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“Sea anemone-like ciliated tumor cells” in a case of serous cystadenocarcinoma of the ovary 卵巢浆液性囊腺癌一例“海葵样纤毛状肿瘤细胞”
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171247
U. Handa, S. Goyal, H. Mohan
{"title":"“Sea anemone-like ciliated tumor cells” in a case of serous cystadenocarcinoma of the ovary","authors":"U. Handa, S. Goyal, H. Mohan","doi":"10.4103/0970-9371.171247","DOIUrl":"https://doi.org/10.4103/0970-9371.171247","url":null,"abstract":"Address for correspondence: Dr. Shilpa Goyal, Department of Pathology, Government Medical College and Hospital, Sector 32, Chandigarh, Punjab and Haryana, India. E-mail: drshilpag@gmail.com Cilia, the organs of motility, are normally observed in many cell types including those of respiratory system, fallopian tubes, gastrointestinal tract, and inner ear.[1,2] They have also been demonstrated in benign lesions such as intestinal metaplasia of pyloric mucosa, endosalpingiosis, ciliated cysts, and tumors of müllerian origin.[1] Among the ovarian tumors, cilia have been well-documented on cytologic examination in cells of both benign and borderline neoplasms.[3–5] Only a few papers have documented the presence of ciliated tumor cells in ovarian adenocarcinoma.[3,6] We report such a rare case with well-formed cilia on tumor cells giving them a “sea anemone-like” appearance. These ciliated cells are an interesting finding and are a visual treat to the eyes of the cytopathologist as well.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122224991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of cell block preparation for improving adequacy of cytology smears 使用细胞块制剂提高细胞学涂片的充分性
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171259
A. Chowhan, R. Nandyala, R. Patnayak, Asha Thotta
{"title":"Use of cell block preparation for improving adequacy of cytology smears","authors":"A. Chowhan, R. Nandyala, R. Patnayak, Asha Thotta","doi":"10.4103/0970-9371.171259","DOIUrl":"https://doi.org/10.4103/0970-9371.171259","url":null,"abstract":"Sir, We read the article “Role of rapid on-site evaluation with cyto-histopathological correlation in diagnosis of lung lesion” by Chandra et al.[1] with interest and appreciate highlighting the importance of multidisciplinary approach with rapid on-site evaluation (ROSE). The authors have aptly described the advantages and limitations of cytology in diagnosing lung lesions. In this study, the on-site evaluation was done by cytopathologists after staining the smears with toluidine blue. Although there are a few similar studies available that have used Diff-Quick, ultrafast Papanicolaou, and brilliant cresyl blue stains,[2] one study by Hemalatha et al.[3] went one step further and tried to evaluate the adequacy on unstained smears. They performed microscopic examination under reduced illumination with low condenser. The authors concluded that this technique offers specific advantage in being rapid and avoiding the inordinate delay that is associated with assessing the sample adequacy after using cytological staining techniques.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132355968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of FNAC, fluid specimens, and cell blocks for cytological diagnosis of lung cancer in the present era FNAC、液体标本和细胞块在当代肺癌细胞学诊断中的作用
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-10-01 DOI: 10.4103/0970-9371.171219
N. Gupta, A. Sekar, A. Rajwanshi
{"title":"Role of FNAC, fluid specimens, and cell blocks for cytological diagnosis of lung cancer in the present era","authors":"N. Gupta, A. Sekar, A. Rajwanshi","doi":"10.4103/0970-9371.171219","DOIUrl":"https://doi.org/10.4103/0970-9371.171219","url":null,"abstract":"Cytoblocks prepared from residual tissue fluids and fine-needle aspirations can be useful adjuncts to smears for establishing a more definitive cytopathologic diagnosis. These paraffin embedded cytoblocks have been popular since these can be handled like any other histologic specimen. Rapid on-site evaluation (ROSE) can help in attaining adequate material in the cytoblock, which is a major concern to the cytopathologists. Ancillary studies can be done using cytoblocks including IHC and various molecular techniques. The opportunities for cytopathologists to influence therapy, and uncover strategies in the complex field of lung cancer are exciting and limitless especially in the presence of an adequate cytoblock","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128630679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience 感觉皮神经细针抽吸治疗汉森氏病的经验回顾分析
