Magnetic resonance imaging最新文献

{"title":"Relationships between diffusion tensor parameters and measures of skeletal muscle fiber size and strength after anterior cruciate ligament injury","authors":"Meredith K. Owen ,&nbsp;Peter A. Hardy ,&nbsp;Bruce M. Damon ,&nbsp;Thorsten Feiweier ,&nbsp;McKenzie S. White ,&nbsp;Nicholas T. Thomas ,&nbsp;Christopher S. Fry ,&nbsp;Brian Noehren","doi":"10.1016/j.mri.2025.110489","DOIUrl":"10.1016/j.mri.2025.110489","url":null,"abstract":"<div><div>Alterations in skeletal muscle morphology after an anterior cruciate ligament (ACL) tear are a major contributing factor to protracted quadriceps muscle weakness limiting person's return to function. Microstructural changes in skeletal muscle are difficult to assess noninvasively, but understanding these changes is vital to provide clinicians with additional information to assess injury and guide recovery.</div><div>The purpose of this study was to evaluate the potential of magnetic resonance diffusion tensor imaging to provide noninvasive metrics of quadriceps muscle morphology and strength. Following a primary ACL tear and prior to surgical reconstruction, 44 individuals underwent bilateral isometric knee extension testing, vastus lateralis muscle biopsies, and diffusion tensor magnetic resonance of the thighs. Significant between limb differences were identified for quadriceps strength, fractional anisotropy, mean diffusivity, radial diffusivity, pooled fiber cross-sectional area, and pooled fiber minimum feret diameter. Fractional anisotropy and radial diffusivity were significantly associated with isometric knee extension peak torque for both limbs, after adjusting for mass. Fractional anisotropy was also significantly associated pooled cross-sectional area in the ACL-deficient limb only, after adjusting for mass. Our findings suggest that fractional anisotropy, mean diffusivity, and radial diffusivity can differentiate between the vastus lateralis of an ACL-injured limb and the healthy limb. Additionally, fractional anisotropy exhibited relationships with both measures of vastus lateral muscle fiber size and quadriceps strength for the ACL-deficient limb. These finding suggest that measures of diffusivity may be used cross-sectionally to infer between limb differences after an ACL-injury and that FA may be used to infer knee extensor strength.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110489"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward standardization and critical appraisal in MRI assessment of Lymphedema","authors":"Deniz Esin Tekcan Sanli ,&nbsp;Ahmet Necati Sanli","doi":"10.1016/j.mri.2025.110496","DOIUrl":"10.1016/j.mri.2025.110496","url":null,"abstract":"","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110496"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amide proton transfer-weighted MRI distinguishes hepatocellular carcinoma from mass-forming intrahepatic cholangiocarcinoma","authors":"Jingcheng Huang ,&nbsp;Dejuan Shen ,&nbsp;Jun Sun ,&nbsp;Jie Shi ,&nbsp;Weiqiang Dou ,&nbsp;Martin Prince ,&nbsp;Jing Ye ,&nbsp;Xianfu Luo","doi":"10.1016/j.mri.2025.110491","DOIUrl":"10.1016/j.mri.2025.110491","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the potential of amide proton transfer-weighted (APTw) MRI in differentiating hepatocellular carcinoma (HCC) from mass-forming intrahepatic cholangiocarcinoma (MF-ICC).</div></div><div><h3>Methods</h3><div>76 Patients with histo-pathologically confirmed HCC or MF-ICC underwent dynamic contrast enhanced(DCE) MRI,APTw and DWI. Mean APTw and apparent diffusion coefficient (ADC) of liver tumors were measured independently by two radiologists. Five-point scale were scored with DCE images. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of APTw, ADC,DCE in differentiating HCC from MF-ICC.</div></div><div><h3>Results</h3><div>The HCC group (<em>n</em> = 53) exhibited higher APTw values compared to the MF-ICC group (<em>n</em> = 23)(1.37 ± 0.99 % vs. −0.31 ± 0.79 %, <em>P</em> &lt; 0.001). The ADC values of HCC were lower than those of MF-ICC (0.87 ± 0.14 mm²/s vs. 1.02 ± 0.20 mm²/s, <em>P</em> &lt; 0.001). In differentiating HCC from MF-ICC, APTw demonstrated significantly higher diagnostic accuracy than ADC (AUC: 0.90 vs. 0.72; P &lt; 0.001) and comparable efficacy to DCE-MRI (AUC: 0.90 vs. 0.92; <em>P</em> &gt; 0.05). The optimal APTw threshold for differentiating HCC from MF-ICC was 0.04 %, with a sensitivity of 92 % and a specificity of 78 %.