Liver Pub Date : 1988-04-01

J H Henriksen, N A Lassen

引用次数: 0

Cyanamide hepatotoxicity. Incidence and clinico-pathological features. 氰氨化肝毒性。发病率及临床病理特征。

Liver Pub Date : 1987-08-01

M Bruguera, A Parés, D Heredia, J Rodés

引用次数: 0

Hepatic venous oxygen content in alcoholic cirrhosis and non-cirrhotic alcoholic liver disease. 酒精性肝硬化和非肝硬化酒精性肝病的肝静脉氧含量。

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00339.x

F Bendtsen, J H Henriksen, A Widding, K Winkler

引用次数: 17

Lymphokines and bile secretion in the rat. 大鼠的淋巴因子和胆汁分泌。

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00335.x

V K Rustgi, D B Jones, C A Dinarello, J H Hoofnagle

引用次数: 10

Identification of different degrees of hepatitis B virus (HBV) replication by serological (HBV-DNAp, HBcAg and HBV-DNA) and histological (HBcAg) methods. 采用血清学(HBV- dnap、HBcAg和HBV- dna)和组织学(HBcAg)方法鉴定不同程度的乙型肝炎病毒(HBV)复制。

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00338.x

J A Quiroga, J Bartolomé, J C Porres, I Mora, J Gutiez, C Hernández Guio, V Carreño

{"title":"Identification of different degrees of hepatitis B virus (HBV) replication by serological (HBV-DNAp, HBcAg and HBV-DNA) and histological (HBcAg) methods.","authors":"J A Quiroga, J Bartolomé, J C Porres, I Mora, J Gutiez, C Hernández Guio, V Carreño","doi":"10.1111/j.1600-0676.1987.tb00338.x","DOIUrl":"https://doi.org/10.1111/j.1600-0676.1987.tb00338.x","url":null,"abstract":"The incidence of HBV-DNA polymerase, HBV-DNA and serum and liver HBcAg in 104 chronic HBsAg carriers was studied. HBV-DNA was the most frequently detected marker, followed by HBcAg and HBV-DNAp. According to their individual or combined presence, four different serological patterns of viral replication were discerned: 53 patients had all these markers, 30 had HBV-DNA but lacked HBV-DNAp (15 with and 15 without HBcAg) and 21 had no such markers detectable. The simultaneous positivity for all of those markers was observed only in HBeAg-positive patients. HBV-DNA alone or along with HBcAg was found in a similar incidence irrespective of the HBe system. Liver HBcAg was found in all but four patients with and in four without HBV-DNA. Viral DNA concentration was significantly (p less than 0.001) higher when HBV-DNAp tested positive. Indeed, HBeAg rather than anti-HBe patients had higher (p less than 0.005) levels of HBV-DNA. In HBeAg-positive patients, the nuclear HBcAg staining was significantly (p less than 0.05) higher when HBV-DNAp tested positive. In DNA polymerase-negative patients, but positive for HBV-DNA, those with or without HBcAg had a similar percentage of core antigen staining. The same distribution was seen in anti-HBe, HBV-DNA-positive patients. However, the mean percentage of hepatocytes displaying cytoplasmic HBcAg did not differ significantly among patients with HBV-DNA, irrespective of the HBe system and the HBV-DNAp status. Such patients had significantly (p less than 0.001) higher ALT levels than those without viral DNA.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":18183,"journal":{"name":"Liver","volume":"7 3","pages":"169-75"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0676.1987.tb00338.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14735921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Possible infectious causes in 651 patients with acute viral hepatitis during a 10-year period (1976-1985). 1976-1985年间651例急性病毒性肝炎患者可能的感染原因

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00337.x

K Kiyosawa, Y Gibo, T Sodeyama, K Furuta, H Imai, H Yoda, Y Koike, K Yoshizawa, S Furuta

