Minerva obstetrics and gynecology最新文献_第10页

Medically assisted reproduction in Italy, 2020 data from the Italian MAR Register. 意大利医学辅助生殖，2020 年意大利 MAR 登记数据。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.23736/S2724-606X.23.05375-7

Giulia Scaravelli, Roberto DE Luca, Roberta Spoletini, Lucia Speziale, Fabiola Fedele, Simone Bolli, Monica Mazzola, Anna Bertini, Cinzia DI Monte, Vincenzo Vigiliano

{"title":"Medically assisted reproduction in Italy, 2020 data from the Italian MAR Register.","authors":"Giulia Scaravelli, Roberto DE Luca, Roberta Spoletini, Lucia Speziale, Fabiola Fedele, Simone Bolli, Monica Mazzola, Anna Bertini, Cinzia DI Monte, Vincenzo Vigiliano","doi":"10.23736/S2724-606X.23.05375-7","DOIUrl":"10.23736/S2724-606X.23.05375-7","url":null,"abstract":"Background: The Italian Medically Assisted Reproduction (MAR) Register (ItMARR) was established by the Decree of the Minister of Health issued on October 7th, 2005. ItMARR has a crucial role in clearly and publicly disseminating epidemiological information on the MAR activities and outcomes.Methods: ItMARR data is collected in aggregate form and is mandatory as set out in Law 40/2004. The aim of this article is to make a snapshot of the authorized centers that perform IUI and ART in Italy. Data used in this article refer to MAR treatments started between January 1st and December 31st, 2020.Results: MAR techniques were performed by 332 centers. In total, 67,927 ART cycles and 12,171 IUI cycles were performed in 2020. Gametes donation cycles represent 12.9% of ART activity and 4.0% of IUI. ART cycles performed per million women of childbearing age was 6525. In 2020, 2.5% of births in the general population in Italy were a result of application of ART techniques. MAR activity in 2020, has been heavily reduced by the limitations to reproductive treatment due to SARS-CoV-2 pandemic. Pregnancy rates per transfers were 26.7% with fresh techniques, 32.6% with FER, 25.7% with FO, 38.0% with OD and 39.1% with SD. There were fewer multiple deliveries than the previous year.Conclusions: The ItMARR, has become a great asset in the reproductive health scenario promoting a better MAR information dissemination. ItMARR is working on the implementation towards a \"cycle-by-cycle\" data collection system. This will bring the Italian monitoring system in line with others European countries.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"118-126"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate delivery versus expectant management in women with chronic hypertension: a meta-analysis of randomized controlled trials. 对患有慢性高血压的妇女进行立即分娩与预产期管理：随机对照试验的荟萃分析。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-04-01 Epub Date: 2023-05-04 DOI: 10.23736/S2724-606X.23.05194-1

Giovanni Sisti, Gal Rubin, Antonio Schiattarella

{"title":"Immediate delivery versus expectant management in women with chronic hypertension: a meta-analysis of randomized controlled trials.","authors":"Giovanni Sisti, Gal Rubin, Antonio Schiattarella","doi":"10.23736/S2724-606X.23.05194-1","DOIUrl":"10.23736/S2724-606X.23.05194-1","url":null,"abstract":"Introduction: The current guidelines regarding chronic hypertension during pregnancy recommend induction of labor at term. The only previous meta-analysis on this topic found two randomized controlled trials but failed to pool together their results. We aimed to find the best literature-based evidence regarding delivery timing in chronic hypertension during pregnancy.Evidence acquisition: We searched the following electronic databases: MEDLINE, EMBASE, Scopus, ClinicalTrials.gov, the PROSPERO International Prospective Register of Systematic Reviews, and the Cochrane Central Register of Controlled Trials, Google Scholar. We selected randomized controlled trials comparing expectant management versus immediate delivery. The search was performed by two authors and the conflicts resolved in meetings. Data collection and analysis: we collected maternal and neonatal outcomes in a metanalysis following the random-effects model.Evidence synthesis: Two studies were found. The summary effect measure was 1.1 (C.I. 0.51-2.1) regarding the maternal outcomes, 2.6 (C.I. 0.91-7.44) regarding the neonatal outcomes, and 1.5 (C.I. 0.8-2.79) combined. There was no statistically significant difference between maternal and neonatal outcomes (P=0.2).Conclusions: The results of our meta-analysis pointed towards a non-difference between immediate delivery and expectant management, in women with chronic hypertension.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"174-180"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luteal phase support in assisted reproductive technology centers: Italian survey. 辅助生殖技术中心的黄体期支持：意大利调查

