Medicine and Pharmacy Reports最新文献

{"title":"Urothelial carcinoma with trophoblastic differentiation: case report and review of literature.","authors":"Bogdan-Petru Tichil, Patricia Inisca, Adelina Gheju, Bogdan Fetica, Anamaria Besleaga, Mihaela Laura Vica, Adrian Florea","doi":"10.15386/mpr-3002","DOIUrl":"https://doi.org/10.15386/mpr-3002","url":null,"abstract":"<p><p>Urothelial carcinoma with trophoblastic differentiation (UCTD) is a rare histological variant of urothelial carcinoma characterized by the presence of trophoblastic elements and expression of β-human chorionic gonadotropin (β-hCG). Published evidence is limited, and the clinical behavior of this variant remains incompletely understood. The objective of this study is to review the available literature regarding the incidence, clinicopathological characteristics, treatment modalities, recurrence patterns, survival outcomes, and prognostic implications and to present the case of a patient with UCTD. A 66-year-old male patient presented in February 2025 with a 2-month history of progressive left inguinal swelling and recurrent left hydrocele. Past medical history revealed: radical cystectomy with ileal neobladder, pelvic lymphadenectomy (for bladder pT2G3 recurrent BCG resistant bladder tumor) performed on the 28th of June 2018. Full body contrast CT scan had been performed on the 24th of December 2024 and revealed a left inguinal adenopathy conglomerate 9.93 cm in length, with the largest lymph node measuring 2.5 cm, bilateral peritesticular fluid collections (hydrocele) with no evidence of local tumor recurrence in the neobladder or prostate bed and a supradiaphragmatic, calcified pleural mass (3.4 × 1.8 cm). Scrotal ultrasound revealed: large bilateral hydrocele, left epididymal and upper testicular pole tumor (~2 cm in size) with increased Doppler vascularity and a large left inguinal adenopathy conglomerate (~10 cm in size) with increased Doppler vascularity. Testicular cancer serum markers were performed and a serum β-hCG of 5893 mIU/ml, was found. Ultrasonographical assessment and positive testicular cancer biomarkers prompted us to suspect a testicular tumor with inguinal lymph node metastases. Patient was referred for surgery. Left inguinal radical orchidectomy was performed along with left inguinal lymphadenectomy. Histopathological examination of the testicle revealed testicular and epididymal inflammation. Lymph node examination revealed urothelial carcinoma with squamous and trophoblastic differentiation, PDL1(22C3) positive, CK7 positive, GATA3 positive, CK20 positive, p16 negative and beta HCG positive on 10% of cells. Patient was started on platinum-based chemotherapy with rapid disease progression and died of metastatic complications approximately 11 months after the initial recurrence signs were visible on the CT scan.</p><p><strong>Conclusions: </strong>UCTD is a rare and aggressive variant of urothelial carcinoma associated with unfavorable oncological outcomes. Available evidence supports aggressive treatment and prolonged follow-up. To our knowledge, this may represent one of the few reported, very late recurrences after radical cystectomy.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"234-241"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrosis-4 index utility for screening liver fibrosis and its association with degenerative complications in patients with type 2 diabetes mellitus: a monocentric study.","authors":"Hanae Rachedi, Abdessamad Malki, Alou Moussa Baraya, Nisrine Bouichrat, Siham Rouf, Hanane Latrech","doi":"10.15386/mpr-2954","DOIUrl":"https://doi.org/10.15386/mpr-2954","url":null,"abstract":"<p><strong>Backgrounds: </strong>The fibrosis-4 index is a simple biomarker tool widely recommended to diagnose advanced hepatic fibrosis in patients with type 2 diabetes mellitus (T2DM). The primary aim of this study was to assess liver fibrosis risk among type 2 diabetes mellitus patients using the Fib-4 score, secondary to compare the prevalence of degenerative complications between patients according to Fib-4 index risk, and to evaluate the prevalence of metabolic dysfunction-associated-steatotic liver disease in our population.</p><p><strong>Methods: </strong>This is a descriptive-analytical cross-sectional study including 600 patients with type 2 diabetes mellitus who were followed at the Endocrinology-Diabetology and Nutrition Department of a university hospital center, for a period of 8 years and 10 months from January 2016 to October 2024.