Materials science & engineering. C, Materials for biological applications最新文献

{"title":"Macromolecular modulation of a 3D hydrogel construct differentially regulates human stem cell tissue-to-tissue interface.","authors":"D. Pereira, J. Silva-Correia, J. Oliveira, R. Reis, A. Pandit","doi":"10.1016/j.msec.2021.112611","DOIUrl":"https://doi.org/10.1016/j.msec.2021.112611","url":null,"abstract":"","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"66 1","pages":"112611"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73377975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralized collagen as a bioactive ink to support encapsulation of human adipose stem cells: A step towards the future of bone regeneration.","authors":"G. S. Diogo, Catarina F Marques, Sara Freitas-Ribeiro, C. G. Sotelo, R. Pérez-Martín, R. Pirraco, R. Reis, T. H. Silva","doi":"10.1016/j.msec.2021.112600","DOIUrl":"https://doi.org/10.1016/j.msec.2021.112600","url":null,"abstract":"","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"29 1","pages":"112600"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78783812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of GNRs-PEI/cGAMP-laden macrophages-based photothermal induced in situ tumor vaccines and immune checkpoint blockade for synergistic anti-tumor immunotherapy.","authors":"C. Jin, Yan Zhang, Guangxing Zhang, Bin Wang, Peiyan Hua","doi":"10.1016/j.msec.2021.112603","DOIUrl":"https://doi.org/10.1016/j.msec.2021.112603","url":null,"abstract":"","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"331 1","pages":"112603"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91226583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of curcumin-quaternized carbon quantum dots with enhanced broad-spectrum antibacterial activity for promoting infected wound healing.","authors":"Lina Wu, Yaoran Gao, Chengfei Zhao, Dandan Huang, Wenxin Chen, Xinhua Lin, Ailin Liu, Liqing Lin","doi":"10.1016/j.msec.2021.112608","DOIUrl":"https://doi.org/10.1016/j.msec.2021.112608","url":null,"abstract":"","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"2008 1","pages":"112608"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82514434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of multifunctional ursolic acid with kinase inhibitors for anti-cancer drug carrier vesicles","authors":"A. Lőrincz ,&nbsp;J. Mihály ,&nbsp;A. Wacha ,&nbsp;Cs. Németh ,&nbsp;B. Besztercei ,&nbsp;P. Gyulavári ,&nbsp;Z. Varga ,&nbsp;I. Peták ,&nbsp;A. Bóta","doi":"10.1016/j.msec.2021.112481","DOIUrl":"10.1016/j.msec.2021.112481","url":null,"abstract":"<div><p>A sterically stabilized unilamellar nanocarrier vesicle (SSV) system containing dipalmitoylphosphatidylcholine, cholesterol, ursolic acid and PEGylated phospholipid has been developed by exploiting the structural advantages of ursolic acid: by spontaneously attaching to the lipid head groups, it induces curvature at the outer side of the bilayers, allowing the preparation of size-limited vesicles without extrusion. Ursolic acid (UA) also interacts with the PEG chains, supporting steric stabilization even when the amount of PEGylated phospholipid is reduced. Using fluorescence immunohistochemistry, vesicles containing ursolic acid (UA-SSVs) were found to accumulate in the tumor in 3 h on xenografted mouse, suggesting the potential use of these vesicles for passive tumor targeting.</p><p>Further on, mono- and combination therapy with UA and six different kinase inhibitors (crizotinib, erlotinib, foretinib, gefitinib, refametinib, trametinib) was tested on seven cancer cell-lines. In most combinations synergism was observed, in the case of trametinib even at very low concentration (0.001 μM), which targets the MAPK pathway most often activated in human cancers. The coupled intercalation of UA and trametinib (2:1 molar ratio) into vesicles causes further structural advantageous molecular interactions, promoting the formation of small vesicles. The high drug:lipid molar ratio (~0.5) in the novel type of co-delivery vesicles enables their direct medical application, possibly also overcoming the multidrug resistance effect.