Journal of Cytology / Indian Academy of Cytologists最新文献_第3页

A case of papillary microcarcinoma of the thyroid with abundant colloid (masquerading as colloid goiter with papillary hyperplasia): Cytological evaluation with histopathological correlation 甲状腺乳头状微癌伴丰富胶质(伪装为胶质甲状腺肿伴乳头状增生)1例:细胞学评价与组织病理学相关性

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171252

E. Muthalagan, Priya Subashchandrabose, P. Sivasubramanian, S. Venkateswaran

{"title":"A case of papillary microcarcinoma of the thyroid with abundant colloid (masquerading as colloid goiter with papillary hyperplasia): Cytological evaluation with histopathological correlation","authors":"E. Muthalagan, Priya Subashchandrabose, P. Sivasubramanian, S. Venkateswaran","doi":"10.4103/0970-9371.171252","DOIUrl":"https://doi.org/10.4103/0970-9371.171252","url":null,"abstract":"Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. On fine-needle aspiration (FNA) cytology smears of conventional PTC, the background usually shows scanty, bubble gum-like colloid. But the macrofollicular variant and papillary microcarcinoma reveals abundant thin colloid in the background. We report a case of papillary carcinoma of thyroid in a 37-year-old female with abundant thin colloid, obscuring the nuclear morphology in many clusters, along with the presence of typical nuclear features within occasional clusters in FNA cytology and hence, masquerading as colloid goiter with papillary hyperplasia. Histopathological examination of the total thyroidectomy specimen revealed papillary microcarcinomatous focus in a background of nodular hyperplasia. The differential diagnosis of PTC should be entertained even in colloid-rich FNA smears if the typical nuclear features are present. Hence, a meticulous search for any fragment with nuclear features of PTC is mandatory before labeling the smears as benign nodular hyperplasia.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128828943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FNAC accuracy in diagnosis of thyroid neoplasms considering all diagnostic categories of the Bethesda reporting system: A single-institute experience 考虑到Bethesda报告系统的所有诊断类别，FNAC诊断甲状腺肿瘤的准确性:单一研究所的经验

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171234

F. Hajmanoochehri, Elham Rabiee

{"title":"FNAC accuracy in diagnosis of thyroid neoplasms considering all diagnostic categories of the Bethesda reporting system: A single-institute experience","authors":"F. Hajmanoochehri, Elham Rabiee","doi":"10.4103/0970-9371.171234","DOIUrl":"https://doi.org/10.4103/0970-9371.171234","url":null,"abstract":"Background: Thyroid fine-needle aspiration cytology (FNAC) is a valuable test used for diagnosing diseases of the thyroid gland. Aims: Using all satisfactory categories of the Bethesda system, this study aimed to determine the accuracy with which FNAC diagnoses thyroid neoplasms. We also discuss the factors that affect diagnosis accuracy. Settings and Design: A comparison was drawn between FNAC results and final histological diagnosis using samples collected over a period of 3 years. Materials and Methods: For all patients, age, sex, cytological features, and histological types were determined. All cases of false negative (FN) and false positive (FP) diagnosis were reanalyzed. Statistical Analysis Used: The chi-square test and univariate analysis were performed to examine the relationship between different variables. Results: About 52% of the cases were found malignant, and they were of six different histological types. Papillary carcinoma was the commonest type of malignancy at 76.9%. The rate of malignancy was 63% in males and 49.4% in females. In two of the FN cases, the tumor had a diameter of ≥35 mm. Of the 12 FP cases, nine were in the follicular neoplasm or suspicious for follicular neoplasm Bethesda category. FNAC diagnosis had 95.2% sensitivity, 68.4% specificity, 83.3% positive predictive value, 89.6% negative predictive value, and 85.14% accuracy. Conclusions: FNAC was found to have a high level of sensitivity and an acceptable degree of specificity in diagnosing different types of thyroid neoplasms. The presence of microfollicular structures or crowded cellular clusters is a challenge to diagnosis, particularly in low-quality specimens.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133303758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Cytopathological diagnosis of gallbladder mass and mural thickening based on imaging findings: A prospective study of 51 cases 51例胆囊肿块及壁壁增厚的影像学诊断

