Medical Journal of Indonesia最新文献_第10页

Multi-hole spherical CT scan method to characterize large quantities of bones in rats 多孔球形CT扫描方法表征大鼠大量骨骼

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-10-01 DOI: 10.13181/mji.oa.215452

Neng Nenden Mulyaningsih, Ariadne Lakshmidevi Juwono, Djarwani Soeharso Soejoko, Dewi Apri Astuti

{"title":"Multi-hole spherical CT scan method to characterize large quantities of bones in rats","authors":"Neng Nenden Mulyaningsih, Ariadne Lakshmidevi Juwono, Djarwani Soeharso Soejoko, Dewi Apri Astuti","doi":"10.13181/mji.oa.215452","DOIUrl":"https://doi.org/10.13181/mji.oa.215452","url":null,"abstract":"BACKGROUND New therapeutic options are often explored in in vivo studies using animals like rats. Since rats are small, it is difficult to examine them in a computed tomography (CT) scan. This study aimed to introduce a multi-hole spherical model CT scan method as a new, fast, economical, and reliable method to characterize large quantities of rat bones at once in estimating the timing of osteoporosis in ovariectomized white rats. \u0000METHODS 50 female white rats (12 weeks old) were treated as the control group, and 40 rats of the same age were ovariectomized to establish the osteoporosis model. Sham rats were sacrificed at 13, 15, 17, 19, and 21 weeks old, while the ovariectomized rats were sacrificed at 15, 17, 19, and 21 weeks old. Afterward, tibia bones were removed, placed in the multi-hole spherical model, and characterized using a CT scan. Their characteristics were compared using a scanning electron microscope (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). \u0000RESULTS The Hounsfield unit scores resulted from the multi-hole spherical model CT scan method of tibia bones of rats were consistent with the percentage of the osteocyte cavities, canalicular diameters, and crystal size. The multi-hole spherical model CT scan method could produce 50 times more data than the SEM, TEM, or XRD. \u0000CONCLUSIONS Multi-hole spherical model CT scan was considered good and reliable in assessing bone quality parameters in rat samples simultaneously.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48322601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of augmentation cystoplasty in patients with bladder abnormalities undergoing renal transplantation: a systematic review 肾移植术中膀胱异常患者膀胱扩大成形术的安全性：一项系统综述

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-09-30 DOI: 10.13181/mji.oa.204358

Bobby Sutojo, Gampo Alam Irdam

{"title":"Safety of augmentation cystoplasty in patients with bladder abnormalities undergoing renal transplantation: a systematic review","authors":"Bobby Sutojo, Gampo Alam Irdam","doi":"10.13181/mji.oa.204358","DOIUrl":"https://doi.org/10.13181/mji.oa.204358","url":null,"abstract":"BACKGROUND Augmentation cystoplasty (AC) has been recently proposed to improve a bladder condition before or after a renal transplantation for an optimal allograft function. Until now, AC in adults with end-stage renal disease (ESRD) is uncommon and rarely practiced. This study aimed to investigate the safety of AC in patients with bladder abnormalities who required renal transplantation. \u0000METHODS Studies of patients with ESRD and abnormal bladder who underwent AC were searched in ProQuest, PubMed, EBSCO, and Cochrane Library online databases. Only studies published in English from January 1985 to May 2020 were included. The keywords used were renal transplantation, bladder dysfunction, cystoplasty, and their synonyms. Data were extracted by two independent authors who selected, screened, and assessed the articles’ eligibility and quality. The outcomes were graft survival rate and complications of AC. \u0000RESULTS A total of 19 articles were included. AC improved an intravesical pressure, a bladder capacity, and a compliance in patients with ESRD and bladder abnormalities, allowing patients to undergo the renal transplantation. Even though AC in patients with renal transplantation resulted in a significantly higher urinary tract infection rate than patients who underwent renal transplantation only, performing AC after renal transplantation was considered safe. \u0000CONCLUSIONS AC was considered safe for patients with bladder abnormalities who underwent renal transplantation.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43007541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic 新冠肺炎大流行期间糖尿病患者远程医疗使用及血糖状况的横断面研究

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-09-30 DOI: 10.13181/mji.oa.215558

