Medical Research Journal最新文献_第3页

The impact of primary radical treatment on the effectiveness and safety of systemic treatment with ribociclib in female patients with advanced breast cancer 原发性根治性治疗对女性晚期乳腺癌患者全身核波西尼治疗的有效性和安全性的影响

Medical Research Journal Pub Date : 2023-10-26 DOI: 10.5603/mrj.97119

Emilia Barańska-Bała, Paulina Małachowska, Agnieszka Koper, Sławomir Wileński, Krzysztof Koper

引用次数: 0

The development of malaria vaccine: a beacon of hope? 疟疾疫苗的发展:希望的灯塔?

Medical Research Journal Pub Date : 2023-10-19 DOI: 10.5603/mrj.97178

Moyinoluwa Joshua Oladoye, Chinelo Geraldine Ikele

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Importance of genetic diagnosis for treatment and prognosis in acute lymphoblastic leukaemia (ALL) — a case report 基因诊断对急性淋巴细胞白血病(ALL)治疗和预后的重要性- 1例报告

Medical Research Journal Pub Date : 2023-10-13 DOI: 10.5603/mrj.96967

Mateusz Raniewicz, Maciej Dubaj, Karol Bigosiński, Aleksandra Dembowska, Małgorzata Mitura-Lesiuk

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Graft loss from a living donor due to flash recurrence of focal segmental glomerular sclerosis — case report 活体供者因局灶节段性肾小球硬化的短暂复发而导致移植物丢失- 1例报告

Medical Research Journal Pub Date : 2023-10-13 DOI: 10.5603/mrj.96872

Marta Głuchowska, Łukasz Gawlik, Azita Razaei, Marcin Gregorczyk, Piotr Jagodowski, Paweł Wróbel

引用次数: 0

Diagnosis and treatment of obstructive sleep apnea in patients with pauses in Holter ECG monitoring: case series 动态心电图监测暂停患者阻塞性睡眠呼吸暂停的诊断和治疗:病例系列

Medical Research Journal Pub Date : 2023-10-13 DOI: 10.5603/mrj.96809

Piotr Pawłucki, Łukasz Domagalski, Michał Jakub Sekuła, Natalia Kaleta, Anna Maciak, Katarzyna Kopeć, Paulina Cuper

{"title":"Diagnosis and treatment of obstructive sleep apnea in patients with pauses in Holter ECG monitoring: case series","authors":"Piotr Pawłucki, Łukasz Domagalski, Michał Jakub Sekuła, Natalia Kaleta, Anna Maciak, Katarzyna Kopeć, Paulina Cuper","doi":"10.5603/mrj.96809","DOIUrl":"https://doi.org/10.5603/mrj.96809","url":null,"abstract":"Obstructive sleep apnea (OSA) is a common disease in today's society and may affect even more of the population in the near future. Ailments and complications of OSA result from a decrease in the muscle tone of the soft palate, which causes shallow breathing or complete apnea. The consequences of such episodes may be the development of arterial hypertension, the occurrence of cardiac arrhythmias, and also a deterioration in the quality of life. Diagnosis is based on polysomnography in people with suspected OSA. Continuous Positive Airway Pressure (CPAP) therapy is the most effective treatment for OSA. We present a case series in which patients with OSA risk factors and nocturnal pauses in Holter ECG monitoring (HEM) were diagnosed due to suspected OSA. In the polysomnographic test, severe OSA was diagnosed and CPAP therapy was introduced. Follow-up HEM performed during treatment showed complete resolution or significant reduction in the number and length of nocturnal pauses. Based on the case series, current medical knowledge and guidelines for pacemaker implantation, we concluded that in the event of pauses in the HEM, the diagnosis of OSA should be considered in each patient, especially if the pauses occur mainly at night and the patient is at high risk of OSA. Such a procedure may protect the patient from serious complications related to the pacemaker implantation. It should be emphasized, however, that CPAP therapy requires close cooperation of the patient, because it brings effects only when it is used for each sleep.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135855413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rh negativity seems to predispose to a milder COVID-19 course Rh阴性似乎倾向于较温和的COVID-19病程