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171231

Nikhilesh Kumar, Paresh Singhal, A. Agarwal, M. Khan

{"title":"Cytopathological diagnosis of gallbladder mass and mural thickening based on imaging findings: A prospective study of 51 cases","authors":"Nikhilesh Kumar, Paresh Singhal, A. Agarwal, M. Khan","doi":"10.4103/0970-9371.171231","DOIUrl":"https://doi.org/10.4103/0970-9371.171231","url":null,"abstract":"Background: Image-guided fine-needle aspiration cytology (FNAC) serves as first-line diagnostic modalities for the assessment of mural thickening of the gallbladder (GB). Aim: The main objective of the present study was to correlate the diagnostic accuracy of preoperative image-guided FNAC of the thickened GB wall based on imaging findings to arrive at a final diagnosis in a tertiary care center. Materials and Methods: Fifty-seven image-guided fine-needle aspirations (FNAs) were performed from mural thickening of the GB over a period of 4 years and the smears prepared were stained with Leishman and Papanicolaou (Pap) stain. Out of 57 cases, 51 were included in the study for which follow-up histopathology was performed. Result: Out of 51 aspirations, 43 (84.3%) were adequate, 5 (9.8%) were inconclusive, and 3 (5.9%) were inadequate. Among the adequate aspirations, the most common was adenocarcinoma—36 (70.5%). The correlation between confirmatory cytological diagnosis and adequacy was significantly high (P = 0.0001). The overall diagnostic accuracy for adequate aspiration was 95.3%. The common diagnostic pitfalls were necrotic areas, aspiration of reactive hepatocytes adjacent to the GB mass, and mucus islands. No procedural complication was observed in any patient. Conclusions: Image-guided FNAC can be used as a safe, rapid, and successful diagnostic procedure with high sensitivity, specifically for supporting and confirming ultrasonography(USG)/computed tomography (CT) diagnosis of GB mass or mural thickening of the wall.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129840598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comparative cytomorphometric analysis of oral mucosal cells in normal, tobacco users, oral leukoplakia and oral squamous cell carcinoma 正常人、吸烟者、口腔白斑和口腔鳞状细胞癌的口腔黏膜细胞形态比较分析

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171241

M. Nivia, S. Sunil, R. Rathy, T. Anilkumar

{"title":"Comparative cytomorphometric analysis of oral mucosal cells in normal, tobacco users, oral leukoplakia and oral squamous cell carcinoma","authors":"M. Nivia, S. Sunil, R. Rathy, T. Anilkumar","doi":"10.4103/0970-9371.171241","DOIUrl":"https://doi.org/10.4103/0970-9371.171241","url":null,"abstract":"Background: Squamous cell carcinoma (SCC) is the third most common cause of oral morbidity in India despite the numerous advances made in the treatment protocol. Aim: To compare the cytomorphometric changes of oral mucosal cells in normal subjects (Group I) with that of tobacco users without any lesion (Group II), tobacco users with oral leukoplakia (Group III), and tobacco users with oral SCC (Group IV) through a semi-automated image analysis system. Materials and Methods: Oral mucosal cells collected from study subjects (n = 100) stained using rapid Papanicolaou stain. Photomicrograph of 50 nonoverlapping cells captured at 50× magnification with a digital image capture system. Cytomorphometric analysis of cells in the captured images was performed with Image-Pro image analysis software. Image analysis was performed to obtain cell diameter (CD), cytoplasmic area (CyA), nuclear diameter (ND), nuclear area (NA), and nuclear-to-cytoplasmic ratio. These values were statistically compared among the groups using one-way analysis of variance (ANOVA) and Mann-Whitney U test. Results: The ND, NA, and nuclear-to-cytoplasmic ratio values were found to be increased in the samples collected from leukoplakia and oral SCC. The CD and CyA decreased compared to the normal mucosa in oral SCC samples. Conclusion: The cytomorphometric changes observed in samples from oral SCC and oral leukoplakia were consistent with the current diagnostic features. Hence, the semi-automated cytomorphometric analysis of oral mucosal cells can be used as an objective adjunct diagnostic tool in the diagnosis of these lesions.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130062282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The utility of ROSE (rapid on-site evaluation) in endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA): Is the picture rosy? ROSE(快速现场评估)在支气管超声(EBUS)引导下经支气管针吸(TBNA)中的应用:前景乐观吗?

