Mechanisms of Ageing and Development最新文献

Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections 种间相互作用与衰老：预测致老细菌和微生物感染的关键人类蛋白靶点

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-05-24 DOI: 10.1016/j.mad.2025.112076

Yuping Dai , Ni Boussaguet , Jérôme Teulière , Hugo Bonnefous , Elphège Budzinski , Philippe Lopez , Louis-Patrick Haraoui , Eric Bapteste

{"title":"Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections","authors":"Yuping Dai , Ni Boussaguet , Jérôme Teulière , Hugo Bonnefous , Elphège Budzinski , Philippe Lopez , Louis-Patrick Haraoui , Eric Bapteste","doi":"10.1016/j.mad.2025.112076","DOIUrl":"10.1016/j.mad.2025.112076","url":null,"abstract":"<div><div>Bacteria permeate every niche of the human body with major consequences on our health and senescence that have not been fully described. Here, we predict which bacteria and which bacterial proteins could interfere with proteins associated with human aging using bipartite networks showing interspecific protein interactions coupled with investigations of published experimental evidence and transcriptomic data. We introduce the term of “gerogenic” bacteria, literally bacteria that could induce some aging in their host and discuss the mechanisms by which such bacteria could serve as age-distorters of humans. <em>Salmonella</em>, <em>Escherichia</em> and <em>Shigella</em> appear as major candidate age-distorters, characterized by a higher experimentally demonstrated potential than other bacteria to interact with human proteins associated with human aging and human cellular senescence. Our analysis also highlights an evolutionary convergence among bacterial and viral candidate age-distorting proteins, since 14 human proteins associated with aging can be commonly targeted by bacteria and viruses in case of microbial infection. Since infections are common and <em>Salmonella</em>, <em>Escherichia</em> and <em>Shigella</em> are frequently found as pathogens in our microbiomes, characterizing bacterial influence on our aging and our cellular senescence through molecular hijacking could enhance the understanding of the causes of aging and suggest new anti-aging therapies.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112076"},"PeriodicalIF":5.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways Cyr61通过调节Wnt/β-catenin信号通路促进d -gal诱导的衰老C2C12细胞纤维化

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-05-06 DOI: 10.1016/j.mad.2025.112067

Xinchen Huang , Xiaoling Kui , Jiyao Ma , Jiaxin Chen , Yilong Huang , Bo He

{"title":"Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways","authors":"Xinchen Huang , Xiaoling Kui , Jiyao Ma , Jiaxin Chen , Yilong Huang , Bo He","doi":"10.1016/j.mad.2025.112067","DOIUrl":"10.1016/j.mad.2025.112067","url":null,"abstract":"<div><div>Sarcopenia is characterized by age-related muscle mass/function loss and fibrosis. Satellite cell (SC) dysfunction during aging promotes fibrotic transdifferentiation and extracellular matrix (ECM) deposition. Cyr61, a pro-fibrotic matricellular protein, and Wnt/β-catenin signaling pathway are implicated in muscle regeneration-fibrosis balance, but their interaction in sarcopenia remains unclear. This study first compared the expression of Cyr61 and fibrosis markers (TGF-β1, collagen type I and III) in skeletal muscle of young and old mice. <em>In vitro</em>, D-gal-induced C2C12 aging models were used to assess Cyr61 and Wnt signaling pathway by proliferation/apoptosis assays, ECM analysis, and detecting the changes of myogenic/fibrotic markers (MyoD, α-SMA). Pathway modulation (FH535 inhibitor/LiCl activator) and combined with Cyr61 overexpression and knockout experiments defined mechanistic roles. Cyr61 was upregulated in skeletal muscle of aged mice, which was positively correlated with increased TGF-β1 and collagen deposition. In D-gal-induced C2C12 cells showed suppressed cell proliferation, increased apoptosis and enhanced ECM deposition, accompanied by elevated Cyr61. Cyr61 knockdown or Wnt signaling pathway inhibition (FH535) reversed fibrosis (α-SMA, collagen) and restored myogenesis (MyoD).This study reveals for the first time that Cyr61 drives sarcopenic fibrosis via Wnt/β-catenin activation, promoting myocyte-to-fibrotic transition. Targeting the Cyr61-Wnt axis may ameliorate age-related muscle degeneration, warranting translational validation in preclinical models.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112067"},"PeriodicalIF":5.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of stem cells in ageing and age-related diseases 干细胞在衰老和年龄相关疾病中的作用

