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Self-consciousness features of persons with gender identity disorder 性别认同障碍患者的自我意识特征
Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-36-49
V. Malygin, E. A. Kutukova, A. S. Iskandirova, E. E. Pahtusova, Y. Merkurieva, Y. Malygin
{"title":"Self-consciousness features of persons with gender identity disorder","authors":"V. Malygin, E. A. Kutukova, A. S. Iskandirova, E. E. Pahtusova, Y. Merkurieva, Y. Malygin","doi":"10.21886/2219-8075-2022-13-3-36-49","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-36-49","url":null,"abstract":"Purpose: to study the formed images of sexual self-consciousness in persons who applied for permission to change their sex. Materials and methods: 80 people were examined, 40 of whom applied for permission to change their sex (20 people male and 20 people of the female biological sex). The comparison group — 20 men and 20 women, whose gender identity coincides with the biological sex. Methods — Sandra Bem's BSRI (Bem Sex-Role Inventory) test, V.V. Stolin's self-attitude questionnaire, O.L. Kustovoi's questionnaire. Results: it has been established that in the group of transsexuals with a female biological sex, images of a man and a woman are clearly distinguished, the self-image is closer to the desired image of a man, while the image of a woman is less achievable. The group of male transsexuals is closer to the image of the “Ideal Man” than to the image of the “Ideal Woman”. The key features that correspond to their self-determination as women are revealed: passivity, dependence on others, compromise, gullibility. According to the self-perception of all 4 groups, the “Ideal Woman” is happier than the “Ideal Man”. In the transsexuals’ group of male biological sex, were found no differences with the indicators of conditionally healthy groups of both sexes in the parameter “Love for children”, in contrast to the group of female transsexuals of the biological sex. Male transsexuals are looking for a radically new way to meet their needs without judgment from society. Summary: the indicators of self-relationship in the comparison groups are higher than in the groups of persons striving for a sex change.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87925892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of acute kidney injury in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock who underwent percutaneous coronary intervention 经皮冠状动脉介入治疗st段抬高型心肌梗死并发心源性休克患者急性肾损伤的预测因素
Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-118-126
O. V. Arsenicheva
{"title":"Predictors of acute kidney injury in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock who underwent percutaneous coronary intervention","authors":"O. V. Arsenicheva","doi":"10.21886/2219-8075-2022-13-3-118-126","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-118-126","url":null,"abstract":"Objective: to study predictors of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) who underwent percutaneous coronary intervention. Materials and methods: 109 patients with STEMI complicated by CS were studied after interventional intervention (mean age 63.1±10.1 years). The observation group included 33 patients with AKI, and the comparison group — 76 patients without AKI. AKI was diagnosed with an increase in plasma creatinine level by ≥26.5 mmol/l from the baseline level within 48 hours or by ≥1.5 times from its known or assumed basal level. To identify predictors of AKI, the method of simple and multiple logistic regression was used. Results: among patients with AKI, patients aged over 70 years (54.5% vs 15.8%, p<0.001), with concomitant chronic kidney disease (57.6% vs 26.3%, p=0.002), chronic heart failure with a low ejection fraction (69.7% vs 36.8%, p=0.001), an initial glomerular filtration rate of less than 60 ml/min/1.73 m2 (54.5% vs 22.4%, p=0.001) and a left ventricular ejection fraction below 40% (75.8% vs 51.3%, p=0.022) and a three-vascular lesion of the coronary arteries (63.6% vs 40.8%, p=0.028) were significantly more often observed. Conclusions: AKI in patients with STEMI complicated by CS after intracoronary intervention was associated with an age older than 70 years, the presence of a left ventricular ejection fraction of less than 40% and a glomerular filtration rate of less than 60 ml/min/1.73 m2.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85791870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and socio-demographic factors influencing social adaptation in individuals with gender incongruence 影响性别不一致个体社会适应的临床和社会人口因素
Medical Herald of the South of Russia Pub Date : 2022-07-11 DOI: 10.21886/2219-8075-2022-13-3-50-58
N. V. Solovieva, S. A. Kremenitskaya, E. Makarova
