Medicine and Pharmacy Reports最新文献

{"title":"Association between proton pump inhibitors and anti-coagulants for a better prevention of gastrointestinal bleeding.","authors":"Fahad Mudhi Alotaibi, Nasser Faihan Alotaibi, Faisal Farraj Alsubaie, Hussain Ali Ekhuraidah, Mohammed Ahmed Koshan, Rayan Hassan Alzahrani, Hamdan Saleh Alghamdi, Abed Houmod Allehibi, Abdulrahman Abdullah Aljumah","doi":"10.15386/mpr-2767","DOIUrl":"10.15386/mpr-2767","url":null,"abstract":"<p><strong>Background and aim: </strong>Gastrointestinal bleeding (GIB) is one of the most common medical emergencies. Proton pump inhibitors (PPI) are among the most widely used drugs in gastroenterology to treat various types of acid-related disorders. We aim to investigate the safety of proton pump inhibitors (PPIs) when used concurrently with anticoagulants in patients with upper and lower gastrointestinal bleeding (GIB) and assess the risk of hospitalization, GIB, and mortality in patients receiving this combined treatment.</p><p><strong>Methods: </strong>A retrospective multicenter study was conducted at two tertiary care hospitals. Patients were selected according to inclusion and exclusion criteria. Demographic data, vital signs, medical history, physical examinations, comorbid conditions, medications, laboratory investigations, endoscopy findings, management, and complications were retrieved from the medical records of all participants.Data obtained from all patients' medical records were reviewed. Endoscopic findings and management of the bleeding site were collected according to the presenting symptoms. Statistical analyses were performed using IBM SPSS version 25.0 software.</p><p><strong>Results: </strong>Our results revealed a significant increase in acute GIB risk with the number of concurrent anticoagulants used, particularly in patients not using PPIs. Those using four anticoagulants along with PPIs had a lower likelihood of acute GIB at 6.3% (P = 0.0001). Patients taking two or three anticoagulants also experienced reduced GIB risk when PPIs were added (P ≤ 0.05). Age played a role, with a statistically significant difference between PPI users and non-users, especially in the 31-40 age group, where PPI users had a higher incidence of GIB (69.80%) compared to non-users (30.20%) (P < 0.05). Comparing patients on anticoagulants with or without PPIs, the study found a lower risk of hospitalization (adjusted hazard ratio, AHR: 1.02; 95% CI: 0.92-1.57) and mortality (AHR: 1.00; 95% CI: 0.84-1.11) in those using Rivaroxaban and PPIs concurrently. By contrast, patients using Rivaroxaban alone without PPIs faced an increased risk of hospitalization (AHR: 1.15; 95% CI: 0.98-2.35) and mortality (AHR: 1.12; 95% CI: 0.90-1.37).</p><p><strong>Conclusions: </strong>Combining PPIs with anticoagulant drugs reduced the risk of GIB, hospitalization, and mortality, particularly in older adults, thereby mitigating potential complications.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"333-341"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing immunization gaps in children with congenital heart disease - a narrative review.","authors":"Diana Jecan-Toader, Cristina Filip, Simona Sorana Căinap","doi":"10.15386/mpr-2814","DOIUrl":"10.15386/mpr-2814","url":null,"abstract":"<p><p>Vaccination programs have had a pivotal part in the successful reduction of global morbidity and mortality of infectious diseases. Despite their undeniable success, vaccination rates among children with congenital heart disease (CHD) remain suboptimal. This article aims to address the challenges surrounding immunization in CHD patients and provide guidance for immunization practices within this population. Most experts advocate for adherence to standard immunization practices in CHD patients who are immunocompetent and in good health. Supplemental vaccinations against rotavirus, varicella, meningococcus, hepatitis A and influenza are recommended. RSV prophylaxis with palivizumab is advisable in patients with hemodynamically significant CHD during winter season. However, special considerations are warranted in specific situations, such as around cardiac surgery or in patients who are immunocompromised. Furthermore, adjustments to the vaccination schedule might be necessary for patients who require antithrombotic prophylaxis or blood transfusions. Lastly, special attention should be given to individuals at a high risk of decompensation after immunization, who might require close parental or medical monitoring for up to 72 hours post-vaccination.