Network Pharmacology Approach to Understanding the Antidiabetic Effects of Pineapple Peel Hexane Extract

Malacca Pharmaceutics Pub Date : 2024-03-29 DOI:10.60084/mp.v2i1.162

Christa Hana Angle Pendong, E. Suoth, Fatimawali Fatimawali, T. Tallei

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Abstract

The increased interest in exploring alternative treatments for type 2 diabetes mellitus is accompanied by a rise in the prevalence of type 2 diabetes mellitus. Pineapple peel is one of the by-products of pineapple fruit and is known to possess potential for anti-diabetic activity. In this study, the n-hexane extract of pineapple peel was analyzed using network pharmacology methods to ascertain its potential in treating type 2 diabetes mellitus. The GC-MS analysis of the n-hexane extract of pineapple peel revealed the presence of 42 compounds, with 8 of them considered safe as they met the Lipinski Rule of Five criteria for drug-likeness and were classified as safe with toxicity levels in classes IV and V. The pineapple peel extract targeted 55 proteins related to type 2 diabetes mellitus (DMT2), potentially affecting DMT2 through the AGE-RAGE pathway in diabetes complications and insulin resistance. Network pharmacology analysis identified five genes targeted by pineapple peel, namely MAPK1, JAK2, MAPK8, PRKCD, and PPARA. Among these genes, MAPK1 exhibited a higher overall score than the others. Apart from its role in diabetes, MAPK1 is also implicated in cancer.

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用网络药理学方法了解菠萝皮己烷提取物的抗糖尿病作用

随着 2 型糖尿病发病率的上升，人们对探索 2 型糖尿病的替代疗法越来越感兴趣。菠萝皮是菠萝果实的副产品之一，具有潜在的抗糖尿病活性。本研究采用网络药理学方法分析了菠萝皮的正己烷提取物，以确定其治疗 2 型糖尿病的潜力。菠萝果皮正己烷萃取物的气相色谱-质谱分析显示，其中含有 42 种化合物，其中 8 种化合物符合药物相似性的利平斯基五项原则标准，被归类为毒性水平在 IV 级和 V 级的安全化合物。菠萝果皮萃取物针对 55 种与 2 型糖尿病（DMT2）相关的蛋白质，可能通过 AGE-RAGE 通路影响 DMT2 在糖尿病并发症和胰岛素抵抗中的作用。网络药理学分析确定了菠萝皮针对的五个基因，即 MAPK1、JAK2、MAPK8、PRKCD 和 PPARA。在这些基因中，MAPK1 的总得分高于其他基因。除了在糖尿病中的作用外，MAPK1 还与癌症有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Malacca Pharmaceutics

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