Medical Journal of Indonesia最新文献_第2页

Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis 爪哇儿童重型β地中海贫血症的面部侧面轮廓：摄影测量分析

IF 0.5

Medical Journal of Indonesia Pub Date : 2023-12-22 DOI: 10.13181/mji.oa.236834

Wulan Geraldine Parengkuan, Sri Kuswandari, I. Soeprihati

{"title":"Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis","authors":"Wulan Geraldine Parengkuan, Sri Kuswandari, I. Soeprihati","doi":"10.13181/mji.oa.236834","DOIUrl":"https://doi.org/10.13181/mji.oa.236834","url":null,"abstract":"BACKGROUND Impairment of globin chain synthesis in patients with β-thalassemia major causes ineffective erythropoiesis. This condition triggers bone marrow hyperplasia and can lead to craniofacial bone abnormalities. This study aimed to evaluate the lateral facial profile of β-thalassemia major, identify any differences when compared with a control group of similar age and ethnicity, and reveal the facial profile of β-thalassemia major in Javanese children. \u0000METHODS This cross-sectional study included 35 β-thalassemia major children aged 7–15 years. They were divided into 3 groups based on their age. Lateral facial photogrammetry was taken by measuring the forehead protrusion and nasolabial angle. Data were then mapped to the normal group of children in the same age group and descriptively analyzed using SPSS software. \u0000RESULTS The 1 and 2 SD group had a higher prevalence of β-thalassemia major in children aged 7–9 years for both sexes. The older age group had a closer mean value to those of children without thalassemia. \u0000CONCLUSIONS The forehead and maxillary profile of Javanese β-thalassemia major children tended to be protrusive, especially in the 7–9 years age group, while the older age groups had closer mean values to those of children without thalassemia.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138947103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats 文冠果皮提取物对血脂异常 Sprague-Dawley 大鼠胆固醇和甘油三酯水平的影响

IF 0.5

Medical Journal of Indonesia Pub Date : 2023-12-22 DOI: 10.13181/mji.oa.236960

Taufik Saputra, Haidar Satya Naufal, Astika Widy Utomo, N. S. Widyastiti, Muhammad Farhan Kurniawan, Arfianty Nur Azizah

{"title":"Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats","authors":"Taufik Saputra, Haidar Satya Naufal, Astika Widy Utomo, N. S. Widyastiti, Muhammad Farhan Kurniawan, Arfianty Nur Azizah","doi":"10.13181/mji.oa.236960","DOIUrl":"https://doi.org/10.13181/mji.oa.236960","url":null,"abstract":"BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats. \u0000METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method. \u0000RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively). \u0000CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of methotrexate, Moringa oleifera, and Andrographis paniculata extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats 甲氨蝶呤、油橄榄和穿心莲提取物对链脲佐菌素-烟酰胺诱导的高血糖大鼠心肌和主动脉组织的影响

IF 0.5

Medical Journal of Indonesia Pub Date : 2023-12-22 DOI: 10.13181/mji.oa.236944

Dimas Bathoro Bagus Pamungkas, V. Kalanjati, Abdurachman, Dwi Martha Nur Aditya, Muhammad Husni Fansury Nasution, Maya Rahmayanti Syamhadi

