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Histopathology of the intrahepatic biliary tree. 肝内胆道树的组织病理学。
Liver Pub Date : 1983-06-01
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引用次数: 0
Spontaneous "primary biliary cirrhosis" in rabbits. 兔自发性“原发性胆汁性肝硬化”。
Liver Pub Date : 1982-06-01
V Tison, F Callea, C Morisi, A M Mancini, V J Desmet
{"title":"Spontaneous \"primary biliary cirrhosis\" in rabbits.","authors":"V Tison,&nbsp;F Callea,&nbsp;C Morisi,&nbsp;A M Mancini,&nbsp;V J Desmet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A syndrome resembling human Primary Biliary Cirrhosis (PBC) and occurring spontaneously in a strain of domesticated rabbits from the Faenza region in Italy, is reported. The syndrome is characterized by histological liver changes consisting of chronic non-suppurative destructive cholangitis and copper accumulation, biochemical and immunological abnormalities mainly represented by an elevation of serum alkaline phosphatase and a positive antimitochondrial antibody test. The abnormalities were not observed in newborn rabbits from the same area nor in control rabbits from the island of Sardinia. A toxic effect related to some environmental factor may be responsible for the disease. Alternatively, a continuous process of partial inbreeding among consanguineous animals may have resulted in a selection of a strain genetically predisposed to the development of PBC. Whatever the etiology, the domesticated Faenza rabbit proves to be an interesting animal model for a chronic nonsuppurative destructive cholangitis, very similar to the human disease known as PBC.</p>","PeriodicalId":18183,"journal":{"name":"Liver","volume":"2 2","pages":"152-61"},"PeriodicalIF":0.0,"publicationDate":"1982-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18193746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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