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-05-03 DOI: 10.1016/j.mad.2025.112069

Jitendra Kumar Chaudhary , Ajay Kumar Danga , Anita Kumari , Akshay Bhardwaj , Pramod C. Rath

{"title":"Role of stem cells in ageing and age-related diseases","authors":"Jitendra Kumar Chaudhary , Ajay Kumar Danga , Anita Kumari , Akshay Bhardwaj , Pramod C. Rath","doi":"10.1016/j.mad.2025.112069","DOIUrl":"10.1016/j.mad.2025.112069","url":null,"abstract":"<div><div>Stem cell functions and ageing are deeply interconnected, continually influencing each other in multiple ways. Stem cells play a vital role in organ maintenance, regeneration, and homeostasis, all of which decline over time due to gradual reduction in their self-renewal, differentiation, and growth factor secretion potential. The functional decline is attributed to damaging extrinsic environmental factors and progressively worsening intrinsic genetic and biochemical processes. These ageing-associated deteriorative changes have been extensively documented, paving the way for the discovery of novel biomarkers of ageing for detection, diagnosis, and treatment of age-related diseases. Age-dependent changes in adult stem cells include numerical decline, loss of heterogeneity, and reduced self-renewal and differentiation, leading to a drastic reduction in regenerative potential and thereby driving the ageing process. Conversely, ageing also adversely alters the stem cell niche, disrupting the molecular pathways underlying stem cell homing, self-renewal, differentiation, and growth factor secretion, all of which are critical for tissue repair and regeneration. A holistic understanding of these molecular mechanisms, through empirical research and clinical trials, is essential for designing targeted therapies to modulate ageing and improve health parameters in older individuals.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112069"},"PeriodicalIF":5.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice 衰老小鼠肝脏代谢和胰岛素敏感性的转录组学和表观基因组特征

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-05-03 DOI: 10.1016/j.mad.2025.112068

John T. González , Olivia H. Scharfman , Wanling Zhu , Jessica Kasamoto , Victoria Gould , Rachel J. Perry , Albert T. Higgins-Chen

{"title":"Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice","authors":"John T. González , Olivia H. Scharfman , Wanling Zhu , Jessica Kasamoto , Victoria Gould , Rachel J. Perry , Albert T. Higgins-Chen","doi":"10.1016/j.mad.2025.112068","DOIUrl":"10.1016/j.mad.2025.112068","url":null,"abstract":"<div><div>Age-related declines in insulin sensitivity and glucose metabolism contribute to metabolic disease. Despite the liver’s central role in glucose homeostasis, a comprehensive phenotypic characterization and concurrent molecular analysis of insulin resistance and metabolic dysfunction in the aging liver is lacking. We characterized hepatic insulin resistance and mitochondrial metabolic defects through metabolic cage, hyperinsulinemic-euglycemic clamp, and tracer studies paired with transcriptomic and DNA methylation analyses in young and aged male mice. Aged mice exhibited benchmark measures of whole body and liver insulin resistance. Aged mice showed lower pyruvate dehydrogenase flux, decreased fatty acid oxidation and citrate synthase fluxes, and increased pyruvate carboxylase flux under insulin-stimulated conditions. Molecular analysis revealed age-related changes in metabolic genes Pck1, Socs3, Tbc1d4, and Enpp1. Unsupervised network analysis identified an intercorrelated phenotype module (ME-Glucose), RNA module, and DNA methylation module. The DNA methylation module was enriched for lipid metabolism pathways and TCF-1 binding, while the RNA module was enriched for MZF-1 binding and regulation by miR-155–5p. Protein-protein interaction network analysis revealed interactions between module genes and canonical metabolic pathways, highlighting genes including Ets1, Ppp1r3b, and Enpp3. This study reveals novel genes underlying age-related hepatic insulin resistance as potential targets for metabolic interventions to promote healthy aging.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112068"},"PeriodicalIF":5.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts HRasV12诱导小鼠骨骼肌母细胞凋亡，而非细胞衰老

