Medical hypotheses最新文献_第2页

Postnatal hemoglobin P50 as a surrogate marker for hypoxia-driven NEC in preterm infants: a mechanistic hypothesis P50 and NEC risk 出生后血红蛋白P50作为早产婴儿缺氧驱动NEC的替代标志物：P50和NEC风险的机制假说

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-07-04 DOI: 10.1016/j.mehy.2025.111707

Emrah Can , Yakup Karakurt

{"title":"Postnatal hemoglobin P50 as a surrogate marker for hypoxia-driven NEC in preterm infants: a mechanistic hypothesis P50 and NEC risk","authors":"Emrah Can , Yakup Karakurt","doi":"10.1016/j.mehy.2025.111707","DOIUrl":"10.1016/j.mehy.2025.111707","url":null,"abstract":"<div><div>Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in preterm infants. Despite decades of investigation, clinicians lack an early, physiologically grounded biomarker that signals risk before clinical deterioration. We hypothesize that persistently elevated hemoglobin P<sub>50</sub> during the first 72 h of life reflects impaired oxygen unloading and evolving systemic hypoxia, particularly affecting the splanchnic circulation. This rightward shift in the oxygen dissociation curve, driven by increased 2,3-diphosphoglycerate (2,3-DPG), may precede lactate elevation and herald the onset of intestinal injury. Mechanistically, this pathway is underpinned by hypoxia-inducible factor-1α (HIF-1α) stabilization and Toll-like receptor 4 (TLR4) activation, both implicated in NEC pathogenesis. We present a physiologic rationale supported by prior data, including preliminary observations, and propose clinical and experimental approaches to validate the hypothesis. If confirmed, P<sub>50</sub> could represent a routinely accessible, noninvasive biomarker for early NEC risk stratification.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"201 ","pages":"Article 111707"},"PeriodicalIF":2.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal carbon dioxide monitoring as the optimal indicator for assessing pediatric recovery in the post-anesthesia care unit 鼻二氧化碳监测作为评估麻醉后护理单位儿童康复的最佳指标

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-30 DOI: 10.1016/j.mehy.2025.111706

Xu Yan , Shuzhen Liu , Shiyong Li , Xing Li , Ailin Luo , Yilin Zhao , Xue Zhang

引用次数: 0

Can physical exercise and its mimetics enhance mitochondrial transfusion for Parkinson’s disease therapy? 体育锻炼及其模拟运动能促进线粒体输血治疗帕金森病吗？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-29 DOI: 10.1016/j.mehy.2025.111697

Bogdan-Alexandru Hagiu

引用次数: 0

Partial heart transplantation can provide a pulsatile and growing Fontan conduit: A rightward shift for a better Fontan 部分心脏移植可以提供搏动和生长的Fontan导管：向右移动可以获得更好的Fontan

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-27 DOI: 10.1016/j.mehy.2025.111694

Harma K. Turbendian , Taufiek Konrad Rajab

引用次数: 0

Redefining the pathogenesis of Gestational Diabetes Mellitus: The cumulative impact of endocrine disrupting environmental chemicals in key metabolic pathways 重新定义妊娠期糖尿病的发病机制：内分泌干扰环境化学物质在关键代谢途径中的累积影响

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-26 DOI: 10.1016/j.mehy.2025.111693

Mahesh Vallabi Aayush , Gopichandran Nikthesh , Dhanush Rajmohan , Charan Praneeth Ravindran , Ramasamy Vasantharekha , Swarnalingam Thangavelu , Barathi Seetharaman

{"title":"Redefining the pathogenesis of Gestational Diabetes Mellitus: The cumulative impact of endocrine disrupting environmental chemicals in key metabolic pathways","authors":"Mahesh Vallabi Aayush , Gopichandran Nikthesh , Dhanush Rajmohan , Charan Praneeth Ravindran , Ramasamy Vasantharekha , Swarnalingam Thangavelu , Barathi Seetharaman","doi":"10.1016/j.mehy.2025.111693","DOIUrl":"10.1016/j.mehy.2025.111693","url":null,"abstract":"<div><div>Gestational Diabetes Mellitus (GDM) is a common pregnancy complication with a prevalence rate of 10–14 % in India. In GDM high blood glucose level and insulin resistance is observed. Several hormones secreted from placenta during pregnancy changes the metabolic state and interferes with insulin functions and blocks insulin and increases blood glucose level/hyperglycemia. Emerging evidence links GDM to environmental exposures, particularly endocrine-disrupting chemicals (EDCs) such as Bisphenol A (BPA), phthalates, parabens, and microplastics. These EDCs impair glucose metabolism and insulin signaling through oxidative stress, inflammation, hormonal interference, and pathway disruptions, including the hypothalamic-pituitary-thyroid (HPT) axis and PI3K-AKT signaling. This paper hypothesizes that frequent EDC exposure in pregnant women might trigger HPT axis thereby increasing insulin resistance and impair glucose homeostasis increasing the risk of GDM. Supporting evidence from mechanistic and epidemiological studies highlights the need for regulatory policies and early detection strategies. Validating this hypothesis could reshape GDM prevention and management by identifying therapeutic targets and minimizing EDC exposure.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"201 ","pages":"Article 111693"},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond limits in bone repair: A hypothesis for 3D-printed, exosome-enhanced autograft substitutes 骨修复的极限：3d打印，外泌体增强的自体移植物替代品的假设

