Malacca Pharmaceutics最新文献

Exploring the Medicinal Potential of Blumea balsamifera: Insights from Molecular Docking and Molecular Dynamics Simulations Analyses 探索香脂树的药用潜力：分子对接和分子动力学模拟分析的启示

Malacca Pharmaceutics Pub Date : 2024-03-31 DOI: 10.60084/mp.v2i1.168

N. B. Maulydia, K. Khairan, T. Tallei, Salaswati Salaswati, Annisa Musdalifah, Fiki Farah Nabila, R. Idroes

{"title":"Exploring the Medicinal Potential of Blumea balsamifera: Insights from Molecular Docking and Molecular Dynamics Simulations Analyses","authors":"N. B. Maulydia, K. Khairan, T. Tallei, Salaswati Salaswati, Annisa Musdalifah, Fiki Farah Nabila, R. Idroes","doi":"10.60084/mp.v2i1.168","DOIUrl":"https://doi.org/10.60084/mp.v2i1.168","url":null,"abstract":"Blumea balsamifera from the Ie-Jue geothermal area in Aceh Province, Indonesia, has been reported to have a variety of secondary metabolites. However, there is limited information about the activity of these chemical metabolites from B. balsamifera. The aim of this study is to evaluate the therapeutic potential of these compounds using molecular docking and molecular dynamics simulations. Six selective compounds were thoroughly evaluated using molecular docking techniques for their inhibitory effects on both Coronavirus protease and human interleukin receptors. Additionally, druglikeness assessments based on the Lipinski rule of five were performed to evaluate these six ligands. Our results show that stigmasterol, a key component of B. balsamifera, has demonstrated low binding free energy values across four receptors. Furthermore, molecular dynamics simulations confirmed the stability of the top ligand-receptor complex, particularly stigmasterol-1IRA, based on five parameters, indicating its stability as an inhibitor. This research highlights the potential of stigmasterol as a therapeutic agent derived from medicinal plants of B. balsamifera and underscores the value of our molecular approach in identifying opportunities for pharmaceutical development.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"85 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140360393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Pharmacology Approach to Understanding the Antidiabetic Effects of Pineapple Peel Hexane Extract 用网络药理学方法了解菠萝皮己烷提取物的抗糖尿病作用

Malacca Pharmaceutics Pub Date : 2024-03-29 DOI: 10.60084/mp.v2i1.162

Christa Hana Angle Pendong, E. Suoth, Fatimawali Fatimawali, T. Tallei

{"title":"Network Pharmacology Approach to Understanding the Antidiabetic Effects of Pineapple Peel Hexane Extract","authors":"Christa Hana Angle Pendong, E. Suoth, Fatimawali Fatimawali, T. Tallei","doi":"10.60084/mp.v2i1.162","DOIUrl":"https://doi.org/10.60084/mp.v2i1.162","url":null,"abstract":"The increased interest in exploring alternative treatments for type 2 diabetes mellitus is accompanied by a rise in the prevalence of type 2 diabetes mellitus. Pineapple peel is one of the by-products of pineapple fruit and is known to possess potential for anti-diabetic activity. In this study, the n-hexane extract of pineapple peel was analyzed using network pharmacology methods to ascertain its potential in treating type 2 diabetes mellitus. The GC-MS analysis of the n-hexane extract of pineapple peel revealed the presence of 42 compounds, with 8 of them considered safe as they met the Lipinski Rule of Five criteria for drug-likeness and were classified as safe with toxicity levels in classes IV and V. The pineapple peel extract targeted 55 proteins related to type 2 diabetes mellitus (DMT2), potentially affecting DMT2 through the AGE-RAGE pathway in diabetes complications and insulin resistance. Network pharmacology analysis identified five genes targeted by pineapple peel, namely MAPK1, JAK2, MAPK8, PRKCD, and PPARA. Among these genes, MAPK1 exhibited a higher overall score than the others. Apart from its role in diabetes, MAPK1 is also implicated in cancer.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"25 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140367061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Efficacy of Clerodendrum minahassae Ethanol Extract on Insulin Regulation in Diabetic Wistar Rats 评估小檗乙醇提取物对糖尿病 Wistar 大鼠胰岛素调节的功效