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-28 DOI: 10.1016/j.mad.2025.112066

Shinichiro Suzuki , Takuya Fukunaga , Tatsuya Hayashi , Tatsuro Egawa

引用次数: 0

Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3 延长寿命的基因操作在MJD/SCA3动物模型中的差异效应

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-24 DOI: 10.1016/j.mad.2025.112064

Marta Daniela Costa , Jorge Diogo Da Silva , Dulce Almeida , Joana Pereira-Sousa , Daniela Vilasboas-Campos , Jorge Humberto Fernandes , Andreia Teixeira-Castro , Patrícia Maciel

{"title":"Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3","authors":"Marta Daniela Costa , Jorge Diogo Da Silva , Dulce Almeida , Joana Pereira-Sousa , Daniela Vilasboas-Campos , Jorge Humberto Fernandes , Andreia Teixeira-Castro , Patrícia Maciel","doi":"10.1016/j.mad.2025.112064","DOIUrl":"10.1016/j.mad.2025.112064","url":null,"abstract":"<div><div>Aging is a natural biological process, but evidence suggests that some aspects of aging can be delayed and reduce the prevalence of neurodegenerative diseases, for which aging is a key risk factor. In a neuronal <em>Caenorhabditis elegans</em> model of a Polyglutamine disease-Spinocerebellar Ataxia Type 3 (SCA3), or Machado-Joseph disease (MJD)- we assessed the hypothesis that delaying aging is neuroprotective, investigating the effect of genetically manipulating multiple lifespan-determinant mechanisms. Lifespan-increasing mutations causing insulin/IGF-1 signaling downregulation, mitochondrial dysfunction, germline ablation and dietary restriction/innate immune activation had distinct impacts on MJD/SCA3 phenotypes, suggesting that not all genetic strategies of stalling aging are equally neuroprotective and challenging the idea that delaying aging is a guaranteed therapy for these diseases. Lifespan-extension improved the SCA3/MJD motor phenotype only when induced by altered nutrient-sensing pathways such as those mediated by insulin/IGF-1 and <em>eat-2</em> signaling, but their effects on neuronal aggregation differed. These pathways exhibited differential proteostasis profiles, but both activated the heat shock response suggesting that they operate through partially independent mechanisms to confer neuroprotection. The therapeutic value of the insulin/IGF-1 downregulation was demonstrated through the chronic treatment of the SCA3/MJD model with an insulin/IGF-1 signaling inhibitor, underscoring the relevance of aging manipulations in guiding therapeutic strategies for these diseases.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112064"},"PeriodicalIF":5.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaempferol, a widely ingested dietary flavonoid and supplement, enhances biological performance via hormesis, especially for ageing-related processes 山奈酚是一种广泛摄入的膳食类黄酮和补充剂，通过刺激效应提高生物性能，特别是与衰老相关的过程

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-24 DOI: 10.1016/j.mad.2025.112065

Edward J. Calabrese , Peter Pressman , A. Wallace Hayes , Linda Baldwin , Evgenios Agathokleous , Harshita Kapoor , Gaurav Dhawan , Rachna Kapoor , Vittorio Calabrese