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"283-289"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multi-plug flow control technique treating high flow cirsoid renal arteriovenous malformations.","authors":"Emre Can Çelebioğlu, Aysegul Coruh Gursoy, Matheus Dabus, Sadık Bilgiç","doi":"10.15386/mpr-2769","DOIUrl":"10.15386/mpr-2769","url":null,"abstract":"<p><strong>Introduction: </strong>Renal arteriovenous malformations (AVMs) are rare vascular lesions mostly diagnosed when they become symptomatic. These lesions can be treated using a variety of endovascular techniques and devices.</p><p><strong>Case report: </strong>We present a 51-year-old male who presented with acute onset right flank pain, hematuria and refractory hypertension. The patient was treated using a multi-plug flow control technique using multiple balloon catheters and microcatheters. Two operators worked synchronously during the procedure using two different dilutions of glue. The patient's symptoms resolved immediately after the embolization and at 1 month follow up the CT demonstrated complete obliteration of the AVM with little renal parenchymal loss. The patient remained clinically asymptomatic at the 6-months follow-up.</p><p><strong>Conclusion: </strong>This case illustrates the feasibility and safety use of synchronous embolization in the treatment of complex renal AVMs.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"398-402"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional distress and quality of life in high and moderate penetrance germline mutations carriers diagnosed with breast cancer: a preliminary study.","authors":"Claudiu Ioan Filip, Lorin-Manuel Pîrlog, Andrada-Adelaida Pătrăşcanu, Mariela Sanda Militaru, Irina Iordănescu, George Călin Dindelegan","doi":"10.15386/mpr-2898","DOIUrl":"10.15386/mpr-2898","url":null,"abstract":"<p><strong>Background/objectives: </strong>Genetic testing plays a critical role in breast cancer management by identifying individuals with high or moderate penetrance gene mutations. While clinical implications are well established, less is known about the psychological and quality-of-life impact of different genetic risk levels. This preliminary study aimed to explore whether breast cancer patients with high penetrance mutations experience different levels of distress compared to those with moderate penetrance mutations.</p><p><strong>Methods: </strong>A total of 110 breast cancer patients treated at the Regina Maria Private Health Network in Cluj-Napoca, Romania, were included based on specific eligibility criteria. Participants completed a shortened version of the BREAST-Q questionnaire, focused on core dimensions such as emotional distress, self-concept, appearance, relationships, and financial burden. Descriptive statistics were calculated, and independent t-tests were performed to compare responses between the two genetic risk groups.</p><p><strong>Results: </strong>Patients with high penetrance mutations reported significantly higher distress levels in several domains, including overall emotional distress (p = 0.039), concern for daughters or relatives (p = 0.043), changes in appearance (p = 0.038), and self-concept (p = 0.043). Other factors, such as fear of diagnosis, financial burden, and impact on sexuality, did not show statistically significant differences between groups.</p><p><strong>Conclusions: </strong>This preliminary study suggests that genetic risk classification may influence the psychosocial experience of breast cancer patients, with high penetrance mutation carriers experiencing greater distress in specific areas. These findings highlight the need for personalized psychosocial support based on genetic profiles and warrant further investigation in larger, longitudinal cohorts.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"349-357"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early cognitive and quality of life changes after transfemoral transcatheter aortic valve replacement.","authors":"Mihnea Istrate, Mihaela Ioana Dregoesc, Victor Stefan Buiga, Julien Redfern, Adrian Corneliu Iancu","doi":"10.15386/mpr-2885","DOIUrl":"10.15386/mpr-2885","url":null,"abstract":"<p><strong>Background and aims: </strong>Cognitive impairment has been associated with the presence of severe aortic stenosis (AS). Our study evaluated the early changes in cognitive function and quality of life in patients with severe AS who underwent transfemoral transcatheter aortic valve replacement (TAVR).