articles without a control group. The objective of this narrative review is to explore the literature and establish the safety profile of barbed suture compared to conventional laparoscopic sutures. Additionally, given the potential for postoperative adhesion formation with the use of barbed sutures, the review also emphasizes reproductive outcomes. Consistent with previous literature, patients undergoing barbed suture laparoscopic myomectomy experienced significantly lower suturing time and blood loss. Regarding obstetric outcomes, all studies analyzing this aspect concluded that barbed sutures in myomectomy are as safe as, and represent an easier alternative to, conventional sutures. Importantly, these findings did not adversely affect pregnancy outcomes.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"128-136"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights of the March-April 2025 issue. 2025年3 - 4月刊的亮点。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 DOI: 10.23736/S2724-606X.25.05774-4

Antonio La Marca

引用次数: 0

Relationship between patient safety indicator events and hospital location for inpatient hysterectomy. 患者安全指标事件与住院患者子宫切除术的医院地点之间的关系。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-03-21 DOI: 10.23736/S2724-606X.24.05431-9

Sarah Sears, Diana Mitchell, Anne Sammarco, David Sheyn

{"title":"Relationship between patient safety indicator events and hospital location for inpatient hysterectomy.","authors":"Sarah Sears, Diana Mitchell, Anne Sammarco, David Sheyn","doi":"10.23736/S2724-606X.24.05431-9","DOIUrl":"10.23736/S2724-606X.24.05431-9","url":null,"abstract":"Background: Previous studies suggest surgical quality outcomes are similar between rural and urban hospitals, but data about gynecology in rural hospitals is sparse.Methods: This was a retrospective cohort study utilizing the National Inpatient Sample database from the Agency of Healthcare Research and Quality. Patients who underwent benign hysterectomy for non-prolapse indications between 2012-2016 were identified using ICD-9 and 10 codes. Patients were stratified into rural or urban non-teaching groups; urban teaching hospitals were the referent group. The primary outcome was the rate of patient safety indicator (PSI) events. PSI events were identified using ICD-9 and 10 codes. Statistical analysis was performed using analysis of variance and uni- and multivariate Poisson regressions.Results: 154,810 patients met all inclusion criteria. The cumulative rate of PSI events was 11.9% at rural hospitals, 13.9% at urban non-teaching hospitals and 16.9% at urban teaching hospitals, P<0.001. The most common PSI events were postoperative metabolic derangement, hemorrhage, and accidental puncture. The rate of transfusion was highest in urban teaching hospitals (6.7%) and similar for rural (5.1%) and urban non-teaching hospitals (5.5%), P<0.001. The rate of genitourinary tract injury was between 1.4-1.6%, and similar across sites, P=0.89. After adjusting for confounders, the risk of PSI events was similar across locations. The risk of transfusion was lower at rural hospitals (aRR=0.84, 95% CI: 0.74-0.94).Conclusions: Hysterectomy performed at rural hospitals, typically thought of as having low surgical volume compared to urban hospitals, is associated with similar risk of PSI events and lower risk of transfusion.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"67-74"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New characteristics of polycystic ovary syndrome phenotypes according to gas chromatography-mass spectrometry-based study of urinary steroid metabolome. 基于气相色谱-质谱法的尿液类固醇代谢组研究揭示多囊卵巢综合征表型的新特征

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-07-17 DOI: 10.23736/S2724-606X.24.05461-7

Maria I Yarmolinskaya, Olga B Glavnova, Natalia V Vorokhobina, Ludmila I Velikanova, Ekaterina V Malevanaya

{"title":"New characteristics of polycystic ovary syndrome phenotypes according to gas chromatography-mass spectrometry-based study of urinary steroid metabolome.","authors":"Maria I Yarmolinskaya, Olga B Glavnova, Natalia V Vorokhobina, Ludmila I Velikanova, Ekaterina V Malevanaya","doi":"10.23736/S2724-606X.24.05461-7","DOIUrl":"10.23736/S2724-606X.24.05461-7","url":null,"abstract":"Background: The most common cause of hyperandrogenism in women is polycystic ovary syndrome (PCOS), the prevalence of which among women of reproductive age ranges from 8.0 to 21%. The clinical manifestations of PCOS are diverse, and the degree of metabolic and hormonal disorders depends on the PCOS phenotype. The non-classic congenital adrenal hyperplasia (NCCAH) ranks second in the structure of diseases associated with hyperandrogenism. PCOS and NCCAH have a similar clinical picture and laboratory parameters, which requires differential diagnosis.Methods: Urinary steroid profiles were studied by gas chromatography-mass spectrometry.Results: We revealed differences in glucocorticoid and androgen metabolism in women with different PCOS phenotypes, which is reflected in the clinical manifestation of the disease. It was evaluated the activity of enzymes involved in the metabolism of steroid hormones. In patients with NCCAH, it was found that polycystic ovarian changes are secondary and develop due to the presence of prolonged adrenal hyperandrogenism.Conclusions: The results obtained are important for understanding the mechanisms of disorders in various variants of hyperandrogenism and determining further tactics for managing patients.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"93-102"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age and phytoestrogen use, but not resilience, influence urinary incontinence in postmenopausal women. 年龄和植物雌激素的使用（而非复原力）会影响绝经后妇女的尿失禁。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2024-10-08 DOI: 10.23736/S2724-606X.24.05440-X

Ana M Fernández-Alonso, Isabel M Fernández-Alonso, Ignacio Rodríguez, Faustino R Pérez-López

{"title":"Age and phytoestrogen use, but not resilience, influence urinary incontinence in postmenopausal women.","authors":"Ana M Fernández-Alonso, Isabel M Fernández-Alonso, Ignacio Rodríguez, Faustino R Pérez-López","doi":"10.23736/S2724-606X.24.05440-X","DOIUrl":"10.23736/S2724-606X.24.05440-X","url":null,"abstract":"Background: The aim of this study was to determine factors involved in urinary incontinence (UI), and psychological resilience in postmenopausal women.Methods: In this cross-sectional study, 137 postmenopausal women (aged 50-75 years) filled out the 4-item International Consultation on Incontinence Questionnaire short form (ICIQ-SF), the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), the 10-item Connor-Davidson Resilience Scale (CD-RISC), and a questionnaire containing personal data. We designed a directed acyclic graph (DAG) to identify covariates related to urinary incontinence and resilience in postmenopausal women.Results: The mean age of all surveyed women was 58.7±5.1 years, the majority were Caucasian (92.7%). There was an inverse correlation between item-1 ICIQ-SF scores and CD-RISC Scores. Women with severe UI had a higher median total ICIQ-SF score and lower total CD-RISC Scores as compared to those with nil or mild (P<0.05 for both). Odds ratios of sociodemographic and clinical characteristics indicate that phytoestrogen use (OR: 10.80; 95% CI 2.42-48.13) and economic problems (OR: 2.46; 95% CI 1.22-4.93) were associated with UI. However, a multivariable logistic model only identified urinary incontinence significantly associated with phytoestrogen use and age (P<0.05). The effect of other variables was attenuated in the model when controlling for population confounders, and significance was not achieved.Conclusions: Urinary incontinence was significantly associated with economic problems, phytoestrogen use, and depressive symptoms compared to women without urinary complaints. The multivariable logistic model confirmed age and phytoestrogen use as causal factors for urinary incontinence.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"75-84"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0