Mass Spectrometry Letters最新文献_第9页

Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry 用电喷雾电离质谱分析金属动力学的软电离

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Mass Spectrometry Letters Pub Date : 2015-06-30 DOI: 10.5478/MSL.2015.6.2.43

H. Abdelhamid, Hui-Fen Wu

引用次数: 15

Mass Spectrometric Determination of Zn 2+ Binding/Dissociation Constant for Zinc Finger Peptides 锌指肽中zn2 +结合/解离常数的质谱测定

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Mass Spectrometry Letters Pub Date : 2015-03-30 DOI: 10.5478/MSL.2015.6.1.7

Choong Sik Lee, Soojin Park, Jae Young Lee, Sungsu Park, K. Jo, H. Oh

引用次数: 2

The Stabilizing Role of Cyclodextrins on Keggin Phosphotungstic Acid by Complexation Unveiled by Electrospray Mass Spectrometry 电喷雾质谱法揭示环糊精对Keggin磷钨酸络合的稳定作用

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Mass Spectrometry Letters Pub Date : 2015-03-30 DOI: 10.5478/MSL.2015.6.1.13

Yanxuan Fan, Yan Zhang, Qiaodi Jia, Jie Cao, Wenjie Wu

引用次数: 4

Amino-β-cyclodextrin Complex Assisted Ionization for Labile Sesamins and their Ion-mobility Separation in ESI Q-TOF MS 氨基-β-环糊精配合物辅助电离不稳定芝麻素及其离子迁移率ESI Q-TOF质谱分离

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Mass Spectrometry Letters Pub Date : 2015-03-30 DOI: 10.5478/MSL.2015.6.1.17

Kohtaro Sugahara, M. Horikawa, T. Yamagaki

引用次数: 3

Characterizations of Two-step Matrix Application Procedures for Imaging Mass Spectrometry 成像质谱的两步矩阵应用程序的表征

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Mass Spectrometry Letters Pub Date : 2015-03-30 DOI: 10.5478/MSL.2015.6.1.21

S. Shimma

引用次数: 0

Direct Analysis in Real Time Mass Spectrometry: a Powerful Tool for Fast Analysis 实时质谱直接分析:快速分析的强大工具

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Mass Spectrometry Letters Pub Date : 2015-03-30 DOI: 10.5478/MSL.2015.6.1.1

Xianjiang Li, Xin Wang, Linnan Li, Yu Bai, Huwei Liu

引用次数: 29

Evaluation of MALDI Biotyping for Rapid Subspecies Identification of Carbapenemase-Producing Bacteria via Protein Profiling MALDI生物分型在碳青霉烯酶产生菌亚种快速鉴定中的应用

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Mass Spectrometry Letters Pub Date : 2014-12-30 DOI: 10.5478/MSL.2014.5.4.110

A. Somboro, D. Tiwari, A. Shobo, L. Bester, H. G. Kruger, T. Govender, S. Essack

{"title":"Evaluation of MALDI Biotyping for Rapid Subspecies Identification of Carbapenemase-Producing Bacteria via Protein Profiling","authors":"A. Somboro, D. Tiwari, A. Shobo, L. Bester, H. G. Kruger, T. Govender, S. Essack","doi":"10.5478/MSL.2014.5.4.110","DOIUrl":"https://doi.org/10.5478/MSL.2014.5.4.110","url":null,"abstract":"The method of direct mass spectrometry profiling is reliable and reproducible for the rapid identification of clinical isolates of bacteria and fungi. This is the first study evaluating the approach of MALDI-TOF mass spectrometry profiling for rapid identification of carbapenemase-resistant enterobacteriaceae (CRE). Proof of concept was achieved by the discrimination of CRE using MALDI Biotyper MS based on the protein. This profiling appears promising by the visual observation of consist- ent unique peaks, albeit low intensity, that could be picked up from the mean spectra (MSP) method. The Biotyper MSP creation and identification methods needed to be optimized to provide significantly improved differences in scores to allow for subspe- cies identification with and without carbapenemases. These spectra were subjected to visual peak picking and in all cases; there were pertinent differences in the presence or absence of potential biomarker peaks to differentiate isolates. We also evaluated this method for potential discrimination between different carbapenemases bacteria, utilizing the same strategy. Based on our data and pending further investigation in other CREs, MALDI-TOF MS has potential as a diagnostic tool for the rapid identification of even closely related carbapenemases but would require a paradigm shift in which Biotyper suppliers enable more flexible software control of mass spectral profiling methods.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86509689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Solid Phase Extraction of Phospholipids from Brazil Nut (Bertholletia excelsa) and Their Characterization by Mass Spectrometry Analysis 巴西坚果磷脂的固相萃取及质谱分析