{"title":"Kaempferol, a widely ingested dietary flavonoid and supplement, enhances biological performance via hormesis, especially for ageing-related processes","authors":"Edward J. Calabrese , Peter Pressman , A. Wallace Hayes , Linda Baldwin , Evgenios Agathokleous , Harshita Kapoor , Gaurav Dhawan , Rachna Kapoor , Vittorio Calabrese","doi":"10.1016/j.mad.2025.112065","DOIUrl":"10.1016/j.mad.2025.112065","url":null,"abstract":"<div><div>Kaempferol is a polyphenol in various fruits and vegetables. It is also commercially developed and sold to consumers as a supplement. It has been extensively assessed in clinical trials for clinical utility based upon its numerous experimentally based chemopreventive properties. Kaempferol has been evaluated at the levels of molecule, cell, and individual animal, showing a broad spectrum of biological effects. Kaempferol-induced hormetic concentration responses are common, being reported in many cell types and biological models for numerous endpoints. While the hormetic effects of kaempferol are biologically diverse, there has been a strong focus on age-related endpoints affecting numerous organ systems and endpoints, indicating that kaempferol is a senolytic agent, showing similar properties as quercetin and fisetin. This paper offers the first integrated evaluation of kaempferol-induced hormetic dose responses, their quantitative characteristics, mechanistic explanations, extrapolative strengths or limitations, and related experimental design, biomedical, therapeutic, ageing, and public health, including ageing related applications.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112065"},"PeriodicalIF":5.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease 粘胶放线菌促进秀丽隐杆线虫帕金森病模型的神经保护作用

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-19 DOI: 10.1016/j.mad.2025.112061

G. Sophie Ngana , Mercedes A. Di Bernardo , Michael G. Surette , Lesley T. MacNeil

{"title":"Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease","authors":"G. Sophie Ngana , Mercedes A. Di Bernardo , Michael G. Surette , Lesley T. MacNeil","doi":"10.1016/j.mad.2025.112061","DOIUrl":"10.1016/j.mad.2025.112061","url":null,"abstract":"<div><div>Parkinson’s Disease is characterized by selective degeneration of dopaminergic neurons, primarily in the substantia nigra pars compacta, as well as accumulation of alpha-synuclein enriched protein aggregates within neurons. The pathogenesis of PD is still not completely understood, and no treatments exist that alter disease progression. Obvious genetic causes are detected in only a small number of PD patients (5–10 %), suggesting that environmental factors play a significant role the development of PD. Correlative studies suggest that the microbiota could be an important environmental modifier of neurodegeneration. We identified a microbiotal isolate, <em>Actinomyces viscosus,</em> that reduced neurodegeneration in <em>C. elegans</em> expressing a pathological mutant form (G2019S) of leucine-rich repeat kinase 2 (<em>LRRK2</em>) in dopaminergic neurons. <em>A. viscosus</em> also suppressed autophagic dysfunction in these animals and reduced alpha-synuclein aggregation in a synucleinopathy model. Global gene expression analysis revealed increased expression of aspartic cathepsins in response to <em>A. viscosus.</em> Consistent with the involvement of these proteins in neuroprotection, we found that reducing aspartic cathepsin function increased neurodegeneration in the <em>LRRK2</em> transgenic model. Our findings contribute to the current understanding of how the gut microbiota may influence PD, elucidating one potential mechanism of microbiota-mediated neuroprotection.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112061"},"PeriodicalIF":5.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-132–3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer’s disease 从轻度阿尔茨海默病患者分离的血浆和 CD171+ 细胞外囊泡中下调 miR-132-3p

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-17 DOI: 10.1016/j.mad.2025.112063

Matilde Sbriscia , Tatiana Spadoni , Patrizia Ambrogini , Michele Guescini , Rachele Agostini , Laura Graciotti , Francesco Piacenza , Cinzia Giuli , Monia Cecati , Anna Rita Bonfigli , Salvatore Vaiasicca , Marica Pagliarini , Iryna Rusanova , Francesca Fazioli , Jacopo Sabbatinelli , Maria Cristina Albertini , Fabiola Olivieri , Angelica Giuliani