Malacca Pharmaceutics Pub Date : 2024-03-25 DOI: 10.60084/mp.v2i1.137

Chrisa P. Rumangu, Fatimawali Fatimawali, A. Manampiring, B. Kepel, Fona Dwiana Hermina Budiarso, W. Bodhi

{"title":"Evaluating the Efficacy of Clerodendrum minahassae Ethanol Extract on Insulin Regulation in Diabetic Wistar Rats","authors":"Chrisa P. Rumangu, Fatimawali Fatimawali, A. Manampiring, B. Kepel, Fona Dwiana Hermina Budiarso, W. Bodhi","doi":"10.60084/mp.v2i1.137","DOIUrl":"https://doi.org/10.60084/mp.v2i1.137","url":null,"abstract":"Leilem plant (Clerodendrum minahassae Teisjm & Binn.) from the genus Clerodendrum has the potential as antidiabetic, antihypertensive, anti-inflammatory, antioxidant, antimalarial, antitumor, antidiarrheal, antimicrobial and antihyperlipidemic. This study aimed to see the effect of ethanol extract of Clerodendrum minahassae (CM) leaves on increasing insulin levels in diabetic Wistar rats induced with streptozotocin. This study was conducted in vivo, using 20 rats as experimental animals. The experimental animals were divided into four groups, namely the negative control group (Na-CMC 0.5%), the ethanol extract group of leilem leaves 250 mg and 500 mg, and the positive control group (glibenclamide) as a comparison. Each experimental animal was induced streptozotocin intraperitoneally; then, each solution was given for 14 days according to the test group. After the treatment, the animals were terminated for blood collection; the blood was then centrifuged to obtain blood plasma serum. Blood plasma serum was measured by the ELISA Kit (Rat/Mouse Insulin) method, and then the results were read on a spectrophotometric device. The results of the sample insulin concentration obtained showed that 250 mg/kgBW and 500 mg/kgBW of the CM ethanol extract group could increase insulin levels in diabetic Wistar rats, the same as the positive control group glibenclamide. In contrast, the Na-CMC 0.5% as a negative control group did not show a significant increase in insulin levels. Leilem leaves can be developed for further research on their antidiabetic activity both in vitro, in vivo, and in silico, as well as their toxicity.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potent Antimicrobial Spectrum of Patchouli: Systematic Review of Its Antifungal, Antibacterial, and Antiviral Properties 广藿香的强效抗菌谱：对其抗真菌、抗菌和抗病毒特性的系统回顾

Malacca Pharmaceutics Pub Date : 2024-03-16 DOI: 10.60084/mp.v2i1.156

Pati Kemala, R. Idroes, K. Khairan, Muliadi Ramli*, T. Tallei, Z. Helwani, Sunarti Abd Rahman

{"title":"The Potent Antimicrobial Spectrum of Patchouli: Systematic Review of Its Antifungal, Antibacterial, and Antiviral Properties","authors":"Pati Kemala, R. Idroes, K. Khairan, Muliadi Ramli*, T. Tallei, Z. Helwani, Sunarti Abd Rahman","doi":"10.60084/mp.v2i1.156","DOIUrl":"https://doi.org/10.60084/mp.v2i1.156","url":null,"abstract":"ntention towards natural essential oils from medicinal plants has increased rapidly over the past decade as these oils have antimicrobial and antioxidant properties against various chronic diseases. One essential oil source with antimicrobial properties is the essential oil from Pogostemon cablin (Blanco) Benth. This review aims to provide information on using patchouli oil as an antimicrobial against bacterial, fungal, and viral pathogens in the last five years. There were 37 articles found in the PUBMED database by June 15, 2023. After searching, 6 of them were duplicates. A total of 2 papers were inaccessible, 4 were not research articles, and five were excluded because they were irrelevant to the scope of this study. This review shows that research related to patchouli as an antimicrobial in the last five years involves Pogostemon cablin leaf samples as silver nanoparticle bioreductors. Patchouli oil is used in membrane, nanocomposite film, and starch hydrogel manufacturing. Patchouli oil is a prestigious antimicrobial agent because it can fight numerous pathogenic microbes from bacteria, fungi, and viruses.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140390963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population: A Comprehensive Meta-Analysis 益生菌及其在降低老年人腹泻患病率方面的作用：综合元分析