</div></div><div><h3>Conclusion</h3><div>APTw MRI demonstrated superior discrimination to DWI and comparable diagnostic efficacy to DCE-MRI in differentiating HCC from MF-ICC.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110491"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated DESPOT1 with variable parameters for 3D T1 brain mapping","authors":"Ronal Coronado ,&nbsp;Gabriel Varela-Mattatall ,&nbsp;Guillermo Sahonero-Alvarez ,&nbsp;René Botnar ,&nbsp;Cecilia Besa ,&nbsp;Pablo Irarrazaval ,&nbsp;Claudia Prieto","doi":"10.1016/j.mri.2025.110487","DOIUrl":"10.1016/j.mri.2025.110487","url":null,"abstract":"<div><h3>Purpose</h3><div>Driven equilibrium single pulse observation of T1 (DESPOT1) is a reliable technique for clinical 3D T1 brain mapping. However, its fixed repetition time (TR) and bandwidth (BW) and its linear modeling to estimate T1 conveys to an inefficient imaging protocol. We propose a variable DESPOT1 (vDESPOT1) acquisition and modeling strategy to improve scan efficiency and to accelerate image acquisition.</div></div><div><h3>Methods</h3><div>vDESPOT1 uses SPGR acquisitions with optimized combinations of TRs, BWs, and FAs, coupled with dictionary-based reconstruction to achieve faster acquisition and more efficient T1 mapping. The proposed vDESPOT1 method was compared to DESPOT1 and inversion recovery spin echo (IR-SE) in phantom and in ten brain healthy subjects.</div></div><div><h3>Results</h3><div>Results demonstrate a reduction in scan time of approximately 40 %, allowing faster 3D brain T1 mapping while maintaining accuracy and T1NR in comparison to conventional DESPOT1. Also, the computational efficiency of a pre-computed dictionary of vDESPOT1 reduces the reconstruction time by ∼50× in comparison linear regression of conventional DESPOT1. Variable BW can enhance scan efficiency without significantly affecting the SNR for T1 when using vDESPOT1.</div></div><div><h3>Conclusion</h3><div>These time improvements make vDESPOT1 particularly valuable for dynamic and high-field MRI applications, such as thermal therapy monitoring, pharmacokinetic analysis in DCE-MRI, and imaging in anatomies prone to motion, including the heart, liver, and lungs.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110487"},"PeriodicalIF":2.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible ultrathin metasurface with open-ring spiral resonators for SNR enhancement in low-field 0.2 T MRI","authors":"Ce Xiang ,&nbsp;Shufeng Wei ,&nbsp;Hongyan He ,&nbsp;Lei Li ,&nbsp;Chengwei Lu ,&nbsp;Liguo Fan ,&nbsp;Wenhui Yang","doi":"10.1016/j.mri.2025.110493","DOIUrl":"10.1016/j.mri.2025.110493","url":null,"abstract":"<div><div>Low-field magnetic resonance imaging (MRI) systems (&lt;0.5 T) have emerged as increasingly valuable tools for emergency and bedside imaging due to their cost-effectiveness and portability, but their adoption is limited by low signal-to-noise ratio (SNR). Conventional optimization methods offer limited improvements, while current metasurface technologies face challenges related to clinical integration, such as excessive dimensionality, and inadequate SNR enhancement at low magnetic field strengths. Addressing these challenges, we present an ultrathin (0.136 mm) flexible open-ring spiral metasurface (ORSM) engineered via subwavelength resonator optimization. Through rigorous theoretical modeling (equivalent circuit analysis) and comprehensive electromagnetic simulations (0.2 T full-wave analysis), we demonstrate concurrent achievement of: (i) unprecedented 137.1-fold surface field enhancement, (ii) deep-tissue penetration reaching 140 mm, and (iii) exceptional mechanical stability (&lt;0.05 MHz frequency shift under deformation). Experimental validation on a 0.2 T MRI scanner quantitatively confirmed the clinical impact of the ORSM. Testing on a large-volume phantom (180 mm in diameter) demonstrated 97.4–133.2 % SNR enhancement across various regions, resulting in an increase in mean SNR by over 2.3 times. Importantly, the ORSM also optimized field homogeneity, reducing the spatial coefficient of variation from 18.9 % to 3.8 % and the relative SNR variation from 58.3 % to 24.6 %, all while ensuring full compliance with safety standards. This technology uniquely combines clinical-grade flexibility, deep penetration, and substantial SNR amplification with field uniformity, creating a practical pathway for advancing portable MRI in critical care.