Lung最新文献 - Book学术

Right Ventricular-Pulmonary Arterial Coupling in Acute Pulmonary Embolism: Beyond Traditional Prognostic Models. 急性肺栓塞的右心室-肺动脉耦合：超越传统的预后模型。

IF 4.6 2区医学

Lung Pub Date : 2025-06-29 DOI: 10.1007/s00408-025-00831-5

Marco Zuin

引用次数: 0

Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism. 急性肺栓塞的右心室-肺动脉解耦阈值。

IF 4.6 2区医学

Lung Pub Date : 2025-06-29 DOI: 10.1007/s00408-025-00826-2

F Zeba, I Singh, J Gomez, A Khosla

{"title":"Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism.","authors":"F Zeba, I Singh, J Gomez, A Khosla","doi":"10.1007/s00408-025-00826-2","DOIUrl":"https://doi.org/10.1007/s00408-025-00826-2","url":null,"abstract":"Introduction/purpose: Right ventricle (RV) dysfunction in the setting of acute pulmonary embolism (PE) is associated with worse outcomes. The ratio of tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) provides an estimate of right ventricular-arterial (RV-PA) coupling and has been associated with adverse outcomes in patients with pulmonary hypertension. In this study, we examined if RV-PA uncoupling can further risk stratify acute PE.Methods: This is a single-center, retrospective analysis of patients admitted to a tertiary center with the diagnosis of acute PE. The Kruskal-Wallis Rank Sum, Wilcoxon Rank Sum, and Chi-square tests were used to identify clinical features associated with reduced RV-PA uncoupling at three distinct thresholds, severe (< 0.31), moderate (0.31-0.4) and mild (> 0.4-1.75) derived from prior studies.Results: 146 patients were included in our analysis. Patients with severely impaired RV-PA uncoupling ratios were more likely to have RV dysfunction by CT defined as CT RV/LV ratio > 0.9 (p < 0.01) and were more likely to need veno-arterial extracorporeal membrane oxygenation (VA-ECMO) compared to those that had moderate or mild impairment (p < 0.01). We also found a correlation between BNP (r = - 0.44, p < 0.01), lactate levels (r = - 0.18 p = 0.04), and the TAPSE/PASP ratio. European Society of Cardiology, sPESI, and BOVA risk stratification scores did not distinguish between patients with mild, moderate, or severe RV-PA uncoupling.Conclusion: Patients with acute PE who have severely impaired RV-PA uncoupling ratios have more severe disease, characterized by elevated biomarkers and need for VA-ECMO. TAPSE/PASP values can be used to risk stratify and guide treatment of acute PE.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"71"},"PeriodicalIF":4.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study. 遗传因素解释了一半的个体对慢性支气管炎、气流阻塞和慢性阻塞性肺病的易感性，而不考虑肺活量测定的定义：一项全国性的双胞胎研究。

IF 4.6 2区医学

Lung Pub Date : 2025-06-27 DOI: 10.1007/s00408-025-00825-3

Howraman Meteran, Simon Francis Thomsen, Jacob Hjelmborg, Martin R Miller, Kaare Christensen, Torben Sigsgaard, Vibeke Backer

{"title":"Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study.","authors":"Howraman Meteran, Simon Francis Thomsen, Jacob Hjelmborg, Martin R Miller, Kaare Christensen, Torben Sigsgaard, Vibeke Backer","doi":"10.1007/s00408-025-00825-3","DOIUrl":"10.1007/s00408-025-00825-3","url":null,"abstract":"Background: Smoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individual susceptibility to these traits cannot be explained solely by environmental risk factors.Aim: To estimate the relative contribution of genetic and environmental factors to lung function, chronic bronchitis and COPD.Methods: 12,449 twins aged 40-80 years participated in a nationwide survey using the Danish Twin Registry, which included a questionnaire, clinical examination and spirometry. Clinical COPD was defined by respiratory symptoms plus airflow obstruction. Biometric models of genetic and environmental latent factors were used to estimate the heritability after adjusting for sex, age, and height.Results: Mean (SD) age of the study population was 58.4 (9.6) years and mean BMI (kg/m2) was 26.6 (4.4); 20% were current smokers and 52% were females. The heritability of FEV1, FVC and FEV1/FVC was 64% (60-67%), 61% (57-65%), and 50% (46-55%), respectively. Genetic factors explained 48% (24-72%) and 47% (16-78%), respectively, of the individual susceptibility to chronic bronchitis and clinical COPD.Conclusion: Genetic factors explain at least half of the variation in lung function and around half of the individual susceptibility to chronic bronchitis and clinical COPD, respectively, when adjusted for sex, age, height.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"70"},"PeriodicalIF":4.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway. BPIFB4过表达通过PI3K/AKT通路抑制M1巨噬细胞激活减轻COPD炎症损伤