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2024-04-01 Epub Date: 2023-04-14 DOI: 10.23736/S2724-606X.22.05219-8

Antonio La Marca, Paola Anserini, Andrea Borini, Giuseppe D'Amato, Ermanno Greco, Claudia Livi, Enrico Papaleo, Rocco Rago

{"title":"Luteal phase support in assisted reproductive technology centers: Italian survey.","authors":"Antonio La Marca, Paola Anserini, Andrea Borini, Giuseppe D'Amato, Ermanno Greco, Claudia Livi, Enrico Papaleo, Rocco Rago","doi":"10.23736/S2724-606X.22.05219-8","DOIUrl":"10.23736/S2724-606X.22.05219-8","url":null,"abstract":"Background: In assisted reproductive cycles (ART), the fine balance of controlling corpus luteum function is severely disrupted. To challenge this iatrogenic deficiency, clinicians aim to provide exogenous support. Several reviews have investigated progesterone route of administration, dosage and timing.Methods: A survey about luteal phase support (LPS) after ovarian stimulation was conducted among doctors in charge in Italian II-III level ART centers.Results: With regards to the general approach to LPS, 87.9% doctors declare to diversify the approach; the reasons for diversifying (69.7%) were based on the type of cycle. For all the most important administration routes (vaginal, intramuscular, subcutaneous) it appears that in frozen cycles there is a shift towards higher dosages. The 90.9% of the centers use vaginal progesterone, and when a combined approach is required, in 72.7% of cases vaginal administration is combined with injective route of administration. When Italian doctors were asked about the beginning and duration of LPS, 96% of the centers start the day of the pickup or the day after, while 80% of the centers continue LPS until week 8-12. The rate of participation of the centers confirms the low perceived importance of LPS among Italian ART centers, while may be considered quite surprising the relatively higher percentage of centers that measures P level. Tailorization to women's needs is the new objective of LPS: self-administration, good tolerability are the main aspects for Italian centers.Conclusions: In conclusion, results of Italian survey are consistent to results of main international surveys about LPS.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"109-117"},"PeriodicalIF":1.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9299475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gynecologic oncology top-cited articles: an international analysis. 妇科肿瘤学前被引文章:国际分析。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-04-01 Epub Date: 2023-11-23 DOI: 10.23736/S2724-606X.23.05391-5

Gabriel Levin, Yoav Brezinov, Raanan Meyer, Noa Oranim

{"title":"Gynecologic oncology top-cited articles: an international analysis.","authors":"Gabriel Levin, Yoav Brezinov, Raanan Meyer, Noa Oranim","doi":"10.23736/S2724-606X.23.05391-5","DOIUrl":"10.23736/S2724-606X.23.05391-5","url":null,"abstract":"The aim of this paper was to study the top-cited per year (CPY) original articles published in the leading subspecialty journals in gynecologic oncology and in the leading general obstetrics and gynecology journals. We used the Web of Science and iCite databases to mine the original articles and review articles in the field of gynecologic oncology in the following journals: Gynecologic Oncology, The International Journal of Gynecological Cancer, The American Journal of Obstetrics and Gynecology and the Obstetrics & Gynecology. Top CPY articles from the four journals were analyzed and compared in a two-time point analysis. A total of 23,252 original articles and reviews were identified. The 100 Top-CPY articles were published from 1983 to 2021. Seventy (70%) in Gynecologic Oncology journal, 20 (20%) in The International Journal of Gynecological Cancer, eight (8%) in Obstetrics & Gynecology and two (2%) in The American Journal of Obstetrics and Gynecology. The most common study methodology was observational studies (20%), followed by guidelines/consensus papers (19%). The most common study topic was ovarian cancer (41%). North America originating authors composed 62% of the top CPY publications, followed by Europe (21%). The most common country of authorship was the United States (52%) followed by Canada (10%). CPY were similar in the publications before vs. after 2014 (P=.19). Study designs, study topics and continent of authorship were similar in both periods. The proportion of multi-center studies was higher after 2014 (66.6% vs. 28.8%, P=0.002) and the proportion of open access publications was higher after 2014 (66.6% vs. 15.4%, P<.001). Funded studies were more common after 2014 (75.0% vs. 53.8%, P=0.028). Ovarian cancer is the top CPY area of research in gynecologic oncology. This field is leaded by authors from the United States with multi-center studies proportion increasing in recent years. It is important to promote further high-quality research in other countries to disseminate knowledge and equality.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"188-193"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal use of indomethacin for preterm labor and renal function among very low birth weight infants. 产前使用吲哚美辛治疗早产与极低出生体重儿的肾功能。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-02-01 Epub Date: 2023-02-14 DOI: 10.23736/S2724-606X.22.05137-5