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171226

V. Mallya, Sandeep Kumar, Prabhu Meganathan, S. Shivkumar, R. Mehta

{"title":"The utility of ROSE (rapid on-site evaluation) in endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA): Is the picture rosy?","authors":"V. Mallya, Sandeep Kumar, Prabhu Meganathan, S. Shivkumar, R. Mehta","doi":"10.4103/0970-9371.171226","DOIUrl":"https://doi.org/10.4103/0970-9371.171226","url":null,"abstract":"Background: Mediastinal lymphadenopathy (ML) presents a diagnostic challenge. The technique to sample the lymph nodes has evolved from conventional “blind” transbronchial needle aspiration (TBNA) to the present day endobronchial ultrasound (EBUS)-guided procedure that improves the accuracy of sampling. Objective: This study was undertaken to evaluate the utility of “rapid on-site evaluation” (ROSE) in EBUS-guided TBNA (EBUS-TBNA) for the diagnosis of ML. Patients and Methods: This prospective study included 80 patients who underwent EBUS-TBNA for computed tomography/positron emission tomography (CT/PET) diagnosed ML over a 4-month period at a single tertiary care center. All 80 of these patients underwent histopathological evaluation (HPE) in addition to cytology. Three out of these 80 (3.7%) patients were excluded in view of inadequate material on EBUS-TBNA. After the sampling of nodes was done, the slides were stained with rapid hematoxylin and eosin (H&E) and then on-site evaluation was done. The tissue derived was also processed for HPE in all cases. Results: ROSE revealed granuloma in 27 patients and malignancy in 14 patients, and the remaining patients showed nonspecific inflammation. Concomitant histopathology revealed granuloma in 34 patients and malignancy in 14 patients. Considering HPE as gold standard, the overall sensitivity and specificity of EBUS-TBNA for diagnosis were 85.4% and 89.6%, respectively. For malignancy alone, the sensitivity and specificity were 100% and 98.4%, respectively. Conclusion: This novel approach is safe, has good diagnostic yield, and has an excellent potential in assisting safe and accurate diagnostic interventional bronchoscope.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129404723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration 细针穿刺诊断儿童朗格汉斯细胞组织细胞增多症

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171237

U. Handa, R. Kundu, R. Punia, H. Mohan

{"title":"Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration","authors":"U. Handa, R. Kundu, R. Punia, H. Mohan","doi":"10.4103/0970-9371.171237","DOIUrl":"https://doi.org/10.4103/0970-9371.171237","url":null,"abstract":"Background: Langerhans cell histiocytosis (LCH) is a rare intricate pediatric neoplasm with varied clinical manifestations and multiple treatment modalities. Aim: To study the cytological features of LCH and the differential diagnoses on fine-needle aspiration (FNA). Materials and Methods: FNA was performed using a 23-gauge needle fitted to a 10 mL syringe mounted on syringe holder. LCH was diagnosed on FNA smears in seven cases confined to the head and neck region, which included three cases of lymphadenopathy, three cases of scalp swelling, and one case of orbital swelling. Results: The age of the patients ranged from 25 days to 11 years and male-to-female ratio was 1:1.3. Clinically, the diagnoses suggested were tuberculosis, inflammatory lesion, abscess, and malignancy. The cytologic findings included high cellularity, isolated Langerhans cells (LCs) with prominent nuclear indentation, grooves and abundant vacuolated cytoplasm, multinucleated giant cells, eosinophils, and lymphocytes. Areas of necrosis were noted in one case. Histopathology, along with positive S-100 immunohistochemistry, confirmed the diagnosis of LCH. Conclusions: LCH is a rare disease occurring predominantly in children and can be diagnosed with ease on FNA cytology by the presence of characteristic Langerhans cells. The S-100 positivity aids in suggesting a diagnosis of LCH.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"6 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120975757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Metastatic cervical carcinoma masquerading as iliopsoas abscess in an HIV negative woman-diagnosed on fine-needle aspiration cytology: A case report 伪装成髂腰肌脓肿的转移性宫颈癌的HIV阴性妇女-诊断细针穿刺细胞学:1例报告

