International Journal of Cancer最新文献

{"title":"Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients.","authors":"Sai San Moon Lu, Martin Rutegård, Christel Häggström, Åsa Gylfe, Sophia Harlid, Bethany Van Guelpen","doi":"10.1002/ijc.35269","DOIUrl":"https://doi.org/10.1002/ijc.35269","url":null,"abstract":"<p><p>Gut microbiota composition has been implicated in surgical site complications after colorectal cancer surgery. Antibiotics affect gut microbiota, but evidence for a role in surgical site complications is inconclusive. We aimed to investigate use of prescription antibiotics during the years before surgery in relation to the risk of surgical site infections, including anastomotic leakage, within 30 days after surgery. Cardiovascular/neurological complications and the urinary antiseptic methenamine hippurate, for which there is no clear link with the microbiota, were used as negative controls. We conducted a patient cohort study using complete population data from Swedish national registers between 2005 and 2020. The final study population comprised 26,527 colon cancer and 12,312 rectal cancer cases with a 4.5 year exposure window. In colon cancer patients, antibiotics use was associated with a higher risk of surgical site infections (adjusted odds ratio (aOR) for any versus no use = 1.20, 95% confidence interval (CI) 1.10-1.33) and anastomotic leakage in particular (aOR =1.19, 95% CI 1.03-1.36), both with dose-response relationships for increasing cumulative antibiotics use (P_trend = <0.001 and P_trend = 0.047, respectively). Conversely, associations in rectal cancer patients, as well as for the negative controls cardiovascular/neurological complications and methenamine hippurate, were null. In conclusion, prescription antibiotics use up to 4.5 years before colorectal cancer surgery is associated with a higher risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery. These findings support a role for antibiotics-induced intestinal dysbiosis in surgical site infections.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Selective Depletion of Tumor Neovasculature by Microbubble Destruction with Appropriate Ultrasound Pressure","authors":"","doi":"10.1002/ijc.35277","DOIUrl":"10.1002/ijc.35277","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: <span>J. Wang</span>, <span>Z. Zhao</span>, <span>S. Shen</span>, <span>C. Zhang</span>, <span>S. Guo</span>, <span>Y. Lu</span>, <span>Y. Chen</span>, <span>W. Liao</span>, <span>Y. Liao</span>, and <span>J. Bin</span>, “ <span>Selective Depletion of Tumor Neovasculature by Microbubble Destruction with Appropriate Ultrasound Pressure</span>,” <i>International Journal of Cancer</i> <span>137</span>, no. <span>10</span> (<span>2015</span>): <span>2478</span>–<span>2491</span>, https://doi.org/10.1002/ijc.29597.</p><p>This Expression of Concern is for the above article, published online on 26 May 2015 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Prof. Christoph Plass; the Union for International Cancer Control; and John Wiley and Sons Ltd. The Expression of Concern has been published due to concerns raised by a third party regarding the mouse tumor volumes reported in Figure 6c. The tumor sizes reported in Figure 6c exceed community standards for humane endpoint limits in mouse tumor studies, which presents a significant animal welfare concern and a violation of the journal's policy on animal studies. Although the authors have stated in the article that the animal experiments were performed in accordance with NIH guidelines, this statement is not accurate. The authors provided the ethics approval per the journal's request, however, the authors' institutes were not responsive when asked to confirm the compliance with local and national guidelines.</p><p>The authors claim that when reviewing the data, they realized, that the method of depicting tumor boundaries and defining tumor regions was inaccurate, resulting in a great overestimate of the tumor volumes. They have reanalyzed the tumor volume in Figure 6c and they found that all tumor volumes were less than 2000 mm³.</p><p>The journal team did not find the authors response satisfactory and could not exclude that the above-mentioned concerns affect the related conclusions of the article. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":"156 5","pages":"E5"},"PeriodicalIF":5.