{"title":"Clinical and socio-demographic factors influencing social adaptation in individuals with gender incongruence","authors":"N. V. Solovieva, S. A. Kremenitskaya, E. Makarova","doi":"10.21886/2219-8075-2022-13-3-50-58","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-3-50-58","url":null,"abstract":"Objective: to identify potentially reversible clinical and socio-demographic factors influencing the social adaptation of patients with gender incongruence (GI). Materials and methods: a retrospective analysis of 926 patient records with MtF and FtM GI was performed. Results: among the patients who applied, 44.38% were MtF, 55.62% were FtM. The mean age was 24.0 years (from 13 to 65 years). The educational level of patients is mainly represented by higher (44.2%) and specialized (22.3%) education, 43% of persons lived in the village, 57% - in urban areas. The majority of those who applied grew up in a complete family (82.02%). The first manifestations of GI started mainly in the prepubertal (26.4%) and parapubertal (61.6%) period (up to 13 years). The average age of accepting oneself as a transgender person was 17.0 years. Steps to reduce dysphoria and receive specialized care are usually taken after the age of 20. 83.1% of transgender patients had depressive episodes, and a third (38.5%) had autoaggression. Additional psychiatric diagnoses were present in 24.5% of patients and are represented by 3 groups of diseases: group 1 (6.2%) — potentially reversible neurotic disorders; group 2 (14.1%) — background mental illnesses that are not the cause of GI; group 3 (4.3%) — other mental states with “ideas of sex change”. Conclusions: improvement of social adaptation and prevention of emotional and psychological experiences in persons with GI, assistance is possible at several levels: family, educational institutions, medical community, patient organizations.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86647705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Menopausal hormone therapy and postcovid syndrome: new realities 绝经期激素治疗和covid后综合征:新的现实
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-26-33
M. Khamoshina, I. S. Zhuravleva, E. Dmitrieva, M. Lebedeva
{"title":"Menopausal hormone therapy and postcovid syndrome: new realities","authors":"M. Khamoshina, I. S. Zhuravleva, E. Dmitrieva, M. Lebedeva","doi":"10.21886/2219-8075-2022-13-2-26-33","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-26-33","url":null,"abstract":"Due to the total aging of the population, within the framework of the concept of “active longevity”, age-related aspects of women’s health have been paid close attention in the last decade. The physiological features of the menopausal period of life are due to the consequences of estrogen deficiency, while the protective effect of menopausal hormone therapy (MHT) in relation to diseases associated with age and aging leaves no doubt. At the same time, in the context of the ongoing COVID-19 pandemic, there are many open questions related to the appointment of MHT, both in terms of possible additional mechanisms for protecting the vascular wall, and in terms of risks, including against the background of changes in the state of immunity and the coagulation system. New realities require the development and justification of often fundamentally different approaches to the management of patients in gynecological practice, both in connection with coronavirus infection and in the postcovid period. That is why the organization of gynecological care during a pandemic requires a personalized approach to the management of patients with hormone-dependent diseases and the risk of unplanned pregnancy, as well as the development of clear algorithms that can be relied on in the daily work of both a practitioner and health care organizers.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84420676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Modern possibilities for the prevention of pelvic organ prolapse 预防盆腔器官脱垂的现代可能性
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-7-17
Y. A. Boldyreva, V. Tskhay, A. Polstyanoy, O. Polstyanaya
{"title":"Modern possibilities for the prevention of pelvic organ prolapse","authors":"Y. A. Boldyreva, V. Tskhay, A. Polstyanoy, O. Polstyanaya","doi":"10.21886/2219-8075-2022-13-2-7-17","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-7-17","url":null,"abstract":"In the practice of an obstetrician-gynecologist, the problem of pelvic organ prolapse is increasingly being raised. Symptoms of pelvic organ prolapse are noted from a young age, gradually progressing and reducing the patient’s quality of life. Various surgical methods of treatment also don’t solve the problem of prolapse. The recurrence rate after correction of prolapse with own tissues reaches 40%, and operations using mesh implants have a number of specific complications, the fight against which sometimes becomes more difficult than primary intervention. Despite the steady increase in the prevalence of the disease, effective methods of dealing with it have not yet been developed. Also, the