</p><p><strong>Results: </strong>The mean age in our population was 59±12.8 years. The median duration of diabetes was 6.4 years (1-15 years) with a median HbA1c value of 10.2±2.7%. Overweight and obesity were found in 39.2% and 34.5% of patients respectively, with a mean BMI of 28.2±5.9 kg/m². The median of fibrosis-4 index was 1.09. Sixty-one percent of patients had a low risk of advanced liver fibrosis, 31% had an intermediate risk, and 8% had a high risk to develop an advanced liver fibrosis. Patients with a Fib-4 score ≥1.3 (indicating intermediate to high risk of liver fibrosis) had a statistically significantly higher prevalence of all microvascular complications and ischemic heart disease (p<0.001) compared to those with a Fib-4<1.3. There was no significant difference in HbA1c, arterial hypertension, metabolic syndrome, and dyslipidemia. However, the mean LDL-cholesterol was lower in the group with a Fib-4≥1.3 (p:0.024). Liver ultrasonography showed signs of metabolic dysfunction-associated steatotic liver disease in 47.7% of cases.</p><p><strong>Conclusion: </strong>Fibrosis-4 index should be considered for routine screening of liver fibrosis in patients with type 2 diabetes mellitus. This simple and cost-effective tool can help identify patients at high risk. The current study highlighted the benefits of using this score among patients with T2DM and supported the high prevalence of microvascular complications and ischemic heart disease among patients with Fib-4 index ≥1.3. Furthermore prospective studies are required to evaluate the incidence outcomes in this population.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"184-190"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional vs. 3D-printed complete dentures in an irradiated edentulous patient: a case report with clinical comparison.","authors":"Alessandra-Aniela Cerghedi, Manuela Chibelean, Mariana Pacurar, Melinda Szekely, Cristina-Stanca Molnar-Varlam","doi":"10.15386/mpr-2973","DOIUrl":"https://doi.org/10.15386/mpr-2973","url":null,"abstract":"<p><strong>Background and aims: </strong>In recent years, digital workflows for the fabrication of complete dentures have been developed, enabling patients to benefit from reduced chairside time, fewer clinical sessions, and improved comfort compared to conventional techniques. Additive manufacturing through 3D printing has emerged as a viable alternative to heat-cured acrylics, offering enhanced adaptation, esthetics, and clinical efficiency. The objective of this clinical case report is to compare two pairs of newly fabricated complete dentures: one produced through a conventional manufacturing process and the other through additive manufacturing (3D printing). The comparison focused on denture retention and peripheral seal, manufacturing time, and esthetic outcomes.</p><p><strong>Case presentation: </strong>A fully edentulous male patient with a history of head and neck cancer presented for prosthetic rehabilitation. Clinical challenges included advanced mandibular ridge atrophy, post-radiotherapy hyposalivation, and recurrent prosthetic stomatitis. The existing prosthesis was repurposed as an individual tray, and functional impressions were recorded using a closed-mouth technique with addition-cured silicone material. Two sets of dentures were fabricated: a pair of conventional heat-cured acrylic dentures and a pair of digitally designed and 3D-printed dentures (maxillary and mandibular). A comparative evaluation was performed focusing on clinical adaptation, retention, esthetics, and fabrication efficiency.The digitally produced complete dentures fabricated by 3D printing demonstrated comparable fit, retention, and suction to those achieved with conventional heat-cured acrylic dentures. Despite the patient's advanced mandibular ridge atrophy and hyposalivation, both sets of dentures provided functional adaptation and adequate stability. However, the additive manufacturing process offered less fabrication time and required fewer clinical visits. Esthetically, the printed dentures were rated as satisfactory by both the patient and the clinician, matching the outcome of the conventional pair.</p><p><strong>Conclusions: </strong>These findings suggest that the digital workflow of complete dentures might be considered a promising alternative for prosthetic rehabilitation, particularly in medically complex geriatric patients. Further clinical studies are warranted to confirm long-term outcomes.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"242-249"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of healthcare professionals of the application of the National Program for Women and Child Health in Bacău County, Romania: a cross-sectional study.","authors":"Oana-Lia Mocondoi Botezatu, Veronica Mocanu, Dana Teodora Anton Păduraru, Irina Mihaela Eşanu, Elena Mihaela Cărăuşu","doi":"10.15386/mpr-2946","DOIUrl":"https://doi.org/10.15386/mpr-2946","url":null,"abstract":"<p><strong>Aim: </strong>To explore the local application of the Romanian National Program for Women and Child Health (NPWHC) in Bacău County from the perspective of healthcare professionals, focusing on perceived program relevance, resource allocation, adherence to procedures, and operational challenges.