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.35277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in childhood leukemia survival for Asian, Native Hawaiian, and Pacific Islanders in the United States.","authors":"Mia Hashibe, Kimberly A Herget, Joshua D Schiffman, Vivian Y Chang","doi":"10.1002/ijc.35259","DOIUrl":"https://doi.org/10.1002/ijc.35259","url":null,"abstract":"<p><p>While some previous studies disaggregated the Asian, Native Hawaiian, and Pacific Islander (ANHPI) population to investigate survival for childhood leukemia, further studies are needed to understand the differences between subpopulations. The aim of our study was to estimate 5-year relative survival for patients with childhood leukemia and to investigate disparities in prognostic factors with disaggregation of the ANHPI population. We used the Surveillance, Epidemiology, and End Results Program 17 database and included 1881 ANHPI patients with childhood leukemia and 8772 non-Hispanic White (NHW) patients with childhood leukemia. The Cox proportional hazards model was used to estimate hazard ratios for the risk of death. We observed lower 5-year relative survival rates for Southeast Asian and East Asian compared to NHW patients with childhood leukemia for acute lymphoid leukemia (ALL). The survival rates were higher for patients diagnosed at 1-9 years of age, more recent years of diagnosis, and patients residing in urban areas. The risk of death was 42% higher for East Asian patients and 50% higher for Southeast Asian patients compared to NHW patients for childhood ALL. For prognostic factors among East Asian patients with childhood leukemia, higher risks of death were observed for patients diagnosed at <12 months old and for acute myeloid leukemia compared to ALL. Further studies are needed to elucidate the reasons behind the disparities in survival rates for Southeast Asian and East Asian patients with childhood leukemia, including socioeconomic and genetic contributions to leukemia risk and clinical responses to different therapeutic modalities.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining risk-adapted starting age and interval for breast cancer screening based on reproductive and hormonal factors.","authors":"Tung Hoang, Jeonghee Lee, So-Youn Jung, Jeongseon Kim","doi":"10.1002/ijc.35265","DOIUrl":"https://doi.org/10.1002/ijc.35265","url":null,"abstract":"<p><p>This study aimed to elucidate the risk of developing breast cancer (BC) by reproductive and hormonal profiles to suggest risk-adapted starting screening ages and to investigate risks after negative mammography results to inform screening intervals in the Korean setting. Participants who performed health examinations between 2002 and 2023 at the National Cancer Center were analyzed. Risk-adapted starting age of screening was defined as the age at which women with various reproductive and hormonal profiles obtained a 10-year cumulative risk level similar to women aged 40 years in the general population. The Cox progression model was used to assess BC risk according to the reproductive and hormonal score and time since the last negative mammography. Of the 24,597 women enrolled in this study, 606 had BC (median follow-up 13.2 years, IQR = 9.5-16.5 years). The 10-year cumulative risk of BC at age 40 years in general women was estimated at 2.35%. Women with different reproductive and hormonal profiles reached this risk level 8.55 years earlier to 4.61 years later. We found that women with various reproductive and hormonal profiles had similar incident cases in both low- and high-score groups beyond 5 years after a negative finding from mammography (p > .05), compared to those screened within 0 to <2 years after negative screening results. This study identifies possible risk-based starting ages for BC screening based on reproductive and hormonal factors. Our findings suggest that extending the current biennial screening interval beyond 5 years may still detect a comparable number of cases.