{"title":"miR-132–3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer’s disease","authors":"Matilde Sbriscia , Tatiana Spadoni , Patrizia Ambrogini , Michele Guescini , Rachele Agostini , Laura Graciotti , Francesco Piacenza , Cinzia Giuli , Monia Cecati , Anna Rita Bonfigli , Salvatore Vaiasicca , Marica Pagliarini , Iryna Rusanova , Francesca Fazioli , Jacopo Sabbatinelli , Maria Cristina Albertini , Fabiola Olivieri , Angelica Giuliani","doi":"10.1016/j.mad.2025.112063","DOIUrl":"10.1016/j.mad.2025.112063","url":null,"abstract":"<div><div>Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder in aging populations, demands minimally invasive biomarkers for early diagnosis and monitoring. Circulating microRNAs (miRNAs) show promise as such biomarkers. In this study, we examined the levels of five selected miRNAs, implicated in neurodegenerative processes, in plasma and neuron-derived extracellular vesicles (EVs) from cognitively healthy controls (n = 5), and patients with mild (n = 10) and moderate AD (n = 10), stratified by Mini-Mental State Examination (MMSE). miR-23a-3p, miR-223a-3p, and miR-132–3p were significantly downregulated in both plasma and EVs of AD patients, with miR-132–3p emerging as the strongest biomarker candidate for mild AD. Plasma miRNA levels strongly correlated with EV cargo, supporting plasma-based assessments. To validate these findings, miR-132–3p levels were analyzed in expanded cohorts, including cognitively healthy subjects (n = 36), mild AD (n = 37), and moderate AD (n = 40), as well as a cohort of subjects with mild cognitive impairment (MCI, n = 31) and an additional external cohort of cognitively healthy subjects (CTR external, n = 37). Results confirmed miR-132–3p downregulation in AD patients and revealed a significant elevation in MCI individuals, suggesting a potential neuroprotective role in AD early stages. These findings highlight miR-132–3p as a promising, minimally invasive biomarker for early AD diagnosis and disease progression monitoring.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112063"},"PeriodicalIF":5.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards defining optimal concentrations of micronutrients in adults to optimize health 确定成人微量营养素的最佳浓度以优化健康

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-04-16 DOI: 10.1016/j.mad.2025.112062

Muhammad Daniel Azlan Mahadzir , Sheryl Tan , Sandalova Elena , Ee Moon Chin , Vandana Garg , Konstantinos Mantantzis , Szabolcs Péter , Andrea B. Maier

{"title":"Towards defining optimal concentrations of micronutrients in adults to optimize health","authors":"Muhammad Daniel Azlan Mahadzir , Sheryl Tan , Sandalova Elena , Ee Moon Chin , Vandana Garg , Konstantinos Mantantzis , Szabolcs Péter , Andrea B. Maier","doi":"10.1016/j.mad.2025.112062","DOIUrl":"10.1016/j.mad.2025.112062","url":null,"abstract":"<div><div>Micronutrients are essential for maintaining physiological homeostasis and optimizing healthspan, defined as the years lived in good health without chronic diseases or disabilities. Despite increasing global life expectancy, improvements in healthspan have not kept pace, partly due to subclinical micronutrient deficiencies that often precede clinical symptoms. The triage theory highlights how micronutrient insufficiencies compromise long-term health by prioritizing critical metabolic functions. Micronutrients such as Vitamins B6, B9, B12, D, and K are particularly crucial to optimizing healthspan, by influencing energy metabolism, neurological health, immune regulation, and bone integrity. Traditional tools like Dietary Reference Intakes (DRIs) provide population-level guidelines but fail to account for individual factors such as genetics, lifestyle, and nutrient interactions. Quantitative assessment of micronutrient concentrations using biomarkers offers a more precise approach but faces challenges, including high costs and limited accessibility. National nutrition surveys demonstrate potential in addressing population-level deficiencies and form the basis for advancing precision supplementation strategies to improve health outcomes and extend healthspan by defining optimal micronutrient concentrations. Future efforts should aim to establish evidence-based thresholds for optimal micronutrient concentrations by integrating biomarker data with clinical outcomes, genetic profiles, and lifestyle factors, providing a framework to guide personalized and population-level supplementation strategies.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"225 ","pages":"Article 112062"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0