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-25 DOI: 10.1016/j.mehy.2025.111696

Ahmed O. Sabry , Rana Ali Ahmed , Omar Mohamed Kamal Abdelaziz , Amr Hesham Kamel Abdelgawad , Mohamed Hegazy

{"title":"Beyond limits in bone repair: A hypothesis for 3D-printed, exosome-enhanced autograft substitutes","authors":"Ahmed O. Sabry , Rana Ali Ahmed , Omar Mohamed Kamal Abdelaziz , Amr Hesham Kamel Abdelgawad , Mohamed Hegazy","doi":"10.1016/j.mehy.2025.111696","DOIUrl":"10.1016/j.mehy.2025.111696","url":null,"abstract":"<div><div>We hypothesize that a personalized 3D-printed hydroxyapatite scaffold augmented with autologous biological components (exosomes or mesenchymal stem cells) can address the challenge of large intercalary bone defects by enhancing bone regeneration.</div><div>Current treatments like autografts, allografts, and synthetic scaffolds have significant limitations, including donor site morbidity, immune rejection, and insufficient osteogenesis. In our proposed approach, patient-specific HA scaffolds are fabricated via 3D printing and infused with osteogenic factors from the patient’s bone marrow–derived MSCs or their exosomes. We will evaluate the osteogenic and angiogenic potential of these bio-enhanced constructs in preclinical models. Additionally, the scaffolds are designed with structural features (e.g., intramedullary pegs or plate-like extensions) to ensure stable fixation within the defect site. To test this hypothesis, a comparative study is envisioned with four groups: (1) an autologous bone graft (gold-standard control), (2) a 3D-printed HA scaffold without any biological augmentation, (3) a 3D-printed HA scaffold seeded with autologous MSCs, and (4) a 3D-printed HA scaffold seeded with autologous MSCs supplemented with their osteogenic exosomes.</div><div>Outcome measures will include the rate and quality of bone healing (time to graft incorporation and radiographic union), restoration of function, and complication rates (including any need for revision surgery). We will also assess biological endpoints such as new bone formation and vascularization using micro-CT imaging and histology.</div><div>If successful, this strategy would provide a customizable, biologically active alternative for critical-sized bone defects, reducing donor-site complications and preserving native bone function.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"201 ","pages":"Article 111696"},"PeriodicalIF":2.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From infection to inflammation: mycobacterium tuberculosis as a candidate trigger for ankylosing spondylitis 从感染到炎症：结核分枝杆菌作为强直性脊柱炎的候选触发因素

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-23 DOI: 10.1016/j.mehy.2025.111695

Farzad Rafiei , Hamidreza Soltani

引用次数: 0

Can making parametric finite element models of the knee that include anatomical details important for osteoarthritis improve the clinical effectiveness of treatment methods? 制作包含骨关节炎重要解剖细节的膝关节参数化有限元模型能否提高治疗方法的临床效果？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-20 DOI: 10.1016/j.mehy.2025.111691

Fatemeh Abdollahpour , Goldis Darbemamieh , Mohammad Nikkhoo , Kamran Hassani , Sadegh Rahmati

{"title":"Can making parametric finite element models of the knee that include anatomical details important for osteoarthritis improve the clinical effectiveness of treatment methods?","authors":"Fatemeh Abdollahpour , Goldis Darbemamieh , Mohammad Nikkhoo , Kamran Hassani , Sadegh Rahmati","doi":"10.1016/j.mehy.2025.111691","DOIUrl":"10.1016/j.mehy.2025.111691","url":null,"abstract":"<div><div>Osteoarthritis (OA) is a degenerative condition that impacts synovial joints, particularly the knee joint, impairing patients’ capacity to engage in regular physical activity. Regrettably, there is no remedy for this musculoskeletal condition. Currently, numerous researchers focus on developing ways to model individualized risks for the initiation and progression of osteoarthritis and assess the impact of various conservative preventive measures. Finite element analysis (FEA) is now known as a potential technique for the management of knee osteoarthritis. The FEA pipeline comprises three recognized phases: pre-processing, processing, and post- This study aims to introduce an innovative concept in the customization of knee prosthesis, considering the anatomical characteristics influencing osteoarthritis, to enhance treatment efficacy. We posited that anatomical parameters in simplified knee models can be adjusted so that the estimation of the tissue mechanical response from a parametric model matches that of a model with precise geometry. Consequently, we want to integrate simpler models with individualized modeling to provide successful treatment solutions that will help clinicians identify individuals at high risk of knee OA and provide more conservative treatments for patients.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"201 ","pages":"Article 111691"},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variants in ciliary genes are an important genetic cause of recurrent pregnancy loss: A hypotheses 纤毛基因变异是反复流产的重要遗传原因：假设