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global variations in gallbladder cancer incidence: What do recorded data and national estimates tell us?","authors":"Marion Piñeros,&nbsp;Jerome Vignat,&nbsp;Murielle Colombet,&nbsp;Mathieu Laversanne,&nbsp;Catterina Ferreccio,&nbsp;Katy Heise,&nbsp;Sharayu Mhatre,&nbsp;Jill Koshiol,&nbsp;Freddie Bray","doi":"10.1002/ijc.35232","DOIUrl":"10.1002/ijc.35232","url":null,"abstract":"<p>On a global scale, gallbladder cancer is a relatively rare cancer with a striking variability in incidence across countries and world regions. We examined recent geographic variations worldwide based on national gallbladder cancer incidence estimates for the year 2022 from the GLOBOCAN database for 185 countries alongside recorded incidence data from the most recent volume of Cancer Incidence in Five Continents. In 2022, 122,491 new gallbladder cancer cases and 89,055 deaths were estimated to occur worldwide, of which 64.5% and 64.7% respectively were among females. The highest reported rates (ASR per 100,000) were in subpopulations of Northeastern regions of India and Southern Chile in both males (ASR of 6.1 and 5.3, respectively) and in females, though rates were two times higher than males (ASR of 14.9 and 15.4). The lowest incidence rates were reported in subpopulations of Uganda for males and South Africa for females (0.21 and 0.14, respectively). Recorded gallbladder cancer incidence rates among subnational populations within countries differed considerably from their respective national estimates and revealed a 100-fold variation in gallbladder cancer, highlighting the importance of subnational population-based cancer registry data in pinpointing areas of high risk, driving research and prioritizing tailored public health actions.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":"156 7","pages":"1358-1368"},"PeriodicalIF":5.7,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation and relative cost of attendance by direct-mail compared to opt-in invitation strategy for HPV self-sampling targeting cervical screening non-attenders: A large-scale, randomized, pragmatic study.","authors":"Birgitte Tønnes Pedersen, Si Brask Sonne, Helle Pedersen, Emilie Korsgaard Andreasen, Reza Serizawa, Ditte Møller Ejegod, Jesper Bonde","doi":"10.1002/ijc.35263","DOIUrl":"https://doi.org/10.1002/ijc.35263","url":null,"abstract":"<p><p>Broad accessibility to cervical cancer screening and high participation rate is essential to reduce cervical cancer incidence. HPV self-sampling is an alternative to clinician collected cervical samples to increase accessibility and screening coverage. To inform on deployment strategies of HPV self-sampling, this large-scale, randomized, pragmatic study compared two invitation modalities; direct-mail and opt-in. The study included screening non-attenders from the Capital Region of Denmark randomly allocated (1:4) to a direct-mail or opt-in invitation for cervical screening by HPV self-sampling. Primary endpoint was screening participation; secondary endpoints were HPV prevalence and histology outcome. Adherence to follow-up and cost were also evaluated. After exclusion of hysterectomized/non-accessible women, 49,393 women were invited: 9639 by direct-mail, and 39,754 by the opt-in offer. A direct-mail invitation for HPV self-sampling yielded a significant higher participation than an opt-in invitation. HPV self-sample participation for direct-mail was 25.2% (n = 2426), opt-in participation was 20.2% (n = 8047), adjusted OR = 1.27, 95% CI 1.20-1.34. Participation increased with age (p < .0001) for both strategies and decreased with screening history of non-attendance (p < .0001). Interaction between invitation strategy and age/screening history was found; more women below 50 years of age participated by direct-mail compared to opt-in (p < .0001) and higher participation by direct-mail group was found in women with a short history of non-attendance (p < .0001). Participation of long-term unscreened women was similar between arms. The relative cost was ≈14 HPV self-sample kits distributed per additional participant by direct-mail over opt-in. HPV prevalence, adherence to follow-up, and detection of high-grade cervical intraepithelial neoplasia was similar between invitation strategies.