International Journal of Cancer最新文献_第9页

Efficacy of postoperative immunotherapy on MPM patients after CRS + HIPEC: A single-center retrospective study based on propensity score matching. CRS + HIPEC术后免疫治疗对MPM患者的疗效：基于倾向评分匹配的单中心回顾性研究

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-02 DOI: 10.1002/ijc.70128

Xin-Li Liang, Yan-Dong Su, Yu-Bin Fu, Yang Yu, Xin-Bao Li, Zhong-He Ji, Ru Ma, Rui Yang, He-Liang Wu, Yu-Run Cui, Yan Li

{"title":"Efficacy of postoperative immunotherapy on MPM patients after CRS + HIPEC: A single-center retrospective study based on propensity score matching.","authors":"Xin-Li Liang, Yan-Dong Su, Yu-Bin Fu, Yang Yu, Xin-Bao Li, Zhong-He Ji, Ru Ma, Rui Yang, He-Liang Wu, Yu-Run Cui, Yan Li","doi":"10.1002/ijc.70128","DOIUrl":"https://doi.org/10.1002/ijc.70128","url":null,"abstract":"To investigate the efficacy of postoperative immunotherapy in patients with malignant peritoneal mesothelioma (MPM) after cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). The clinical data of 160 MPM patients who underwent CRS + HIPEC at our center from April 2015 to February 2024 were retrospectively analyzed. All patients received postoperative chemotherapy and were divided into the Chemo-only group and the Immunotherapy group according to whether they received postoperative immunotherapy or not. Propensity score matching (PSM) was used to match baseline characteristics. The median overall survival (OS) was compared between the two groups. The Cox regression model was used to determine the independent prognostic factors, and subgroup analysis was performed to calculate the interaction. After matching, a total of 70 patients were included for final analysis, consisting of 35 patients each in the Chemo-only and Immunotherapy groups. Survival analysis showed that the median OS was significantly longer in the Immunotherapy group than the Chemo-only group (not-reached [NR] vs. 28.4 months) (p = 0.001). Univariate and multivariate Cox analyses indicated that postoperative immunotherapy was an independent protective factor for OS. Furthermore, subgroup analysis suggested that the results were generally robust, with no significant interactions. The median OS of sintilizumab was probably superior to camrelizumab (NR vs. 40.0 months, p = 0.052) and significantly longer than other immunotherapy regimens (pembrolizumab, cardunnilumab, nivolumab+ipilimumab) (NR vs. 26.7 months, p = 0.008). Postoperative immunotherapy, when compared to postoperative chemotherapy alone, could enhance the survival of MPM patients following CRS + HIPEC.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term human papillomavirus genotype-specific risk of cervical high-grade intraepithelial lesion and cancer-By age group and triage cytology. 人乳头瘤病毒基因型对宫颈高级别上皮内病变和癌症的长期特异性风险——按年龄组和细胞学分类。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-01 DOI: 10.1002/ijc.70123

Maija Vahteristo, Sirpa Heinävaara, Joakim Dillner, Ilkka Kalliala, Pekka Nieminen, Tytti Sarkeala, Maarit K Leinonen

{"title":"Long-term human papillomavirus genotype-specific risk of cervical high-grade intraepithelial lesion and cancer-By age group and triage cytology.","authors":"Maija Vahteristo, Sirpa Heinävaara, Joakim Dillner, Ilkka Kalliala, Pekka Nieminen, Tytti Sarkeala, Maarit K Leinonen","doi":"10.1002/ijc.70123","DOIUrl":"https://doi.org/10.1002/ijc.70123","url":null,"abstract":"Human papillomavirus (HPV) genotypes possess different cervical high-grade intraepithelial lesion and cancer (CIN2+) risks. HPV genotyping is a promising method to increase the specificity of primary HPV screening, but the optimal management of the infections with different genotypes has not been established. We aimed to assess long-term HPV genotype-specific CIN2+ risks, stratified by age and triage cytology result in a population-based cervical cancer screening program. This is a prospective study of 5253 HPV-positive individuals from the Finnish randomized HPV screening trial, with up to 18 years of follow-up. HPV-positive samples were genotyped using Luminex and BD Onclarity assays. The genotyping data were linked to data from four different nationwide health registries. The primary outcome was HPV genotype-specific cumulative incidence of CIN2+. The CIN2+ cumulative incidence was the highest for HPV16 (38.1%), followed by HPV33/58 (25.4%) and HPV31 (22.2%). The lowest incidences were observed for HPV56/59/66 (4.4%), HPV35/39/68 (6.5%), and HPV51 (7.5%). Individuals aged 50 or older at the entry test had lower cumulative incidences for the highest-risk genotypes. The cytology stratification showed that for the infections with the highest risks, normal cytology triage did not guarantee a low CIN2+ risk. On the other hand, HPV51 and HPV56/59/66 had a low risk even with an abnormal cytology result. The findings suggest that individuals with HPV16, HPV33/58, and HPV31 infections could be referred immediately to colposcopy. Sending individuals with low-risk genotypes, HPV35/39/68, HPV51, or HPV56/59/66 infections with normal cytology back to routine screening could increase screening specificity.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune checkpoint inhibitors combined with anti-angiogenic therapy as second- or further-line treatment for small cell lung cancer: Efficacy, safety, and prognostic biomarkers. 免疫检查点抑制剂联合抗血管生成治疗作为小细胞肺癌的二线或二线治疗：疗效、安全性和预后生物标志物