{"title":"Possible infectious causes in 651 patients with acute viral hepatitis during a 10-year period (1976-1985).","authors":"K Kiyosawa, Y Gibo, T Sodeyama, K Furuta, H Imai, H Yoda, Y Koike, K Yoshizawa, S Furuta","doi":"10.1111/j.1600-0676.1987.tb00337.x","DOIUrl":"https://doi.org/10.1111/j.1600-0676.1987.tb00337.x","url":null,"abstract":"Six hundred and fifty-one patients with acute viral hepatitis were identified serologically between January 1976 and December 1985. Of these, 109 (17%) had hepatitis A, 135 (21%) had hepatitis B, and 407 (62%) had hepatitis non-A, non-B. The possible infectious causes for acquisition of viral hepatitis occurring within 6 months before the onset of hepatitis were analysed. Approximately 80% of cases of hepatitis A and 70% of hepatitis B had no known risk factor, while in 67% of cases of hepatitis non-A, non-B possible risk factors for infection were documented. Infectious causes for hepatitis A were ingestion of raw shellfish (11%) and previous familial contact with patients with hepatitis A (10%). For hepatitis B, risk factors included medicare (24%), such as transfusion, surgical operation, accidental needle stick and acupuncture, and sexual contact (6%). For hepatitis non-A, non-B, the most important infectious cause was medical procedures (65%). The numbers of hospital employees were 2 (2%) with hepatitis A, 15 (11%) with hepatitis B and 14 (3%) with hepatitis non-A, non-B. These data suggest that hepatitis non-A, non-B can be a kind of nosocomial disease.","PeriodicalId":18183,"journal":{"name":"Liver","volume":"7 3","pages":"163-8"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0676.1987.tb00337.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14243580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man. 用吲哚菁绿估计人肝血流和ICG清除率的方法学问题。

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00336.x

C Skak, S Keiding

{"title":"Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man.","authors":"C Skak, S Keiding","doi":"10.1111/j.1600-0676.1987.tb00336.x","DOIUrl":"https://doi.org/10.1111/j.1600-0676.1987.tb00336.x","url":null,"abstract":"Liver blood flow (Q) is often measured by constant infusion of ICG (i), concentration measurements in an artery (A) and a hepatic vein (V): Q = (A-V)/A. Some authors use ICG clearance, Cl = i/A, as a measure of Q assuming complete hepatic extraction. During the infusion, the ICG concentration often increases. The importance of this for calculated values of Q and Cl was examined, and the use of Cl as a measure of Q was reevaluated. ICG was given as 0.06-0.20 mumol/min to 52 subjects with liver disease, and about 0.20 mumol/min to 86 subjects with no liver disease. ICG concentration increased steeply during the first 90 min after start of the infusion; thereafter the increment was constant as evaluated in successive 40-min periods in eleven 320-min studies (analysis of variance P greater than 0.5); on average, 6 +/- 1% per hour (+/- SD). Q was not time-dependent (P greater than 0.5). ICG clearance decreased significantly, on average 5 +/- 2% per hour (+/- SD). Hepatic extraction fraction, (A-V)/A, (measurement period 90-130 min) was 0.34 +/- 0.21 in liver patients (+/- SD) and 0.61 +/- 0.80 in controls. Cl and Q were positively correlated in both groups but with substantial scatter. Thus, not only is the calculated ICG clearance time-dependent but the extraction fraction is further so low and variable, that any use of ICG clearance as a measure of liver flow is not justified.","PeriodicalId":18183,"journal":{"name":"Liver","volume":"7 3","pages":"155-62"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0676.1987.tb00336.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14735920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 102

Diagnosis of acute type B hepatitis by a solid phase u-antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study. 针对乙型肝炎核心抗原的IgM类抗体，采用固相u抗体捕获放射免疫分析法诊断急性乙型肝炎:一项基于前瞻性研究的诊断建议

