Medical hypotheses最新文献_第2页

Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis? 特发性脊柱侧弯症青少年的异常皮层电动力模式是否意味着非典型平衡控制？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-09 DOI: 10.1016/j.mehy.2024.111520

Carole Fortin , Inga Sophia Knoth , Catherine Bluteau , Sarah Lippé , Martin Simoneau

{"title":"Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?","authors":"Carole Fortin , Inga Sophia Knoth , Catherine Bluteau , Sarah Lippé , Martin Simoneau","doi":"10.1016/j.mehy.2024.111520","DOIUrl":"10.1016/j.mehy.2024.111520","url":null,"abstract":"<div><div>Adolescent idiopathic scoliosis (AIS) is a developmental disorder described as a three-dimensional spine deformity with multifactorial etiology. The multifactorial model of AIS suggests that the patient population is diverse. Identifying individuals with sensorimotor control impairments could enable personalized treatments, potentially leading to improved outcomes for those with AIS. We hypothesize that abnormal electrocortical dynamics within the sensorimotor cortex will be related to less efficient balance control in standing during ankle proprioception alteration in the absence or presence of vision. To test this hypothesis, the balance control performance of adolescents with AIS will be assessed on a force platform by computing the root mean square value of the scalar distance between the center of pressure and the center of gravity. Electroencephalography will be recorded while challenging balance control by altering ankle proprioception in the presence and absence of visual cues. Time-frequency analyses will be calculated to determine alpha, and beta band power in both conditions. Pilot data from 13 participants with AIS were analyzed to support our hypothesis. Three participants with less efficient balance control showed electrocortical dynamics changes, such as an increase in beta band power in the presence and absence of vision and a decrease in alpha band power in the presence of vision compared to the AIS group with efficient balance control. These findings support our hypothesis of suboptimal sensorimotor information processing in the subgroup of adolescents with AIS with less efficient balance control, which could have significant implications for developing personalized treatments for AIS.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111520"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential role of fixation eye movements in the development of myopia 固定眼球运动在近视发展中的潜在作用

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-09 DOI: 10.1016/j.mehy.2024.111515

Hao Yuan , Jiarui Yang , Xuemin Li

{"title":"The potential role of fixation eye movements in the development of myopia","authors":"Hao Yuan , Jiarui Yang , Xuemin Li","doi":"10.1016/j.mehy.2024.111515","DOIUrl":"10.1016/j.mehy.2024.111515","url":null,"abstract":"<div><div>Myopia, a globally public health problem, referring to an abnormal refractive state in which the focus falls in front of retina due to extended axial length, is always regarded as an excessive emmetropia process and extreme ocular growth. Fixation eye movements (FEMs), small eye movements occurring incessantly during our gazes to maintain continuous attention and keep clear vision, have been considered to participate in the emmetropization process, yet their role in relation to myopia development has not been clearly demonstrated. It is possible that abnormal fixation eye movements could contribute to the onset and progression of myopia. Although the role of fixation eye movements (FEMs) in the setting of myopia has not yet been investigated, previous researches have demonstrated that patients with myopic refractive error performed significantly abnormal FEMs characteristics, suggesting the potential association between FEMs and myopia development. In this article, we hypothesized that abnormal fixation movements would result in disturbed spatiotemporal and defocus visual signal, abnormal longitudinal chromatic aberration, amplified eye-growth signal and extraocular muscle pressure, thereby inducing myopia development. In order to dissect any association between FEMs and myopia, further work is required to prospectively investigate the characteristics of FEMs during development and/or in populations affected by myopia or hyperopia. Future studies will be needed to update new understanding of myopia mechanism and propose suggestive prevention measures.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111515"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “Clinically-relevant reductions in oxygen partial pressure as possible contributor to cardiovascular benefits of sauna practice” 关于 "与临床相关的氧分压降低可能是桑拿浴对心血管有益的因素 "的评论

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-08 DOI: 10.1016/j.mehy.2024.111518

David C. Poole, Andrew G. Horn

引用次数: 0

COVID-19 era and GLP-1 RA era: Is it a renaissance when the dusk of global tragedy co-occurring with the dawn of magical remedy? COVID-19 时代和 GLP-1 RA 时代：当全球悲剧的黄昏与神奇疗法的黎明同时到来时，这是否是一种复兴？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-08 DOI: 10.1016/j.mehy.2024.111516

Deepak Gupta , Berhane Seyoum , Sarwan Kumar , Shushovan Chakrabortty

引用次数: 0

The anti-inflammatory role of therapeutic ultrasound and low-level laser in chronic rhinosinusitis: A fractional exhaled nitric oxide outcome hypothesis 治疗性超声波和低强度激光在慢性鼻炎中的抗炎作用：分量呼出一氧化氮结果假设

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-08 DOI: 10.1016/j.mehy.2024.111519

