Minerva pediatrica最新文献_第6页

Pegylated interferon and ribavirin gone but not forgotten in the era of direct-acting antivirals. 聚乙二醇干扰素和利巴韦林在直接作用抗病毒药物时代消失了，但没有被遗忘。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2021-01-01 DOI: 10.23736/S0026-4946.20.05881-8

M. Pluta, M. Pokorska-Śpiewak, M. Aniszewska, Z. Lewandowski, B. Kowalik-Mikołajewska, M. Marczyńska

{"title":"Pegylated interferon and ribavirin gone but not forgotten in the era of direct-acting antivirals.","authors":"M. Pluta, M. Pokorska-Śpiewak, M. Aniszewska, Z. Lewandowski, B. Kowalik-Mikołajewska, M. Marczyńska","doi":"10.23736/S0026-4946.20.05881-8","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.05881-8","url":null,"abstract":"BACKGROUND\u0000Therapy with pegylated interferon and ribavirin (PEG-IFN+RBV) for chronic hepatitis C (CHC) still remains the only option available for children in many Eurasian and European countries. Our aim was to evaluate the influence of host and viral factors on response to IFN-based therapy to optimize it for those in whom directly acting antivirals (DAA) are currently unavailable.\u0000\u0000\u0000METHODS\u0000Seventeen vertically infected, treatment naive children (10 male and 7 female) aged 5-16 years with CHC underwent a course of PEG-IFN+RBV. The end point was sustained virologic response (SVR). Host and virus factors were divided into pre- and ontreatment predictors of response to therapy.\u0000\u0000\u0000RESULTS\u0000Eleven patients obtained SVR (64%), 4 were nonresponders (23%), and 2 were relapsers (12%). Significant relationship was found between HCV RNA elimination and following variables: virus genotype and early virologic response (EVR) (p< .037, p< .029 respectively). Higher eradication rate was observed in patients infected with genotype 3 HCV (100% vs. 65% with genotype 1 or 4), and in those with undetectable HCV RNA by week 12 (88% vs. 66% with viremia). EVR was associated with SVR (83% vs. 0% in nonresponders; p< .004). C allele of IL28B rs12979860 was a predictor of EVR (p < .043). The SVR rates among CC, CT, and TT carriers were as follows: 75%, 67%, and 33%.\u0000\u0000\u0000CONCLUSIONS\u0000Detection of favourable HCV and IL28B genotype prior to commencement of PEG-IFN+RBV, and continuing it in patients with EVR is of major importance for those in whom DAA are still unavailable.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48470808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal lymphangioendotheliomatosis with thrombocytopenia. 伴血小板减少的多灶性淋巴管内皮瘤病。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2021-01-01 DOI: 10.23736/S0026-4946.20.06069-7

E. Petrone, G. Santini, A. Correra, R. Lista

引用次数: 0

Insights on Kawasaki disease and multisystem inflammatory syndrome; relationship with COVID-19 infection. 川崎病与多系统炎症综合征的研究进展与COVID-19感染的关系。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-11 DOI: 10.23736/S0026-4946.20.06140-X

