Macromolecular Symposia最新文献_第9页

Colloidal Stability of Chitosan/DNA Polyelectrolyte Complexes in Presence of Biological Polyanions 壳聚糖/DNA 聚电解质复合物在生物多阳离子存在下的胶体稳定性

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400112

Jesrael Luz Elena Nando Rodríguez, Edgar Benjamín Figueroa Ochoa, Maite Renteria Urquiza, Lourdes Mónica Bravo-Anaya

{"title":"Colloidal Stability of Chitosan/DNA Polyelectrolyte Complexes in Presence of Biological Polyanions","authors":"Jesrael Luz Elena Nando Rodríguez, Edgar Benjamín Figueroa Ochoa, Maite Renteria Urquiza, Lourdes Mónica Bravo-Anaya","doi":"10.1002/masy.202400112","DOIUrl":"https://doi.org/10.1002/masy.202400112","url":null,"abstract":"Natural or synthetic polycations are used in nucleic acid-based therapies as complexing agents which interact electrostatically with nucleic acids, condense them into nanoparticles, protect them and control their entry into cells. However, although the literature on the formation of nanoparticles known as complexes is well documented, fewer studies have focused on the physical chemistry behind their disassembly, especially under physicochemical conditions found in an intracellular environment. There are several theories of the disassembly of these complexes, one of them consisting in the exchange between the polycations of these particles with biological polyanions. This project is focused on the study of the complexation mechanism of chitosan and calf-thymus DNA, as well as the stability of the obtained complexes in presence of biological polyanions, i.e., glycosaminoglycans (GAGs). In the presence of polyelectrolyte complexes, GAGs that are present in cells are expected to compete with nucleic acids and dissociate the complex if polycation–GAG association is thermodynamically favored. It is found that chitosan/DNA complexes colloidal stability depends on its [N+]/[P−] charge ratio (R). Furthermore, it is determined that the aggregation onset of the complexes, generated by the addition of different GAGs, depends on the structure and the charge density of the GAGs.","PeriodicalId":18107,"journal":{"name":"Macromolecular Symposia","volume":"413 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/masy.202400112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopolymer-Based Nanogels Synthesis, Characterization, and Stability for Doxorubicin Encapsulation and Delivery 基于生物聚合物的纳米凝胶的合成、表征和稳定性，用于多柔比星的封装和输送

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400114

Karla Gricelda Fernández-Solís, Guillermo Toriz González, Edgar Benjamín Figueroa Ochoa, Julien Rosselgong, Eduardo Mendizabal Mijares, Lourdes Mónica Bravo-Anaya

{"title":"Biopolymer-Based Nanogels Synthesis, Characterization, and Stability for Doxorubicin Encapsulation and Delivery","authors":"Karla Gricelda Fernández-Solís, Guillermo Toriz González, Edgar Benjamín Figueroa Ochoa, Julien Rosselgong, Eduardo Mendizabal Mijares, Lourdes Mónica Bravo-Anaya","doi":"10.1002/masy.202400114","DOIUrl":"https://doi.org/10.1002/masy.202400114","url":null,"abstract":"Nanogels are nanostructures with dimensions within the nanoscale, composed of crosslinked polymers through their functional groups. Nanogels can display sensitiveness to stimuli, such as pH or temperature. This characteristic has been used in the design of new platforms for the transport and release of active ingredients. Biopolymer-based nanogels are of great interest due to their biodegradability, biocompatibility, nontoxicity, and among others. In this project, pH-responsive nanogels are synthesized through a novel methodology, using two polysaccharides classified as safe, biocompatible, and easily accessible materials, i.e., chitosan (CS) and maltodextrin (MD). A reductive amination reaction between CS and partially oxidized MDs allows to synthesized MD/CS nanogels with sizes ranging from 90 ± 5 to 194 ± 40 nm and with a colloidal stability up to 7 weeks. It is found that the variation of nanogels size and charge depends on CS concentration, molecular weight, and pH, as well as on the % oxidation of the MD. As evidence of nanogels pH-responsiveness, an increase of size and ζ-potential is observed by decreasing the pH. This size increase is attributed to the swelling of the nanogels upon a change in pH. Finally, doxorubicin is encapsulated in MD/CS nanogels, with a loading capacity up to 57%.","PeriodicalId":18107,"journal":{"name":"Macromolecular Symposia","volume":"413 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/masy.202400114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractionation and Characterization of Commercial Low Acyl Gellan Gum 商用低酰基结冷胶的分馏和表征

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400001

Gulnur S. Tatykhanova, Sami-Pekka Hirvonen, Yuliia V. Bardadym, Nargiz N. Gizatullina, Moldir A. Saulimbay

引用次数: 0

The Effect of Crosslinking Density on the Dynamic Behavior of Thermo-Responsive Poly(N-Isopropylacrylamide) Hydrogels 交联密度对热响应性聚（N-异丙基丙烯酰胺）水凝胶动态行为的影响