Medical Research Journal Pub Date : 2023-10-12 DOI: 10.5603/mrj.96960

Monika Paskudzka, Aleksandra Kumorek, Aleksandra Kijak, Marcin Śmiarowski, Dagmara Kogut, Milena Małecka-Giełdowska, Olga Ciepiela

{"title":"Rh negativity seems to predispose to a milder COVID-19 course","authors":"Monika Paskudzka, Aleksandra Kumorek, Aleksandra Kijak, Marcin Śmiarowski, Dagmara Kogut, Milena Małecka-Giełdowska, Olga Ciepiela","doi":"10.5603/mrj.96960","DOIUrl":"https://doi.org/10.5603/mrj.96960","url":null,"abstract":"Introduction: Infection with the SARS-CoV-2 virus can lead to the development of COVID-19. Currently, more than 700 million people worldwide have been diagnosed with COVID-19, of which nearly 7 million have died from the severe course of the disease. Recent reports suggest that patients with blood group A are most at risk of developing COVID-19, and people with natural anti-A antibodies (especially those with blood type 0) have a milder course of the disease. This study aimed to assess the humoral response to infection with SARS-CoV-2 depending on the patient’s blood type. Material and methods: The study group consisted of 147 patients with confirmed previous COVID-19 (convalescents) and 147 individuals who declared no previous infection with SARS-CoV-2. All enrolled subjects were blood donors registered at Regional Blood Center. The concentration of SARS-CoV-2 anti-nucleocapsid antibodies was determined in the serum of the patients using the Elecsys Anti-SARS-CoV-2 test. The blood group was determined by a manual method using anti-A, anti-B, and anti-D monoclonal sera and A, B, and 0 standard red blood cells (RBC). Results and conclusions: Based on anti-SARS-CoV-2 detection 68 people who denied contact with SARS-CoV-2 had previous asymptomatic infection. Blood type distribution differed between the asymptomatic convalescents and the declared convalescents, p = 0.0013. People with Arh–, BRh+, BRh–, and 0Rh– blood type were more often asymptomatically infected. Moreover, the Rh- subjects more often didn’t know about the previous infection than those with Rh+, p = 0.0012. It seems that subjects with Rh– blood type have a significantly milder course of disease than Rh+.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136014517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple new therapeutic options for the treatment of obesity 治疗肥胖的多种新疗法

Medical Research Journal Pub Date : 2023-09-29 DOI: 10.5603/mrj.97463

Julia M. Umińska

引用次数: 0

Therapeutic strategies targeting metabolic syndrome 针对代谢综合征的治疗策略

Medical Research Journal Pub Date : 2023-09-29 DOI: 10.5603/mrj.97482

Jacek Kubica

引用次数: 0

COVID-19 occurrence and symptoms depending on vaccination status: a retrospective single-centre analysis of 27,209 patients COVID-19的发生和症状取决于疫苗接种状况:对27,209例患者的回顾性单中心分析

Medical Research Journal Pub Date : 2023-09-20 DOI: 10.5603/mrj.96746

Zuzanna Głowacka, Paulina Ryszka, Lidia Wydeheft, Klaudyna Grzelakowska, Michał Kasprzak, Jacek Kubica