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110493"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject-specific acceleration of simultaneous quantification of blood flow and T1 of the brain using a dual-flip-angle phase-contrast stack-of-stars sequence","authors":"Yanzeng Wang,&nbsp;Mengzhu Wang,&nbsp;Bei Liu,&nbsp;Zekang Ding,&nbsp;Huajun She,&nbsp;Yiping P. Du","doi":"10.1016/j.mri.2025.110495","DOIUrl":"10.1016/j.mri.2025.110495","url":null,"abstract":"<div><h3>Purpose</h3><div>To develop a highly accelerated MRI technique for simultaneous quantification of blood flow and T₁ of the brain tissue.</div></div><div><h3>Methods</h3><div>A dual-flip-angle phase-contrast stack-of-stars (DFA PC-SOS) sequence was developed for simultaneous acquisition of highly-undersampled data for the quantification of velocity of arterial blood and T₁ mapping of brain tissue. A deep learning-based algorithm, combining hybrid-feature hash encoding implicit neural representation with explicit sparse prior knowledge (INRESP), was used for image reconstruction. Magnitude and phase images were used for T₁ mapping and velocity measurements, respectively. The accuracy of the measurements was assessed in a quantitative phantom and six healthy volunteers.</div></div><div><h3>Results</h3><div>T₁ mapping obtained with DFA PC-SOS showed high correlation and consistency with reference measurements in phantom experiments (y = 0.916x + 4.71, R² = 0.9953, ICC = 0.9963). Blood flow measurements in healthy volunteers demonstrated strong correlation and consistency with reference values measured by SFA PC-SOS (y = 1.04x - 0.187, R² = 0.9918, ICC = 0.9967). The proposed technique enabled an acceleration of 16× with high correlation and consistency with fully sampled data in volunteers (T₁: y = 1.06x + 1.44, R² = 0.9815, ICC = 0.9818; flow: y = 1.01x - 0.0525, R² = 0.9995, ICC = 0.9998).</div></div><div><h3>Conclusion</h3><div>This study demonstrates the feasibility of 16-fold accelerated simultaneous acquisition for flow quantification and T₁ mapping in the brain. The proposed technique provides a rapid and comprehensive assessment of cerebrovascular diseases with both vascular hemodynamics and surrounding brain tissue characteristics, and has potential to be used in routine clinical applications.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110495"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-pool model-based amide proton transfer imaging in grading of gliomas and evaluating tumor proliferation: Comparison to apparent diffusion coefficient and magnetization transfer ratio asymmetry","authors":"Yasukage Takami ,&nbsp;Takashi Norikane ,&nbsp;Naruhide Kimura ,&nbsp;Katsuya Mitamura ,&nbsp;Yuri Manabe ,&nbsp;Mitsumasa Murao ,&nbsp;Yuka Yamamoto ,&nbsp;Keisuke Miyake ,&nbsp;Mitsuharu Miyoshi ,&nbsp;Yoshihiro Nishiyama","doi":"10.1016/j.mri.2025.110488","DOIUrl":"10.1016/j.mri.2025.110488","url":null,"abstract":"<div><h3>Background</h3><div>Magnetization transfer ratio asymmetry (MTRasym) is a semiquantitative analysis used for chemical exchange saturation transfer (CEST). Recently, we developed new parameters for CEST imaging using a multi-pool model (MPM) to produce quantitative results. This study evaluated the clinical significance of new parameters on MPM-based amide proton transfer (APT) imaging, the most common type of CEST, by assessing glioma grading and tumor proliferation compared with conventional apparent diffusion coefficient (ADC) and MTRasym.</div></div><div><h3>Methods</h3><div>25 patients with gliomas underwent MRI. Two-dimensional axial APT imaging was conducted using a single-shot fast-spin echo acquisition at 3 T. Apparent diffusion coefficient (ADC), MTRasym (3.5 ppm), and MPM-based APT imaging parameters were calculated using a region-of-interest analysis. The Ki-67 index was obtained from tumor specimens. The parameters were compared among three glioma grades using one-way ANOVA. Pearson's correlation coefficient was used to assess correlations between the parameters. Receiver operating characteristic analysis determined the optimal cutoff values and assessed diagnostic performances for tumor grades.