Liver Pub Date : 1987-06-01 DOI: 10.1111/j.1600-0676.1987.tb00340.x

C M Chu, Y F Liaw, C Y Yang, I S Sheen

{"title":"Diagnosis of acute type B hepatitis by a solid phase u-antibody capture radioimmunoassay for IgM class antibody to hepatitis B core antigen: a diagnostic proposal based on a prospective study.","authors":"C M Chu, Y F Liaw, C Y Yang, I S Sheen","doi":"10.1111/j.1600-0676.1987.tb00340.x","DOIUrl":"https://doi.org/10.1111/j.1600-0676.1987.tb00340.x","url":null,"abstract":"The diagnostic and prognostic significance of IgM anti-HBc, studied by a solid phase u-antibody capture radioimmunoassay at a serum dilution of 1:4000, was prospectively evaluated in 73 adult patients with acute hepatitis seropositive for hepatitis B surface antigen (HBsAg). Of the 73 cases, 20 (27.4%) cleared their HBsAg within 6 months, while the remaining 53 (72.6%) did not. HBsAg seroconversion to its antibody occurred in 15 (93.8%) of the 16 patients positive for IgM anti-HBc with S/N ratios above 5.0, as did 5 (26.3%) of the 19 with S/N ratios between 2.1 to 5.0, and none (0%) of the 38 negative for IgM anti-HBc (S/N ratios less than 2.1). Therefore, a S/N ratio of IgM anti-HBc above 5.0 is diagnostic for acute type B hepatitis. However, low S/N ratios (2.1-5.0) of IgM anti-HBc were observed in the early stage of some patients with acute type B hepatitis, and would increase to a level greater than 5.0 when assayed again 1-2 weeks later. It was therefore suggested that repeated testing of anti-HBc IgM is mandatory for accurate diagnosis of acute type B hepatitis in patients whose initial serum specimens showed low S/N ratios of IgM anti-HBc. According to this criterion, only 22 (30.1%) of the 73 patients with acute hepatitis seropositive for HBsAg in Taiwan were true acute type B hepatitis, of whom 2 (9.1%) subsequently became chronic HBsAg carriers, while the remaining 51 (69.9%) were chronic HBsAg carriers with other superimposed forms of acute hepatic injury.","PeriodicalId":18183,"journal":{"name":"Liver","volume":"7 3","pages":"182-7"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0676.1987.tb00340.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14735923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Glandular elements around the intrahepatic bile ducts in man; their morphology and distribution in normal livers. 人肝内胆管周围的腺体成分;正常肝脏的形态和分布。

Liver Pub Date : 1987-02-01 DOI: 10.1111/j.1600-0676.1987.tb00308.x

T Terada, Y Nakanuma, G Ohta

引用次数: 122

Differential diagnosis of jaundice: applicability of the Copenhagen Pocket Chart proved in Stockholm patients. 黄疸的鉴别诊断:哥本哈根袖珍图在斯德哥尔摩患者中的适用性证明。

Liver Pub Date : 1987-02-01 DOI: 10.1111/j.1600-0676.1987.tb00314.x

G Lindberg, C Thomsen, A Malchow-Møller, P Matzen, J Hilden

{"title":"Differential diagnosis of jaundice: applicability of the Copenhagen Pocket Chart proved in Stockholm patients.","authors":"G Lindberg, C Thomsen, A Malchow-Møller, P Matzen, J Hilden","doi":"10.1111/j.1600-0676.1987.tb00314.x","DOIUrl":"https://doi.org/10.1111/j.1600-0676.1987.tb00314.x","url":null,"abstract":"This paper shows that an algorithm for differential diagnosis of jaundice developed in Denmark has been successfully transferred for use in a Swedish hospital. The algorithm, which is based on data from nearly 1000 patients, utilises 21 items of information from the medical history, physical examination and blood chemistry. The algorithm recognises four diagnostic groups: benign obstructive jaundice, malignant obstructive jaundice, acute non-obstructive jaundice, and chronic non-obstructive jaundice. To each item of information, a score is attached reflecting its weight of evidence. Summing the scores for the symptoms and signs that are present leads to a probabilistic statement about the diagnosis. Because of missing data in the Swedish patient material, three of the items were excluded from the original algorithm. Corrections were made for differences in the distribution of diseases. In reclassification of 985 Danish patients the modified algorithm's \"best bid\", i.e. the diagnosis given the highest probability, was correct in 78% of cases. More important, 93% of the cases given a \"confident\" diagnosis (probability greater than 0.80) were correct. The corresponding figures when the algorithm was applied to Swedish patients were 76% and 93%, respectively. In both series the predicted probabilities were matched by a corresponding proportion of actual diagnostic hits. It is concluded that the algorithm leads to reliable estimates of diagnostic probabilities in jaundice and that the algorithm seems to work well in Sweden also.","PeriodicalId":18183,"journal":{"name":"Liver","volume":"7 1","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0676.1987.tb00314.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14675795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

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