Medical Herald of the South of Russia最新文献_第8页

Gas chromatography-mass spectrometry based steroid metabolomics in women with different phenotypes of polycystic ovarian syndrome and normal body weight 基于气相色谱-质谱法的多囊卵巢综合征不同表型和正常体重妇女的类固醇代谢组学

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-107-117

O. Glavnova, N. Vorokhobina, L. Velikanova, M. Yarmolinskaya, E. Malevanaya, E. Strelnikova, K. A. Balandina

{"title":"Gas chromatography-mass spectrometry based steroid metabolomics in women with different phenotypes of polycystic ovarian syndrome and normal body weight","authors":"O. Glavnova, N. Vorokhobina, L. Velikanova, M. Yarmolinskaya, E. Malevanaya, E. Strelnikova, K. A. Balandina","doi":"10.21886/2219-8075-2022-13-3-107-117","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-107-117","url":null,"abstract":"Objective: to study the steroid metabolomics in women with normal body weight and various PCOS phenotypes by gas chromatography-mass spectrometry (GC-MS). Materials and methods: forty-eight(48)women with PCOS aged 25±0,3 yearswith a BMI less than 25 kg/m2 were examined. The control group (CG) consisted of twenty-five (25) healthy women aged 26±0,6 years with a BMI of 23 (21-24) kg/m2. Immunoassays were used to determine the levels of hormones in serum. Urinary steroid profiles (USP) were studied by GC-MS method. Statistical data processing was performed using the software system STATISTICA for WINDOWS (ver. 10). Results: the article provides an analysis of the metabolism of androgens, glucocorticoids and progestogens in women with different phenotypes of polycystic ovary syndromeaccording to gas chromatography-mass spectrometry. Summary: the urinary excretion of androstenedione metabolites was increased in PCOS patients with androgen excess and anovulation (A and B phenotypes), dehydroepiandrosterone metabolites - in PCOS patients with androgen excess (A, B and C phenotypes). PCOS women with phenotype C showed raised urinary excretion of 11-oxo-pregnanetriol, pregnanetriol and 17-hydroxypregnanolone, a decrease in the ratios of the sum of tetrahydro derivatives of cortisol and cortisone to these progestogens, as well as determination of tetrahydro-21-deoxycorticol and nonclassical 5-ene-pregnenes according to GC-MS data. In fact, it indicated to deficiency of the 21-hydroxylase enzyme in these patients. It was found PCOS patients with androgen excess (A, B and C phenotypes) had the signs of insufficient 3β-hydroxysteroid dehydrogenase activity. PCOS women with phenotype A were revealed deficiency of 11β-hydroxysteroid dehydrogenase (type 1).","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76313736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative analysis of the effectiveness of different methods of surgical hemostasis in patients with placenta accreta spectrum disorders 不同手术止血方法治疗增生性胎盘谱系障碍的疗效比较分析

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-161-172

V. Tskhay, A. A. Bakunina

{"title":"Comparative analysis of the effectiveness of different methods of surgical hemostasis in patients with placenta accreta spectrum disorders","authors":"V. Tskhay, A. A. Bakunina","doi":"10.21886/2219-8075-2022-13-3-161-172","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-161-172","url":null,"abstract":"Currently, the medical community has accumulated significant experience in the use of endovascular methods in obstetric practice to achieve hemostasis and prevent massive hemorrhage, including in patients with placenta accreta spectrum (PAS) disorders. Objective — to evaluate the effectiveness of various methods of uterine devascularization in reducing blood loss during caesarean section in patients with PAS. In this review, we analyzed relevant literature and assessed the quality of clinical trials based on a systematic search in the Embase, PubMed, Web of Science, and Cochrane Library databases. The review presents an overview of modern methods of uterine devascularization aimed at reducing intraoperative blood loss in patients with PAS. A comparative analysis of the effectiveness of such methods of uterine devascularization as temporary balloon occlusion of the internal iliac arteries, common iliac arteries, abdominal aorta, as well as arterial compression using distal hemostasis was carried out. We evaluated effectiveness of the methods by such indicators as the mean amount of blood loss and the frequency of hysterectomy. The most effective methods of hemostasis in patients with PAS are temporary balloon occlusion of the abdominal aorta and the method of distal hemostasis. At the same time, there is still no ideal method for uterine devascularization in PAS, and clinical research in this direction should be continued.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83654930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glucocorticoid therapy is a risk factor for cardiovascular diseases 糖皮质激素治疗是心血管疾病的危险因素

