Materials science & engineering. C, Materials for biological applications最新文献_第5页

Delivery of coenzyme Q10 with mitochondria-targeted nanocarrier attenuates renal ischemia-reperfusion injury in mice 线粒体靶向纳米载体递送辅酶Q10可减轻小鼠肾缺血再灌注损伤

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112536

Zhaohui Liu, Yan Li, Chunlei Li, Lili Yu, Yulin Chang, Min Qu

{"title":"Delivery of coenzyme Q10 with mitochondria-targeted nanocarrier attenuates renal ischemia-reperfusion injury in mice","authors":"Zhaohui Liu, Yan Li, Chunlei Li, Lili Yu, Yulin Chang, Min Qu","doi":"10.1016/j.msec.2021.112536","DOIUrl":"10.1016/j.msec.2021.112536","url":null,"abstract":"<div><p>Ischemia-reperfusion (I/R) injury causes high morbidity, mortality, and healthcare costs. I/R induces acute kidney injury through exacerbating the mitochondrial damage and increasing inflammatory and oxidative responses. Here, we developed the mitochondria-targeted nanocarrier to delivery of Coenzyme Q10 (CoQ10) for renal I/R treatment in animal model. The mitochondria-targeted TPP CoQ10 nanoparticles (T-NP<sub>CoQ10</sub>) were synthesized through ABC miktoarm polymers method and characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The I/R mouse model and oxygen-glucose deprivation/reperfusion (D/R) model were created to examine the role of T-NP<sub>CoQ10</sub> on renal I/R. Mitochondrial DNA damage, apoptosis, and inflammatory cytokines were measured in I/R injury mice. Plasma creatinine, urea nitrogen, tubular injury score was tested to assess the renal function. T-NP<sub>CoQ10</sub> nanoparticles could be delivered to renal mitochondria preciously and efficiently. T-NP<sub>CoQ10</sub> administration attenuated oxidative injury in both cell and animal models significantly, alleviated mtDNA damage, suppressed inflammatory and apoptotic responses, and improved renal function. The mitochondria specific CoQ10 delivery provided a precious and efficient method for protecting inflammatory and oxidative responses of I/R-induced renal damage.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112536"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006767/pdfft?md5=3679848fb04952b471f8448473bdc16d&pid=1-s2.0-S0928493121006767-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Spinal cord injury target-immunotherapy with TNF-α autoregulated and feedback-controlled human umbilical cord mesenchymal stem cell derived exosomes remodelled by CRISPR/Cas9 plasmid. 用CRISPR/Cas9质粒重塑的TNF-α自调节和反馈控制的人脐带间充质干细胞来源的外泌体靶向免疫治疗脊髓损伤

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112624

Baocheng Wang, Minmin Chang, Renwen Zhang, Jin Wo, Bo Wu, Hua Zhang, Zhigang Zhou, Zhi-Zhong Li, Feng Zhang, Cheng Zhong, Shujie Tang, Shuxian Yang, Guodong Sun

引用次数: 15

Enhanced activity of AZD5582 and SM-164 in rabies virus glycoprotein-lactoferrin-liposomes to downregulate inhibitors of apoptosis proteins in glioblastoma. 增强狂犬病毒糖蛋白-乳铁蛋白脂质体AZD5582和SM-164活性，下调胶质母细胞瘤细胞凋亡抑制蛋白。

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112615

Y. Kuo, Yin-Jung Lee, R. Rajesh

引用次数: 7

Effect of silicon content on the microstructure evolution, mechanical properties, and biocompatibility of β-type TiNbZrTa alloys fabricated by laser powder bed fusion. 硅含量对激光粉末床熔敷制备β型TiNbZrTa合金显微组织演变、力学性能和生物相容性的影响

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112625

X. Luo, C. Yang, R. Li, H. Wang, H. Z. Lu, T. Song, H. W. Ma, D. D. Li, A. Gebert, Y. Y. Li

引用次数: 10

Bacteria capture with magnetic nanoparticles modified with cationic carbosilane dendritic systems. 用阳离子碳硅烷枝晶系统修饰的磁性纳米颗粒捕获细菌。

