Mechanisms of Ageing and Development最新文献_第2页

Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence fto介导的m6A去甲基化调控YAP1在髓核细胞衰老中的机制

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-08-26 DOI: 10.1016/j.mad.2025.112101

Rui Sun , Xiao-Tao Wu , Hang Shi , Feng Wang , Jia-Wei Gao , Pei-Yang Wang , Zheng-Yuan Xu , Wen-Wu Gan , Yun-Tao Wang , Cong Zhang

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Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing 百岁老人的脑电活动：弹性脑老化的神经生理EEG标记。

IF 5.1 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-08-09 DOI: 10.1016/j.mad.2025.112100

Fabrizio Vecchio , Chiara Pappalettera , Alessia Cacciotti , Federico Frasca , Gabriella Marcon , Paolo Maria Rossini

{"title":"Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing","authors":"Fabrizio Vecchio , Chiara Pappalettera , Alessia Cacciotti , Federico Frasca , Gabriella Marcon , Paolo Maria Rossini","doi":"10.1016/j.mad.2025.112100","DOIUrl":"10.1016/j.mad.2025.112100","url":null,"abstract":"<div><div>Centenarians are an increasing population, in particular in high income countries. Studying cognitively intact Centenarians’ brain becomes fundamental to understand physiological ageing and how it diverges from pathological one. Resting state EEG were recorded using 27 channels in more than 130 subjects (referred to Young, Adults, Elderly, Centenarians and Alzheimer Disease patients), and the power spectral density (PSD) was computed. The paper demonstrates that Centenarians electrical brain activity is more similar to Elderly’s than expected, despite approximately 30 years of age gap, provided they are cognitively intact. Centenarians EEG signal was expected to progressively approach AD one, but surprisingly they seem to slow-down their ageing and maintain non-pathological and resilient EEG patterns, particularly in Alpha bands: occipital region Centenarians PSD has lower values than Young and Adults but not than Elderly, and higher values than AD. These interesting results suggests that Centenarians brain needs to be investigated to extrapolate its characteristics and try to replicate its mechanisms for a widespread healthy ageing.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"227 ","pages":"Article 112100"},"PeriodicalIF":5.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins 循环microrna和身体功能和虚弱的横断面和纵向测量：一项对大龄双胞胎的探索性研究。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-07-16 DOI: 10.1016/j.mad.2025.112099

Rossella La Grotta , Cecilie Agergaard Sørensen , Asmus Cosmos Skovgaard , Mikael Thinggaard , Serena Dato , Giuseppina Rose , Jonas Mengel-From , Mette Soerensen

{"title":"Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins","authors":"Rossella La Grotta , Cecilie Agergaard Sørensen , Asmus Cosmos Skovgaard , Mikael Thinggaard , Serena Dato , Giuseppina Rose , Jonas Mengel-From , Mette Soerensen","doi":"10.1016/j.mad.2025.112099","DOIUrl":"10.1016/j.mad.2025.112099","url":null,"abstract":"<div><div>During aging, physical functioning declines, and disability and frailty increase; phenotypes which are bidirectionally linked. MicroRNAs (miRNAs) are epigenetic regulators of various physiological processes and suggested aging biomarkers. Here we investigate the association between circulating plasma miRNAs and hand grip strength, chair stand, (Rockwood) frailty, and activity of daily living (ADL) in 86 monozygotic twins (73–88 years). In cross-sectional analysis, both individual and twin-pair level analyses were performed, the latter controlling genetic confounding. The majority (74–100 %) of miRNAs identified in the individual-level analysis were validated by twin-pair-level analysis, with 14 miRNAs showing significance (p < 0.05) in both. Longitudinal analysis (up to eight years of follow-up) yielded more significant results (75–93 miRNAs), indicating that miRNAs might be more accurate in predicting functional decline over time. Of these miRNAs, seven showed consistent directions of effects across phenotypes. For all analyses, most (65–79 %) of the observed effect sizes were negative, reflecting reduced functionality with increased miRNA levels. Enrichment analyses revealed pathways of gene expression (incl. p53- and FOXO-mediated transcription), signal transduction, the immune system, metabolism of RNA, among others. Of specific miRNAs, miR-1274a demonstrated negative association in both cross-sectional and longitudinal investigations of ADL. These findings support miRNAs as biomarkers of age-related functional decline.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"227 ","pages":"Article 112099"},"PeriodicalIF":5.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Genome-wide RNAi analysis in adult Caenorhabditis elegans unveils genes controlling age-related fat accumulation 成年秀丽隐杆线虫全基因组RNAi分析揭示了控制年龄相关脂肪积累的基因。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-07-03 DOI: 10.1016/j.mad.2025.112089