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168843
D. Prasoon, S. Mandal, P. Agrawal
{"title":"Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience","authors":"D. Prasoon, S. Mandal, P. Agrawal","doi":"10.4103/0970-9371.168843","DOIUrl":"https://doi.org/10.4103/0970-9371.168843","url":null,"abstract":"Background: Leprosy affects peripheral nerves. As Mycobacterium leprae has unique tropism for Schwann cells, thickened sensory cutaneous nerves provide an easy target for the detection of lepra bacilli and other changes associated with the disease. Materials and Methods: The data of patients with sensory cutaneous nerve involvement were retrieved from our record for the period January 2006 to December 2014. The hematoxylin and eosin (H and E)- and May-Grünwald-Giemsa (MGG)-stained slides were screened for Schwann cells, granuloma, and necrosis. Modified Ziehl-Neelsen (ZN)-stained smears were searched for lepra bacilli and globi. Morphological index was calculated in multibacillary lesions. Result: Twenty-nine sensory cutaneous nerves were aspirated in 23 patients. While 15 cases showed skin and nerve involvement, 8 cases showed only nerve involvement. Terminal cutaneous branch of the radial nerve was most often aspirated. No motor loss was observed after aspiration. Five cytologic pictures were seen — Epithelioid cell granuloma only in 6 cases, epithelioid cell granuloma with necrosis in 1 case, epithelioid cell granuloma with lepra bacilli in 3 cases, necrosis with lepra bacilli in 1 case, and only lepra bacilli in 12 cases. Morphological index ranged from 20% to 80%. Conclusion: Sensory cutaneous nerve fine-needle aspiration (FNA) is a feasible, viable, effective, and safe procedure. It adds to diagnostic FNA yield in patients with concomitant skin involvement and offers a way to evaluate patients with only nerve involvement. Calculation of morphological index allows prognostication and may have a role in assessing response to therapy and/or relapse.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130243484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Histoplasmosis presenting as isolated cervical lymphadenopathy: A rare presentation 组织胞浆菌病表现为孤立的颈部淋巴结病:一种罕见的表现
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168855
D. Mishra, S. Ramamurthy, S. Behera
{"title":"Histoplasmosis presenting as isolated cervical lymphadenopathy: A rare presentation","authors":"D. Mishra, S. Ramamurthy, S. Behera","doi":"10.4103/0970-9371.168855","DOIUrl":"https://doi.org/10.4103/0970-9371.168855","url":null,"abstract":"Histoplasmosis is an opportunistic fungal infection caused by inhaling the spores of a fungus called Histoplasma capsulatum. Disseminated histoplasmosis is the most common form associated with acquired immune deficiency syndrome (AIDS). Here, we report a case of histoplasmosis presenting as isolated cervical lymphadenopathy in a human immunodeficiency virus (HIV)-infected patient diagnosed by a less invasive method (fine-needle aspiration cytology) and confirmed by fungal culture of fine-needle aspiration material. Due to varied and nonspecific clinical manifestations of histoplasmosis, most of the infections are misdiagnosed or underreported. It has to be considered in differential diagnosis of cervical lymphadenopathy, particularly in immunocompromised patients so that patients can be treated medically at an early stage before dissemination occurs and unnecessary surgery can be avoided. Here, we present this case because of its rare presentation as isolated cervical lymphadenopathy and classical cytological picture.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132606186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Pleomorphic lipoma: A gentle giant of pathology 多形性脂肪瘤:一个温和的病理巨人
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168904
Uma Sakhadeo, Rajesh Mundhe, M. Desouza, R. Chinoy