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-93-106

I. Dzherieva, N. Volkova, I. Davidenko, I. Reshetnikov, S. Brovkina, S. M. Avakova, Y. Tishchenko

引用次数: 0

Gender nonconformity as a problem of mentalization 性别不一致作为心理化问题

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-7-12

K. S. Vinogradova

{"title":"Gender nonconformity as a problem of mentalization","authors":"K. S. Vinogradova","doi":"10.21886/2219-8075-2022-13-3-7-12","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-7-12","url":null,"abstract":"Objective — to study and analyze the current trends among Western scientists and mental health professionals regarding issues of gender identity; to study the data of foreign and domestic studies concerning the problems of gender incongruence, gender dysphoria and their comorbidity with mental disorders, personality disorders, especially with schizophrenia and autism spectrum disorders; to identify promising areas of scientific research in this direction. Source search in electronic databases was carried out mainly for the past 5 years among foreign and russian publications, including Web of science, Researchgate.net, Google Scholar, Elibrary, Cyberleninka systems, using phrases such as gender identity disorder, gender identity disorder comorbidity, gender identity disorder schizophrenia, gender identity disorder autism, gender nonconformity, mentalization personality disorder. The article presents the data of modern publications and studies, showing, on the one hand, the tendency of Western experts to depathologize gender incongruence, promote gender transition, on the other hand, an active study of the relationship between this phenomenon with autism and schizophrenia spectrum disorders, personality disorders. According to the presented studies, the influence of mentalization features on the presence of mental disorders and gender incongruence is revealed.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82256301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical case of gender dysphoria in a patient with a procedural disease 程序性疾病患者性别不安的临床病例

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-67-74

A. I. Kovalev, O. Bukhanovskaya, A. Dyachenko, M. Temirova

引用次数: 0

Phenomenology of ideas of gender change in patients with schizotypic disorder 精神分裂型障碍患者性别改变观念的现象学研究

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-32-35

G. Vvedensky

{"title":"Phenomenology of ideas of gender change in patients with schizotypic disorder","authors":"G. Vvedensky","doi":"10.21886/2219-8075-2022-13-3-32-35","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-32-35","url":null,"abstract":"Objective: a psychopathological analysis of the ideas of sex change and a description of the state of the sexual sphere in patients with schizotypal disorder. Materials and methods: we examined 38 patients who applied with a request to change their passport sex and were diagnosed with schizotypal disorder, 27 of them were women, 9 were men. Methods: clinical-psychopathological, sexological. To assess the sexual sphere and identify the motivation for changing sex and plans for the future a specially designed questionnaire was used. Results: variants of the ideas of gender reassignment were identified: obsessive, fixed, dominant, overvalued, delusional, their features specific to schizotypal disorder were described. For each variant, varying degrees of severity of violations of criticality and features of sexual behavior are described. An analysis of the characteristics of the sexual sphere of the studied groups showed the predominance of delays in psychosexual development and the associated deactualization of this sphere. In order to characterize the ability to adequately assess one's state, it is necessary to assess criticality as a variant of capacity, the issue of its methodology needs to be developed. Conclusions: the selected options differ in the degree of violation of criticality, which should be taken into account when deciding whether to change the passport gender.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84197179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Psychiatric ethical issues of transgender people 跨性别者的精神病学伦理问题

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-13-20

A. Perekhov, M. N. Kryuchkova

{"title":"Psychiatric ethical issues of transgender people","authors":"A. Perekhov, M. N. Kryuchkova","doi":"10.21886/2219-8075-2022-13-3-13-20","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-13-20","url":null,"abstract":"Today, psychiatric care for people with transgender people in the Russian Federation is difficult due to non-compliance with ethical principles in the work of the psychiatric service. The article deals with the unresolved ethical conflict regarding gender reassignment procedures between proponents of \"not allowed, forbidden\" with the attitude of psychiatrists to issue permission for sex reassignment only to \"real\" transsexuals, and supporters of the opposite liberal attitude towards issuing permission. for gender reassignment procedures for almost all applicants. Our article discusses ethical issues to help transgender people. The ethical principles of autonomy, harmlessness and beneficence in this article are intended to help transgender people. The authors ethically write about adding and not adding a transgender diagnosis to the International Classification of Diseases. This article raises concerns about the benefits and harms, the principle of respect for autonomy and the principle of beneficence, in order to provide good quality ethical care for transgender people. The authors discuss the problem of the ethical attitude of a psychiatrist to the mental health of transgender subjects. The authors discuss the ethical problem of the psychiatrist's attitude to the mental health of transgender subjects, medicalization and medical paternalism with the help of transgender people. This article raises considerations about the ethical role of the psychiatrist in gender reassignment procedures for subjects with varying degrees of mental health. The authors propose an algorithm for providing psychiatric care to persons who have undergone gender reassignment, which includes an in-depth examination by psychiatrists, psychologists, sexologists and a collegial conclusion on the state of mental health of a transgender person in the triad: mentally healthy or \"have mental disorders\", \"borderline\" or \"mental psychotic disorders\".","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80897323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biomarkers of anaphylaxis 过敏反应的生物标志物