</div></div><div><h3>Results</h3><div>Ki-67 index was significantly correlated with APT_T1, MTRasym, and ADC. APT_T1 significantly differed between grades II and III, grades III and IV, and grades II and IV. MTRasym and ADC significantly differed between grades II and III and grades II and IV. APT_T1 showed the largest area under the curve (0.94), followed by MTRasym, ADC, and APT_T2 in differentiating grade IV from other-grade gliomas.</div></div><div><h3>Conclusion</h3><div>APT_T1 showed the highest potential for differentiating grade IV glioma from other grades. Moreover, APT_T1 may be useful in assessing tumor proliferation and predicting tumor grade.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110488"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquisition and reconstruction with motion suppression DWI in total knee arthroplasty for metal artifact reduction: An in-vitro and in-vivo investigation","authors":"Zhangyan Xu ,&nbsp;Tongxin Zhu ,&nbsp;Shaoxin Xiang ,&nbsp;Dan Liu ,&nbsp;Wei Zeng ,&nbsp;Yongliang Pu ,&nbsp;Haitao Yang","doi":"10.1016/j.mri.2025.110494","DOIUrl":"10.1016/j.mri.2025.110494","url":null,"abstract":"<div><h3>Background</h3><div>Applying diffusion-weighted imaging (DWI) to identify periprosthetic infectious complications continues to present challenges in patients with total knee arthroplasty (TKA). This study aimed to investigate the feasibility of DWI combined with acquisition and reconstruction with motion suppression (ARMS-DWI) in TKA.</div></div><div><h3>Methods</h3><div>ARMS-DWI with multiple bandwidths (300, 500, 700 Hz/px), voxel sizes (1.2*1.2*3, 1.5*1.5*3, 1.8*1.8*3 mm³) and B-values (0–400, 0–600, 0–800 s/mm²) were obtained in vitro. Qualitative scores (QS) of image quality and artifacts severity and quantitative measurements of maximum artifact width (MAW), maximum artifact area (MAA), signal-to-noise ratio (SNR) and coefficients of variation (CV) were assessed. Seventeen TKA patients underwent ARMS-DWI with the optimal parameters, obtained from aforementioned assessments. The ADC values generated from ARMS-DWI and echo-planar DWI were compared.</div></div><div><h3>Results</h3><div>ARMS-DWI with 700 Hz/px bandwidth showed minimum artifacts with the highest QS, and the lowest MAW, MAA, CV, and SNR (all <em>p</em> ≤ 0.009). An uptrend of QS and a downtrend of MAW, MAA, SNR, and CV were observed with the decrease in voxel sizes. ARMS-DWI with 800 s/mm² B-value yield the highest MAW and MAA and the lowest QS (all <em>p</em> ≤ 0.012). No significant difference in QS and MAW were found between 400 and 600 s/mm² (both <em>p</em> &gt; 0.05). ADC values showed no significant differences (<em>p</em> = 0.056–0.851). The optimal ARMS-DWI protocol-700 Hz/px bandwidth, 1.2*1.2*3 mm³ voxel size and 600 s/mm² B-value-achieved acceptable artifacts and soft-tissue visualization in TKA.</div></div><div><h3>Conclusions</h3><div>ARMS-DWI with the optimal parameters could be applied in TKA patients to detect periprosthetic infections.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110494"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent diffusion MRI for 2023 FIGO stage of uterine endometrial cancer","authors":"Fumitaka Ejima ,&nbsp;Yoshihiko Fukukura ,&nbsp;Kiyohisa Kamimura ,&nbsp;Takuro Ayukawa ,&nbsp;Ryoji Yamagishi ,&nbsp;Fumiko Kanzaki ,&nbsp;Hirokazu Otsuka ,&nbsp;Shintaro Yanazume ,&nbsp;Hiroaki Kobayashi ,&nbsp;Ikumi Kitazono ,&nbsp;Hiroshi Imai ,&nbsp;Thorsten Feiweier ,&nbsp;Takashi Yoshiura","doi":"10.1016/j.mri.2025.110486","DOIUrl":"10.1016/j.mri.2025.110486","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigated the utility of time-dependent diffusion MRI in assessing pathological characteristics of endometrial cancer (EC) associated with the 2023 revised International Federation of Gynecology and Obstetrics (FIGO) stage, including histological type, substantial lymphovascular space invasion (LVSI), and lymph node metastasis (LNM).