tactics of managing patients at the initial stage of prolapse, when there are complaints, but they are not given enough attention, both by the doctor and the patient, are not defined. The main risk factors for the disease are: perineal ruptures during childbirth, episiotomy, menopause, repeated pregnancies and childbirth, polyhydramnios, multiple pregnancy, fetal macrosomia, conditions accompanied by a chronic increase in intraabdominal pressure, heavy physical labor, impaired innervation and circulation of the pelvic floor, genetic predisposition, hysterectomy and connective tissue dysplasia. The review is devoted to the causes and methods of prevention of pelvic organ prolapse at the present stage. Methods such as pelvic floor muscles training, including in the biofeedback mode using vaginal simulators, electrical impulse stimulation, high-intensity focused electromagnetic stimulation, and non-ablative Er:YAG laser therapy are considered. A systematic literature search was carried out using Scopus, web of Science, MedLine, PubMed and eLibrary data base system.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85662661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical features of the combination of agoraphobia and non-psychotic mental disorders 广场恐怖症与非精神病性精神障碍合并的临床特征
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-146-153
A. I. Kovalev
{"title":"Clinical features of the combination of agoraphobia and non-psychotic mental disorders","authors":"A. I. Kovalev","doi":"10.21886/2219-8075-2022-13-2-146-153","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-146-153","url":null,"abstract":"The review article gives a modern definition of the concept of agoraphobia. Different classification approaches in the typing of agoraphobia are presented. Its role as a factor aggravating the course of non-psychotic mental disorders is shown. The features of its manifestation depending on the nosological affiliation are analyzed. It was revealed that agoraphobia is a predictor of an unfavorable outcome in people with panic disorder. In turn, panic disorder often causes the development of agoraphobia. At the same time, gender and age aspects are noted. The comorbidity of agoraphobia and somato-vegetative type of generalized anxiety disorder is shown. Agoraphobia increases the risk of suicidal behavior in depression, has a high correlation with the severity of personality disorders, especially of the avoidant and dependent type. At the same time, some researchers dispute the point of view that these types of personality disorders are predisposing factors for panic disorder and agoraphobia, based on retrospective data on the premorbid personality structure of patients with anxiety disorders. The relationship between PTSD and panic disorder is emphasized in connection with the emergence of a circular model of the development of feelings of fear, which postulates a similar etiology of anxiety disorders. There is a comorbidity of agoraphobia with disorders of the hypochondriac spectrum: from the degree of fixation to obsessive nature. reduces the effectiveness of therapy for schizophrenic spectrum disorders and the quality of life of patients. The picture of the panic disorder itself with agoraphobia becomes heavier if the patient has chronic alcoholism (in particular, the frequency of seizures increases), while the presence of agoraphobic symptoms leads to a relapse of alcoholic illness, which is explained by taking alcohol to relieve symptoms, and also increases the likelihood of developing dependence on tranquilizers.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86457378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thymic stromal lymphopoietin in bronchial asthma patients of different age groups: correlation with other markers, lung function results and disease control 不同年龄组支气管哮喘患者胸腺基质淋巴生成素与其他指标、肺功能结果及疾病控制的相关性
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-113-121
A. V. Kamaev, S. A. Krivskaya, N. Lyashenko, I. Kamaeva, Y. Mizernitsky, N. Shaporova
{"title":"Thymic stromal lymphopoietin in bronchial asthma patients of different age groups: correlation with other markers, lung function results and disease control","authors":"A. V. Kamaev, S. A. Krivskaya, N. Lyashenko, I. Kamaeva, Y. Mizernitsky, N. Shaporova","doi":"10.21886/2219-8075-2022-13-2-113-121","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-113-121","url":null,"abstract":"Objective: to investigate correlation between thymic stromal lymphopoietin and bronchial asthma course and control in patients of different age groups. Materials and methods: one hundred and four patients were included in 1-year long open prospective study. There were three age groups: children (6 –11 y.o., n=38), adolescents (14–17 y.o., n=35) and adults (25 –50 y.o., n=31). we used asthma duration ≥12 months, uncontrolled asthma and acute respiratory infection absence for ≥14 days as