Mariateresa Sinelli, Sara Ornaghi, Daniela Doni, Giuseppe Paterlini, Anna Locatelli, Davide P Bernasconi, Patrizia Vergani, Maria L Ventura

{"title":"Prenatal use of indomethacin for preterm labor and renal function among very low birth weight infants.","authors":"Mariateresa Sinelli, Sara Ornaghi, Daniela Doni, Giuseppe Paterlini, Anna Locatelli, Davide P Bernasconi, Patrizia Vergani, Maria L Ventura","doi":"10.23736/S2724-606X.22.05137-5","DOIUrl":"10.23736/S2724-606X.22.05137-5","url":null,"abstract":"Background: Indomethacin is administered as a tocolytic agent for threatening preterm labor <28weeks of gestation. Only a few, not conclusive, studies have investigated its nephrotoxicity in very low birth weight (VLBW) infants. We investigated whether indomethacin increases the incidence of acute kidney injury (AKI) among VLBW infants.Methods: This is a retrospective study including all VLBW infants born at our center between January 1, 2005, and December 31, 2013. Indomethacin was administered to women with preterm labor and intact membranes. Neonatal AKI was defined according to KDIGO classification. Univariate analyses were performed comparing VLBW infants exposed to and not exposed to indomethacin. In the multivariable model, the association of indomethacin and AKI was adjusted for patent ductus arteriosus, use of nephrotoxic medications, birth weight, and gestational age.Results: Five hundred seventy-five VLBW infants were included, 49 (8.5%) of whom were exposed to indomethacin in utero. The univariate analysis showed that infants exposed to indomethacin had lower birth weight, lower gestational age, and higher incidence of AKI than infants not exposed. The multivariable model adjusted for confounding factors confirmed an increased risk of AKI in relation to gestational age at birth <27 weeks, but not to indomethacin.Conclusions: Our data suggest that extreme prematurity, but not the use of indomethacin, is associated with AKI.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"36-42"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9262325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An updated meta-analysis comparing the efficacy and safety of biosimilar medicinal products to the original follitropin alfa. 比较生物仿制药与原研促性腺激素α的疗效和安全性的最新荟萃分析。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-02-01 Epub Date: 2022-12-19 DOI: 10.23736/S2724-606X.22.05175-2