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400021

Elisa Toto, Eleonora Franco, Gianluca Ciarleglio, Maria Gabriella Santonicola

引用次数: 0

Thermoforming of Printed Conductive Silver on Flexible Substrates 在柔性基底上热成型印刷导电银

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400109

Antonio Imparato, Anna De Girolamo Del Mauro, Maria Rosaria Ricciardi, Vincenza Antonucci

引用次数: 0

Study of the Behavior of 3D Printed Thermoplastic Elastomers Structures Aimed at Emulating Traditional Polyurethane Foams 旨在模仿传统聚氨酯泡沫的 3D 打印热塑性弹性体结构行为研究

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400027

Paola Natali, Laura Mazzocchetti, Denis Bertoldo, Enrico Gianfranco Campari, Tiziana Benelli, Emanuele Maccaferri, Niccolò Giani, Loris Giorgini

{"title":"Study of the Behavior of 3D Printed Thermoplastic Elastomers Structures Aimed at Emulating Traditional Polyurethane Foams","authors":"Paola Natali, Laura Mazzocchetti, Denis Bertoldo, Enrico Gianfranco Campari, Tiziana Benelli, Emanuele Maccaferri, Niccolò Giani, Loris Giorgini","doi":"10.1002/masy.202400027","DOIUrl":"https://doi.org/10.1002/masy.202400027","url":null,"abstract":"The present paper introduces a preliminary analysis and the recent development of three-dimensional (3D) printed thermoplastic polyurethane (TPE-U) as a replacement of polyurethane (PU) foams that has led to a recyclable product. Among the various 3D printing techniques available, the team focuses on Fused Deposition Modeling (FDM) because of its simplicity, affordability, and versatility in printing geometries and recyclability of materials. Four thermoplastic polyurethane (TPU) elastomers with different stiffness (in the range of Shore A) are used. Therefore, through the combination of different printing geometries, modulation of the main printing parameters, and different materials, an attempt is made to simulate the mechanical behavior of PU foams, which are commonly used for the production of paddings. The mechanical evaluation, by means of dynamic mechanical analysis (DMA), of the of 3D printed specimens has highlighted a qualitatively different and potentially superior behavior with respect to that of PU foam.","PeriodicalId":18107,"journal":{"name":"Macromolecular Symposia","volume":"413 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating Network Lifetime of AUN in Photo-Aging by Kinetic Modeling and “Degelation” Model 通过动力学模型和 "退化 "模型估算光老化过程中 AUN 的网络寿命

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202300247

Takato Ishida, Emmanuel Richaud, Hideaki Hagihara, Ryoma Kitagaki

引用次数: 0

Si/Polymer/Natural Drug Materials Prepared by Sol–Gel Route: Study of Release and Antibacterial Activity 采用溶胶-凝胶路线制备的硅/聚合物/天然药物材料：释放和抗菌活性研究

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202300251

Veronica Viola, Antonio D'Angelo, Anna Maria Piccirillo, Michelina Catauro

{"title":"Si/Polymer/Natural Drug Materials Prepared by Sol–Gel Route: Study of Release and Antibacterial Activity","authors":"Veronica Viola, Antonio D'Angelo, Anna Maria Piccirillo, Michelina Catauro","doi":"10.1002/masy.202300251","DOIUrl":"https://doi.org/10.1002/masy.202300251","url":null,"abstract":"This study aims to develop a new class of versatile silica-based materials for medical applications, synthesized via the sol–gel method. Different molecules are incorporated into the silica matrix to improve its biological properties and to use these materials as better-performing implants. Polyethylene glycol (PEG) is added to silica-based materials to improve biocompatibility, increase hydrophilicity, and enhance cellular adhesion and growth. The effect of loading the silica/PEG matrix with chlorogenic acid (CGA), a natural compound present in different types of plants, is investigated to understand how the material is affected. The interactions among different components in the hybrid materials are studied by Fourier-transform infrared (FTIR) spectroscopy. Furthermore, the materials are encapsulated in 2% w/v of alginate to evaluate the different releases of CGA, using UV-Vis Spectrophotometer. Finally, antimicrobial assessment against Escherichia coli and Pseudomonas aeruginosa of the several hybrids is observed by measuring the diameter of the zone of inhibition.","PeriodicalId":18107,"journal":{"name":"Macromolecular Symposia","volume":"413 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Screen-Printed Thermoelectric Materials Based on PEDOT:PSS/DWCNT Composites 基于 PEDOT:PSS/DWCNT 复合材料的柔性丝网印刷热电材料

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400129

Anna De Girolamo Del Mauro, Antonio Imparato, Riccardo Miscioscia, Paolo Tassini

引用次数: 0

Numerical Relaxation Analysis of Carbon Fiber Reinforced Polymers 碳纤维增强聚合物的数值松弛分析

Macromolecular Symposia Pub Date : 2024-08-16 DOI: 10.1002/masy.202400038

Flavia Palmeri, Lucia Lambertini, Susanna Laurenzi

引用次数: 0