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-20 DOI: 10.1016/j.mehy.2025.111692

Zhaochu Yin , Haiyan Zhou , Teng Liu , Wanqin Xie

{"title":"Variants in ciliary genes are an important genetic cause of recurrent pregnancy loss: A hypotheses","authors":"Zhaochu Yin , Haiyan Zhou , Teng Liu , Wanqin Xie","doi":"10.1016/j.mehy.2025.111692","DOIUrl":"10.1016/j.mehy.2025.111692","url":null,"abstract":"<div><div>Genetic factor is an important aspect of the etiology of recurrent pregnancy loss (RPL). Primary cilium is a cell surface and hair-like sensory structure that plays a crucial role during embryonic development. We hypothesize that the recessive variants of ciliary genes in couples could be an important genetic cause of RPL. Our rationales are as follows: first, hundreds of genes encode structural or regulatory proteins within the cilia to maintain their normal morphology and function, and a deficiency in any of these genes may affect early embryo development; second, ciliary genes are predominant among the candidate genes identified using whole exome sequencing (WES) of family trios with RPL in existing studies; third, knockout mouse models of ciliary genes showed various defects in embryonic cilia that may cause pregnancy loss. To test the hypothesis, WES based on a cohort of couples with RPL and their euploid miscarriages can be performed to identify potential pathogenic variants of ciliary genes to validate the disease-gene associations. An enrichment of ciliary gene among the candidate genes is expected by Gene ontology analysis. Furthermore, immunofluorescence staining of paraffin-fixed placenta tissues from miscarriages carrying clinically relevant variants can be used to visualize the defects in embryonic cilia to establish a genotype-phenotype correlation. Findings from this proposed study may promote establishment of a ciliary gene panel associated with RPL, which will facilitate the precision medicine of RPL, such as preimplantation genetic screening for patients with recurrent implantation failure.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"200 ","pages":"Article 111692"},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole body vibration alleviates depressive symptoms through its anti-inflammatory effects 全身振动通过抗炎作用减轻抑郁症状

IF 2.1 4区医学

Medical hypotheses Pub Date : 2025-06-20 DOI: 10.1016/j.mehy.2025.111690

Duan Yunfei , Xiong Lijun , Li Jingchi , Jiang Jun , Chen Yi , Zhou Jia , Li Tao

{"title":"Whole body vibration alleviates depressive symptoms through its anti-inflammatory effects","authors":"Duan Yunfei , Xiong Lijun , Li Jingchi , Jiang Jun , Chen Yi , Zhou Jia , Li Tao","doi":"10.1016/j.mehy.2025.111690","DOIUrl":"10.1016/j.mehy.2025.111690","url":null,"abstract":"<div><div>Conventional treatments for major depressive disorder (MDD) often show limited efficacy and may be accompanied by side effects, prompting the need for alternative strategies. Whole-body vibration (WBV) is a passive physical intervention with emerging evidence of antidepressant potential, though its mechanisms remain incompletely understood. We hypothesize that the mechanism by which WBV improves depressive symptoms is partly through its anti-inflammatory effects. Inflammation contributes to depressive symptoms through multiple mechanisms, including disruption of dopaminergic signaling in the VTA–NAc circuit, impairment of monoamine transmission, and induction of neurotoxicity via the kynurenine pathway, which leads to quinolinic acid accumulation, oxidative stress, and synaptic dysfunction. By suppressing pro-inflammatory cytokines and enhancing anti-inflammatory mediators, WBV may help reverse these inflammation-induced neurobiological alterations and ultimately alleviate depressive symptoms. This hypothesis could be tested using chronic unpredictable mild stress (CUMS) rat models, with animals randomly assigned to control, stress, and stress + WBV intervention groups. Behavioral performance, cytokine levels, central serotonin, and synaptic markers such as brain-derivedneurotrophicfactor(BDNF) would be assessed at multiple timepoints to evaluate treatment effects. Such findings would support the therapeutic potential of WBV as a safe, low-barrier, non-pharmacological strategy for both depression—particularly forms associated with inflammation—and broader inflammatory conditions, especially in individuals unable to tolerate medication or engage in conventional exercise.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"200 ","pages":"Article 111690"},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0