{"title":"Effects of methotrexate, Moringa oleifera, and Andrographis paniculata extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats","authors":"Dimas Bathoro Bagus Pamungkas, V. Kalanjati, Abdurachman, Dwi Martha Nur Aditya, Muhammad Husni Fansury Nasution, Maya Rahmayanti Syamhadi","doi":"10.13181/mji.oa.236944","DOIUrl":"https://doi.org/10.13181/mji.oa.236944","url":null,"abstract":"BACKGROUND Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, M. oleifera, and A. paniculata leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta. \u0000METHODS 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) injection consisting of positive control (STZ-NA only), M. oleifera (500 mg/kgBW/day), A. paniculata (500 mg/kgBW/day), MTX (7 mg/kgBW/week), MTX (7 mg/kgBW/week)+M. oleifera (500 mg/kgBW/day), and MTX (7 mg/kgBW/week)+A. paniculata (500 mg/kgBW/day). We analyzed oral MTX, M. oleifera, and A. paniculata leaf extracts’ effects on random blood glucose, myocardial IL-6, and cardiac histopathology of STZ-NA-induced hyperglycemic male rats. Data were analyzed using Wilcoxon and Kruskal–Wallis tests. \u0000RESULTS Myocardial IL-6 in the M. oleifera group was significantly lower compared to the positive control group (p = 0.041). Compared to the positive control group, the myocardial necrosis and aortic intima–media thickness in the MTX+A. paniculata group were significantly reduced (p = 0.005 and 0.001, respectively). \u0000CONCLUSIONS MTX, M. oleifera, and A. paniculata showed antihyperglycemic effect, both individually and in combination. A. paniculata leaf extract had a significant cardioprotective effect in STZ-NA-induced hyperglycemia.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study 2 型糖尿病患者的维生素 D 水平与抑郁：一项横断面研究

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Medical Journal of Indonesia Pub Date : 2023-12-14 DOI: 10.13181/mji.oa.237005

Rudi Putranto, Kresna Adhiatma, Tri Juli Edi Tarigan, C. Rumende, Hamzah Shatri, I. Rengganis, Pringgodigdo Nugroho, I. Rinaldi

{"title":"Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study","authors":"Rudi Putranto, Kresna Adhiatma, Tri Juli Edi Tarigan, C. Rumende, Hamzah Shatri, I. Rengganis, Pringgodigdo Nugroho, I. Rinaldi","doi":"10.13181/mji.oa.237005","DOIUrl":"https://doi.org/10.13181/mji.oa.237005","url":null,"abstract":"BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare. \u0000METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II <14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed. \u0000RESULTS Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (p = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; p = 0.045). \u0000CONCLUSIONS Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9) 印尼语版 9 项炎症性肠病问卷 (IBDQ-9) 的有效性和可靠性

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Medical Journal of Indonesia Pub Date : 2023-12-11 DOI: 10.13181/mji.oa.236848

Dekta Filantropi Esa, H. Shatri, C. Rumende, Adityo Susilo, Hasan Maulahela, Achmad Fauzi, M. Simadibrata

{"title":"Validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9)","authors":"Dekta Filantropi Esa, H. Shatri, C. Rumende, Adityo Susilo, Hasan Maulahela, Achmad Fauzi, M. Simadibrata","doi":"10.13181/mji.oa.236848","DOIUrl":"https://doi.org/10.13181/mji.oa.236848","url":null,"abstract":"BACKGROUND Decreasing the quality of life (QoL) of patients with inflammatory bowel disease (IBD) will increase morbidity and mortality. A valid and reliable instrument is needed to assess the QoL of patients with IBD. This study aimed to analyze the validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9). \u0000METHODS This cross-sectional study was conducted using the Indonesian version of the IBDQ-9 in adult patients with IBD at the Gastroenterology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, in November 2022. Patients aged 18 to 59 years who had experienced IBD for at least 2 weeks and provided informed consents were included. The total score of the IBDQ-9 Indonesian version was compared with the 36-item Short-Form Health Survey (SF-36) using the Spearman's correlation test. Reliability tests were examined using Cronbach’s alpha and the intraclass correlation coefficient (ICC). \u0000RESULTS A total of 124 participants were included in this study. The Spearman's test showed a high and significant result for the IBDQ-9 Indonesian version and the SF-36 (r = 0.769 and p<0.001). Cronbach’s alpha and ICC coefficient were equal to 0.883. \u0000CONCLUSIONS This study provided evidence of the good validity and reliability of the IBDQ-9 Indonesian version for assessing the QoL of patients with IBD in Indonesia.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bambara groundnut ameliorates kidney histology in female mice with protein deficiency 班巴拉花生改善蛋白质缺乏症雌性小鼠的肾脏组织学状况

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Medical Journal of Indonesia Pub Date : 2023-12-11 DOI: 10.13181/mji.oa.237030