G. Calcaterra, J. Mehta, V. Fanos, P. Bassareo

{"title":"Insights on Kawasaki disease and multisystem inflammatory syndrome; relationship with COVID-19 infection.","authors":"G. Calcaterra, J. Mehta, V. Fanos, P. Bassareo","doi":"10.23736/S0026-4946.20.06140-X","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.06140-X","url":null,"abstract":"At the beginning of coronavirus disease 2019 (COVID-19) children seemed to be less affected and with milder symptoms than adults. Afterward, however, a warning was released regarding the possible association between COVID-19 and Kawasaki disease (KD) or Kawasaki-like disease. Thereafter, labels of Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS) in Europe and Multisystem Inflammatory Syndrome in Children (MIS-C) in the USA were coined to refer to this new disease entity. The reality is that PIMS-TS/MIS-C resembles certain KD complications such as toxic shock syndrome and macrophage activation syndrome than to classic KD. PIMS-TS/MIS-C and KD share the viral origin (however just supposed for KD) and consequent dysregulated innate immune system inflammatory reaction. PIMS-TS/MISC symptoms occur about 2-4 weeks after the onset of COVID-19 or having been exposed to somebody positive for COVID-19, rather than in the acute phase of the infection. Clinically PIMS-TS/MIS-C affects older children than KD and presents more often with gastrointestinal symptoms, shock, and multi-organ dysfunction. myocarditis is more common in PIMS-TS/MIS-C than coronary artery aneurysms formation seen in KD. There are also differences in laboratory tests and immunology responses in KD and PIMS-TS/MIS-C. Thus PIMS-TS/MIS-C seems to be a new and multifaceted entity, distinct from KD, notwithstanding some common features in both. The dysregulated innate immune system reaction is responsible for PIMS-TS/MIS-C onset and outcome. A multidisciplinary approach, involving paediatric intensivists, paediatric cardiologists, infectious disease specialists, immunologists, and rheumatologists, is needed for the treatment of these children.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45911794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Nutrition and growth in children. 儿童的营养和生长。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 Epub Date: 2020-07-29 DOI: 10.23736/S0026-4946.20.05981-2

Lorena Matonti, Annalisa Blasetti, Francesco Chiarelli

引用次数: 0

Novel approach to portal vein thrombosis following paediatric liver blunt trauma: the "pullout" technique. 儿童肝脏钝性损伤后门静脉血栓形成的新方法：“拔出”技术。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 DOI: 10.23736/S0026-4946.20.06109-5

P. Muiesan, A. Parente, A. Schlegel, S. Mcguirk, K. Sharif, M. Kasahara

引用次数: 0

Fecal calprotectin in the pediatric population: a 2020 update. 儿科人群中的粪钙保护蛋白:2020年更新。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 Epub Date: 2020-07-29 DOI: 10.23736/S0026-4946.20.06002-8

Fabio CisarÒ, Antonio Pizzol, Caterina Rigazio, Pier L Calvo

{"title":"Fecal calprotectin in the pediatric population: a 2020 update.","authors":"Fabio CisarÒ, Antonio Pizzol, Caterina Rigazio, Pier L Calvo","doi":"10.23736/S0026-4946.20.06002-8","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.06002-8","url":null,"abstract":"Calprotectin is a calcium and zinc-binding protein, formed by a hetero complex of S100A8 and S100A9 proteins, which belong to the S-100 protein family consisting in more than 20 different proteins with a tissue-specific expression pattern. This protein is secreted extracellularly from stimulated neutrophils or released by cell disruption or death. The presence of calprotectin in feces quantitatively relates to neutrophil migration toward the gastrointestinal (GI) tract; thus, it represents a useful marker of intestinal inflammation. Fecal calprotectin (FC) has been proven largely useful for determining the inflammatory origin of GI symptoms differentiating between organic and non-organic diseases. Indeed, increased FC levels are also seen in gastroenteritis, microscopic colitis, polyps, malignancies and cystic fibrosis. To date, there are many evidences regarding usefulness in the detection of fecal calprotectin for the management of gastrointestinal disorders, both in children and adults but, especially in the pediatric population, still clear indications for its use are lacking. Its incorporation in primary care reduces the risk of missing an organic disease and facilitates the indication for expensive and invasive investigations as colonoscopy. We herein review and discuss the last evidence on the usefulness of FC in children, with its current indications and future prospective.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":"72 6","pages":"514-522"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38209493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Physiology and abnormalities of growth and puberty. 发育和青春期的生理和异常。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 Epub Date: 2020-07-29 DOI: 10.23736/S0026-4946.20.06018-1

Francesco Chiarelli

引用次数: 0

Inflammatory bowel disease associates growth retardation even before presenting digestive symptoms. 炎症性肠病甚至在出现消化系统症状之前就与生长迟缓有关。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 DOI: 10.23736/S0026-4946.20.06063-6

R. Martín-Masot, V. Navas-López

引用次数: 0

Tall stature in children and adolescents. 儿童和青少年身材高大。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 Epub Date: 2020-08-04 DOI: 10.23736/S0026-4946.20.05971-X