IF 4.6 2区医学

Lung Pub Date : 2025-06-16 DOI: 10.1007/s00408-025-00824-4

Lexin Xue, Jingran Xu, Hui Gong, Zulipikaer Abudureheman, Ayiguli ALimu, Yun Chen, Aifang Zheng, Liang Gao, Xiuqi Lu, Chengxin Xie, Li Li

{"title":"Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway.","authors":"Lexin Xue, Jingran Xu, Hui Gong, Zulipikaer Abudureheman, Ayiguli ALimu, Yun Chen, Aifang Zheng, Liang Gao, Xiuqi Lu, Chengxin Xie, Li Li","doi":"10.1007/s00408-025-00824-4","DOIUrl":"10.1007/s00408-025-00824-4","url":null,"abstract":"Background: Macrophage polarization is essential for inflammatory regulation in COPD. The precise role of BPI Fold-Containing Family B Member 4 (BPIFB4) in regulating the inflammatory processes underlying COPD pathogenesis remains to be fully elucidated. This investigation seeks to clarify how BPIFB4 modulates macrophage polarization by activating the phosphoinositide 3-kinase (PI3K)-AKT1 signaling pathway, thereby influencing inflammatory progression in COPD.Methods: In a COPD mouse model induced by cigarette smoke (CS) and lipopolysaccharide (LPS) and in cigarette smoke extract (CSE)-treated THP-1 cells, BPIFB4 was overexpressed or silenced. Bronchoalveolar lavage fluid, lung tissues, and serum were collected. qPCR and western blots assessed BPIFB4 and PI3K-AKT1 pathway expression in lung tissues and THP-1 cells. Flow cytometry evaluated M1/M2 macrophage polarization, and enzyme-linked immunosorbent assay (ELISA) measured related cytokine levels.Results: The results demonstrated how BPIFB4 gene silencing resulted in more pronounced lung tissue and functional damage compared to BPIFB4 overexpression, alongside an elevated presence of M1 macrophages and associated pro-inflammatory factors. In contrast, BPIFB4 overexpression in both COPD mice and CSE-treated THP-1 cells significantly enhanced p-AKT1 and p-PI3K levels while reducing the number of M1 macrophages. In addition, inhibition of the PI3K-AKT1 pathway reversed these effects, resulting in a marked increase in M1 macrophages and their associated cytokines.Conclusion: BPIFB4 overexpression alleviates M1 macrophage polarization by activating the PI3K-AKT1 pathway, thereby reducing lung tissue damage and dysfunction in COPD mice.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"69"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far? 丙酮酸激酶M2在肺部疾病中的作用：到目前为止我们知道什么？

IF 4.6 2区医学

Lung Pub Date : 2025-06-04 DOI: 10.1007/s00408-025-00821-7

Diandian Li, Lian Liu, Jiangyue Qin, Cheng Shen, Bo Wang

引用次数: 0

Functional Status Trends for Adults and Children on Extracorporeal Membrane Oxygenation at Time of Lung Transplantation. 肺移植时成人和儿童体外膜氧合的功能状态趋势。

IF 4.6 2区医学

Lung Pub Date : 2025-06-04 DOI: 10.1007/s00408-025-00822-6

Wonshill Koh, JangDong Seo, Nicholas J Ollberding, Don Hayes

引用次数: 0

Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy. 妊娠期哮喘和阻塞性睡眠呼吸暂停对中枢气道阻力的影响。

IF 4.6 2区医学

Lung Pub Date : 2025-06-03 DOI: 10.1007/s00408-025-00817-3

Christopher Theroux, Christina Raker, Melissa Guillen, Annaly Aldana, Ashanti Avalos, F Dennis McCool, Ghada Bourjeily