Vykra Aulia Firdiana, R. Gunanegara, Sunarti, A. Nuriliani

{"title":"Bambara groundnut ameliorates kidney histology in female mice with protein deficiency","authors":"Vykra Aulia Firdiana, R. Gunanegara, Sunarti, A. Nuriliani","doi":"10.13181/mji.oa.237030","DOIUrl":"https://doi.org/10.13181/mji.oa.237030","url":null,"abstract":"BACKGROUND Protein deficiency (PD) can lead to kidney damage. Consuming plant-based proteins may improve this condition. Bambara groundnut (Vigna subterranea)has an essential amino acid score of 80%, which is higher than other legumes; thus, it is potent in overcoming malnutrition. This study aimed to determine the effect of Bambara groundnut supplementation on kidney histology in adult female mice with PD. \u0000METHODS The study was conducted for 2 months in randomly selected female mice. These mice were grouped into the control, PD, and PD supplemented with Bambara groundnuts at 100, 200, and 300 g/kg of feed. 1 day after the last treatment, the kidneys of the mice were collected and processed histologically using the paraffin method (stained with hematoxylin and eosin and Masson’s trichrome). Parameters for observation included histopathological scoring (glomerular and interstitial space fibrosis and tubular damage), kidney histomorphometry, and organ index. Semi-quantitative data were analyzed using the Kruskal–Wallis test, while quantitative data were analyzed using one-way ANOVA (followed by Tukey’s test) and nested t-test. Statistical analysis was performed using SPSS software version 20 (IBM Corp., USA) (p≤0.05). \u0000RESULTS PD caused cell sloughing (moderate level) and dilatation (severe level) of the kidney tubules. It also reduced glomerular diameter and area by approximately 17.66% and 29%, respectively. PD and Bambara groundnut administration had no significant effects on the glomerular number, cortex and medulla thickness, distal and proximal tubule diameter, and kidney organ index (p>0.05). \u0000CONCLUSIONS Bambara groundnut (V. subterranea) administration prevented damage to the kidney’s histological structure of protein-deficient mice.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study 印度尼西亚一家三级医院老年患者压力损伤的特点:一项横断面研究

Medical Journal of Indonesia Pub Date : 2023-11-14 DOI: 10.13181/mji.oa.237092

Shannaz Nadia Yusharyahya, Lili Legiawati, Rinadewi Astriningrum, Reganedgary Jonlean, Vega Andhira

{"title":"Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study","authors":"Shannaz Nadia Yusharyahya, Lili Legiawati, Rinadewi Astriningrum, Reganedgary Jonlean, Vega Andhira","doi":"10.13181/mji.oa.237092","DOIUrl":"https://doi.org/10.13181/mji.oa.237092","url":null,"abstract":"BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia. METHODS This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline. RESULTS 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden. CONCLUSIONS No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134901539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of kidney transplantation as a healthcare development model to achieve Indonesia Emas 2045 发展肾移植作为医疗保健发展模式，以实现印度尼西亚Emas 2045

Medical Journal of Indonesia Pub Date : 2023-11-13 DOI: 10.13181/mji.com.237171

Nur Rasyid, Endang Susalit, Arry Rodjani

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Atypical orbital primary optic nerve sheath meningioma with severe disfiguring proptosis: an alternative surgical approach 非典型眼眶原发性视神经鞘脑膜瘤伴严重畸形突出:一种替代手术入路

Medical Journal of Indonesia Pub Date : 2023-11-01 DOI: 10.13181/mji.cr.236936

Sylves Patrick, Yeap Boon Tat, Muhamad Zarif Mohd Amin, Maftuhim Addenan, Shuaibah Ab.Ghani, Hanida Hanafi

引用次数: 0

Role of a journal for the publication of doctoral dissertations 期刊发表博士论文的作用

Medical Journal of Indonesia Pub Date : 2023-10-20 DOI: 10.13181/mji.ed.237163

Harrina Erlianti Rahardjo

引用次数: 0