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112622

Sara Quintana-Sánchez, A. Barrios-Gumiel, J. Sánchez-Nieves, J. Copa-Patiño, F. J. de la Mata, R. Gómez

引用次数: 10

Incorporation of magnesium oxide nanoparticles into electrospun membranes improves pro-angiogenic activity and promotes diabetic wound healing. 将氧化镁纳米颗粒掺入电纺丝膜可提高促血管生成活性，促进糖尿病伤口愈合。

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112609

Mingyue Liu, Ruilan Wang, Jiajie Liu, Weixing Zhang, Zhengni Liu, X. Lou, Huali Nie, Hongsheng Wang, X. Mo, A. Abd-Elhamid, Rui Zheng, Jinglei Wu

引用次数: 17

Physical and chemical properties of carbon nanotubes in view of mechanistic neuroscience investigations. Some outlook from condensed matter, materials science and physical chemistry 从机械神经科学的角度研究碳纳米管的物理化学性质。从凝聚态物质、材料科学和物理化学的角度展望

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112480

Stefano A. Mezzasalma , Lucia Grassi , Mario Grassi

{"title":"Physical and chemical properties of carbon nanotubes in view of mechanistic neuroscience investigations. Some outlook from condensed matter, materials science and physical chemistry","authors":"Stefano A. Mezzasalma , Lucia Grassi , Mario Grassi","doi":"10.1016/j.msec.2021.112480","DOIUrl":"10.1016/j.msec.2021.112480","url":null,"abstract":"<div><p>The open border between non-living and living matter, suggested by increasingly emerging fields of nanoscience interfaced to biological systems, requires a detailed knowledge of nanomaterials properties. An account of the wide spectrum of phenomena, belonging to physical chemistry of interfaces, materials science, solid state physics at the nanoscale and bioelectrochemistry, thus is acquainted for a comprehensive application of carbon nanotubes interphased with neuron cells. This review points out a number of conceptual tools to further address the ongoing advances in coupling neuronal networks with (carbon) nanotube meshworks, and to deepen the basic issues that govern a biological cell or tissue interacting with a nanomaterial. Emphasis is given here to the properties and roles of carbon nanotube systems at relevant spatiotemporal scales of individual molecules, junctions and molecular layers, as well as to the point of view of a condensed matter or materials scientist. Carbon nanotube interactions with blood-brain barrier, drug delivery, biocompatibility and functionalization issues are also regarded.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112480"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006202/pdfft?md5=eeda0b6e508404ddef5c7237d2691dfe&pid=1-s2.0-S0928493121006202-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A balanced charged hydrogel with anti-biofouling and antioxidant properties for treatment of irradiation-induced skin injury 一种具有抗生物污垢和抗氧化特性的平衡带电水凝胶，用于治疗辐射引起的皮肤损伤

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112538

Jiamin Zhang , Yingnan Zhu , Yumin Zhang , Wenjing Lin , Jia Ke , Jianfeng Liu , Lei Zhang , Jinjian Liu

{"title":"A balanced charged hydrogel with anti-biofouling and antioxidant properties for treatment of irradiation-induced skin injury","authors":"Jiamin Zhang , Yingnan Zhu , Yumin Zhang , Wenjing Lin , Jia Ke , Jianfeng Liu , Lei Zhang , Jinjian Liu","doi":"10.1016/j.msec.2021.112538","DOIUrl":"10.1016/j.msec.2021.112538","url":null,"abstract":"<div><p>Skin injury caused by large doses of ionizing radiation is the common and severe side effect of radiotherapy. However, its therapeutic efficacy is always hindered by early reactive oxygen species generation, repetitive inflammatory microenvironment and bacterial infection risk. Herein, we report an anti-biofouling hydrogel with anti-inflammation and anti-oxidative properties for the treatment of irradiation-induced skin injury. The anti-biofouling hydrogel can be achieved by balancing oppositely charged alginate, hyaluronic acid (HA) and polylysine (PLL) at the optimal ratio, which effectively resist protein and bacterial adhesion, and evades immune response. Moreover, curcumin and epigallocatechin gallate (EGCG) can be facially encapsulated and substantially released from the hydrogel. Results showed that the resulting AHP-Cur/EGCG hydrogel can significantly weaken the development of skin injury and accelerate its healing process by alleviating inflammation, scavenging ROS and promoting angiogenesis. Therefore, the findings presented in this work provide an effective strategy for clinical management and treatment of ionizing radiation-induced skin injury.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112538"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006780/pdfft?md5=9caa1fdf33dd982f4a04709962360902&pid=1-s2.0-S0928493121006780-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing 载mof α-硫辛酸壳聚糖基水凝胶可促进糖尿病创面愈合