inclusion criteria. Clinical history, validated questionnaires, spirometry, common blood count, serum and nasal material to evaluate thymic stromal lymphopoietin were obtained during first visit. Patient were consequently examined twice with 6 months intervals. Statistical analyses included ANOVA (Kruskal-wallis test) and Pearson’s correlation (r). Differences accepted significant with р<0,05. Resuts: prevalence of main risk factors of asthma control lost (poor compliance, obesity, non-atopic phenotype, fixed airway obstruction) was different in age groups. we didn’t find any thymic stromal lymphopoietin in nasal material. Thymic stromal lymphopoietin concentration correlate significantly with duration of uncontrolled asthma in previous 12 months (r=0,74). we have found greater serum thymic stromal lymphopoietin concentration in patients who demonstrated FEV1 below normal at Visit 3. Conclusion. Serum thymic stromal lymphopoietin level can be used as risk factor of asthma future exacerbation and spirometry results decline.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77239873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implantation zone as an echographic criterion identification of types of cicatricial and isthmic pregnancies in women with a scar on the uterus 着床区作为超声鉴别子宫瘢痕型和峡型妊娠的标准
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-72-79
M. Esetov, A. M. Esetov
{"title":"Implantation zone as an echographic criterion identification of types of cicatricial and isthmic pregnancies in women with a scar on the uterus","authors":"M. Esetov, A. M. Esetov","doi":"10.21886/2219-8075-2022-13-2-72-79","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-72-79","url":null,"abstract":"Objective: the purpose of this publication is to present the establishment of the implantation zone of the fetal egg during ultrasound diagnostics at 5-7 weeks to differentiate the types of cicatricial and isthmian pregnancies in women with a scar on the uterus after cesarean section. Materials and methods: the study included 11 women with low implantation of the fetal egg in the presence of a scar on the uterus. All underwent ultrasound with transabdominal and transvaginal approaches at 5–7 weeks of pregnancy to establish the place of implantation of the fetal egg relative to the scar on the uterus. Results: according to the results of ultrasound evaluation of the implantation zone of the fetal egg in 5–7 weeks were differentiated: type 1 of scar pregnancy (1 case); type 2 of scar pregnancy (7 cases) and low implantation along the posterior wall of the uterus at the level of the scar intact from it (2 cases). Conclusions: ultrasound at 5–7 weeks is a necessary method of examination in women with a scar on the uterus for the diagnosis of scar pregnancy. The establishment of the implantation zone of the fetal egg is a tool that allows differentiating the types of cicatricial and isthmic pregnancies.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74726110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota of the vagina and myoma nodes in uterine myoma 子宫肌瘤中阴道和肌瘤淋巴结的微生物群
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-50-58
E. S. Nikitina, A. N. Rymashevsky, Y. L. Naboka, M. A. Rymashevsky, I. Gudima, E. G. Svirava
{"title":"Microbiota of the vagina and myoma nodes in uterine myoma","authors":"E. S. Nikitina, A. N. Rymashevsky, Y. L. Naboka, M. A. Rymashevsky, I. Gudima, E. G. Svirava","doi":"10.21886/2219-8075-2022-13-2-50-58","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-50-58","url":null,"abstract":"Objective: to study the microbiota of the vagina, myomatous nodes, their bed in patients with fibroids. Materials and methods: a comprehensive examination of 83 patients aged 26 to 50 years with diagnosed interstitial, interstitial-subserous uterine myoma was carried out. By age, all women are divided into 3 groups. Standard clinical and clinical laboratory studies, colposcopy, microbiological examination of the detachable posterior vaginal fornix, biopsy specimens of myomatous nodes and their bed, as well as morphological examination of biopsy specimens of myomatous nodes and their bed were performed.Results: in the structure of clinical manifestations of uterine fibroids, pain syndrome was the leading one (p<0.05). The number of myoma nodes in patients varied from 1 to 22. The duration of the operation and the amount of blood loss did not differ significantly (p>0.05). According to the results of a bacteriological study of the detachable posterior vaginal fornix in patients in the 2nd group, a decrease in the frequency of detection and the number of lactobacilli was revealed compared to the 1st group, and in women in the 3rd group, these microorganisms were absent. Among the anaerobic microorganisms in the 1st and 2nd groups, Eubacterium spp. dominated, in the 3rd — Peptostreptococcus spp. In patients of group 3, the frequency