Malacca Pharmaceutics Pub Date : 2024-03-14 DOI: 10.60084/mp.v2i1.143

Devika Muliana, V. D. Mulia, Hijra Novia Suardi, Nanda Ayu Puspita, S. Suryawati

{"title":"Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population: A Comprehensive Meta-Analysis","authors":"Devika Muliana, V. D. Mulia, Hijra Novia Suardi, Nanda Ayu Puspita, S. Suryawati","doi":"10.60084/mp.v2i1.143","DOIUrl":"https://doi.org/10.60084/mp.v2i1.143","url":null,"abstract":"Diarrhea is an atypical state of the digestive system characterized by a soft or watery texture in bowel movements. Antibiotic-related diarrhea is common in the elderly due to extensive antibiotic use. Probiotics are vital microorganisms that support the intestinal flora and reduce bacterial colonization in the intestinal wall. This study aimed to assess the effectiveness, type, and dose of probiotics for diarrhea in the elderly. A systematic review with meta-analysis was conducted using PubMed, ScienceDirect, and Google Scholar. Seven records with a total of 2,087 participants were included. A quantitative analysis was carried out using Review Manager version 5 software. A meta-analysis was conducted to assess the frequency of diarrhea. The results showed that using probiotics significantly reduced the risk of antibiotic-related diarrhea 0.53 times compared to the placebo administration (OR 0.53; CI 95% 0.29 to 0.98; I2 = 70%). The type of probiotics frequently given was the genera of Lactobacillus, Bifidobacterium, and Streptococcus, with consumption durations varying from 3 days to a maximum of 4 weeks. The dose of probiotics ranged from a minimum of 1.0 × 10⁶ CFU to a maximum dose of 2 × 10¹⁰ CFU. To conclude, probiotic administration is more effective than placebo in reducing the risk of antibiotic-related diarrhea in the elderly.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction 菊花提取物及其馏分的体外抗氧化活性

Malacca Pharmaceutics Pub Date : 2023-07-19 DOI: 10.60084/mp.v1i2.26

Jeclin Inebel Dolongtelide, Fatimawali Fatimawali, T. Tallei, E. Suoth, H. Simbala, I. Antasionasti, Marko Jeremia Kalalo

{"title":"In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction","authors":"Jeclin Inebel Dolongtelide, Fatimawali Fatimawali, T. Tallei, E. Suoth, H. Simbala, I. Antasionasti, Marko Jeremia Kalalo","doi":"10.60084/mp.v1i2.26","DOIUrl":"https://doi.org/10.60084/mp.v1i2.26","url":null,"abstract":"Chrysanthemum indicum L., commonly known as Chrysanthemum flower, is an herbaceous plant that has a long-established history of medicinal usage. There has been extensive research about C. indicium L, especially about its antioxidant activities, but not much has been done on its fraction. This study aimed to explore the efficacy of the ethanol extract and its fraction derived from Chrysanthemum flowers in scavenging free radicals. The antioxidant potential of the ethanol extract, as well as its aqueous and n-hexane fractions, was evaluated using the 2,2-diphenyl-1-picrilhidrazine (DPPH) method in vitro. The degree of antioxidant activity was quantified by determining the IC50 value, which corresponds to the concentration of the extract or fractions required to inhibit 50% of DPPH free radicals. The results obtained from this investigation provide strong evidence that the ethanolic extract, as well as its aqueous and n-hexane fractions, exhibited significant antioxidant activity. The measured IC50 values for the ethanolic extract, aqueous fraction, and n-hexane fraction were 1.350 µg/mL, 1.109 µg/mL, and 7.588 µg/mL, respectively.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139357524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Usage of Medicinal Plants and Herbal Products in Aceh to Address COVID-19 Symptoms: A Cross-Sectional Survey 调查亚齐使用药用植物和草药产品治疗 COVID-19 症状的情况：横断面调查

