特发性肺纤维化患者肺功能的改变和患者报告的预后。

IF 3.9 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2025-08-27 DOI:10.1007/s00408-025-00845-z

Jamie L Todd, Megan L Neely, Anne S Hellkamp, Daniel A Culver, Justin M Oldham, Peide Li, Divya C Patel, Scott M Palmer

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引用次数: 0

摘要

我们评估了在IPF- pro注册的736例特发性肺纤维化（IPF）患者肺功能变化与患者报告预后（PROs）变化之间的关系。在12个月期间，在强迫肺活量或肺弥散能力（DLco）的百分比预测值的变化与圣乔治呼吸问卷（SGRQ）总得分和活动得分以及12项简短形式调查（SF-12）物理成分总结得分的变化之间观察到弱相关性。SGRQ活动评分恶化或SF-12 PCS评分≥5个单位的患者肺功能下降的数值大于其他患者，但差异很小。肺功能变化与pro变化之间的弱相关性强调了在临床实践和临床试验中评估肺功能变化和HRQL变化的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Changes in Lung Function and Patient-Reported Outcomes in Patients with Idiopathic Pulmonary Fibrosis.

查看原文本刊更多论文

Changes in Lung Function and Patient-Reported Outcomes in Patients with Idiopathic Pulmonary Fibrosis.

We evaluated relationships between changes in lung function and changes in patient-reported outcomes (PROs) in 736 patients with idiopathic pulmonary fibrosis (IPF) enrolled in the IPF-PRO Registry. Weak correlations were observed between changes in percent predicted values for forced vital capacity or diffusing capacity of the lungs (DLco) and changes in St George's Respiratory Questionnaire (SGRQ) total and activity scores and the 12-item Short Form Survey (SF-12) physical component summary score over 12-month periods. Patients who had a deterioration in SGRQ activity score or SF-12 PCS score of ≥ 5 units had numerically larger declines in lung function than other patients, but the differences were small. The weak relationships observed between changes in lung function and changes in PROs underscore the importance of evaluating both changes in lung function and changes in HRQL in clinical practice and clinical trials.

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来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.