</p><p><strong>Methods: </strong>This is a cross-sectional, questionnaire-based study designed to examine perceptions and organizational aspects of NPWHC implementation across public healthcare units in Bacău County. The study was conducted between 2023 and 2024 among 54 professionals from three public hospitals and ten family medicine practices. Participants included physicians and nurses (75.9%), economic specialists (16.7%), and staff responsible for data reporting and centralization (7.4%). Data analysis followed an exploratory and descriptive approach, focusing on perceived program relevance, procedural compliance, and monitoring practices.</p><p><strong>Results: </strong>Most respondents reported substantial professional experience, indicating a high level of institutional knowledge. The program was perceived as strategically relevant, primarily driven by the severity of the targeted health problems and the perceived preventive benefits. Concepts related to population health impact and service coverage were also rated as highly important. In contrast, respondents identified notable weaknesses in resource allocation and utilization, reporting consistency, and the robustness of monitoring mechanisms. Perceived adherence to standardized procedures and use of the IT reporting system were low, highlighting operational implementation challenges at the local level.</p><p><strong>Conclusions: </strong>While the NPWHC is perceived as strategically relevant in Bacău County, the findings reveal important vulnerabilities in its operational implementation. Strengthening procedural standardization, optimizing resource use, and enhancing digital monitoring systems emerge as key areas for improvement, within the limits of an evaluation grounded in professional perceptions rather than objective performance indicators.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"199-217"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complex relationship between endocrine and psychiatric disorders: an epidemiological study of risk estimates.","authors":"Zsófia Orbán, Adriana Mihai, Réka Bodea","doi":"10.15386/mpr-2968","DOIUrl":"https://doi.org/10.15386/mpr-2968","url":null,"abstract":"<p><strong>Backgrounds and aims: </strong>Psychiatric comorbidities are frequently observed in patients with endocrine disorders, yet in Romania the extent and nature of this association remains underexplored in clinical settings. This study aims to evaluate the prevalence and characteristics of endocrine disorders, like Cushing's syndrome, Addison's disease, hypo- and hyperthyroidism, in patients diagnosed with depressive, anxious, and manic disorders.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study using records from the Hipocrate/H3 electronic medical system between January 1, 2020, and September 1, 2024. Patients with ICD-10-coded endocrine diagnoses were identified, and the presence of documented psychiatric diagnoses was assessed. Odds ratios with 95% confidence intervals and chi-square tests were used to compare the odds of psychiatric comorbidity across endocrine diagnostic groups.</p><p><strong>Results: </strong>The statistical analysis revealed that patients with Addison's disease, Cushing's syndrome and hypothyroidism were associated with significantly higher odds of psychiatric comorbidity (p < 0.0001). In contrast, in the case of patients with hyperthyroidism, we observed significantly lower odds of psychiatric disorders (p < 0.0001).</p><p><strong>Conclusion: </strong>The study demonstrates that psychiatric comorbidities are common among patients with endocrine disorders, underscoring a meaningful relationship between endocrine dysfunction and mental health. Because the study was cross-sectional and based on clinical records, causal interpretation is not possible. The findings support the need for integrated endocrine and psychiatric assessment in patients with selected endocrine disorders.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"174-183"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memories about the Academy of Medical Sciences since its reestablishment - July 1969.","authors":"Nicolae Baltă","doi":"10.15386/mpr-2972","DOIUrl":"https://doi.org/10.15386/mpr-2972","url":null,"abstract":"","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"250-253"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation of instruments measuring emotional stress and self-esteem in a dental patient population.","authors":"Nelsi Carmina Turturica, Mindra E Badea, Vlad I Bocanet, Radu Chifor, Iulia C Badea","doi":"10.15386/mpr-2976","DOIUrl":"https://doi.org/10.15386/mpr-2976","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome measures (PROMs) are becoming more popular in dental research for measuring various psychological aspects of patients' experiences. However, it is essential to validate these measures' properties based on the setting where they are applied. This study aims to validate the Romanian versions of the Kessler Psychological Distress Scale (K10) and the Rosenberg Self-Esteem Scale (RSES) for adult dental patients.