{"title":"COVID-19 occurrence and symptoms depending on vaccination status: a retrospective single-centre analysis of 27,209 patients","authors":"Zuzanna Głowacka, Paulina Ryszka, Lidia Wydeheft, Klaudyna Grzelakowska, Michał Kasprzak, Jacek Kubica","doi":"10.5603/mrj.96746","DOIUrl":"https://doi.org/10.5603/mrj.96746","url":null,"abstract":"Introduction: Widespread immunization is critical to bringing the COVID-19 pandemic to an end. The objective of this cross-sectional data analysis was to investigate the impact of vaccination on the frequency of COVID-19 occurrence and the presence of its symptoms and clinical presentations. Material and methods: This was a retrospective, cross-sectional study, analysing medical records of patients hospitalized at the Dr Antoni Jurasz University Hospital No. 1 in Bydgoszcz in the years 2019–2021. The analysis considered age, sex, vaccination status, the result of the reverse transcription polymerase chain reaction (RT-PCR) test for the detection of SARS-CoV-2 RNA, and disease symptoms and clinical presentations in accordance with ICD-10 codes. Results: The study group consisted of 27,209 patients. There were 1,393 persons (5.12%) who tested positive for COVID-19. The vaccinated patients accounted for 17.3% (n = 4,704). Those vaccinated were significantly less likely to test positive for COVID-19 (3.93% vs. 5.38%; p < 0.0001). Among unvaccinated patients with a positive test result for COVID-19, symptoms and/or clinical presentations occurred in 359 study participants (29.72%), while in vaccinated COVID-19-positive patients only in 49 persons (26.49%). The symptoms that occurred in both vaccinated and unvaccinated patients were mainly respiratory and circulatory. The most common clinical presentation, both in the group of vaccinated and unvaccinated patients, was viral pneumonia, not elsewhere classified (J12), which occurred in 17.30% and 9.19% of patients, respectively (p = 0.005). Other symptoms and clinical presentations showing a statistically significant difference in the frequency of occurrence between the groups were pneumonia in diseases classified elsewhere (J17; p = 0.019) and abnormalities of breathing (R06; p = 0.001). Conclusions: Vaccination against COVID-19 protects against symptomatic disease.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136377728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The model for end-stage liver disease excluding international normalized ratio (MELD-XI) predicts three-year mortality in patients with advanced heart failure

Medical Research Journal Pub Date : 2023-09-18 DOI: 10.5603/mrj.97134

Kamila Kurkiewicz-Sawczak, Zofia Gierlotka, Mariusz Gąsior, Bożena Szyguła-Jurkiewicz

{"title":"The model for end-stage liver disease excluding international normalized ratio (MELD-XI) predicts three-year mortality in patients with advanced heart failure","authors":"Kamila Kurkiewicz-Sawczak, Zofia Gierlotka, Mariusz Gąsior, Bożena Szyguła-Jurkiewicz","doi":"10.5603/mrj.97134","DOIUrl":"https://doi.org/10.5603/mrj.97134","url":null,"abstract":"Introduction: Accurate risk stratification is an important element of management in patients with advanced heart failure (adHF). Objectives: We aimed to determine factors associated with three–year mortality in patients with adHF who underwent qualification for heart transplantation. Material and methods: We retrospectively analyzed the data of 417 consecutive adult patients with adHF hospitalized in the Cardiology Department between 2011 and 2017. We included patients with New York Heart Association classes III–IV with at least two episodes of proven congestion requiring high-dose intravenous diuretics in the last 12 months. Exclusion criteria were acute HF, inotropic support, any previous heart surgery, inflammatory diseases, chronic kidney and liver disease, severe obstructive pulmonary disease and hematologic, autoimmune or neoplastic diseases. We analysed prognostic value of the model for end-stage liver disease (MELD), which reflects multiorgan dysfunction. The primary endpoint was death during three years of follow-up. Results: In the overall population of 293 patients the median age was 56 (51–61) years, and 92.8% of the patients were male. During the follow-up period, 160 patients reached the primary endpoint. The MELD-XI score hazard ratio (HR) 1.197; 95% CI (confidence interval) (1.131–1.267), p < 0.001), PLR value [HR 1.100; 95% CI (1.080–1.130), p < 0.001], uric acid [HR 1.013; 95% CI (1.002–1.024), p = 0.0169] and sodium HR 1.079; 95% CI (1.044–1.115), p < 0.001] serum concentrations were independent factors of three–year mortality. Conclusions: Higher MELD-XI scores and PLR values as well as higher uric acid and lower serum sodium concentrations are associated with worse outcomes in patients with adHF.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135209385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0