</p><p><strong>Methods: </strong>The cognitive function and quality of life of patients with severe symptomatic AS who underwent transfemoral TAVR were assessed with the Montreal Cognitive Assessment (MoCA) and the EQ-5D-3L questionnaire, respectively. The tests were performed at the time of admission and at 48 to 72 h after TAVR.</p><p><strong>Results: </strong>The study group included 37 patients with a mean age of 78 years. Cognitive improvement was observed in 72.9% of patients. A higher MoCA score at baseline was correlated with a better functional outcome after TAVR (r=0.49, p=0.02). Patients with an early post-procedural increase in MoCA scores had a smaller aortic valve area at baseline as compared to patients without cognitive improvement (0.5±0.2 vs. 0.7±0.1 sq.cm, p=0.02). The baseline aortic valve area was associated with an increase in MoCA scores at an optimal cutoff value ≤0.65 sq.cm (AUC 0.739; p=0.005). A significant increase in median EQ-5D-3L scores was observed between baseline and follow-up (60 (51-70) vs. 73 (65-80) points, p<0.001). The lack of improvement in functional status was associated with a prolonged stay in the Intensive Care Unit (ICU) (r=-0.46, p=0.02).</p><p><strong>Conclusions: </strong>In patients with severe symptomatic AS, a smaller aortic valve area at baseline was associated with an early cognitive improvement after transfemoral TAVR. Baseline cognition and the length of stay in the ICU influenced the early functional outcomes.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"311-319"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic cancer: a persistently challenging prognosis - a single center three-year retrospective study.","authors":"Paul-Cristian Borz, Mihnea-Bogdan Borz, Oliviu-Cristian Borz, Toader Zaharie, Claudia Hagiu, Lidia Munteanu, Ana Maria Fit, Simona Gurzu","doi":"10.15386/mpr-2848","DOIUrl":"10.15386/mpr-2848","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related mortality due to its aggressive progression and late diagnosis. Despite advances in diagnosis and treatment, survival outcomes remain poor, with a median survival of 5.8 months.</p><p><strong>Objective: </strong>The aim of the study is to evaluate the impact of diagnostic and therapeutic approaches on survival outcomes in patients with pancreatic adenocarcinoma, while also assessing the risk factors for PDAC.</p><p><strong>Methods: </strong>This study is a retrospective analysis of 68 patients with suspected pancreatic tumors who underwent endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) between 2019 and 2022 at the Cluj-Napoca County Emergency Clinical Hospital. Patient demographics, risk factors, histopathological results, and treatment outcomes were analyzed using statistical methods.</p><p><strong>Results: </strong>Of 68 patients, 35 were diagnosed with PDAC. Modifiable risk factors, such as alcohol and smoking, alongside non-modifiable factors like age and hereditary predisposition, were prominent. Among PDAC patients, 42.8% received palliative chemotherapy, while only 8.6% underwent curative surgical intervention due to advanced disease stages. Median survival varied significantly based on treatment: 2.4 months for untreated patients versus 8.1 months for those receiving oncological or surgical management (p=0.0082).</p><p><strong>Conclusion: </strong>Modifiable and non-modifiable risk factors significantly raise the incidence of pancreatic cancer. Therefore, employing a multidisciplinary approach to detect the disease in its early stages and optimize personalized treatment plans can enhance patient outcomes. At the same time, traditional oncological treatments improve survival and quality of life, but newer approaches, such as immunotherapy combined with conventional radiotherapy, chemotherapy, molecular targeted therapy, and other diverse treatment modalities, have the potential to further extend survival.