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-137-147

N. Esakova, A. Lebedenko, A. Pampura

引用次数: 0

A clinical review: schizophrenia, transsexualism or their combination? 临床回顾:精神分裂症、变性欲症还是两者兼而有之?

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-75-82

V. Soldatkin

{"title":"A clinical review: schizophrenia, transsexualism or their combination?","authors":"V. Soldatkin","doi":"10.21886/2219-8075-2022-13-3-75-82","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-75-82","url":null,"abstract":"The change in the position of transsexualism in the new ICD classification, the hot debate about the psychopathological structure of this phenomenon and its relation to other mental disorders determine the relevance of considering the following clinical case.A detailed clinical description demonstrates the possibility of combining two initially independent disorders - transsexualism and schizophrenia - which gave a bright individual color to the clinical picture and caused difficulties both in the medical and legal aspects of patient care.At the age of 25, a patient with clinical signs of transsexualism developed acute paraphrenia psychosis. Without medical assistance, according to the mechanisms of sanogenesis, the severity of the condition decreased, but the psychotic state was not recovered. Features of the onset and dynamics of psychosis typical for the continuous type of paranoid schizophrenia (acuteness of development and absence of signs of syndromotaxis) allow us to attribute it to episodic with progressive or stable deficit paranoid schizophrenia variant. It is noteworthy that after the onset of psychosis, the stereotype of the development of birth-assigned gender rejection syndrome did not undergo significant changes: the formation of crossdressing, inverse psychosexual identity and inverse gender identity were finally completed; mimicry reactions became bright, self-destructive tendencies began to appear more and more clearly, and the patient applied for permission to change gender.In the described clinical situation, the primary task is to overcome the acute schizophrenia psychosis. After solving this problem, the secondary prevention and rehabilitation program development becomes more important. Formally, the patient does not have the right to change sex, since she suffers from schizophrenia, which is a contraindication for sex transformation. In the state of psychosis, the patient essentially loses her civil procedural capacity. Informally, the question remains relevant.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90240690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender Incongruence: clinical, psychological and therapeutic aspects 性别不一致:临床、心理和治疗方面

Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-21-31

M. Yagubov, E. A. Starostina, N. V. Dobaeva, M. A. Ichmelyan

{"title":"Gender Incongruence: clinical, psychological and therapeutic aspects","authors":"M. Yagubov, E. A. Starostina, N. V. Dobaeva, M. A. Ichmelyan","doi":"10.21886/2219-8075-2022-13-3-21-31","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-21-31","url":null,"abstract":"Recently, the issues of violations of gender identity are becoming more relevant and discussed, the number of patients with a request for a sex change is increasing. The complexity of this issue requires clinicians to be competent in helping transgender people, as they sometimes face many obstacles in the way of receiving care in medical institutions: the lack of specialists in the regions, a clear algorithm for helping transgender people, discrimination, stigmatization, and financial difficulties. At the same time, there are more and more foreign studies devoted to \"detransition\", i.e. \"reverse\" gender reassignment, which may indicate existing problems in the diagnosis of these conditions and methods of providing medical care to patients with gender identity disorders. The most difficult issues when working with patients experiencing gender dysphoria, in addition to identifying the true causes of gender identity disorders, are the preservation of fertility after gender-affirmative interventions, possible regrets after operations, and the provision of medical care to minors. Changes in the classification of gender disorders, including the exclusion of transsexualism from the class of mental disorders, creates the basis for discussions about the clinical, psychopathological and phenomenological features of these conditions. The scientific review provides information on the clinical and psychological aspects of gender identity disorders, as well as on therapeutic interventions for individuals with this pathology, using a multidisciplinary approach. Certain stages of the provision of medical and social assistance are described to reduce risks and more successful, professional assistance to persons with a gender incongruence.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81648550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1