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-01 DOI: 10.1002/ijc.70102

Tong Chen, Wei Wang, Yuquan Qian, Mingzhao Wang, Yanchao Chen, Yang Cao, Xingsheng Hu, Xin Wang, Ning Li, Jun Jiang, Lin Yang, Bing Wang, Yutao Liu

{"title":"Immune checkpoint inhibitors combined with anti-angiogenic therapy as second- or further-line treatment for small cell lung cancer: Efficacy, safety, and prognostic biomarkers.","authors":"Tong Chen, Wei Wang, Yuquan Qian, Mingzhao Wang, Yanchao Chen, Yang Cao, Xingsheng Hu, Xin Wang, Ning Li, Jun Jiang, Lin Yang, Bing Wang, Yutao Liu","doi":"10.1002/ijc.70102","DOIUrl":"https://doi.org/10.1002/ijc.70102","url":null,"abstract":"Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options, especially after failure of initial therapy. Immune checkpoint inhibitors (ICIs) and anti-angiogenic agents have emerged as promising options for relapsed SCLC. This observational study aimed to evaluate the effectiveness and safety of ICIs plus anti-angiogenic therapy for relapsed SCLC patients, and to identify potential prognostic indicators. A single-center cohort of SCLC patients treated with ICIs plus anti-angiogenic therapy or anti-angiogenic monotherapy after first-line treatment was established. Efficacy and safety were compared between the two treatment modalities. The endpoints included progression-free survival (PFS), overall survival, disease control rate (DCR), objective response rate, and adverse events (AEs). Prognostic biomarkers, including clinicopathological parameters, plasma proteomics, and extracellular vesicle (EV) membrane proteins, were evaluated using blood samples taken before and after two cycles of combination therapy. The observation and control groups comprised 40 and 21 patients. Baseline information was comparable. Combination therapy significantly improved PFS (4.0 vs. 2.7 months, p = .029) and DCR (77.5% vs. 52.4%, p = .044). Safety profiles were comparable between groups, with low rates of severe AEs. Four clinicopathological factors (liver metastases, baseline NSE levels, smoking history, and sex) and eight plasma proteins were associated with PFS and therapy response. EV membrane protein interleukin-12 was identified as a promising poor-prognosis biomarker. ICIs plus anti-angiogenic therapy showed promising efficacy and safety for relapsed SCLC, outperforming anti-angiogenic monotherapy. Clinicopathological factors and blood-based biomarkers have shown potential to predict PFS and response to combination treatment.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The risk of basal and squamous cell carcinomas of the skin cancer incidence and external radiation in the updated National Registry for radiation workers cohort in the UK. 在更新的英国国家放射工作者队列登记中，基底细胞癌和鳞状细胞癌的皮肤癌发病率和外部辐射的风险

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-01 DOI: 10.1002/ijc.70096

Nezahat Hunter, Richard Haylock

{"title":"The risk of basal and squamous cell carcinomas of the skin cancer incidence and external radiation in the updated National Registry for radiation workers cohort in the UK.","authors":"Nezahat Hunter, Richard Haylock","doi":"10.1002/ijc.70096","DOIUrl":"https://doi.org/10.1002/ijc.70096","url":null,"abstract":"This study presents the most comprehensive evaluation to date of non-melanoma skin cancer (NMSC) risk in the UK National Registry for Radiation Workers, examining separately both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The cohort includes 172,452 workers with over 5.3 million person-years of follow-up (1955-2011) and a mean cumulative dose of 24.9 mSv. Cumulative external radiation was assessed using the personal dose equivalent Hp(10), and Poisson regression estimates the excess relative risk per Sievert (ERR/Sv) of skin cancer incidence. A total of 5748 NMSC cases were identified (4288 BCC, 818 SCC). BCC showed good evidence of a linear dose-response (ERR/Sv = 0.85, 95% CI: 0.39-1.39; p <.001), but this weakened after adjusting for anatomical location as a proxy for ultraviolet radiation (UVR) exposure (ERR/Sv = 0.15; 95% CI: -0.17-0.54; p = 0.28). However, BCC risk remained elevated among workers who were monitored for internal exposure and those workers first employed before 1960, both of whom experienced higher doses and longer follow-up. SCC showed only limited evidence of a radiation dose-response (ERR/Sv = 0.87; 95% CI: 0.03-2.05; p = 0.04), driven largely by a small number of cases at high dose, and lost significance after adjustment for anatomical location. Most BCC and SCC tumors occurred on sun-exposed areas, with notably higher BCC risks on the upper limbs. These findings highlight the importance of accounting for UVR exposure in occupational radiation studies of skin cancer and support further research with individual UVR exposure data and skin dose data to better quantify these risks.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinctive clinical and radiological characteristics of persistent super-multiple ground-glass pulmonary nodules. 持续性超多发磨玻璃肺结节的临床和影像学特征。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-01 DOI: 10.1002/ijc.70066

