Synthesis, Characterization, and Brine Shrimp (Artemia salina) Toxicity Evaluation of Nanocomposites Carrier Phytic Acid/Chitosan/Magnetic Iron Oxide Nanoparticles

Q3 Materials Science

Macromolecular Symposia Pub Date : 2025-02-17 DOI:10.1002/masy.202400237

Monica Namizie Asey, Che Azurahanim Che Abdullah, Mohamed Abdelmonem, Norhaizan Mohd Esa, Mohd Basyaruddin Abdul Rahman

{"title":"Synthesis, Characterization, and Brine Shrimp (Artemia salina) Toxicity Evaluation of Nanocomposites Carrier Phytic Acid/Chitosan/Magnetic Iron Oxide Nanoparticles","authors":"Monica Namizie Asey, Che Azurahanim Che Abdullah, Mohamed Abdelmonem, Norhaizan Mohd Esa, Mohd Basyaruddin Abdul Rahman","doi":"10.1002/masy.202400237","DOIUrl":null,"url":null,"abstract":"<p>The use of polymer-coated magnetic iron oxide nanoparticles (MIONs) to deliver drugs to a specific target site is among the most efficient strategies. We have developed MIONs coated with chitosan (CS) polymer, preloaded with the phytodrug phytic acid (PTA), for drug delivery applications. To fully understand the crystalline structure and surface morphology of the prepared composite nanocarrier, it is thoroughly characterised by powder X-Ray Diffraction, Fourier transform infrared spectroscopy, thermogravimetric analyses, vibrational sample magnetometer, and transmission electron microscopy. Additionally, brine shrimp (<i>Artemia salina</i>) are used to assess the in vitro toxicity of phytodrug-loaded MIONs-CS nanostructures. Our studies on brine shrimp have demonstrated that both the phytodrug and nanocomposite have excellent activity. As a result, our PTA-loaded MIONs/CS nanocomposite can be recommended for real-time diagnostic CS.</p>","PeriodicalId":18107,"journal":{"name":"Macromolecular Symposia","volume":"414 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Symposia","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/masy.202400237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Materials Science","Score":null,"Total":0}

引用次数: 0

Abstract

The use of polymer-coated magnetic iron oxide nanoparticles (MIONs) to deliver drugs to a specific target site is among the most efficient strategies. We have developed MIONs coated with chitosan (CS) polymer, preloaded with the phytodrug phytic acid (PTA), for drug delivery applications. To fully understand the crystalline structure and surface morphology of the prepared composite nanocarrier, it is thoroughly characterised by powder X-Ray Diffraction, Fourier transform infrared spectroscopy, thermogravimetric analyses, vibrational sample magnetometer, and transmission electron microscopy. Additionally, brine shrimp (Artemia salina) are used to assess the in vitro toxicity of phytodrug-loaded MIONs-CS nanostructures. Our studies on brine shrimp have demonstrated that both the phytodrug and nanocomposite have excellent activity. As a result, our PTA-loaded MIONs/CS nanocomposite can be recommended for real-time diagnostic CS.

查看原文本刊更多论文

载体植酸/壳聚糖/磁性氧化铁纳米颗粒纳米复合材料的合成、表征和盐水虾（Artemia salina）毒性评估

使用聚合物包裹的磁性氧化铁纳米颗粒（MIONs）将药物递送到特定的靶点是最有效的策略之一。我们开发了壳聚糖（CS）聚合物包覆的MIONs，预载植物药植酸（PTA），用于药物递送应用。为了充分了解制备的复合纳米载体的晶体结构和表面形貌，通过粉末x射线衍射、傅里叶变换红外光谱、热重分析、振动样品磁强计和透射电子显微镜对其进行了全面表征。此外，用盐水虾（Artemia salina）来评估植物药物负载的纳米结构的体外毒性。我们对卤水虾的研究表明，植物药和纳米复合材料都具有良好的活性。因此，我们的pta负载的MIONs/CS纳米复合材料可以推荐用于实时诊断CS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Macromolecular Symposia Materials Science-Polymers and Plastics

CiteScore

1.50

自引率

0.00%

发文量

226

期刊介绍： Macromolecular Symposia presents state-of-the-art research articles in the field of macromolecular chemistry and physics. All submitted contributions are peer-reviewed to ensure a high quality of published manuscripts. Accepted articles will be typeset and published as a hardcover edition together with online publication at Wiley InterScience, thereby guaranteeing an immediate international dissemination.