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171251

A. Sharma, Aniruna Dey, M. Gupta

引用次数: 2

Fine-needle aspiration cytology of ovarian steroid cell tumor: A rare case report 卵巢类固醇细胞瘤的细针抽吸细胞学:1例罕见报告

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171255

Nidhi Agrawal, H. Vardhan, Singh Khokhar, N. Rai, R. Saxena, S. Riyaz

引用次数: 1

Bax and Bak expression in cervical smears of women with low-and high-risk HPV types: A study of 120 cases 120例低、高危型HPV女性宫颈涂片中Bax和Bak的表达

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171222

Eirini Klapsinou, Elena Argyri, E. Panotopoulou, D. Daskalopoulou, E. Patsouris, A. Nonni, A. Lazaris, Georgia-Heleni Thomopoulou

{"title":"Bax and Bak expression in cervical smears of women with low-and high-risk HPV types: A study of 120 cases","authors":"Eirini Klapsinou, Elena Argyri, E. Panotopoulou, D. Daskalopoulou, E. Patsouris, A. Nonni, A. Lazaris, Georgia-Heleni Thomopoulou","doi":"10.4103/0970-9371.171222","DOIUrl":"https://doi.org/10.4103/0970-9371.171222","url":null,"abstract":"Background: Human papillomavirus (HPV) is known to be involved in the carcinogenesis of squamous cells in uterine cervix cancer, mostly by binding and inactivating the p53 and pRb tumor suppressor genes. Lately, evidence has emerged suggesting that HPV oncoproteins may interact with proteins involved in cellular apoptosis as well. Aim: This study aimed to investigate the expression of proapoptotic proteins Bax and Bak in women with low-risk and high-risk HPV types as opposed to HPV-negative women, and in women with normal pap smear compared to women with abnormal Papanicolau test (Pap) smear. Materials and Methods: A total of 120 liquid-based cervical samples were subtyped for HPV types with microarray hybridization and then stained and evaluated immunocytochemically for Bax and Bak expression. Statistical analysis was performed on the Bax and Bak scores (percentage of positive cells × staining intensity), the overall percentage of positive cells, and the most prevalent staining intensity group found in each sample. Results: A weak association between negative Bax staining and cytologically normal Pap smears was discovered, whereas cytologically abnormal samples tended to stain weakly or moderately positive. No other statistically significant difference was found in the other analyzed parameters. Conclusion: Cytologically normal pap smears seem to have a slight tendency to stain negative for Bax as opposed to cytologically abnormal pap smears. Although the association is weak, it is an indication that there might be a connection between the expression of Bax and the development of cervical intraepithelial dysplasia, which warrants further investigation in larger-scale studies.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116329808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cytodiagnosis of isolated primary hydatid cyst of breast masquerading as a breast neoplasm: A rare case report 乳腺分离原发包虫囊肿伪装成乳腺肿瘤的细胞诊断:1例罕见病例报告

Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171248

Parvej Mujawar, K. Suryawanshi, DR DHIRAJ B NIKUMBH

引用次数: 10