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Mass Spectrometry Letters Pub Date : 2014-12-30 DOI: 10.5478/MSL.2014.5.4.115

B. R. Lima, F. Silva, H. H. F. Koolen, R. A. Almeida, A. D. L. Souza

{"title":"Solid Phase Extraction of Phospholipids from Brazil Nut (Bertholletia excelsa) and Their Characterization by Mass Spectrometry Analysis","authors":"B. R. Lima, F. Silva, H. H. F. Koolen, R. A. Almeida, A. D. L. Souza","doi":"10.5478/MSL.2014.5.4.115","DOIUrl":"https://doi.org/10.5478/MSL.2014.5.4.115","url":null,"abstract":"The Brazil nut (Bertholletia excelsa - Lecythidaceae) is considered a product with high economic value, being a food widely appreciated for its nutritional qualities. Although previous studies have reported the biochemical composition of Brazil nut oil, the knowledge regarding the phospholipid composition exhibits a disagreement: the composition of fatty acids present in the structures of phospholipids is reported as being different from the composition of the free fatty acids present in the oil. In this work, solid phase extraction (SPE) was employed to provide a fast extraction of the phospholipids from Brazil nuts, in order to compare the phospholipid profile of the in nature nuts and their fatty acids precursor present in the oil. The major phospholipids were characterized by mass spectrometry approach. Their fragmentation pattern through direct infusion electrospray ionization ion-trap tandem mass spectrometry (ESI-IT-MS 2 ) proved to be useful to unequivocal characterization of these substances. High resolution (HR) experiments through ESI using a quadruple time of flight mass spectrometry (QTOF) system were performed to reinforce the identifications.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78062881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Study on the Interference of Water Vapor on the Chemical Ionization of OH by Sulfur Hexafluoride Ion 水蒸气对六氟化硫离子OH化学电离干扰的实验研究

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Mass Spectrometry Letters Pub Date : 2014-12-30 DOI: 10.5478/MSL.2014.5.4.120

Jong-Ho Park

引用次数: 1

Simultaneous Determination of Methylphenidate, Amphetamine and their Metabolites in Urine using Direct Injection Liquid Chromatography-Tandem Mass Spectrometry 直接注射液相色谱-串联质谱法同时测定尿中哌甲酯、安非他明及其代谢物

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Mass Spectrometry Letters Pub Date : 2014-12-30 DOI: 10.5478/MSL.2014.5.4.104

Woonyong Kwon, Sungill Suh, M. In, Jin Young Kim

{"title":"Simultaneous Determination of Methylphenidate, Amphetamine and their Metabolites in Urine using Direct Injection Liquid Chromatography-Tandem Mass Spectrometry","authors":"Woonyong Kwon, Sungill Suh, M. In, Jin Young Kim","doi":"10.5478/MSL.2014.5.4.104","DOIUrl":"https://doi.org/10.5478/MSL.2014.5.4.104","url":null,"abstract":"Nonmedical use of prescription stimulants such as methylphenidate (MPH) and amphetamine (AP) by normal per- sons has been increased to improve cognitive functions. Due to high potential for their abuse, reliable analytical methods were required to detect these prescription stimulants in biological samples. A direct injection liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and implemented for simultaneous determination of MPH, AP and their metabolites ritalinic acid (RA) and 4-hydroxyamphetamine (HAP) in human urine. Urine sample was centrifuged and the upper layer (100 µL) was mixed with 800 µL of distilled water and 100 µL of internal standards (0.2 µg/mL in methanol). The mixture was then directly injected into the LC-MS/MS system. The mobile phase was composed of 0.2% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Capcell Pak MG-II C18 (150 mm × 2.0 mm i.d., 5 µm, Shiseido) column and all analytes were eluted within 5 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve and the assay was linear from 20 to 1500 ng/mL (HAP), 40-3000 ng/mL (AP and RA) and 2-150 ng/mL (MPH). The intra- and inter-day precisions were within 16.4%. The intra- and inter-day accuracies ranged from -15.6% to 10.8%. The limits of detection for all the analytes were less than 4.7 ng/mL. The suitability of the method was examined by analyzing urine samples from drug abusers.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84579471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1