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"325-332"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of hardness and microroughness of injection-molded thermoplastic resins used for flexible removable partial dentures.","authors":"Roxana Diana Vasiliu, Anamaria Matichescu, Sorin Daniel Porojan, Diana Uţu, Liliana Porojan","doi":"10.15386/mpr-2849","DOIUrl":"10.15386/mpr-2849","url":null,"abstract":"<p><strong>Background and aim: </strong>This study evaluates and compares three types of thermoplastic resins used for flexible, removable partial dentures, focusing on their microhardness and surface roughness.</p><p><strong>Methods: </strong>Thirty samples with a thickness of 2 mm were obtained from thermoplastic resins and were tested after 24 hours of immersion in distilled water. The samples were obtained from injected resin cartridges of three thermoplastic resins with different degrees of flexibility. Two-way ANOVA and Tukey tests were performed to compare the samples. A Pearson correlation was calculated between the two parameters, surface roughness and Vickers microhardness.</p><p><strong>Results: </strong>After statistical analysis, significant differences were found between the two resins' surface roughness. Regarding Vickers microhardness, one of the resins with the lowest flexibility range exhibited higher microhardness values.</p><p><strong>Conclusions: </strong>Surface roughness values for the three resins were below 0.2 microns. Microhardness test revealed significant differences between Flaxiacryl and Flexifast samples (p<.05).</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 3","pages":"387-391"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profile and a preliminary <i>in ovo</i> screening of the ethanolic extract of <i>Coffea arabica</i> green seeds.","authors":"Graţiana Ruse, Ştefana Avram, Alex-Robert Jîjie, Ana-Maria Vlase, Dalia Pătraşcu, Raluca Dumitru, George Drăghici, Alina-Arabela Jojic, Florina Ardelean, Diana-Simona Tchiakpe-Antal","doi":"10.15386/mpr-2837","DOIUrl":"https://doi.org/10.15386/mpr-2837","url":null,"abstract":"<p><strong>Aims: </strong><i>Coffea arabica</i> has garnered significant attention for its potential therapeutic applications due to its rich phytochemical profile, including chlorogenic acids, flavonoids, and alkaloids like caffeine, which are associated with antioxidant, anti-inflammatory, and antimicrobial effects. This study aimed to (i) evaluate the phytochemical composition of an ethanolic extract derived from green seeds of <i>Coffea arabica</i> and (ii) perform a preliminary <i>in ovo</i> screening to determine its mucosal tolerability, irritant potential, and pro-angiogenic activity using the chick embryo chorioallantoic membrane (CAM) model.</p><p><strong>Methods: </strong>An ethanolic extract was prepared from <i>C. arabica</i> green seeds and subjected to LC-MS analysis for the identification and quantification of polyphenols. The antioxidant capacity was assessed through the DPPH radical-scavenging assay, comparing extract performance to ascorbic acid as a standard. <i>In ovo</i> testing was conducted using the HET-CAM assay to observe potential irritation on the CAM surface and to evaluate angiogenic activity. Chick embryos were monitored for vascular changes, irritant signs (hemorrhage, lysis, coagulation), and overall tolerability post-application over six days.</p><p><strong>Results: </strong>Phytochemical analysis confirmed the presence of chlorogenic acid and 4-O-caffeoylquinic acid in the extract. The extract exhibited substantial antioxidant activity (66.38%), though slightly lower than that of ascorbic acid (97.36%). In the HET-CAM assay, no signs of irritation or toxicity were observed, and the extract was well tolerated for up to six days post-application. Additionally, the extract promoted angiogenesis, with increased vascularization observed, suggesting a stimulatory effect on neovascularization without inducing tissue damage.</p><p><strong>Conclusions: </strong>The ethanolic extract of <i>Coffea arabica</i> green seeds demonstrates promising antioxidant and pro-angiogenic properties, alongside high mucosal biocompatibility. These findings support its potential applications in therapeutic and cosmetic formulations, particularly those targeting tissue regeneration and skin repair. Further studies are recommended to explore the underlying mechanisms and to confirm efficacy in more advanced biological models.