Novi Sulistia Wati, Pokkate Wongsasuluk, P. Soewondo

{"title":"A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic","authors":"Novi Sulistia Wati, Pokkate Wongsasuluk, P. Soewondo","doi":"10.13181/mji.oa.215558","DOIUrl":"https://doi.org/10.13181/mji.oa.215558","url":null,"abstract":"BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic disrupts selfmanagement in diabetic patients in Indonesia. This study aimed to determine the telemedicine usage and factors contributing to glycemic control in type 2 diabetes mellitus (T2DM) patients during the pandemic. \u0000METHODS A cross-sectional study was conducted in T2DM patients aged 25–54 years. The questionnaire included general characteristics, diabetes conditions, consultation factors, and self-care management. Glycemic status was evaluated using glycated hemoglobin (HbA1c) levels, which was categorized into poor (HbA1c≥7%) and good glycemic control (HbA1c<7%). Data were analyzed using chi-square and binary logistic regression. \u0000RESULTS Of 264 patients, only 19.2% used telemedicine and 60.2% had poor glycemic control during the pandemic. Overweight or obesity (odds ratio [OR] = 5.740 [95% confidence interval [CI] = 2.554–12.899]; p<0.001), insulin injection (OR = 3.083 [95% CI = 1.238–7.677]; p = 0.016), and frequent fried food consumption (OR = 5.204 [95% CI = 1.631–16.606]; p = 0.005) were the factors contributing to poor glycemic control. The risk is lower if exercised regularly (OR = 0.036 [95% CI = 0.007–0.195]; p<0.001) and consulted with a doctor using telemedicine (OR = 0.193 [95% CI = 0.044–0.846]; p = 0.029) or in-person visits (OR = 0.065 [95% CI = 0.016–0.260]; p<0.001). \u0000CONCLUSIONS Glycemic control was not optimal during the COVID-19 pandemic. Therefore, keeping a healthy lifestyle and staying connected with a doctor are important to ensure optimal blood glucose control and reduce the risk of diabetesrelated complications.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45950802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride 用苯扎氯铵建立巨结肠相关小肠结肠炎的体内模型

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-08-27 DOI: 10.13181/mji.oa.215339

I. R. Budianto, A. Firmansyah, Y. Moenadjat, A. A. Jusuf, V. Soetikno

{"title":"In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride","authors":"I. R. Budianto, A. Firmansyah, Y. Moenadjat, A. A. Jusuf, V. Soetikno","doi":"10.13181/mji.oa.215339","DOIUrl":"https://doi.org/10.13181/mji.oa.215339","url":null,"abstract":"BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. \u0000METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7, -10, -12, -14, -17, -19, -21, -23, -25, and -28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. \u0000RESULTS Rats that were sacrificed on day-7 to -12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). \u0000CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44800868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Management of bladder exstrophy in an adolescent girl: a case report 一例少女膀胱膨出的治疗

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-08-03 DOI: 10.13181/mji.cr.215249

Ni Made Putri Suastari, N. Margiani, K. Santosa, D. G. Mahiswara, F. Sitanggang, I. Yudiana

引用次数: 0

Effect of hyperglycemia on fertility in streptozotocin-induced diabetic male Wistar rats: focus on glucose transporters and oxidative stress 高血糖对链脲佐菌素诱导的糖尿病雄性Wistar大鼠生育能力的影响：关注葡萄糖转运蛋白和氧化应激

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-07-08 DOI: 10.13181/MJI.OA.214635

S. R. Brodjonegoro, Tanaya Ghinorawa, N. K. R. Wonatorey, Andy Zulfiqqar, D. S. Heriyanto

{"title":"Effect of hyperglycemia on fertility in streptozotocin-induced diabetic male Wistar rats: focus on glucose transporters and oxidative stress","authors":"S. R. Brodjonegoro, Tanaya Ghinorawa, N. K. R. Wonatorey, Andy Zulfiqqar, D. S. Heriyanto","doi":"10.13181/MJI.OA.214635","DOIUrl":"https://doi.org/10.13181/MJI.OA.214635","url":null,"abstract":"BACKGROUND Glucose transporters (GLUTs) and oxidant metabolism are associated with the mechanism of infertility. This study evaluated the impact of hyperglycemia on glucose and oxidant metabolisms of Sertoli cells (SCs). \u0000METHODS This study was an animal study to investigate the expression of messenger RNA monocarboxylate transporter 4 (MCT4), GLUT1, GLUT3, nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione peroxidase, catalase (CAT), and lactate dehydrogenase A (LDHA) of Wistar rats testes that were induced hyperglycemia. Reverse transcription polymerase chain reaction analysis was used. Hyperglycemic state in the Wistar rats was induced by streptozotocin. 24 rats were divided into 3 groups: non-hyperglycemia (control), 2-week, and 4-week hyperglycemic state. All data were collected and analyzed using SPSS version 15.0 (IBM Corp., USA). \u0000RESULTS The expression of glucose transporter (GLUT1 and GLUT3), lactate transporter (MCT4), and cellular defense protein against oxidant (Nrf2 and CAT) was significantly increased in the 2-week and 4-week hyperglycemic state groups with p<0.01, respectively. \u0000CONCLUSIONS Hyperglycemic state affects the metabolism of SCs. Alteration of GLUTs and oxidative metabolism may indicate metabolic alterations by a prolonged exposure to hyperglycemia that may be responsible for diabetes-related male infertility.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46404828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of platinum chain and gold weight implants for paralytic lagophthalmos: a systematic review 铂链和金重量植入物治疗麻痹性兔眼的疗效和安全性：一项系统综述

