Can physical exercise and its mimetics enhance mitochondrial transfusion for Parkinson’s disease therapy?

IF 0.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2025-06-29 DOI:10.1016/j.mehy.2025.111697

Bogdan-Alexandru Hagiu

引用次数: 0

Abstract

The medical hypothesis that preconditioning Parkinson’s patients with aerobic exercise increases the efficiency of mc-mitochondria transfusion is supported by the fact that dopaminergic neurons become more capable of capturing and integrating these mitochondria. In continuation of the hypothesis, it is proposed that mesenchymal stem cells that produce mc-mitochondria be subjected to intermittent hypoxia in order to reduce the amount of oxygen free radicals that the mitochondria intended for therapy will produce. Transfusion of mc-mitochondria could also treat familial amyotrophic lateral sclerosis or neurological diseases where axonal regeneration or synaptogenesis is useful.

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体育锻炼及其模拟运动能促进线粒体输血治疗帕金森病吗？

医学假说认为，通过有氧运动对帕金森患者进行预处理可以提高mc-线粒体输注的效率，这一假说得到了多巴胺能神经元更有能力捕获和整合这些线粒体这一事实的支持。为了延续这一假设，有人提出产生mc-线粒体的间充质干细胞受到间歇性缺氧的影响，以减少用于治疗的线粒体产生的氧自由基的数量。mc-线粒体的输注也可以治疗家族性肌萎缩性侧索硬化症或神经系统疾病，其中轴突再生或突触发生是有用的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.