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 2","pages":"239-251"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of Wilkie's syndrome with infantile hypertrophic pyloric stenosis.","authors":"Petar Stamov, Sylvia Stamova","doi":"10.15386/mpr-2724","DOIUrl":"https://doi.org/10.15386/mpr-2724","url":null,"abstract":"<p><p>Wilkie's syndrome is a rare clinical disorder characterized by partial or complete obstruction of the duodenum. Infantile hypertrophic pyloric stenosis (IHPS) is defined as hyperplasia of the smooth muscle fibers of the pylorus, which is considered responsible for narrowing the pyloric canal and eventually obstructing the gastric outlet. This paper presents a case of a 3-month-old boy who had been vomiting after feeding for one month. The main symptoms, postprandial vomiting, dehydration, alkalosis, and weight reduction, point to the IHPS disease. Imaging studies also confirmed the diagnosis. During the surgical treatment, a concomitant condition known as Wilkie's syndrome was also evidenced. The team performed a complex surgical treatment of a patient diagnosed with both Wilkie's syndrome and IHPS within one single surgical operation. Surgical treatment with pyloromyotomy and duodenal-duodenal anastomosis within one operation is an optimal option for one-stage treatment of patients with IHPS and Wilkie's syndrome.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 2","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of different types of bevels on the fracture resistance of directly restored lower anterior teeth.","authors":"Mădălina Balaj, Simona Iacob, Marius Bud, Ada Delean, Mircea Cristian Dudescu, Smaranda Buduru","doi":"10.15386/mpr-2773","DOIUrl":"https://doi.org/10.15386/mpr-2773","url":null,"abstract":"<p><strong>Background and aims: </strong>In recent years, dental trauma has been on the rise. The most common, regarding permanent dentition, are uncomplicated fractures (involving enamel or enamel and dentin) of the maxillary central incisors, followed by maxillary lateral incisors and mandibular central incisors. In anterior teeth, high impact stresses are frequently produced and because of this it is necessary that the restoration has a high fracture resistance. The aim of this study is to evaluate the influence of marginal cavity preparations (45° bevel and chamfer bevel) on the fracture resistance of teeth treated with direct composite resins.</p><p><strong>Methods: </strong>For this study, 24 extracted mandibular incisors were used. All soft tissue debris and tartar were removed. During the study, the teeth were kept in saline to prevent dehydration. The teeth were divided into three groups of 8 teeth each. Group number 1 was used as a control and named C, in group number 2, named CH, incisors were prepared with a chamfer type of bevel, and in group number 3, named B45, incisors were prepared with a 45° bevel. After preparing all mandibular incisors, they were directly restored with nano-ceramic composite (Ceram.x® Duo, Dentsply Sirona). Subsequently, all three groups were fractured to determine the maximum compressive load using the Instron 3366 universal testing machine. To ensure a standardized fracturing process, all incisors were embedded in self-polymerizing acrylic resin up to the neck to replicate the conditions in the oral cavity.</p><p><strong>Results: </strong>The Student's T-test was employed for statistical analysis, revealing a statistically insignificant difference between the CH and B45 groups. Nonetheless, it was noted that the average values of maximum compressive loads in the chamfer bevel group were higher compared to those in the 45° bevel group, indicating its superior resistance to fracture. Additionally, the results of the fracture resistance test demonstrated that intact mandibular incisors are three times more resistant to fracture than mandibular incisors prepared and restored with dental bevels.</p><p><strong>Conclusion: </strong>Intact teeth present a superior fracture resistance compared to teeth that have been subjected to trauma or carious processes, requiring coronal restoration; dental restorations made with a chamfer bevel marginal preparation withstand higher forces with improved fracture resistance compared to those made with a 45° bevel marginal preparation.</p>","PeriodicalId":18438,"journal":{"name":"Medicine and Pharmacy Reports","volume":"98 2","pages":"223-229"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}