</div></div><div><h3>Methods</h3><div>This retrospective single-center study included 93 patients with EC who underwent diffusion-weighted imaging (DWI) MRI with oscillating gradient spin–echo (OGSE) and pulsed gradient spin–echo (PGSE) sequences. Mean apparent diffusion coefficient (ADC) values for OGSE (ADCOGSE) and PGSE (ADCPGSE) and ADCOGSE/ADCPGSE ratio were measured using tumor regions of interest. Mann–Whitney <em>U</em> test, receiver operating characteristic (ROC) curve analysis, and Spearman's rank correlation coefficients were conducted to evaluate the associations between ADC parameters and pathological factors.</div></div><div><h3>Results</h3><div>ADCPGSE was significantly lower in the presence of LNM (<em>P</em> = 0.011). ADCOGSE/ADCPGSE was significantly higher in aggressive type, substantial LVSI, LNM, and FIGO stages II–IV (all <em>P</em> &lt; 0.001). Area under the ROC curve of the ADCOGSE/ADCPGSE ratio consistently demonstrated statistical superiority over ADCOGSE and ADCPGSE independently for the prediction of aggressive type (0.85, 95 % confidence interval [CI]: 0.76–0.91), substantial LVSI (0.91, 95 % CI: 0.83–0.96), LNM (0.93, 95 % CI: 0.85–0.97), and FIGO stages II–IV (0.78, 95 % CI: 0.68–0.86) (all <em>P</em> &lt; 0.05). ADCOGSE/ADCPGSE was the only metric significantly correlated with the 2023 FIGO stage (P &lt; 0.001, ρ = 0.50).</div></div><div><h3>Conclusion</h3><div>Time-dependent diffusion MRI effectively identifies EC characteristics associated with the 2023 FIGO stage.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110486"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination amide proton transfer imaging with diffusion-weighted imaging for differentiating tumor characteristics and assessing Ki-67 expression in soft tissue tumors","authors":"LiFang Wu ,&nbsp;LuoBing Ding ,&nbsp;YanTao Lin ,&nbsp;YangLin Ou ,&nbsp;Yi Chen ,&nbsp;YiLin Tang ,&nbsp;Yang Lin","doi":"10.1016/j.mri.2025.110490","DOIUrl":"10.1016/j.mri.2025.110490","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the utility of amide proton transfer (APT) imaging in conjunction with diffusion-weighted imaging (DWI) for distinguishing between benign and malignant soft tissue tumors (STTs), and to assess the correlation with Ki-67 expression.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis was performed on 67 patients with soft tissue tumors. According to the pathological findings, the cohort was categorized into 39 cases of benign tumors and 28 cases of malignant tumors. ALL patients underwent APT imaging and DWI examinations, APT and Apparent diffusion coefficient (ADC) values were measured. Independent sample <em>t</em>-tests were used to compare the ADC and APT values between two groups. Receiver operating characteristic (ROC) curves were used to assess the sensitivity, specificity, and area under the curve (AUC) of APT, ADC, and the combination of ADC + APT in distinguishing benign and malignant tumors. The Delong test was employed to compare the diagnostic performance among these measures. Additionally, Spearman's correlation analysis was used to examine the relationship between APT, ADC and Ki-67 expression.</div></div><div><h3>Results</h3><div>The APT values of malignant groups were significantly higher than benign groups (3.32 ± 0.93 % vs. 1.87 ± 0.99 %; <em>P</em> &lt; 0.01). The ADC values of malignant groups were significantly lower than benign groups (1.08 ± 0.55 × 10⁻³ mm²/s vs. 1.67 ± 0.54 × 10⁻³ mm²/s; <em>P</em> &lt; 0.01). The ROC analysis showed that the AUC values of APT, ADC, and APT+ADC in distinguishing benign and malignant tumors were 0.855, 0.795, and 0.911 respectively. The Spearman's correlation analysis showed that APT and ADC values were significantly correlated with Ki-67 expression，and the correlation coefficients were 0.501 and −0.526, respectively.</div></div><div><h3>Conclusions</h3><div>The APT imaging and DWI can effectively differentiate between benign and malignant STTs. Combining these techniques enhances diagnostic efficiency. Furthermore, APT and ADC values show a significant correlation with tumor Ki-67 levels, which provides a robust basis for predicting STTs aggressiveness.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110490"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}