{"title":"Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy.","authors":"Christopher Theroux, Christina Raker, Melissa Guillen, Annaly Aldana, Ashanti Avalos, F Dennis McCool, Ghada Bourjeily","doi":"10.1007/s00408-025-00817-3","DOIUrl":"https://doi.org/10.1007/s00408-025-00817-3","url":null,"abstract":"Purpose: Pregnancy is a risk factor for the development of obstructive sleep apnea (OSA) and for worsening of asthma; the interaction between the two disorders is not well described. We aimed to examine airway mechanics in pregnant patients with and without OSA and asthma.Methods: We studied 217 women with BMI above 25 early in the second trimester of pregnancy. Airways resistance was measured using the forced oscillation technique at 5 Hz (R5), 20 Hz (R20), and 35 Hz (R35). All values were expressed as % predicted. level III sleep studies were scored according to the recommended AASM rules; OSA was diagnosed by AHI ≥ 5 events per hour. Asthma was defined by medical history and record review.Results: Of the 217 women tested, 53 had OSA and 66 had asthma. R20 and R35 were increased in women with both OSA and asthma compared to those with neither asthma nor OSA (adjusted mean difference (aMD) for R20 was 19.7, CI 3.4-36.0, p value = 0.02; aMD for R35 was 36.9 CI 12.4-61.5, p value = 0.003). There was a significant increase in R35 for women with OSA as opposed to those without (aMD 17.6 (CI 1.4-33.8; p value = 0.03).Conclusion: Pregnant women with both OSA and asthma have higher central airways resistance and upper airway resistance as measured at R20 and R35, respectively, compared to those with neither OSA nor asthma. Further work is needed to understand mechanisms underlying the synergistic effects of OSA and asthma on airways mechanics.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"66"},"PeriodicalIF":4.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries? 肺微环境中的周细胞：守护者还是敌人？

IF 4.6 2区医学

Lung Pub Date : 2025-05-31 DOI: 10.1007/s00408-025-00820-8

Yan Lin, Jiaqi Chen, Jiale Tan, Zihang Yu, Ruozheng Pi, Jingrong Xiong, Yi Ding, Minfeng Chen, Xue Bai

引用次数: 0

Role of Slc7a11 in Bleomycin-Induced Lung Injury. Slc7a11在博莱霉素致肺损伤中的作用。

IF 4.6 2区医学

Lung Pub Date : 2025-05-26 DOI: 10.1007/s00408-025-00818-2

Jeffrey D Ritzenthaler, Edilson Torres-Gonzalez, Yvonne Janssen-Heininger, Walter H Watson, Jesse Roman

引用次数: 0

Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review. 喉上神经阻滞治疗神经性咳嗽的疗效和安全性：系统综述。

IF 4.6 2区医学

Lung Pub Date : 2025-05-22 DOI: 10.1007/s00408-025-00819-1

Andrea Campagnolo, Vinícius Nickel, Michael S Benninger

{"title":"Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review.","authors":"Andrea Campagnolo, Vinícius Nickel, Michael S Benninger","doi":"10.1007/s00408-025-00819-1","DOIUrl":"10.1007/s00408-025-00819-1","url":null,"abstract":"Objectives: To systematically review the efficacy and safety, both short and long-term, of superior laryngeal nerve block (SLNB) for managing neuropathic cough.Methods: A literature search was conducted using the keywords \"Superior laryngeal nerve block,\" \"Neurogenic Cough,\" \"Neuropathic Cough,\" and \"Refractory Chronic Cough.\" The primary outcome was cough-specific quality of life (QoL), evaluated with validated patient-reported outcome measures (PROMs) such as the Leicester Cough Questionnaire (LCQ), Cough Severity Index (CSI), and Hull Airway Reflux Questionnaire (HARQ). Additional data included SLNB technique, cough duration, use of neuromodulators and Behavioral Cough Suppression Therapy (BCST), injection frequency, vocal fold dysfunction (VFD), and adverse events. Quality assessments used the Methodological Index for Non-Randomized Studies (MINORS) criteria.Results: Ten studies comprising 625 patients were included. The average cough duration prior to intervention was 78 months, with a mean follow-up of 5.01 months. Patients received an average of 2.5 injections. Short-term outcomes showed consistent improvements in PROMs and cough perception. Long-term outcomes (beyond three months) were reported in four studies, with minimal variations but no statistical comparisons to baseline scores. Significant heterogeneity was noted across studies, including differences in assessment protocols and adjunctive therapies. No significant adverse events were reported.Conclusion: SLNB is a safe and effective treatment for refractory chronic cough, either alone or with systemic medications. However, the variability among studies highlights the need for standardized protocols and further research with long-term follow-up to confirm its efficacy.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"63"},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0