Mina Kashi-Alashti , Noureddin Nakhostin Ansari , Soofia Naghdi , Mojtaba Fathali , Jim Bartley

{"title":"The anti-inflammatory role of therapeutic ultrasound and low-level laser in chronic rhinosinusitis: A fractional exhaled nitric oxide outcome hypothesis","authors":"Mina Kashi-Alashti , Noureddin Nakhostin Ansari , Soofia Naghdi , Mojtaba Fathali , Jim Bartley","doi":"10.1016/j.mehy.2024.111519","DOIUrl":"10.1016/j.mehy.2024.111519","url":null,"abstract":"<div><div>Chronic rhinosinusitis is defined as a complex of disorders whose main feature is nasal and paranasal sinus mucosal inflammation for at least three months. Inflammation plays a key role in chronic rhinosinusitis. Fractional exhaled nitric oxide is used to monitor eosinophilic airway inflammation in the human lower airways. Fractional exhaled nitric oxide levels are paradoxically low in some chronic rhinosinusitis patients. This has been attributed to sinus ostia obstruction. However, a recent study has demonstrated that fractional exhaled nitric oxide levels could serve as a chronic rhinosinusitis inflammation biomarker independent of lower airway inflammatory disease and could be used as a treatment response biomarker. Therapeutic ultrasound and low-level laser therapy have been used in chronic rhinosinusitis management. Through a variety of mechanisms, ultrasound enhances bacterial killing. Low level laser therapy increases nitric oxide release and ATP levels. It also reduces inflammation and accelerates tissue repair. Fractional exhaled nitric oxide levels could be used to evaluate the anti-inflammatory actions of therapeutic ultrasound and low-level laser therapy in chronic rhinosinusitis patients. A hypothesis that fractional expired nitric oxide measurements could be a useful biomarker to evaluate their potential anti-inflammatory mechanisms and monitor their treatment efficacy is proposed. This could contribute to a better understanding of these therapies in chronic rhinosinusitis management. An improved understanding of treatment efficacy could lead to improved management strategies.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111519"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lidocaine nebulization for airway topical anesthesia can be improved by diminish ex-cannula lost and alkalization 利多卡因雾化用于气道局部麻醉可通过减少呼气管外损失和碱化得到改善

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-08 DOI: 10.1016/j.mehy.2024.111511

Ran Duan , Yingying Zhang , Yanxin Cheng , Lei Zhang , Senming Zhao

{"title":"Lidocaine nebulization for airway topical anesthesia can be improved by diminish ex-cannula lost and alkalization","authors":"Ran Duan , Yingying Zhang , Yanxin Cheng , Lei Zhang , Senming Zhao","doi":"10.1016/j.mehy.2024.111511","DOIUrl":"10.1016/j.mehy.2024.111511","url":null,"abstract":"<div><div>Lidocaine nebulization is noninvasive, safe, and easy to perform. However, it does not provide adequate anesthesia due to the following reasons: 1. There is a high wastage of lidocaine aerosol, with at least 70 % of the lidocaine aerosol being lost from the cannula. This loss of lidocaine results in a lower amount of inhaled lidocaine, which is insufficient to provide adequate anesthesia. 2. The commercial lidocaine preparation has a low penetrating potency. The onset of anesthesia is directly related to the amount of local anesthetic in the lipid-soluble form. However, there are only a few lipid-soluble prototypes in the commercially available lidocaine cartridges. This is because the lidocaine is purposely formulated as acidic solutions (with pH levels between 3.5 and 5.5) in order to enhance the solubility and stability of the anesthetic salts. To address these issues and improve lidocaine anesthesia potency while reducing wastage, a “Y” type cannula was used for aerosol inhalation. Additionally, 1/5 vol of 5 % sodium bicarbonate solution was added to 2 % lidocaine to enhance the pH value to 7.2. This alkalized lidocaine nebulization provides an effective topical anesthesia for bronchoscopy.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"194 ","pages":"Article 111511"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bortezomib-based regimen affects cognitive functions in multiple myeloma patients through the VEGF pathway – Hypothesis that connects different knowledge streams 硼替佐米疗法通过血管内皮生长因子途径影响多发性骨髓瘤患者的认知功能--连接不同知识流的假设

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-02 DOI: 10.1016/j.mehy.2024.111510

Marija Stanić Damić , Toni Valković , Duška Petranović , Andrej Belančić , Zinaida Perić