Tatsuhiko Urakami

{"title":"Tall stature in children and adolescents.","authors":"Tatsuhiko Urakami","doi":"10.23736/S0026-4946.20.05971-X","DOIUrl":"https://doi.org/10.23736/S0026-4946.20.05971-X","url":null,"abstract":"Tall stature is usually defined as a height beyond 97th percentile or more than 2 SD above the mean height for age and sex in a defined population. Familiar tall stature, also known as constitutional tall stature, is the most common cause of tall stature. Overnutrition, obesity, also usually causes overgrowth. Tall stature by itself is not a pathological condition, however, there are a number of disorders associated with tall stature. Some genetic disorders and syndromes may be associated with mental retardation and various complications. Therefore, recognition of tall stature and revealing the underlying pathogenic causes and making the diagnosis are important not to miss the serious conditions and to provide adequate medical care and genetic counseling. Pathological causes for tall statute include endocrine disorders, such as excessive growth hormone secretion, hyperthyroidism, precocious puberty and lipodystrophy, chromosome disorders, such as Trisomy X (47, XXX female), Klinefelter Syndrome (47, XXY), XYY syndrome (47, XYY male) and fragile X syndrome, and syndromes and metabolic disorders, such as Marfan Syndrome, Beckwith-Wiedemann Syndrome, Simpson-Golabi-Behmel Syndrome, Sotos Syndrome and homocystinuria. Children may require growth-reductive treatment if the predicted adult height would be excessive and unacceptable. Some hormonal, high doses of sex steroids, or surgical, bilateral percutaneous epiphysiodesis of the distal femur and proximal tibia and fibula, treatment is currently available to reduce adult height.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":"72 6","pages":"472-483"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Food security and nutritional status of children in foster care: new horizons in the protection of a fragile population. 寄养儿童的粮食安全和营养状况：保护脆弱人口的新视野。

IF 2.6 4区医学

Minerva pediatrica Pub Date : 2020-12-01 DOI: 10.23736/S0026-4946.16.04802-7

P. Ferrara, M. Scancarello, Y. M. Khazrai, Lorenza Romani, C. Cutrona, L. De Gara, G. Bona

{"title":"Food security and nutritional status of children in foster care: new horizons in the protection of a fragile population.","authors":"P. Ferrara, M. Scancarello, Y. M. Khazrai, Lorenza Romani, C. Cutrona, L. De Gara, G. Bona","doi":"10.23736/S0026-4946.16.04802-7","DOIUrl":"https://doi.org/10.23736/S0026-4946.16.04802-7","url":null,"abstract":"BACKGROUND\u0000The nutritional status of foster children, the quality of daily menus in group homes and the food security inside these organizations have been poorly studied. For this reason, the aim of this study was to investigate them.\u0000\u0000\u0000METHODS\u0000A sample of 125 children, ranging in age from 0-17 years, among seven group homes (group A) was compared with 121 children of the general population (group B). To evaluate nutritional status, BMI percentiles were used. Mean percentiles of both groups were compared through statistical analysis. Both nutritional and caloric daily distributions in each organization were obtained using the 24-hour recall method. A specific questionnaire was administered to evaluate food security.\u0000\u0000\u0000RESULTS\u0000From the analysis of mean BMI-for-age (or height-for-length) percentiles, we did not observe statistically significant differences between group A and group B. The average daily nutrient and calorie distribution in group homes proves to be nearly optimal except for a slight excess in proteins and a slight deficiency in polyunsaturated fatty acids. Moreover, a low intake of iron and calcium was revealed. All organizations obtained a High Food Security profile.\u0000\u0000\u0000CONCLUSIONS\u0000Nutritional conditions of foster children are no worse than that of children of the general population. Foster care provides the necessary conditions to support their growth.","PeriodicalId":18533,"journal":{"name":"Minerva pediatrica","volume":"72 6 1","pages":"508-513"},"PeriodicalIF":2.6,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42378911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0