Chunxia Qin , Zicheng Liu , Duo Duan , Lianfeng Wu

{"title":"Genome-wide RNAi analysis in adult Caenorhabditis elegans unveils genes controlling age-related fat accumulation","authors":"Chunxia Qin , Zicheng Liu , Duo Duan , Lianfeng Wu","doi":"10.1016/j.mad.2025.112089","DOIUrl":"10.1016/j.mad.2025.112089","url":null,"abstract":"<div><div>Fat accumulation with aging occurs in adults across species, yet its underlying mechanisms remain poorly understood, partly due to limited number of studiesspecifically targeting adulthood. Here, we present the first genome-wide analysis of age-associated fat accumulation during adulthood in <em>Caenorhabditis elegans</em>. Unprecedently, our adult-specific RNAi screen identified a limited subset of genes influencing adult fat dynamics, contrasting with the extensive gene sets uncovered in prior developmental RNAi screens. This disparity suggests a unique genetic architecture governing age-related lipid deposition. Central to this network is the evolutionarily conserved transcription factor DAF-16/FoxO, which progressively accumulates in nuclei during aging. Genetic ablation of <em>daf-16</em> abolished adult fat accumulation, while its adult-specific knockdown reduced adiposity without compromising healthspan or longevity, highlighting its therapeutic potential. Critically, knockdown of the top hits, <em>pals-17</em> and <em>rege-1</em>, markedly attenuated the nuclear localization of DAF-16 and failed to reduce the adult fat content <em>daf-16</em>-deficient animals, establishing DAF-16 as their essential effector. Overall, our work uncouples developmental and adult lipid regulatory mechanisms and highlights potential targets for understanding and managing adult-onset obesity.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112089"},"PeriodicalIF":5.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations 生物合成的能量成本调节小鼠的生长-寿命权衡：四种改变寿命的操作的定量见解

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-07-01 DOI: 10.1016/j.mad.2025.112088

Chen Hou, Fahimeh Taheri

{"title":"Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations","authors":"Chen Hou, Fahimeh Taheri","doi":"10.1016/j.mad.2025.112088","DOIUrl":"10.1016/j.mad.2025.112088","url":null,"abstract":"<div><div>Life history theory proposes a tradeoff between growth rate and lifespan, typically explained by the allocation of limited energy resources between somatic growth and maintenance. However, this explanation does not give a complete picture of the energy tradeoff. This study investigates two energy allocation mechanisms that influence growth and longevity simultaneously: the redirection of metabolic energy from growth to maintenance under energy limitation, and increased energy investment in biosynthesis, enhancing bio-tissue quality and stress resistance but also slowing growth. By analyzing empirical data from laboratory mice subjected to diet restriction (DR), dwarfism through genetic manipulations (Dwarf), rapamycin treatment (Rap), and growth hormone transgenics (Super), we quantify changes in growth rate, metabolic rate, and biosynthesis energy costs (<em>E</em><sub>m</sub>). Our quantitative analyses demonstrate that although both mechanisms slow growth and extend lifespan, they work differently depending on the type of manipulation. In DR, Dwarf, and Rap mice, these mechanisms act synergistically, significantly enhancing lifespan. These manipulations not only channel more energy from growth to somatic maintenance but also increase the energy investment to biosynthesis and therefore enhance the tissues’ ability of resisting stress. Conversely, in Super mice, the mechanisms partially counteract each other. In this case, the treatment drains energy from somatic maintenance to growth, but slightly increases energy investment to biosynthesis, resulting in less pronounced effects on longevity. These findings suggest that the energetic cost of biosynthesis, a previously underappreciated factor, critically influences the balance between growth rate and lifespan, providing deeper insight into life history evolution and aging mechanisms.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112088"},"PeriodicalIF":5.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs 非洲绿松石鳉（Nothobranchius furzeri）：年龄相关疾病和多个器官再生能力下降的模型