{"title":"Bortezomib-based regimen affects cognitive functions in multiple myeloma patients through the VEGF pathway – Hypothesis that connects different knowledge streams","authors":"Marija Stanić Damić , Toni Valković , Duška Petranović , Andrej Belančić , Zinaida Perić","doi":"10.1016/j.mehy.2024.111510","DOIUrl":"10.1016/j.mehy.2024.111510","url":null,"abstract":"<div><div>Multiple myeloma is a chronic hematological malignancy that usually affects older adults. Cancer-related cognitive impairment in multiple myeloma patients significantly impacts the everyday quality of life, however its pathophysiology remains poorly understood. Bortezomib is a commonly used drug in the treatment of multiple myeloma that does not pass the blood–brain barrier. Nevertheless, it can still affect central nervous system (CNS) through yet unknown mechanisms. This article discusses the potential effect of bortezomib-based treatment on cognitive functions in multiple myeloma patients. We hypothesize that bortezomib impairs cognition by decreasing the levels of a neuroprotective cytokine – vascular endothelial growth factor (VEGF). The generation of hypotheses about the pathophysiology of cognitive impairment paves the way for future basic and clinical studies to improve multiple myeloma management. VEGF could serve as a biomarker of cognitive dysfunction while systematic evaluation of cognition could enable early detection of cognitive impairment. Timely recognition of cognitive impairment might be crucial when selecting the most appropriatetreatment. Furthermore, this could allow the implementation of preventive measures against further deterioration in cognitive function and quality of life for patients with multiple myeloma.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111510"},"PeriodicalIF":2.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration 反应性视网膜血管扩张可能会掩盖没有糖尿病视网膜病变和孤立神经变性的眼睛中毛细血管的缺失

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-02 DOI: 10.1016/j.mehy.2024.111513

Virgilio Lima-Gómez , Miguel Angel Quiroz-Reyes , Selma Alin Somilleda-Ventura

{"title":"Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration","authors":"Virgilio Lima-Gómez , Miguel Angel Quiroz-Reyes , Selma Alin Somilleda-Ventura","doi":"10.1016/j.mehy.2024.111513","DOIUrl":"10.1016/j.mehy.2024.111513","url":null,"abstract":"<div><div>Reactive retinal vasodilation occurs in healthy individuals when the demand for oxygen surpasses the supply that the vascular bed can provide. This phenomenon may also occur in individuals with diabetes who do not have diabetic retinopathy, potentially masking circulation deficiencies caused by early capillary closure. As a result, eyes with reactive retinal vasodilation may show a seemingly normal circulation area, while also displaying other diabetes-related changes such as neurodegeneration. Our hypothesis suggests that in eyes without overt ischemia, which is one of the phenotypes of diabetic retinal disease, neurodegeneration could be the result of undetected ischemia in the presence of reactive retinal vasodilation. We propose methodologies to investigate this hypothesis, including the assessment of retinal capillaries using optical coherence tomography angiography, as well as the measurement of neurodegeneration markers such as retinal sensitivity, electroretinogram amplitude reductions, and retinal layer thinning. Additionally, we outline an approach for estimating the contribution of large retinal vessels to the percentage of circulation within a measured retinal area, using variables such as vessel length density and vessel area density. If our hypothesis is confirmed, it could lead to the early identification of ischemia before the onset of diabetic retinopathy and offer an opportunity to assess interventions when endothelial and neural damage can still be mitigated.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111513"},"PeriodicalIF":2.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide? 何时干预主动脉瓣狭窄；晨尿中的心肌肌钙蛋白 I 能作为我们的指南吗？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-01 DOI: 10.1016/j.mehy.2024.111512

Tomo Svaguša , Marko Žarak , Ingrid Prkačin , Frane Paić

{"title":"When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?","authors":"Tomo Svaguša , Marko Žarak , Ingrid Prkačin , Frane Paić","doi":"10.1016/j.mehy.2024.111512","DOIUrl":"10.1016/j.mehy.2024.111512","url":null,"abstract":"<div><div>Aortic stenosis is one of the most prevalent acquired valvular diseases in the Western world. Despite its high incidence, timely intervention through valve replacement remains a diagnostic challenge. Recent studies suggest that measuring cardiac troponins in the first morning urine may have potential clinical applications. In healthy individuals, concentrations of troponin I in the first morning urine are several times higher than in plasma. Various conditions that damage the heart, such as arterial emergencies or cardiotoxic therapy, lead to an increased concentration of cardiac troponin I in the first morning urine. Conversely, in patients with severe aortic stenosis scheduled for operative treatment, concentrations of cardiac troponin I in the first morning urine are barely detectable. This phenomenon may result from myocardial remodeling and altered clearance of troponin I from the heart. We hypothesize that reduction in the concentration of troponin I in the first morning urine indicates the onset of cardiomyocyte necrosis, adverse myocardial remodeling, and myocardial fibrosis during the progression of aortic stenosis.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111512"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential circadian rhythms impacts on amblyopia treatment outcomes 昼夜节律对弱视治疗效果的潜在影响

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-11-01 DOI: 10.1016/j.mehy.2024.111514

Saeed Aljohani

引用次数: 0