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms","authors":"Katherine A. English,&nbsp;Michelle Goldsworthy,&nbsp;Brittannie Willis,&nbsp;Kreepa G. Kooblall,&nbsp;Shweta Birla,&nbsp;Andreas Selberherr,&nbsp;Mark Stevenson,&nbsp;Omair A. Shariq,&nbsp;Ann L. Oberg,&nbsp;Tony Wang,&nbsp;James Carmichael,&nbsp;Konstantinos Mavrommatis,&nbsp;Laure Escoubet,&nbsp;Rajesh V. Thakker,&nbsp;Sarah A. Howles,&nbsp;Kate E. Lines","doi":"10.1002/ijc.35264","DOIUrl":"10.1002/ijc.35264","url":null,"abstract":"<p>Gastroenteropancreatic neuroendocrine tumours (GEP-NETs), which may be hormone secreting (e.g., gastrinomas and insulinomas) or non-secreting (also known as non-functioning NETs) are associated with severe morbidity and have a median overall survival of 75–124 months. Studies have highlighted the importance of epigenetic mechanisms in GEP-NETs pathogenesis, with the most frequently mutated genes being the epigenetic regulators, <i>MEN1</i>, <i>DAXX</i>, and <i>ATRX</i>. However, the consequences of these aberrant epigenetic mechanisms are poorly understood. The calcium sensing receptor (<i>CASR</i>), a G protein coupled-receptor, is epigenetically silenced in cancers, and therefore we examined its role in GEP-NET subtypes. Using RNA-Scope and quantitative PCR analyses in two independent tumour cohorts from Europe (<i>n</i> = 18 patients) and the USA (<i>n</i> = 46 patients) we showed that <i>CASR</i> mRNA is almost completely absent in gastrinomas, insulinomas and non-functioning pancreatic NETs. Furthermore, immunohistochemical staining confirmed a significant reduction in CaSR protein expression in all GEP-NET subtypes, compared to normal islets. DNA methylationEPIC and ATAC-seq analyses in the pancreatic NET cell line QGP-1 showed the CaSR promoter was both hypermethylated and in a region of closed chromatin. Furthermore, transfection of wild type CaSR into QGP-1 cells decreased cell viability, in keeping with the CaSR having a role in cellular proliferation. In summary, our study reveals that CaSR expression is decreased in GEP-NETs and that this reduced expression is likely due to DNA methylation and chromatin changes. Moreover, we demonstrate that transfection of the CaSR into a PNET cell line reduces cell viability, thereby indicating that the CaSR acts as a tumour suppressor in this tumour type.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":"156 5","pages":"980-992"},"PeriodicalIF":5.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.35264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of PD-L1 expression in surgically resected EGFR-mutant lung adenocarcinoma: A real-world database study in Japan (CReGYT-01 EGFR study)","authors":"Kotaro Nomura,&nbsp;Kazuki Takada,&nbsp;Fumihiko Kinoshita,&nbsp;Satoshi Muto,&nbsp;Taichi Matsubara,&nbsp;Yasunobu Kouki,&nbsp;Shinya Katsumata,&nbsp;Akira Hamada,&nbsp;Naoki Haratake,&nbsp;Kosuke Fujino,&nbsp;Mao Yoshikawa,&nbsp;Ken Suzawa,&nbsp;Kazuhiko Shien,&nbsp;Kenichi Suda,&nbsp;Shuta Ohara,&nbsp;Shota Fukuda,&nbsp;Hiroyuki Suzuki,&nbsp;Tatsuro Okamoto,&nbsp;Fumihiko Hirai,&nbsp;Keiju Aokage,&nbsp;Satoshi Shiono,&nbsp;Junichi Soh,&nbsp;Masahiro Tsuboi,&nbsp;Mototsugu Shimokawa,&nbsp;Yasuhisa Ohde","doi":"10.1002/ijc.35270","DOIUrl":"10.1002/ijc.35270","url":null,"abstract":"<p>The expression of programmed cell death-ligand 1 (PD-L1) and mutation in epidermal growth factor receptor (<i>EGFR</i>) are biomarkers used for perioperative treatment of lung adenocarcinoma. However, the clinical significance of PD-L1 expression in surgically resected <i>EGFR</i>-mutant lung adenocarcinoma remains unclear. We conducted a real-world database of patients with surgically resected lung adenocarcinoma from 2015 to 2018 was constructed across 21 centers in Japan. The association among PD-L1 expression, <i>EGFR</i> mutations, and prognosis was evaluated. Among 847 patients, PD-L1 expression was negative (tumor proportion score [TPS] &lt; 1%) in 429 (51%), weakly positive (TPS = 1%–49%) in 275 (32%), and strongly positive (TPS ≥50%) in 143 (17%) patients. <i>EGFR</i> mutations were detected in 331 (39%) patients. PD-L1 expression was associated with poor recurrence-free survival (RFS) (<i>p</i> &lt; .001) in both <i>EGFR</i>-mutant and wild-type patients. However, in <i>EGFR</i>-mutant patients, PD-L1 expression was not associated with overall survival (OS) (<i>p</i> = .506). Multivariable analysis confirmed an association between PD-L1 expression and RFS but not OS. Furthermore, in <i>EGFR</i>-mutant patients treated with EGFR-tyrosine kinase inhibitor (EGFR-TKI) treatment post-relapse, PD-L1 expression was not associated with overall response rate (<i>p</i> = .714), disease control rate (<i>p</i> = .554), or progression-free survival (<i>p</i> = .660). In conclusion, PD-L1 expression predicted poor RFS-independent <i>EGFR</i> status but did not show any association with OS in <i>EGFR</i>-mutant patients. The efficacy of post-relapse EGFR-TKI treatment was independent of PD-L1 expression. The significance of PD-L1 expression in perioperative EGFR-TKI therapy should be evaluated.