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-06-30 DOI: 10.13181/mji.oa.214683

Y. Irawati, T. Gondhowiardjo, H. Soebono

{"title":"Efficacy and safety of platinum chain and gold weight implants for paralytic lagophthalmos: a systematic review","authors":"Y. Irawati, T. Gondhowiardjo, H. Soebono","doi":"10.13181/mji.oa.214683","DOIUrl":"https://doi.org/10.13181/mji.oa.214683","url":null,"abstract":"BACKGROUND Surgery has been proposed as a treatment of paralytic lagophthalmos. However, no consensus has been reached on the best treatment. This study was aimed to investigate the efficacy and safety between platinum chain and gold weight implants to treat paralytic lagophthalmos. \u0000METHODS This study used all randomized controlled trials or observational studies (prospective or retrospective) using platinum chain and gold weight implants for paralytic lagophthalmos surgery that were published from 1990 to 2020 in the PubMed, Cochrane, and Google Scholar databases. Efficacy was indicated by the reduction of ≥3 in lagophthalmos, and safety was measured based on complications after surgery. \u0000RESULTS The efficacy of platinum chain and gold weight implants were 60–100% and 10–93.6%, respectively. The complications of platinum chain implant were 0–2.9% of extrusion and 0–3.3% of migration. However, gold weight implant had 0–13.3% of migration. \u0000CONCLUSIONS Both platinum chain and gold weight implants have similar efficacy to treat paralytic lagophthalmos. However, gold weight implant has a higher rate of complication.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48814812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The importance of registry for systematic review and clinical trial 注册对系统审查和临床试验的重要性

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-06-30 DOI: 10.13181/mji.ed.215620

V. Soetikno

引用次数: 0

Treatment delay of cancer patients in Indonesia: a reflection from a national referral hospital 印度尼西亚癌症患者治疗延误:来自一家国家转诊医院的反思

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-06-30 DOI: 10.13181/mji.oa.204296

S. Gondhowiardjo, Sugandi Hartanto, Sigit Wirawan, V. F. Jayalie, Ida Ayu Putri Astiti, S. S. Panigoro, S. M. Sekarutami, A. Rachman, A. Bachtiar

{"title":"Treatment delay of cancer patients in Indonesia: a reflection from a national referral hospital","authors":"S. Gondhowiardjo, Sugandi Hartanto, Sigit Wirawan, V. F. Jayalie, Ida Ayu Putri Astiti, S. S. Panigoro, S. M. Sekarutami, A. Rachman, A. Bachtiar","doi":"10.13181/mji.oa.204296","DOIUrl":"https://doi.org/10.13181/mji.oa.204296","url":null,"abstract":"BACKGROUND Cancer is a complex disease requiring a multidisciplinary approach in establishing prompt diagnosis and treatment. Treatment in a timely manner is crucial for the outcomes. Hence, this study aimed to provide information on treatment delay including patient and provider delays and its associated factors. \u0000METHODS Cancer patients were recruited conveniently in the outpatient clinic of Department of Radiation Oncology, Cipto Mangunkusumo Hospital, Indonesia between May and August 2015. All patients were asked to fill a questionnaire and interviewed in this cross-sectional study. Treatment delay was explored and categorized into patient delay and provider delay. Patient delay could be happened before (patient-delay-1) or after (patient-delay-2) the patient was diagnosed with cancer. Provider delay could be due to physician, system-diagnosis, and system-treatment delays. \u0000RESULTS Among 294 patients, 86% patient had treatment delay. Patient delay was observed in 153 patients, and 43% of them had a history of alternative treatment. An older age (p = 0.047), lower educational level (p = 0.047), and history of alternative treatment (p<0.001) were associated with patient delay. Meanwhile, 214 patients had provider delay, and 9%, 36%, and 80% of them experienced physician, system-diagnosis, and system-treatment delays, respectively. All types of provider delay were associated with patient delay (p<0.001). \u0000CONCLUSIONS Most of the patient had treatment delay caused by either patient or provider.","PeriodicalId":18302,"journal":{"name":"Medical Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42389112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Everolimus for the treatment of epithelioid hemangioma: a case report 依维莫司治疗上皮样血管瘤1例

IF 0.5

Medical Journal of Indonesia Pub Date : 2021-06-15 DOI: 10.13181/MJI.CR.205036

M. Aisyi, A. Syarif, Dewi Aisiyah Mukarramah, Rio Hermawan, D. Iriani

引用次数: 0