Metal-Based Drugs最新文献_第2页

The in vitro antitumour activity of novel, mitochondrial-interactive, gold-based lipophilic cations. 新型线粒体相互作用的金基亲脂性阳离子的体外抗肿瘤活性。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/864653

Sherika Mahepal, Richard Bowen, Messai Adenew Mamo, Marcus Layh, Constance Elizabeth Jansen van Rensburg

{"title":"The in vitro antitumour activity of novel, mitochondrial-interactive, gold-based lipophilic cations.","authors":"Sherika Mahepal, Richard Bowen, Messai Adenew Mamo, Marcus Layh, Constance Elizabeth Jansen van Rensburg","doi":"10.1155/2008/864653","DOIUrl":"https://doi.org/10.1155/2008/864653","url":null,"abstract":"In this study we compared the effects of two previously described antimitochondrial gold complexes, that is, [A] [Au(dppe)(2)]Cl and [B] [Au(d4pype)(2)]Cl with two novel lipophilic cations, that is, [C] [Au(dpmaaH(2))(dpmaaSnMe(2))]Cl and [D] [Au(dpmaaSnMe(2))(2)]Cl as antimitochondrial agents. The results of this study indicate that [C] and [D] have intermediate partition coefficients and exhibited a selective uptake by cells. They exhibited a higher selectivity for the various cell lines than [A] but were more cytotoxic than [B]. There is a significant correlation between the cytotoxic potential of [A], [B], [C], and [D] and their octanol/water partition coefficients in both MCF-7 (breast cancer) and MCF-12A (nonmalignant breast) cells, whereas their cytotoxic potential and ability to induce the release of cytochrome c correlated only in the case of the MCF-12A cells. Complexes [C] and [D] are promising new chemotherapeutic drugs. These compounds target the mitochondrial membranes of certain cancer cells exploiting the differences between the mitochondrial membrane potential of these cells and normal cells. Although the concentrations of these compounds necessary to eradicate cancer cells are very high, the results provide a basis for the synthesis of a new family of compounds with intermediate partition coefficients compared to [A] and [B] but with increased activity against cancer cells.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":" ","pages":"864653"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2008/864653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27373031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Phthalocyanine-based molecularly imprinted polymers as nucleoside receptors. 酞菁基分子印迹聚合物作为核苷受体。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/281843

Luigia Longo, Giuseppe Vasapollo

引用次数: 14

Nuclear Factor-kappa B as a Resistance Factor to Platinum-Based Antineoplasic Drugs. 核因子κ B对含铂类抗肿瘤药物的耐药作用。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/576104

Vilma Maldonado Lagunas, Jorge Meléndez-Zajgla

引用次数: 23

Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis. 固定化金属亲和色谱和二维凝胶电泳鉴定幽门螺杆菌中镍稳态相关蛋白。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/289490

Xuesong Sun, Ruiguang Ge, Jen-Fu Chiu, Hongzhe Sun, Qing-Yu He

引用次数: 22

DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Co(en)2(py)2]3+ and [Co(en)2(mepy)2]3+. 钴(III)乙二胺吡啶配合物:[Co(en)2(py)2]3+和[Co(en)2(mepy)2]3+的DNA结合和光裂解研究。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/275084

Penumaka Nagababu, D Aravind Kumar, Kotha Laxma Reddy, K Ashwini Kumar, Md B Mustafa, Mynam Shilpa, S Satyanarayana

引用次数: 16

Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monomethyl Ether-Functionalized Porphyrazines: Cellular Uptake and Toxicity Studies. 硫四(乙二醇)单甲基醚功能化卟啉的合成和生物学分析:细胞摄取和毒性研究。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/391418

Sangwan Lee, Benjamin J Vesper, Hong Zong, Neal D Hammer, Kim M Elseth, Anthony G M Barrett, Brian M Hoffman, James A Radosevich

{"title":"Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monomethyl Ether-Functionalized Porphyrazines: Cellular Uptake and Toxicity Studies.","authors":"Sangwan Lee, Benjamin J Vesper, Hong Zong, Neal D Hammer, Kim M Elseth, Anthony G M Barrett, Brian M Hoffman, James A Radosevich","doi":"10.1155/2008/391418","DOIUrl":"https://doi.org/10.1155/2008/391418","url":null,"abstract":"The porphyrazines (pzs), a class of porphyrin analogues, are being investigated for their potential use as tumor imaging/therapeutic agents. We here examine six peripherally-functionalized M[pz(AnB4-n)] pzs with n=4, 3, or 2 (in a trans conformation) and M = H2 or Zn, where A is an [S((CH2)2O)4Me]2 unit and B is a fused beta,beta'-diisopropyloxybenzo group. Cell viability/proliferation assays and fluorescence microscopy were carried out in both tumor and normal cells. Dark toxicity studies disclosed that four of the compounds exhibited toxicity in both normal and tumor cells; one was nontoxic in both normal and tumor cells, and one was selectively toxic to normal cells. Additionally, three of the pzs showed enhanced photo-induced toxicity with these effects in some cases being observed at treatment concentrations of up to ten-fold lower than that needed for a response in Photofrin. All six compounds were preferentially absorbed by tumor cells, suggesting that they have potential as in vitro diagnostic agents and as aids in the isolation and purification of aberrant cells from pathological specimens. In particular, two promising diagnostic candidates have been identified as part of this work.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"2008 ","pages":"391418"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2008/391418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9374514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Synthesis, structure, electrochemistry, and spectral characterization of bis-isatin thiocarbohydrazone metal complexes and their antitumor activity against ehrlich ascites carcinoma in swiss albino mice. 双isatin硫代碳腙金属配合物的合成、结构、电化学、光谱表征及其对瑞士白化小鼠埃利希腹水癌的抗肿瘤活性。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/362105

