从感染到炎症：结核分枝杆菌作为强直性脊柱炎的候选触发因素

IF 0.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2025-06-23 DOI:10.1016/j.mehy.2025.111695

Farzad Rafiei , Hamidreza Soltani

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引用次数: 0

摘要

强直性脊柱炎（AS）是一种慢性炎症性疾病，主要影响中轴骨骼，导致疼痛、僵硬和最终脊柱融合。虽然HLA-B27基因与AS密切相关，但并不是所有的携带者都会患上这种疾病，这表明环境因素起着一定的作用。这篇文章提出了一个新的假设，即结核分枝杆菌引起的结核病（TB）可能引发遗传易感个体的AS发展。as和TB患者的免疫通路失调，如Th17和IL-17信号以及类似的自身抗体，支持了这一假设。本文回顾了最近的文献并讨论了潜在的机制。这项工作旨在为AS病因学提供新的见解，并刺激进一步研究炎症性疾病的感染触发因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From infection to inflammation: mycobacterium tuberculosis as a candidate trigger for ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton, leading to pain, stiffness, and eventual spinal fusion. While the HLA-B27 gene is strongly associated with AS, not all carriers develop the disease, suggesting environmental triggers play a role. This article presents a novel hypothesis that tuberculosis (TB), caused by Mycobacterium tuberculosis, may trigger the development of AS in genetically predisposed individuals. The hypothesis is supported by dysregulation of immunological pathways, such as Th17 and IL-17 signaling and similar autoantibodies in AS and TB patients. This article reviews recent literature and discusses potential mechanisms. This work aims to provide new insights into AS etiology and stimulate further research into infectious triggers of inflammatory diseases.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.