of detection of Bacteroides spp. was significantly increased (p<0.05). Among the aerobic spectrum of microorganisms in all groups, coagulasenegative staphylococci predominated. In a bacteriological study of biopsy specimens, the absence of growth of microorganisms in myomatous nodes was observed in 7.2% of cases, in the tissue of the bed of myomatous nodes in 17.7%. The microbiota of myomatous nodes and their bed in most cases was represented by anaerobic taxa. According to the results of a morphological study of biopsy specimens, no inflammatory reaction of tissues was detected. Conclusions: In women with uterine myoma of different age groups, multidirectional changes in the vaginal microbiota were revealed. In most cases, the myomatous node (92.8%) and its bed (82.3%) are not sterile with the dominance of anaerobic microbiota taxa. Identified significant correlations in the loci «vagina – myomatous node – myomatous node bed» indicate their relationship. The detection of various taxa of microorganisms in the myomatous node and its bed, according to morphological studies, is not associated with the presence of infectious and inflammatory processes in the tissues.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86182947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine fibroids: a look at the problem 子宫肌瘤:一看问题
Medical Herald of the South of Russia Pub Date : 2022-06-29 DOI: 10.21886/2219-8075-2022-13-2-18-25
R. A. Karamyan, I. M. Ordiyats, V. Khorolskiy, D. R. Asatryan
{"title":"Uterine fibroids: a look at the problem","authors":"R. A. Karamyan, I. M. Ordiyats, V. Khorolskiy, D. R. Asatryan","doi":"10.21886/2219-8075-2022-13-2-18-25","DOIUrl":"https://doi.org/10.21886/2219-8075-2022-13-2-18-25","url":null,"abstract":"Despite scientific progress, there is currently no sigle opinion about the cause of the occurrence and recurrence of uterine fibroids, but due to the high level of molecular medicine, progress is being made in the hormonal and molecular genetic mechanisms of initiation, formation and growth of the fibroisds. The issue of pathogenetic treatment and prevention of recurrence of uterine fibroids in reproductive age remains relevant. The aims of the review. The aim of this review is to summarize current data about microRNA in biology of uterine leiomyoma (LM). This information can improve our understanding of the broad molecular interaction of signaling pathways in the formation of LM, and further maintaining epigenetic regulation as an important mechanism in the pathogenesis of uterine leiomyoma. In leiomyomas, the expression of a number of non-proteincoding genes is altered, such as microRNAs (miRNAs), which target genes that code protein. Material and research methods. Original and review articles, book chapters in the PubMed database related to the study of the pathogenesis of uterine fibroids in the period from 2004 to 2022 were found and analyzed. Results and discussions. Based on an analytical review of the literature, it becomes obvious that as evidence should be considered: 1. Abnormal myometrial and fibroid stem cells show an increased response to estrogen and progesterone exposure, stimulating processes such as cell proliferation, inhibition of apoptosis, and extracellular matrix (ECM) formation. 2. A number of tumor suppressor genes are abnormally hypermethylated in the LM when compared to normal myometrium, genes that form and regulate collagen, and a subset of estrogen receptor genes. 3. Multiple studies using microarray analysis or sequencing have demonstrated the existence of dysregulation of a number of protein-coding genes involved in cell proliferation and apoptosis, which are critical for the growth and progression of uterine fibroids. There are no reliable evidence base and do not provide an opportunity for practical application of clinically significant risk factors, the possibility of mathematical prediction of the growth of uterine fibroids in women of reproductive age. Data on the effect of the expression of a number of microRNAs on the growth of uterine fibroids in vivo are rather contradictory. The epigenetic processes of regulation and pathogenesis of the growth of leiofibromyomas in reproductive age have not been fully studied and substantiated. There are practically no data on predicting the growth of uterine fibroids in reproductive age, which will allow us to assess the risk of growth and determine further treatment tactics. Conclusion. Further work on the identification of specific genes, miRNAs, that are involved in the pathogenesis of LM may inspire the creation of new pathogenetic treatments. Such treatment is especially relevant for those groups of patients of reproductive age for whom surgical treatment may be ine","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77426021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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