M P Sathisha, V K Revankar, K S R Pai

{"title":"Synthesis, structure, electrochemistry, and spectral characterization of bis-isatin thiocarbohydrazone metal complexes and their antitumor activity against ehrlich ascites carcinoma in swiss albino mice.","authors":"M P Sathisha, V K Revankar, K S R Pai","doi":"10.1155/2008/362105","DOIUrl":"https://doi.org/10.1155/2008/362105","url":null,"abstract":"The synthesis, structure, electrochemistry, and biological studies of Co(II), Ni(II), Cu(II), and Zn(II) complexes of thiocarbohydrazone ligand are described. The ligand is synthesized starting from thiocarbohydrazide and isatin. It is evident from the IR data that in all the complexes, only one part of the ligand is coordinated to the metal ion resulting mononuclear complexes. The ligand coordinates essentially through the carbonyl oxygen of the isatin fragment, the nitrogen atom of the azomethine group, and sulfur atom after deprotonation to give five membered rings. H1 NMR spectrum of the ligand shows only one set of signals for the aromatic protons, while the NH of isatin and NH of hydrazone give rise to two different singlets in the 11-14 ppm range. The formulations, [Cu(L)Cl].2H2O, [Cu(L)(CH3COO)].2H2O, [Ni(L)Cl], [Ni(L)(CH3COO)], [Co(L2)], and [Zn(L2)].2H2O are in accordance with elemental analyses, physical, and spectroscopic measurements. The complexes are soluble in organic solvents. Molar conductance values in DMF indicate the nonelectrolytic nature of the complexes. Copper complex displays quasireversible cyclic voltametric responses with Ep near -0.659 v and 0.504 v Vs Ag/AgCl at the scan rate of 0.1 V/s. Copper(II) complexes show a single line EPR signals. For the observed magnetic moment and electronic spectral data possible explanation has been discussed. From all the available data, the probable structures for the complexes have been proposed. The compounds synthesized in present study have shown promising cytotoxic activity when screened using the in vitro method and at the same time were shown to have good activity when tested using the Ehrlich ascites carcinoma (EAC) model. The antimicrobial screening showed that the cobalt complex possesses enhanced antimicrobial activity towards fungi.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"2008 ","pages":"362105"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2008/362105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9367109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 68

Kinetic and high-pressure mechanistic investigation of the aqua substitution in the trans-aquaoxotetracyano complexes of re(v) and tc(v): some implications for nuclear medicine. re(v)和tc(v)的反水氧四氰配合物中水取代的动力学和高压机理研究:对核医学的一些启示。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/745989

J Mattheus Botha, Andreas Roodt

{"title":"Kinetic and high-pressure mechanistic investigation of the aqua substitution in the trans-aquaoxotetracyano complexes of re(v) and tc(v): some implications for nuclear medicine.","authors":"J Mattheus Botha, Andreas Roodt","doi":"10.1155/2008/745989","DOIUrl":"https://doi.org/10.1155/2008/745989","url":null,"abstract":"A kinetic study of the aqua substitution in the [TcO(OH(2))(CN)(4)](-) complex by different thiourea ligands (TU = thiourea, NMTU = N-methyl thiourea, NNDMTU = N, N'-dimethylthiourea) yielded second-order formation rate constants (25 degrees C) as follows [NNDMTU, NMTU, TU, respectively]: k(f) = 11.5 +/- 0.1, 11.38 +/- 0.04, and 7.4 +/- 0.1 M(-1)s(-1), with activation parameters: Delta H(#) (k(f) ) : 55 +/- 2, 42 +/- 3, 35 +/- 5 kJ mol(-1); DeltaS(#) (k(f) ) : - 40 +/- 8, - 84 +/- 11, - 110 +/- 17 J K(-1)mol(-1). A subsequent high-pressure investigation of the aqua substitution in the [ReO(OH(2))(CN)(4)](-) and [TcO(OH(2))(CN)(4)](-) complexes by selected entering ligands yielded DeltaV(#) (k(f) ) values as follows: Re(V): -1.7 +/- 0.3(NCS(-)), -22.1 +/- 0.9 (TU) and for Tc(V): -3.5 +/- 0.3(NCS(-)), -14 +/- 1 (NNDMTU), and -6.0 +/- 0.5 (TU) cm(3)mol (-1), respectively. These results point to an interchange associative mechanism for the negative NCS(-) as entering group but even a pure associative mechanism for the neutral thiourea ligands.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"2008 ","pages":"745989"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2008/745989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9374388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Synthesis, structural, and biological studies of some schiff bases and their metal complexes. 一些席夫碱及其金属配合物的合成、结构和生物学研究。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/875410

A P Mishra, Monika Soni

引用次数: 62

Synthesis and cytotoxicity studies of titanocene C analogues. 二茂钛C类似物的合成及细胞毒性研究。

Metal-Based Drugs Pub Date : 2008-01-01 DOI: 10.1155/2008/754358

Megan Hogan, James Claffey, Eoin Fitzpatrick, Thomas Hickey, Clara Pampillón, Matthias Tacke

引用次数: 6