Maria C Budani, Stefania Fensore, Marco DI Marzio, Gian M Tiboni

{"title":"An updated meta-analysis comparing the efficacy and safety of biosimilar medicinal products to the original follitropin alfa.","authors":"Maria C Budani, Stefania Fensore, Marco DI Marzio, Gian M Tiboni","doi":"10.23736/S2724-606X.22.05175-2","DOIUrl":"10.23736/S2724-606X.22.05175-2","url":null,"abstract":"Introduction: The aim of this study was to provide an updated meta-analysis assessing the therapeutic equivalence between follitropin alfa biosimilars and the reference medication in women undergoing assisted reproductive technologies (ART).Evidence acquisition: The studies included in the analysis were pooled together in order to estimate the log odds ratio (OR) for binary outcomes and the mean difference (MD) for continuous outcomes along with the corresponding 95% confidence intervals (CI) by using a random effects model. The heterogeneity between the studies was evaluated with the Higgins and χ2 tests.Evidence synthesis: No differences were found concerning the number of oocytes retrieved at ovum pick-up, the primary endpoint recommended by the European Medicines Agency (EMA) (MD -0.04 CI [-0.78, 0.71], P=0.92). A significantly higher clinical pregnancy rate (OR 0.70 CI [0.53, 0.93], P=0.01) was observed in the reference product group in comparison to the biosimilar follitropin alfa, whereas no statistically significant differences were found for biochemical pregnancy rate, take home baby rate, total follitropin alfa dose, duration of stimulation, and ovarian hyperstimulation syndrome risk.Conclusions: The non-inferiority of biosimilar formulations in comparison to the reference product, with respect to number of oocytes retrieved at ovum pick-up, was shown.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"70-79"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10749241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Training for da Vinci robotic surgery: the Intuitive experience. 达机器人手术培训：直观体验。

IF 1.6

Minerva obstetrics and gynecology Pub Date : 2024-02-01 Epub Date: 2023-10-06 DOI: 10.23736/S2724-606X.23.05309-5

Giorgia Gaia, Maria C Sighinolfi, Stefano Terzoni, Margarita Afonina, Alessandro Morandi, Veronica Iannuzzi, Simone Assumma, Antonio La Marca, Arsenio Spinillo, Anna M Marconi

引用次数: 0

Current and future methods for embryo selection: on a quest for reliable strategies to reduce time to pregnancy. 目前和未来的胚胎选择方法：寻找缩短怀孕时间的可靠策略。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-02-01 Epub Date: 2023-05-10 DOI: 10.23736/S2724-606X.23.05257-0

Francesco Capodanno, Attilio Anastasi, Marialuisa Cinti, Francesca Bonesi, Andrea Gallinelli

{"title":"Current and future methods for embryo selection: on a quest for reliable strategies to reduce time to pregnancy.","authors":"Francesco Capodanno, Attilio Anastasi, Marialuisa Cinti, Francesca Bonesi, Andrea Gallinelli","doi":"10.23736/S2724-606X.23.05257-0","DOIUrl":"10.23736/S2724-606X.23.05257-0","url":null,"abstract":"Introduction: The aim of this study was to analyze the usefulness of the principal embryological strategies to reduce time to pregnancy.Evidence acquisition: A systematic search of publications in the PubMed/MEDLINE, Embase and Scopus databases from inception to present including \"IVF,\" \"blastocyst,\" \"embryo colture,\" \"competent embryo,\" \"time to pregnancy,\" \"aneuploid,\" \"euploid,\" \"vitrification,\" \"preimplantation genetic,\" \"IVF strategies\" and \"embryo selection\" alone or in combinations has been done.Evidence synthesis: We have selected 230 articles and 9 of them have been included in this mini-review.Conclusions: Several embryological strategies aimed to select the most competent embryo and reduce time to pregnancy have been proposed, even if few publications on this specific topic are available. preimplantation genetic testing (PGT-A) represents the unique method able to assess the embryonic chromosomal status, but this does not mean that PGT-A is a reliable strategy to reduce time to pregnancy. There is no consensus on a specific method to reduce time to pregnancy, nevertheless this final goal could be probably reached through a harmonious combination of procedures. Thus, a reliable strategy to reduce time to pregnancy could be achieved when embryo culture, embryo cryopreservation and PGT-A are perfectly integrated and appropriately offered to selected patients.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"80-88"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mosaic embryo: what it means for the doctor and the patient. 马赛克胚胎：对医生和病人的意义。

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2024-02-01 Epub Date: 2023-07-10 DOI: 10.23736/S2724-606X.23.05281-8

Ermanno Greco, Pier F Greco, Ilaria Listorti, Carlo Ronsini, Francesco Cucinelli, Anil Biricik, Manuel Viotti, Noemi Meschino, Francesca Spinella

