Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia

Malacca Pharmaceutics Pub Date : 2023-06-17 DOI:10.60084/mp.v1i1.29

K. Khairan, Musfira Arini, R. Idroes, Khalijah Awang, Claus Jacob

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引用次数: 2

Abstract

The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.

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印尼亚齐省Bener Meriah产正己烷龙血树脂提取物的抑菌活性研究

龙血树脂(Daemonorops draco wild Blume)在民间医学中被用于抗菌、抗病毒、抗炎、胃肠疾病、血液循环障碍、抗肿瘤和癌症等药理活性。本研究旨在评价正己烷龙血树脂提取物对金黄色葡萄球菌ATCC 25923、大肠杆菌ATCC 25922和白色念珠菌10231的抑菌活性。本研究的另一个目的是测定正己烷龙血树脂提取物的次生代谢产物化合物。正己烷龙血树脂提取物对金黄色葡萄球菌ATCC 25923、大肠杆菌ATCC 25922和白色念珠菌10231的抑菌活性在15%浓度时均达到了抑制直径13.20 mm;21.3毫米;分别为13.0 mm。植物化学物质筛选表明，提取物中含有黄酮类化合物的次生代谢产物。气相色谱-质谱分析表明，正己烷龙血树脂提取物中含有48种化学成分，在RT 26处的化合物为龙血素化合物(c17h18o3)，质量比为m/z 270 g/mol。综上所述，正己烷龙血树脂提取物是抗细菌和真菌的良好选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Malacca Pharmaceutics

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