</p><p><strong>Methods: </strong>This is a prospective study for psychometric validation of PROMs for adult dental patients conducted at the Department of Preventive Dentistry, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Internal consistency, structural validity, and construct validity were assessed for these PROMs. Responsiveness was evaluated based on pre-post comparisons during routine dental visits.</p><p><strong>Results: </strong>The RSES showed high internal consistency reliability for adult dental patients (α = 0.77-0.80), whereas K10 showed excellent internal consistency reliability (α = 0.91). Furthermore, it was found that psychological distress was related to affective pain but not sensory pain, whereas self-esteem was not related to any of these measures. Both instruments showed responsiveness across clinical time points.</p><p><strong>Conclusions: </strong>The Romanian versions of K10 and RSES showed satisfactory psychometric properties for adult dental patients and could potentially be useful for psychosocial research in dentistry.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"226-233"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital workflow integration and standardized communication protocols in prosthetic dentistry: a multicenter cross-sectional study on innovation impact and interdisciplinary collaboration.","authors":"Daniela Popa, Marius Negucioiu, Tudor Secasan, Andreea Kui, Andrea Chisnoiu, Alexandra Similea, Codruţa Popescu, Smaranda Buduru","doi":"10.15386/mpr-2979","DOIUrl":"https://doi.org/10.15386/mpr-2979","url":null,"abstract":"<p><strong>Background: </strong>The digitalization of prosthetic dentistry - encompassing CAD/CAM fabrication, intraoral scanning, and digital prescription platforms - represents one of the most transformative biotechnological shifts in contemporary dental practice. Despite these advances, the transition from analog to digital communication workflows remains incomplete in many clinical settings, and the relationship between communication modality, error frequency, and professional satisfaction has not been quantified in a multicenter international sample. This study investigates whether the adoption of structured digital and standardized communication protocols translates into measurable improvements in interdisciplinary collaboration outcomes.</p><p><strong>Methods: </strong>An exploratory cross-sectional online survey was distributed via professional social media groups and institutional networks to dentists and dental technicians in five countries (Germany, Romania, France, Israel, United States). The questionnaire addressed communication modality, error frequency, satisfaction (1-10 scale), and turnaround time. Descriptive statistics and exploratory group comparisons (independent-samples t-test, chi-square) were applied; effect sizes (Cohen's d) are reported where applicable. Given the achieved sample (n=162), all analyses are exploratory and hypothesis-generating.</p><p><strong>Results: </strong>Verbal instructions were the most frequently used modality and were associated with the highest error rate (79% of technicians reported missing or incorrect information). Standardized work-authorization forms yielded the highest satisfaction scores (dentists 8.4/10, n=60; technicians 6.8/10, n=70) yet were incompletely filled in 76% of cases. Non-standard written requests generated the greatest frustration (44% of technicians cited poor communication). Turnaround time was shorter for in-house technicians (mean 5.17 days, SD=1.8) than external laboratories (mean 7.64 days, SD=2.3), though the difference did not reach statistical significance (p=0.08, d=0.24).</p><p><strong>Conclusions: </strong>Structured communication protocols - particularly standardized digital prescriptions - are associated with lower interdisciplinary error rates and higher professional satisfaction in prosthetic workflows. These pilot findings support accelerated adoption of digital workflow solutions as a pragmatic, low-cost innovation with measurable clinical and organizational impact. Integration of CAD/CAM-compatible communication standards into dental education and practice guidelines is recommended to bridge the persistent gap between technological capability and everyday clinical use.