Fatty Acids Dysregulation Correlates with Lung Function in Idiopathic Pulmonary Fibrosis.

IF 3.9 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2025-10-14 DOI:10.1007/s00408-025-00852-0

Filippo Scialò, Raffaella Pagliaro, Monica Gelzo, Maria Gabriella Matera, Vito D'Agnano, Stefano Sanduzzi Zamparelli, Giuseppe Castaldo, Mario Cazzola, Andrea Bianco, Fabio Perrotta

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引用次数: 0

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor survival rate and undefined molecular mechanisms. The identification of reliable biomarkers to help early diagnosis and predict disease progression is crucial for improving patient life. Although many biomarkers have been proposed, there is no consensus on reliable markers for IPF. Alterations in fatty acid (FA) metabolism have drawn increasing attention in the IPF pathogenesis.

Methods: This single-center, prospective, cross-sectional study enrolled 35 IPF patients and 24 control participants. Demographic, clinical, and pulmonary function data were collected. FA profiles were compared between the two groups, with statistical analyses including chi-square tests, ANOVA, Spearman's rank correlation, and ROC curve analysis.

Results: We found significant differences in serum FA levels between IPF patients and controls. Cis-Palmitoleic acid (26.4 mg/L vs 22.1 mg/L; p = 0.04), oleic acid (457.6 mg/L vs 376.4 mg/L, p = 0.04), and elaidic acid (33.7 mg/dL vs 28.2 mg/L, p = 0.02) were increased in IPF patients, while arachidonic acid (79.7 mg/dL vs 97.9 mg/L, p = 0.01) levels were significantly lower compared to the control group. Spearman's correlation analysis revealed positive correlations between these fatty acids. Notably, arachidonic acid levels showed a positive correlation with FEV1% (r = 0.348; p = 0.043) and FVC% (r = 0.431; p = 0.01), although ROC curve analysis indicated that this did not demonstrate strong diagnostic potential for IPF.

Conclusion: In this study, we identified a dysregulation of cis-palmitoleic acid, oleic acid, elaidic acid, and arachidonic acid in IPF patients, indicating alterations in lipid metabolism and inflammatory pathways. Additionally, while arachidonic acid levels correlate with lung function, its diagnostic potential remains uncertain and warrants further evaluation in a larger patient population.

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特发性肺纤维化中脂肪酸失调与肺功能相关。

背景：特发性肺纤维化（IPF）是一种进行性肺部疾病，生存率低，分子机制不明确。确定可靠的生物标志物以帮助早期诊断和预测疾病进展对于改善患者的生活至关重要。虽然已经提出了许多生物标志物，但对于IPF的可靠标志物尚无共识。脂肪酸代谢的改变在IPF发病机制中引起了越来越多的关注。方法：这项单中心、前瞻性、横断面研究纳入了35名IPF患者和24名对照受试者。收集了人口统计学、临床和肺功能数据。比较两组患者FA谱，统计学分析包括卡方检验、方差分析、Spearman秩相关和ROC曲线分析。结果：我们发现IPF患者和对照组血清FA水平有显著差异。顺式棕榈油酸（26.4 mg/L vs 22.1 mg/L, p = 0.04）、油酸（457.6 mg/L vs 376.4 mg/L, p = 0.04）和油酸（33.7 mg/dL vs 28.2 mg/L, p = 0.02）水平在IPF患者中显著高于对照组，花生四烯酸（79.7 mg/dL vs 97.9 mg/L, p = 0.01）水平显著低于对照组。斯皮尔曼的相关分析显示，这些脂肪酸之间存在正相关。值得注意的是，花生四烯酸水平与FEV1% （r = 0.348; p = 0.043）和FVC% （r = 0.431; p = 0.01）呈正相关，尽管ROC曲线分析表明，这并未显示出对IPF的强诊断潜力。结论：在本研究中，我们发现IPF患者中顺式棕榈油酸、油酸、油酸和花生四烯酸的失调，表明脂质代谢和炎症途径的改变。此外，虽然花生四烯酸水平与肺功能相关，但其诊断潜力仍不确定，需要在更大的患者群体中进一步评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.