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112519

Qianyun Li , Kun Liu , Tao Jiang , Sen Ren , Yu Kang , Wenqing Li , Haibo Yao , Xiaofan Yang , Honglian Dai , Zhenbing Chen

{"title":"Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing","authors":"Qianyun Li , Kun Liu , Tao Jiang , Sen Ren , Yu Kang , Wenqing Li , Haibo Yao , Xiaofan Yang , Honglian Dai , Zhenbing Chen","doi":"10.1016/j.msec.2021.112519","DOIUrl":"10.1016/j.msec.2021.112519","url":null,"abstract":"<div><p>The difficulty of wound healing in patients with diabetes mellitus remains a considerable challenge for clinical and scientific research. To address the problem of poor healing that affects chronic wounds in patients with diabetes, we developed an injectable self-healing hydrogel based on chitosan (CS), hyaluronic acid (HA), and kalium γ-cyclodextrin metal organic frameworks (K-γ-CD-MOFs) loaded α-lipoic acid (α-LA) with antibacterial activity and antioxidant performance. In <em>vitro</em> analysis showed that the hydrogel could promote cell proliferation and migration on the basis of Cell Counting Kit-8 (CCK-8) assay and Transwell experiments. Moreover, the addition of α-LA allowed the reversal of oxidative stress-induced cell damage. In <em>vivo</em> analyses were performed involving a full-thickness wound model in diabetic Sprague–Dawley (SD) rats. The hydrogel dressing significantly promoted the wound healing process with better granulation tissue formation and more collagen deposition because of its multifunctional traits, suggesting that it can be an excellent treatment for chronic full-thickness skin wound healing.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112519"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006597/pdfft?md5=b52df23a40b08feb9bd3ba45b057ca76&pid=1-s2.0-S0928493121006597-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Development of light-degradable poly(urethane-urea) hydrogel films 光降解聚脲-尿素水凝胶膜的研制

IF 7.9 1区工程技术

Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI: 10.1016/j.msec.2021.112520

Carlos T.B. Paula , Patrícia Pereira , Jorge F.J. Coelho , Ana C. Fonseca , Arménio C. Serra

{"title":"Development of light-degradable poly(urethane-urea) hydrogel films","authors":"Carlos T.B. Paula , Patrícia Pereira , Jorge F.J. Coelho , Ana C. Fonseca , Arménio C. Serra","doi":"10.1016/j.msec.2021.112520","DOIUrl":"10.1016/j.msec.2021.112520","url":null,"abstract":"<div><p>Biocompatible hydrogels are exciting platforms that have stood out in recent years for their outstanding potential for biomedical applications. For these applications, the ability of the material to respond to an external stimulus can be a relevant addition. This responsiveness allows the material to modify its physical properties in such a way that it can deliver molecules that support the healing process or allow easy removal of the films from the tissue. Among the polymers used to produce these systems, polyurethane (PU) and polyurethane-urea (PUU) are some of the most cited examples. In this work, a new hydrogel-sensitive PUU film is proposed. These films are prepared from polyethylene glycol (PEG) and contain a ROS-responsive telechelic β-aminoacrylate bond. The hydrogel films showed interesting mechanical and thermal properties, good water uptake and low cytotoxicity, which makes them suitable for biomedical applications. More importantly, the hydrogel films exhibited a light-degradable profile through an innovative ROS-mediated cleavage process, as indicated by the loss of mechanical properties.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112520"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006603/pdfft?md5=ed4e30849a8e892fe67d7d9290f80c89&pid=1-s2.0-S0928493121006603-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5