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":"156 7","pages":"1480-1491"},"PeriodicalIF":5.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based differences in histologic lung cancer incidence trends in the United States, 2005-2019.","authors":"Todd Burus, Manali I Patel, W Jay Christian, Bin Huang, Krystle A Lang Kuhs","doi":"10.1002/ijc.35268","DOIUrl":"https://doi.org/10.1002/ijc.35268","url":null,"abstract":"<p><p>Decreases in lung cancer incidence in the United States (US) have paralleled decreasing smoking prevalence for several decades; however, recent data has revealed slower declines among females than males. Sex-based differences in histologic lung cancer-and specifically adenocarcinoma-for all 50 US states and the District of Columbia have never been investigated. Using population-based cancer registry data from the US Cancer Statistics, we examined age-adjusted histologic lung cancer incidence rates and trends by sex and state of residence at diagnosis. We compared state-level adenocarcinoma incidence to lung cancer screening (LCS) adherence and smoking prevalence estimates. Average annual percentage change (AAPC) and incidence rate ratios (IRR) were used to assess changes over time. Nationally, females experienced faster increases in adenocarcinoma incidence than males (1.75%/year vs. 0.35%/year), and slower decreases in incidence of squamous cell (-0.06%/year vs. -1.58%/year) and small cell carcinoma (-2.06%/year vs. -3.19%/year). Adenocarcinoma incidence increased significantly (AAPC>0) in 41 states among females compared to 10 among males. Significant adenocarcinoma increases in individuals under age 55 (IRR >1) occurred among females in six states (four in the southeastern US) and none among males. State-level LCS adherence was significantly associated with adenocarcinoma incidence among females (r = 0.39; p<.01) but not males, though screening cannot account for increases among females under age 55. Our results highlight sex-based differences in histologic lung cancer incidence trends, with specific concern for increases in adenocarcinoma in the southeastern US. Further research is needed into appropriate LCS eligibility criteria and the risk factors driving sex-based disparities.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental tobacco smoking (ETS) and esophageal cancer: A population-based case-control study in Jiangsu Province, China.","authors":"Zi-Yi Jin, Kuangyu Liu, Gina Wallar, Jin-Yi Zhou, Li-Na Mu, Xing Liu, Li-Ming Li, Na He, Ming Wu, Jin-Kou Zhao, Zuo-Feng Zhang","doi":"10.1002/ijc.35254","DOIUrl":"https://doi.org/10.1002/ijc.35254","url":null,"abstract":"<p><p>Esophageal cancer continues to pose a significant public health issue in areas with increased incidence rates such as China. Although involuntary smoking was defined as a group 1 carcinogen for lung cancer, few studies have explored the impact of environmental tobacco smoking (ETS) on esophageal cancer. In this paper, we examined the association between ETS and esophageal cancer in high-risk groups in Jiangsu Province, China. Epidemiologic data were collected for 2969 newly diagnosed cases and 8019 population controls including exposure to active/passive smoking and risk factors. The unconditional logistic regression model and the semi-Bayes (SB) method were applied to assess adjusted odds ratios (ORs) and confidence intervals (CIs). ETS exposure (ever vs. never) was positively associated with esophageal cancer with an SB-adjusted OR (95% CI) of 1.44 (1.31-1.58) among overall population, and 1.56 (1.35-1.82) among non-smokers (i.e., non-active smokers), with corresponding population attributable fractions of 15.0% (95% CI: 10.3%-18.9%) and 12.1% (95% CI: 8.8%-19.8%), respectively. The association was more prominent in men at work and in women at home, with SB-adjusted OR (95% CI) of 1.36 (1.17-1.58) and 1.61 (1.35-1.58), respectively. A dose-response relationship between ETS exposure and the disease was detected across the entire population as well as in non-smokers. This is the largest population-based case-control study of ETS and esophageal cancer and the first study to evaluate such association among non-smokers in a Chinese population. We recommend strengthening the ongoing anti-tobacco public health initiatives in China with a particular emphasis on creating a tobacco-free work/home environment.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}