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112481"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006214/pdfft?md5=f80964ca9ae7e8a45c706644c80297d5&pid=1-s2.0-S0928493121006214-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable nanocomposite hydrogels as an emerging platform for biomedical applications: A review","authors":"Amir Mellati ,&nbsp;Elham Hasanzadeh ,&nbsp;Mazaher Gholipourmalekabadi ,&nbsp;Seyed Ehsan Enderami","doi":"10.1016/j.msec.2021.112489","DOIUrl":"10.1016/j.msec.2021.112489","url":null,"abstract":"<div><p>Hydrogels have attracted much attention for biomedical and pharmaceutical applications due to the similarity of their biomimetic structure to the extracellular matrix of natural living tissues, tunable soft porous microarchitecture, superb biomechanical properties, proper biocompatibility, <em>etc.</em> Injectable hydrogels are an exciting type of hydrogels that can be easily injected into the target sites using needles or catheters in a minimally invasive manner. The more comfortable use, less pain, faster recovery period, lower costs, and fewer side effects make injectable hydrogels more attractive to both patients and clinicians in comparison to non-injectable hydrogels. However, it is difficult to achieve an ideal injectable hydrogel using just a single material (<em>i.e.</em>, polymer). This challenge can be overcome by incorporating nanofillers into the polymeric matrix to engineer injectable nanocomposite hydrogels with combined or synergistic properties gained from the constituents. This work aims to critically review injectable nanocomposite hydrogels, their preparation methods, properties, functionalities, and versatile biomedical and pharmaceutical applications such as tissue engineering, drug delivery, and cancer labeling and therapy. The most common natural and synthetic polymers as matrices together with the most popular nanomaterials as reinforcements, including nanoceramics, carbon-based nanostructures, metallic nanomaterials, and various nanosized polymeric materials, are highlighted in this review.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112489"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006299/pdfft?md5=ff8c7cc495a09a0b0d1ed679a2f40410&pid=1-s2.0-S0928493121006299-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional 3D printed porous GelMA/xanthan gum based dressing with biofilm control and wound healing activity","authors":"Zhenming Yang ,&nbsp;Xuehong Ren ,&nbsp;Yu Liu","doi":"10.1016/j.msec.2021.112493","DOIUrl":"10.1016/j.msec.2021.112493","url":null,"abstract":"<div><p>Bacterial infections are the major challenges of wound treatment in current clinical applications. In this study, Three-dimensional (3D) antibacterial wound dressing has been fabricated <em>via</em> introducing N-halamine/TiO₂ to gelatin methacrylate and xanthan gum. The prepared 3D printed dressings showed ideal swelling ratio and excellent water uptake efficiency. TiO₂ nanoparticles were introduced by <em>in-situ</em> to improve the ultraviolet stability of N-halamines. The 3D printed GX2-TiO₂-PSPH-Cl prepared dressings containing titanium dioxide retained 0.19% active chlorine after ultraviolet irradiation for 20 min, which was much higher than that of N-halamine dressings without the addition of TiO₂. The 3D printed dressings showed good antibacterial activity, and 100% of <em>Escherichia coli</em> O157:H7 and <em>Staphylococcus aureus</em> were inactivated after 60 min of contact. Furthermore, the biofilm test indicated that the 3D antibacterial dressings were able to inhibit the formation of bacterial biofilm. The 3D printed dressings possess outstanding biocompatibility. Moreover, <em>in vivo</em> data demonstrated that the 3D printed dressings could significantly accelerate wound healing in a mouse model, indicating that the developed 3D printed dressings are ideal candidates for wound treatment.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112493"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006330/pdfft?md5=ff06e051d666d83ad986da4de0dd66eb&pid=1-s2.0-S0928493121006330-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically retained and glucose-fueled hydroxyl radical nanogenerators for H2O2-self-supplying chemodynamic therapy of wound infections","authors":"Minhui Gong ,&nbsp;Jiayu Xiao ,&nbsp;Huan Li ,&nbsp;Luo Hai ,&nbsp;Ke Yang ,&nbsp;Junqin Li ,&nbsp;Zefeng Wang ,&nbsp;Le Deng ,&nbsp;Dinggeng He","doi":"10.1016/j.msec.2021.112522","DOIUrl":"10.1016/j.msec.2021.112522","url":null,"abstract":"<div><p>Chemodynamic therapy (CDT) involving the highly toxic hydroxyl radical (<img>OH) has exhibited tremendous potentiality in combating bacterial