{"title":"Pleomorphic lipoma: A gentle giant of pathology","authors":"Uma Sakhadeo, Rajesh Mundhe, M. Desouza, R. Chinoy","doi":"10.4103/0970-9371.168904","DOIUrl":"https://doi.org/10.4103/0970-9371.168904","url":null,"abstract":"Pleomorphic lipoma is a relatively rare adipocytic neoplasm, occurring predominantly in elderly males in the subcutaneous tissues of the neck or shoulder. To the best of our knowledge, only five cases have been reported in which the lesion was intramuscular. We hereby report a case of a 60-year-old female patient, presenting with an intramuscular, posterior shoulder mass. The aspirate showed a giant cell-rich lesion, admixed with short, plump-looking, spindly cells. There was no overt evidence of malignancy; however, the cell cytology was sufficiently atypical to warrant concern. Subsequent excision revealed a classical pleomorphic lipoma on histology with no evidence of malignancy. CD34 staining by immunohistochemistry further supported the diagnosis. Differential diagnosis and the cytological diagnostic pitfalls of pleomorphic lipomas have been discussed with a review of the literature.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"12 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126245466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Chromophobe renal cell carcinoma, oncocytic variant: Cytological and ultrastructural observations 嗜色性肾细胞癌，嗜瘤变异体:细胞学和超微结构观察
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168846
Tadanori Yamaguchi, E. Hirota, N. Kuroda
{"title":"Chromophobe renal cell carcinoma, oncocytic variant: Cytological and ultrastructural observations","authors":"Tadanori Yamaguchi, E. Hirota, N. Kuroda","doi":"10.4103/0970-9371.168846","DOIUrl":"https://doi.org/10.4103/0970-9371.168846","url":null,"abstract":"There is only one report on cytological findings of oncocytic variant of chromophobe renal cell carcinoma (RCC). In this article, we report a new case with focus on cytological, and ultrastructural findings. A 60-year-old Japanese man was found to have a right renal tumor on medical checkup. In imprint cytological materials, the smears consisted of slightly discohesive clusters and isolated tumor cells with granular green colored cytoplasm on Papanicolaou staining. Nuclei were generally round and centrally located in the cytoplasm, but nuclear irregularity or perinuclear halo was absent. Ultrastructurally, the tumor was full of mitochondria with tubulovesicular cristae. Fluorescence in situ hybridization study using histological material showed multiple chromosomal losses including chromosomes 7, 10, 13, and 17. This finding supports the hypothesis that this variant may ultrastructurally show the nature of chromophobe RCC rather than renal oncocytoma.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114806551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Grey zone lesions of breast: Potential areas of error in cytology 乳腺灰色区病变:细胞学上潜在的错误区域
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168812
S. Mitra, P. Dey
{"title":"Grey zone lesions of breast: Potential areas of error in cytology","authors":"S. Mitra, P. Dey","doi":"10.4103/0970-9371.168812","DOIUrl":"https://doi.org/10.4103/0970-9371.168812","url":null,"abstract":"Fine-needle aspiration cytology (FNAC) of the breast is a rapid, cost-effective, and sensitive procedure to diagnose breast lesions, and was widely employed to diagnose breast lesions in the past. However, in recent times, core needle biopsy of the breast is gaining popularity and acceptability, although FNAC still looms large. There are some intrinsic disadvantages to FNAC, of which the most important is probably difficulty in classification of a significant percentage of breast lesions. Such lesions are usually denoted by the rubric “grey zone lesions of the breast.” This article attempts to review these grey zone lesions and highlight the difficulties in diagnosing them.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123824741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Fine needle aspiration cytology of non-hematological neoplasms in pediatric age group: Our experience 小儿非血液学肿瘤的细针抽吸细胞学:我们的经验
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168841
Mimi Gangopadhyay, I. Chakrabarti, P. Ghosh, N. Ghosh, M. Sinha