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"218-225"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in axial spondyloarthritis: biological mechanisms, clinical phenotypes, and therapeutic implications - a narrative review.","authors":"Diana Maria Margareta Moldovan, Clementina López-Medina, Daniela Fodor","doi":"10.15386/mpr-2998","DOIUrl":"https://doi.org/10.15386/mpr-2998","url":null,"abstract":"<p><p>Sex differences in axial spondyloarthritis (axSpA) are gaining recognition as clinically significant, but they are still not well incorporated into diagnostic practice and outcome assessment. Although long viewed as a predominantly male disease, axSpA affects women at nearly comparable rates and often follows a distinct phenotype. These differences extend beyond variations in severity and appear to reflect different biological and clinical expressions of disease. Women with axSpA typically report higher levels of pain, fatigue, and disease activity, frequently alongside lower inflammatory markers and slower radiographic progression. They also experience longer diagnostic delays and more often present with peripheral manifestations or overlapping pain conditions such as fibromyalgia. In contrast, men more commonly exhibit the classical axial phenotype, elevated C-reactive protein, and greater structural damage. This discordance between symptom burden and objective inflammation creates challenges for disease assessment, as conventional tools may not perform equally across sexes. Emerging evidence also indicates sex-related differences in treatment response and drug persistence. Recognizing sex as a biological determinant of disease expression, rather than merely a covariate for statistical adjustment, offers an opportunity to improve diagnostic precision, refine outcome interpretation, and support more individualized patient care.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive educational intervention to reduce depression, anxiety and complications in Greek patients with ostomy.","authors":"Maria Evgenia Tzani, Ourania Govina, Theodoros Katsoulas, Anna Kavga, Marianna Drakopoulou, Ioanna Tsatsou, Ioannis Kalemikerakis","doi":"10.15386/mpr-2941","DOIUrl":"https://doi.org/10.15386/mpr-2941","url":null,"abstract":"<p><strong>Background and aims: </strong>The creation of an ostomy constitutes a profound surgical intervention, invariably introducing a multitude of potential difficulties and challenges into a patient's life. The aim of the study was to assess the effectiveness of a structured educational intervention, combined with nursing follow-up for self-care, in reducing anxiety, depression, and peristomal complications among patients who have undergone intestinal or urinary ostomy surgery, compared to those receiving standard care (control group).</p><p><strong>Methods: </strong>A randomized, prospective comparative study was conducted from June 2023-April 2024, involving 100 adult patients with recently formed ostomies residing in the capital of Greece. Participants were randomly assigned to either an Intervention Group (IG) (n=48) or a Control Group (CG) (n=52). The IG received a structured, in-home educational intervention with printed materials and systematic nursing monitoring. Both groups had reinforcement sessions at 45 and 90 days. The study featured dual outcome assessments at baseline, 45 and 90 days. Peristomal complications were measured using the Ostomy Skin Tool (OST), while anxiety and depression were assessed with the Hospital Anxiety and Depression Scale (HADS). For the study purposes, a structured educational tool was developed in three versions, each adapted to the specific needs and characteristics of colostomy, ileostomy and urostomy.</p><p><strong>Results: </strong>The analysis of HADS scores indicated a statistically significant difference in the IG versus the CG at both 45 days for anxiety (p=0.002) and depression (p<0.0005), and at 90 days for anxiety (p=0.001) and depression (p<0.0005). Furthermore, analysis of OST scores identified a statistically significant difference in the complication index at 90 days (p<0.0005) for the IG compared to the CG. Regarding the change in the severity index, a statistically significant difference was also recorded in the IG versus the CG at both 45 days (p=0.001) and 90 days (p<0.0005).</p><p><strong>Conclusions: </strong>A structured, educational intervention significantly improves ostomy patients' psychological well-being (anxiety and depression) and reduces clinical complications. The practical success of this intervention is largely attributed to its accessible printed tool and dedicated nursing follow-up.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"99 3","pages":"191-198"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}