infection. However, its antibacterial efficacy is still unsatisfactory due to the insufficient H₂O₂ levels and near neutral pH at infection site. Herein, a glucose-fueled and H₂O₂-self-supplying <img>OH nanogenerator (pFe₃O₄@GOx) based on cascade catalytic reactions is developed by immobilizing glucose oxidase (GOx) on the surface of PAA-coated Fe₃O₄ (pFe₃O₄). Magnetic pFe₃O₄ can act as a horseradish peroxidase-like nanozyme, catalyzing the decomposition of H₂O₂ into <img>OH under acidic conditions for CDT. The immobilized GOx can continuously convert non-toxic glucose into gluconic acid and H₂O₂, and the former improves the catalytic activity of pFe₃O₄ nanozymes by decreasing pH value. The self-supplying H₂O₂ molecules effectively enhance the <img>OH generation, resulting in the high antibacterial efficacy. <em>In vitro</em> studies demonstrate that the pFe₃O₄@GOx conducts well in reducing pH value and improving H₂O₂ level for self-enhanced CDT. Moreover, the cascade catalytic reaction of pFe₃O₄ and GOx effectively avoids strong toxicity caused by directly adding high concentrations of H₂O₂ for CDT. It is worth mentioning that the pFe₃O₄@GOx performs highly efficient <em>in vivo</em> CDT of bacteria-infected wound <em>via</em> the localized long-term magnetic retention at infection site and causes minimal toxicity to normal tissues at therapeutic doses. Therefore, the developed glucose-fueled <img>OH nanogenerators are a potential nano-antibacterial agent for the treatment of wound infections.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112522"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006627/pdfft?md5=0a9c7c6cff7b62784165710b70807afe&pid=1-s2.0-S0928493121006627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing.","authors":"Xin Geng, Ye Qi, Xintong Liu, Yijie Shi, Hong-dan Li, Liang Zhao","doi":"10.1016/j.msec.2021.112613","DOIUrl":"https://doi.org/10.1016/j.msec.2021.112613","url":null,"abstract":"","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"19 1","pages":"112613"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75647528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermosensitive hydrogel-functionalized gold nanorod/mesoporous MnO2 nanoparticles for tumor cell-triggered drug delivery","authors":"Zheng Zhang ,&nbsp;Yuanhui Ji ,&nbsp;Chengqi Lin ,&nbsp;Li Tao","doi":"10.1016/j.msec.2021.112504","DOIUrl":"10.1016/j.msec.2021.112504","url":null,"abstract":"<div><p>MnO₂ owns distinct redox, imaging, and degradable properties corresponding to the tumor microenvironment. However, the onefold structure and non-modifiable property cause many obstacles to anticancer applications. In this report, we first prepared a typical core-shell gold nanorod (GNR)/manganese dioxide (MnO₂) nanoparticles (GNR/MnO₂ NPs). Interestingly, the MnO₂ had a mesoporous channel and modifiable hydroxyl group (<img>OH). Here, the unique ‘<img>OH’ groups were modified and further grafted with poly(N-isopropylacrylamide-<em>co</em>-acrylic acid) (PNA). As a dual-sensitive hydrogel, it was selected as the thermal/pH-sensitive component in the hybrid nanoparticles (GNR/MnO₂/PNA NPs). The anticancer drug doxorubicin hydrochloride (DOX) was selected and loaded into the hybrid nanoparticles (GNR/MnO₂/PNA-DOX NPs). The GNR/MnO₂/PNA NPs achieved satisfying drug-loading efficiency and glutathione (GSH)/pH/thermal-responsive drug-controlled release. As a side benefit, the GNR/MnO₂/PNA NPs showed potential as excellent near-infrared (NIR)-excited nanoplatforms for photothermal therapy (PTT). Delightedly, the studies demonstrated that the GNR/MnO₂/PNA-DOX NPs showed a noticeable killing effect on tumor cells, whether it is tumor cell-triggered drug release or photothermal effect. Besides, it not only could enhance mitochondrial damage but also could inhibit the migration and invasion of tumor cells. Quite the reverse, it had little negative impact on normal cells. The feature can prevent anticancer drugs and nanoparticles from killing normal cells. Consequently, GNR/MnO₂/PNA NPs have potential applications in drug delivery and synergistic therapy due to these advantageous features.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":"131 ","pages":"Article 112504"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0928493121006445/pdfft?md5=dab961dd176f30892b4889c38b9ab850&pid=1-s2.0-S0928493121006445-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}