Malacca Pharmaceutics Pub Date : 2023-07-18 DOI: 10.60084/mp.v1i2.38

S. Suryawati, Ahmad Rasydi, Nanda Ayu Puspita, T. Hertiani

{"title":"Investigating the Usage of Medicinal Plants and Herbal Products in Aceh to Address COVID-19 Symptoms: A Cross-Sectional Survey","authors":"S. Suryawati, Ahmad Rasydi, Nanda Ayu Puspita, T. Hertiani","doi":"10.60084/mp.v1i2.38","DOIUrl":"https://doi.org/10.60084/mp.v1i2.38","url":null,"abstract":"Medicinal plants have been used worldwide as supportive therapy in reducing symptoms of various diseases, including COVID-19 symptoms. The objective of this study was to investigate the use of medicinal plants and herbal products in respondents who experienced symptoms of COVID-19 in Aceh, Indonesia. A cross-sectional study was conducted, involving 384 respondents from the age group over 18 years old residing in Aceh Province, Indonesia. Data was collected via an online questionnaire consisting of 4 structured questions to assess the types and names of medicinal plants, the time of use, and the purpose of using medicinal plants. The results showed that nearly half of the study population (181 respondents) consumed medicinal plants and commercial products, mainly for the reason to enhance their immunity (49.7%), followed by to overcome the COVID-19 symptoms (26.7%). Amongst all medicinal remedies mentioned in this study, Ginger (Zingiber officinale) and turmeric (Curcuma longa) are the most widely used, which were consumed by 65.5% of medicinal plant and herbal products users. The other medicinal plant chosen by the study population were lemon (Citrus lemon), Java Ginger/temulawak (Curcuma zanthorrhiza), and Habbatus sauda (Nigella sativa). Although the majority of the respondents had used the herbal remedies prior contracting COVID-19 symptoms (45.5%), a third of the respondents consumed traditional medicine during the symptomatic period only (less than two weeks). This study has demonstrated the characteristics of the consumption of medicinal plants and their commercial products in Aceh, during the occurrence of COVID-19 symptoms in the study population.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139358294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Antibacterial Activity of Averrhoa bilimbi L. Fruits Extract in Vegetable Oil-Based Liquid Hand Soap 油基洗手液中大黄果提取物的配方及抗菌活性研究