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-06-30 DOI: 10.1016/j.mad.2025.112087

Takayoshi Otsuka, Hideaki Matsui

{"title":"The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs","authors":"Takayoshi Otsuka, Hideaki Matsui","doi":"10.1016/j.mad.2025.112087","DOIUrl":"10.1016/j.mad.2025.112087","url":null,"abstract":"<div><div>African turquoise killifish (<em>Nothobranchius furzeri</em>) has emerged as a promising vertebrate model for aging research because of its unique characteristics. Its exceptionally short lifespan and rapid aging make it an ideal model for studying age-related phenomena in compressed timeframes. This species exhibits hallmarks of aging observed in longer-lived vertebrates, including motor neuron degeneration, muscle weakness, and impaired regenerative capacity. These features make it valuable for investigating molecular and cellular mechanisms of age-related diseases and tissue regeneration. However, current research has primarily focused on brain aging and neurodegeneration, while systemic age-related changes across organs remain underexplored. The impact of aging on tissue regeneration in this model needs comprehensive investigation. This review summarizes current research using African turquoise killifish on age-related diseases and tissue regeneration in multiple organs. By integrating aging and regeneration biology, this review offers a perspective that expands the utility of this species beyond neurobiology, positioning it as a promising model for gerontology and regenerative medicine. We discuss limitations and future directions to advance its use in aging studies across multiple organs. Future research on African turquoise killifish will contribute to identifying therapeutic targets and developing interventions for age-related diseases, ultimately extending healthy life expectancy in humans.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112087"},"PeriodicalIF":5.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [Mech. Ageing Dev. 225 (2025) 112043] 巨细胞病毒血清状态与ELOVL2甲基化的关系：对MARK-AGE研究人群脂质代谢、炎症、DNA损伤和修复能力的影响老龄发展，225(2025)112043。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-06-26 DOI: 10.1016/j.mad.2025.112085

Robertina Giacconi , Chiara Pirazzini , Maria Giulia Bacalini , Paolo Garagnani , Miriam Capri , Claudio Franceschi , Carlo Fortunato , Gretta Veronica Badillo Pazmay , Alexander Bürkle , María Moreno-Villanueva , Maurizio Cardelli , Francesco Piacenza , Monia Cecati , Laura Cianfruglia , Martijn E.T. Dollé , Eugène Jansen , Tilman Grune , Efstathios S. Gonos , Birgit Weinberger , Ewa Sikora , Marco Malavolta

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Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study 半乳糖凝集素-3结合蛋白是糖尿病、代谢综合征和炎症的危险因素。InCHIANTI研究的横断面和纵向结果

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-06-26 DOI: 10.1016/j.mad.2025.112086

Raffaello Pellegrino , David Perpetuini , Roberto Paganelli , Angelo Di Iorio , Serena Filoni , Nicola Tinari , Antonino Grassadonia , Gianluca Sala , Matteo Candeloro , Stefania Bandinelli , Toshiko Tanaka , Luigi Ferrucci