{"title":"Fine needle aspiration cytology of non-hematological neoplasms in pediatric age group: Our experience","authors":"Mimi Gangopadhyay, I. Chakrabarti, P. Ghosh, N. Ghosh, M. Sinha","doi":"10.4103/0970-9371.168841","DOIUrl":"https://doi.org/10.4103/0970-9371.168841","url":null,"abstract":"Background: The role of aspiration cytology has largely been ignored in pediatric population. The present study was undertaken to evaluate the role of fine needle aspiration cytology (FNAC) in non-hematological neoplasms in children in our institution, which is a rural tertiary care center. Materials and Methods: A total of 88 cases of non-hematological pediatric mass lesions were studied in which cytopathological diagnosis could be corroborated with histopathology. Results: Out of all the cases, 70 (80%) cases were benign tumors and 18 (20%) were malignant tumors. Fibroadenoma (37.9%) comprised the majority of cases in the benign category while small round cell tumors (SRCTs) (44.4%) comprised the majority of cases in the malignant category. Definite diagnosis could be offered based on the cytomorphology in 79.5% cases, while in 20.5% of cases only a broad cytological classification could be offered. Among the malignant lesions, FNAC showed 100% sensitivity while a specific diagnosis was made in 90% of cases. Conclusion: FNAC proved to be a rapid and fairly accurate tool in diagnosing non-hematological tumors in the pediatric age group.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126400499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study 细胞学在肺腺癌诊断中的应用:一项三级保健中心的研究
Journal of Cytology / Indian Academy of Cytologists Pub Date : 2015-07-01 DOI: 10.4103/0970-9371.168838
S. Shukla, K. Malhotra, N. Husain, Anurag Gupta, N. Anand
{"title":"The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study","authors":"S. Shukla, K. Malhotra, N. Husain, Anurag Gupta, N. Anand","doi":"10.4103/0970-9371.168838","DOIUrl":"https://doi.org/10.4103/0970-9371.168838","url":null,"abstract":"Introduction: Pulmonary adenocarcinoma harbors various molecular abnormalities that include epidermal growth factor mutation, anaplastic lymphoma kinase gene re-arrangement, K-RAS mutations. The availability of targeted therapy against these molecular markers has revolutionized personalized medicine. Accurate cytological diagnosis of pulmonary adenocarcinoma will aid in utilising the cytology smears for molecular testing. Objective: The objective of this retrospective study was to evaluate the diagnostic efficacy of various cytology samples in the diagnosis of pulmonary adenocarcinoma. Materials and Methods: The study included a retrospective case series of 50 patients with biopsy proven non small cell lung carcinoma of adenocarcinoma subtype. The corresponding cytology reports of all the 50 cases were analyzed for different samples including broncho-alveolar lavage (BAL), bronchial washings, bronchial brush smears, pleural fluid, sputum and guided fine needle aspiration cytology (FNAC) of lung and metastatic lymph nodes. The overall cyto-diagnosis efficacy as well that of various cytological samples were analyzed. Results: Multiple cytology samples were received in 14 of 50 cases. The overall diagnostic efficacy of the various cytology samples in the diagnosis of malignancy was 78% and 66.6% cases were accurately typed as non small cell lung carcinoma-adenocarcinoma. The best cytological sample for the detection of pulmonary adenocarcinoma was bronchial brush smears which had a detection rate of 70%. In fine needle aspiration cytology samples and bronchial washings the detection rate was 65.5% and 25% respectively. Discussion and Conclusion: In cases where the cytological diagnosis is certain the tissue biopsies can be simultaneously tested for EGRF and ALK gene mutations. Repeat biopsies are often required due to small amount of tumor tissue or necrotic biopsies. Alternate use of cytological specimen for molecular testing can be done when a diagnosis of pulmonary adenocarcinoma is established.","PeriodicalId":182593,"journal":{"name":"Journal of Cytology / Indian Academy of Cytologists","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124382138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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