{"title":"The mosaic embryo: what it means for the doctor and the patient.","authors":"Ermanno Greco, Pier F Greco, Ilaria Listorti, Carlo Ronsini, Francesco Cucinelli, Anil Biricik, Manuel Viotti, Noemi Meschino, Francesca Spinella","doi":"10.23736/S2724-606X.23.05281-8","DOIUrl":"10.23736/S2724-606X.23.05281-8","url":null,"abstract":"Introduction: Mosaic embryos are embryos that on preimplantation genetic analysis are found to be composed of euploid and aneuploid cells. Although most of these embryos do not implant when transferred into the uterus following IVF treatment, some may implant and are capable of giving rise to babies.Evidence acquisition: There is currently an increasing number of reports of live births following the transfer of mosaic embryos. Compared to euploid, mosaic embryos have lower implantation rates and higher rates of miscarriage, and occasionally aneuploid component persists. However, their outcome is better than that obtained after the transfer of embryos consisting entirely of aneuploid cells. After implantation, the ability to develop into a full-term pregnancy is influenced by the amount and type of chromosomal mosaicism present in a mosaic embryo. Nowadays many experts in the reproductive field consider mosaic transfers as an option when no euploid embryos are available. Genetic counseling is an important part of educating patients about the likelihood of having a pregnancy with healthy baby but also on the risk that mosaicism could persist and result in liveborn with chromosomal abnormality. Each situation needs to be assessed on a case-by-case basis and counseled accordingly.Evidence synthesis: So far, the transfers of 2155 mosaic embryos have been documented and 440 live births resulting in healthy babies have been reported. In addition, in the literature to date, there are 6 cases in which embryonic mosaicism persisted.Conclusions: In conclusion, the available data indicate that mosaic embryos have the potential to implant and develop into healthy babies, albeit with lower success rates than euploids. Further clinical outcomes should be collected to better establish a refined ranking of embryos to transfer.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"89-101"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collecting semen samples at home for fertility assessment: time for a new standard? 在家采集精液样本进行生育能力评估:是时候制定新标准了?

IF 1.8

Minerva obstetrics and gynecology Pub Date : 2023-12-01 Epub Date: 2023-05-04 DOI: 10.23736/S2724-606X.23.05165-5

Paola Scaruffi, Francesca Bovis, Claudia Massarotti, Elena Maccarini, Sara Stigliani, Caterina DE Leo, Irene Gazzo, Fausta Sozzi, Paola Anserini

{"title":"Collecting semen samples at home for fertility assessment: time for a new standard?","authors":"Paola Scaruffi, Francesca Bovis, Claudia Massarotti, Elena Maccarini, Sara Stigliani, Caterina DE Leo, Irene Gazzo, Fausta Sozzi, Paola Anserini","doi":"10.23736/S2724-606X.23.05165-5","DOIUrl":"10.23736/S2724-606X.23.05165-5","url":null,"abstract":"Background: In fertility clinics the standard approach to semen collection involves a private room close to the laboratory to avoid fluctuations in temperature and to control the time between collection and processing. There are still no firm conclusions whether collecting semen at home has any influence on sperm quality and reproductive competence. The purpose of this study was to assess whether the site of semen collection affects semen parameters.Methods: This retrospective cohort study performed at a tertiary level public fertility center included 8634 semen samples from 5880 men undergoing fertility assessment from 2015 to 2021. The impact of sample collection site was evaluated using a generalized linear mixed model. A subgroup analysis comparing clinic to home collection within the same patient was performed on 1260 samples from 428 men by paired t-test or Wilcoxon Signed Rank Test.Results: Samples collected at home (N.=3240) had significantly higher semen volume, sperm concentration and total sperm count respect to samples collected at clinic (N.=5530) (median (range): 2.9 (0.0-13.9) mL versus 2.9 (0.0-11.5) mL, P=0.016; 24.0 (0.0-252.0) million/mL versus 18.0 (0.0-390.0), P<0.0001; 64.6 (0.0-946.0) million versus 49.3 (0.0-1045.0), P<0.0001, respectively). There was no difference in abstinence period and sperm motility. Paired comparisons of semen characteristics in 428 patients with home-collected (N.=583) and clinic-collected (N.=677) samples confirmed a no negative effect on volume and total sperm count.Conclusions: Our data provide evidence for a not disadvantage with collection at home.","PeriodicalId":18572,"journal":{"name":"Minerva obstetrics and gynecology","volume":" ","pages":"535-543"},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0