{"title":"Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study","authors":"Raffaello Pellegrino , David Perpetuini , Roberto Paganelli , Angelo Di Iorio , Serena Filoni , Nicola Tinari , Antonino Grassadonia , Gianluca Sala , Matteo Candeloro , Stefania Bandinelli , Toshiko Tanaka , Luigi Ferrucci","doi":"10.1016/j.mad.2025.112086","DOIUrl":"10.1016/j.mad.2025.112086","url":null,"abstract":"<div><div>Galectin-3-binding protein (Lgals3bp), a heavily glycosylated protein that plays a role in cell growth, inflammation, and cellular adhesion, has been associated with tumor development and more recently with carbohydrate and lipid metabolism. The primary aims of these analyses are to examine in the InCHIANTI study participants: 1) the cross-sectional correlations of Lgals3bp serum levels with biomarkers of inflammation, glucose, and cholesterol metabolism; 2) the longitudinal association between baseline Lgals3bp serum levels with changes over time of inflammatory markers, blood glucose, and cholesterol. The InCHIANTI study enrolled representative samples from the registry lists of two towns in Tuscany, Italy. Baseline data were collected in 1998, with follow up visits every three years up to nine years. For this analysis, we used 866 subjects whose variables of interest had been recorded. Subjects were divided in two groups according to Lgals3bp levels, above median AM-Lgals3bp and below median BM-Lgals3bp. In cross-sectional analyses higher blood glucose, plasma insulin, elevated leptin, lower LDL-cholesterol, and inflammatory makers were associated to AM-Lgals3bp levels. Longitudinally, baseline AM-Lgals3bp levels were associated with incident diabetes, MetS, chronic liver diseases, and high multimorbidity score. Lastly AM-Lgals3bp levels predicted high blood-glucose, and high HS-C-Reactive-protein, and low HDL-cholesterol throughout the time of the study. These results point to the role of Lgals3bp in affecting low-grade age-related inflammation, low circulating cholesterol levels, and diabetes. Therefore, Lgals3bp could be further evaluated for diagnostic and therapeutic purposes.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112086"},"PeriodicalIF":5.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial: Aging and osteoporosis 社论：衰老与骨质疏松症。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-06-24 DOI: 10.1016/j.mad.2025.112084

Abhishek Chandra, Robert J. Pignolo

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Dietary ingredients inducing cellular senescence in animals and humans: A systematic review 诱导动物和人类细胞衰老的膳食成分：系统综述。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2025-06-06 DOI: 10.1016/j.mad.2025.112083

Lihuan Guan , Kristina Zdantsevich , Elena Sandalova , Karen C. Crasta , Andrea B. Maier

{"title":"Dietary ingredients inducing cellular senescence in animals and humans: A systematic review","authors":"Lihuan Guan , Kristina Zdantsevich , Elena Sandalova , Karen C. Crasta , Andrea B. Maier","doi":"10.1016/j.mad.2025.112083","DOIUrl":"10.1016/j.mad.2025.112083","url":null,"abstract":"<div><h3>Background</h3><div>Cellular senescence (CS) is a hallmark of ageing and age-related diseases. While dietary interventions are often explored to reduce CS, less is known about dietary ingredients that induce it. This study systematically reviews the evidence on dietary ingredients that promote CS in animal models and humans.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines (PROSPERO: CRD42022338885), PubMed and Embase were searched for studies on dietary ingredients administered via the gastrointestinal tract affecting CS markers in animal models or adults. Risk of bias was assessed using SYRCLE’s and Cochrane’s tools.</div></div><div><h3>Results</h3><div>From 10,806 articles, 80 studies (77 animal, 3 human) were included. In animals, high-fat diets commonly induced CS across tissues. The plant extract Teng Long Bu Zhong Tang and certain bioactives promoted CS in tumor tissues, potentially offering anti-cancer benefits. Excessive ethanol intake caused CS in the liver and other organs. In humans, increased CS load was linked to red meat-based meals, high protein intake, and DHA-enriched fish oil. Most studies showed unclear risk of bias.</div></div><div><h3>Conclusions</h3><div>High-fat diets and anti-cancer natural products promote CS in animal models. Preliminary human evidence suggests similar effects from high-protein, red meat-based diets, or DHA-enriched fish oil. Further research is needed to clarify mechanisms and guide dietary and public health recommendations.</div></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"226 ","pages":"Article 112083"},"PeriodicalIF":5.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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