Malacca Pharmaceutics Pub Date : 2023-06-19 DOI: 10.60084/mp.v1i1.35

Rima Hayati, A. Sari, F. Hanum, Nada Nabilah, Nanda Earlia, E. Lukitaningsih

{"title":"Formulation and Antibacterial Activity of Averrhoa bilimbi L. Fruits Extract in Vegetable Oil-Based Liquid Hand Soap","authors":"Rima Hayati, A. Sari, F. Hanum, Nada Nabilah, Nanda Earlia, E. Lukitaningsih","doi":"10.60084/mp.v1i1.35","DOIUrl":"https://doi.org/10.60084/mp.v1i1.35","url":null,"abstract":"The main method of preventing infections is good hand cleanliness. Bilimbi (Averrhoa bilimbi) fruits contains flavonoids, which have been tested for antibacterial activity. Polar chemicals like flavonoids are often extracted using ethanol as a solvent. Therefore, this study aimed to formulate an ethanol extract of A. bilimbi fruits in the form of hand soap. This formulation used vegetable oils such as olive oil, coconut oil, and castor oil, which are high in fatty acids to maintain healthy skin. Antibacterial activity was carried out against Staphylococcus aureus and Escherichia coli. The extract was prepared by maceration for 5 days using an ethanol solvent. Liquid soap contained A. bilimbi fruit extracts at 5% (F1) and 10% (F2). The F1 and F2 organoleptic tests showed the preparation as a thick liquid with a distinctive coconut oil aroma, light brown (F1) and brown (F2) color. pH values of 5.8 (F1) and 5.6 (F2). Foam height stability was 71.5% (F1) and 73.1% (F2). The specific gravity for the two formulas was 1.02 g/mL. The viscosity of F1 and F2 was 137.6 cP and 163.5 cP, respectively. Inhibition power against S. aureus using the agar diffusion method by measuring the diameter of the inhibition zone showed strong (F1) and very strong (F2) categories The inhibition against S. aureus showed strong (F1) and very strong (F2) categories. While F1 has no inhibitory power against E. coli, F2 showed inhibition in the strong category. Based on our research, it can be concluded that A. bilimbi fruit extract can produce good hand soap and have bacteria-inhibiting activity. However, further formula development is still needed to obtain preparations that meet all the requirements and stability tests.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128764394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia 印尼亚齐省Bener Meriah产正己烷龙血树脂提取物的抑菌活性研究

Malacca Pharmaceutics Pub Date : 2023-06-17 DOI: 10.60084/mp.v1i1.29

K. Khairan, Musfira Arini, R. Idroes, Khalijah Awang, Claus Jacob

{"title":"Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia","authors":"K. Khairan, Musfira Arini, R. Idroes, Khalijah Awang, Claus Jacob","doi":"10.60084/mp.v1i1.29","DOIUrl":"https://doi.org/10.60084/mp.v1i1.29","url":null,"abstract":"The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115405189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prediction of Pharmacokinetic Parameters from Ethanolic Extract Mane Leaves (Vitex pinnata L.) in Geothermal Manifestation of Seulawah Agam Ie-Seu’um, Aceh 亚齐白荆荆叶乙醇提取物在地温表现中的药动学参数预测

Malacca Pharmaceutics Pub Date : 2023-06-16 DOI: 10.60084/mp.v1i1.33

N. B. Maulydia, K. Khairan, T. R. Noviandy

{"title":"Prediction of Pharmacokinetic Parameters from Ethanolic Extract Mane Leaves (Vitex pinnata L.) in Geothermal Manifestation of Seulawah Agam Ie-Seu’um, Aceh","authors":"N. B. Maulydia, K. Khairan, T. R. Noviandy","doi":"10.60084/mp.v1i1.33","DOIUrl":"https://doi.org/10.60084/mp.v1i1.33","url":null,"abstract":"The Mane plant (Vitex pinnata L.) is traditionally used as medicine in Aceh Province, Indonesia. This study aimed to predict the pharmacokinetic parameters of compounds in the ethanolic extract of Mane leaf (EEML), including the absorption, distribution, metabolism, excretion, and toxicity (ADMET), by in-silico approach. The method used was to analyze the compounds using a web-predictor server and molecular docking. Gas chromatography-mass spectrometry (GCMS) analysis of EEML showed the presence of active compounds, including phytol (60.93%), acorenol (8.56%), n-hexadecanoic acid (4.89%), trans-Z-alpha-bisabolene epoxide (2.7%) and cedrane (2.03%). Lipinski's rule of five states that all compounds had a deviation of less than 2. Pharmacokinetic parameters suggested that phytol was moderately absorbed in the gastrointestinal tract and had a toxicity level of 5 with lethal doses (LD50) >5000 mg/kg. Molecular docking results showed that phytol could be used against the targeted enzyme Staphylococcus aureus. In conclusion, our study suggests that the active compounds of EEML may have potential as a drug candidate.","PeriodicalId":182386,"journal":{"name":"Malacca Pharmaceutics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127046191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8