Junhan Wu, Aotian Mo, Weitao Zhuang, Rixin Chen, Haotian Li, Haijie Xu, Zijie Li, Ziguo Chen, Dezhao Tang, Xin Xia, Zhe He, Yong Tang, Guibin Qiao

{"title":"Distinctive clinical and radiological characteristics of persistent super-multiple ground-glass pulmonary nodules.","authors":"Junhan Wu, Aotian Mo, Weitao Zhuang, Rixin Chen, Haotian Li, Haijie Xu, Zijie Li, Ziguo Chen, Dezhao Tang, Xin Xia, Zhe He, Yong Tang, Guibin Qiao","doi":"10.1002/ijc.70066","DOIUrl":"https://doi.org/10.1002/ijc.70066","url":null,"abstract":"The clinical characteristics and pathophysiological processes of super-multiple ground-glass nodules (GGNs) remain poorly understood due to their rare incidence. This retrospective-prospective study aimed to elucidate these aspects by analyzing 75 patients with \"super-multiple GGNs,\" having more than five persistent nodules, each measuring at least 5 mm, identified from a larger cohort of 2589 patients. We compared these patients with those having solitary GGNs (N = 691) and 2-5 GGNs (N = 458) to evaluate clinical and radiological characteristics. All patients underwent a minimum 12-month follow-up with detailed documentation of nodule changes and treatments. Patients with super-multiple GGNs were significantly older, predominantly female, had lower smoking rates, and showed higher smog exposure and cough prevalence than other patients (p < .05). Radiologically, super-multiple GGNs appeared mostly unilaterally, predominantly in the right lung and upper lobes (p < .001). Progression occurred in 33.3% of these patients, of whom 44.0% exhibited simultaneous growth of multiple nodules. Compared with solitary GGNs (HR = 6.64, 95% CI = 3.18-13.84, p < .001) and 2-5 GGNs (HR = 3.26, 95% CI = 1.67-6.31, p < .001), super-multiple GGNs carried significantly higher progression risk. These findings highlight the distinct clinical characteristics and radiological evolutionary patterns of super-multiple GGNs, suggesting possible links to pulmonary inflammation.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRANCANSURV: A comprehensive analysis of childhood cancer survival in Iran. IRANCANSURV：伊朗儿童癌症生存的综合分析。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-09-01 DOI: 10.1002/ijc.70100

Elnaz Saeedi, Saeed Nemati, Fereshte Lotfi, Allison Domingues, Sepideh Abdi, Habiballah Pirnejad, Maria Cheraghi, Abbas Rezaeianzadeh, Roya Dolatkhah, Nastaran Niami, Azam Bazarafshan, Arash Golpazir, Majid Yaghoobi-Ashrafi, Saba Alvand, Zahra Ravankhah, Elham Mohebbi, Azin Nahvijou, Kazem Zendehdel

{"title":"IRANCANSURV: A comprehensive analysis of childhood cancer survival in Iran.","authors":"Elnaz Saeedi, Saeed Nemati, Fereshte Lotfi, Allison Domingues, Sepideh Abdi, Habiballah Pirnejad, Maria Cheraghi, Abbas Rezaeianzadeh, Roya Dolatkhah, Nastaran Niami, Azam Bazarafshan, Arash Golpazir, Majid Yaghoobi-Ashrafi, Saba Alvand, Zahra Ravankhah, Elham Mohebbi, Azin Nahvijou, Kazem Zendehdel","doi":"10.1002/ijc.70100","DOIUrl":"https://doi.org/10.1002/ijc.70100","url":null,"abstract":"We aimed to assess the 5-year survival probability of childhood cancer in Iran, utilizing data from eight population-based cancer registries across the country. The study employed data from 1809 childhood cancer patients aged 0-14 years, diagnosed between 2014 and 2016. Patients underwent active and passive follow-up procedures, and cases with uncertain vital status were excluded. We used the relative survival method to estimate age-standardized net survival probability for childhood cancer in Iran. The 5-year net survival for leukemia was 67.85% (95% confidence interval [CI] = 64.57, 70.90), while for central nervous system (CNS) cancers, it was 48.63% (95% CI = 43.21, 53.82). An analysis of regional disparities revealed a significant discrepancy of 14.56% in the 5-year survival of childhood leukemia, from 56.96 % in West Azerbaijan to 71.52% in Fars province. The geographical disparity in the 5-year survival of childhood CNS cancer became more pronounced, with a staggering 57.33% difference ranging from 73.50% in Khuzestan to 16.17% in Isfahan provinces. The study highlights low childhood cancer survival rates in Iran and calls for a robust surveillance system, public awareness campaigns, implementing national clinical practice guidelines, and financial support from government and NGOs to improve patient outcomes.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases. 原发性结直肠癌及其配对同步和异时转移的遗传差异。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-08-30 DOI: 10.1002/ijc.70116

Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki

{"title":"Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases.","authors":"Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki","doi":"10.1002/ijc.70116","DOIUrl":"https://doi.org/10.1002/ijc.70116","url":null,"abstract":"As the second most deadly cancerous disease worldwide, colorectal cancer (CRC) stands in the center of scientific interest in hope to develop novel approaches for precise diagnostics and prognosis determination. Metastatic disease remains the main cause of CRC mortality. To investigate the underlying genetic differences between CRC patients with synchronous and metachronous liver metastases, we performed whole-exome sequencing of 210 patient samples using formalin-fixed paraffin-embedded samples from primary tumors and the paired liver metastatic tissue. The analyses included types and levels of mutations and copy number variation. APC and TP53 were the most commonly mutated genes in all samples with differing frequency between primary CRC (both 50%) and its metachronous metastasis (both 64%). While MPDZ gene mutations were restricted to primary tumors that developed metachronous metastases only, mutations in VCAN, MTCL1, MDN1, SHROOM2, SPEG, and GLI2 were more prevalent in primary tumors giving rise to synchronous metastases. FBN1 mutations were unique to synchronous liver metastatic tissue. Analysis of genetic interactions revealed different associations between mutated genes in patients with tumors of different chronicity, including driver genes such as TP53, which was associated with APC in synchronous patients, while in primary tumors with metachronous metastases it co-occurs with mutations in NBPF11 and PRAMEF15, respectively. The results suggest that distinct tumor progression pathways account for different chronicity outcomes further affecting patients' survival. However, larger studies are needed incorporating transcriptomic and epigenomic data to shed further light on the mechanistic chain from mutations to downstream gene expression regulation.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive biomarkers for regression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2: A prospective multicenter study in Italy. 在意大利进行的一项前瞻性多中心研究中，对宫颈上皮内瘤变2级积极监测的妇女进行回归的预测性生物标志物。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-08-30 DOI: 10.1002/ijc.70104

Helena Frayle, Silvia Gori, Alessio Pagan, Marika Soldà, Cesare Romagnolo, Egle Insacco, Licia Laurino, Mario Matteucci, Giuseppe Sordi, Enrico Busato, Manuel Zorzi, Tiziano Maggino, Annarosa Del Mistro

{"title":"Predictive biomarkers for regression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2: A prospective multicenter study in Italy.","authors":"Helena Frayle, Silvia Gori, Alessio Pagan, Marika Soldà, Cesare Romagnolo, Egle Insacco, Licia Laurino, Mario Matteucci, Giuseppe Sordi, Enrico Busato, Manuel Zorzi, Tiziano Maggino, Annarosa Del Mistro","doi":"10.1002/ijc.70104","DOIUrl":"https://doi.org/10.1002/ijc.70104","url":null,"abstract":"Cervical intraepithelial neoplasia grade 2 (CIN2) can spontaneously regress in a sizable proportion of cases. The aim of this prospective multicenter cohort study was to identify the biomarkers associated with a high probability of regression. A total of 319 women aged 25-45 years fulfilling predefined inclusion and exclusion criteria (full visibility of transformation zone and lesion; no previous history of CIN2+ or immune impairment) were enrolled and subjected to active surveillance for 24 months. HPV genotyping, p16/ki67 expression, methylation status of FAM19A4/miR124-2 genes, and cytology were evaluated at baseline. The probability of CIN2 regression according to the different biomarkers was evaluated through binomial logistic regression. At follow-up, regression, persistence, and progression (evaluated on 294 women) were recorded in 165 (56%), 68 (23%), and 61 (21%) cases, respectively; no association with age was observed. Overall, 110 women underwent excisional treatment during follow-up; 53 CIN2 and 50 CIN3+ were diagnosed. The probability of CIN2 regression significantly increased with early HPV negativity (odds ratio [OR] 6.45, 95% confidence intervals [CI] 1.68-42.6), no p16/ki67 expression (OR 2.49, 95%CI 1.38-4.52), and unmethylated status (OR 2.12, 95%CI 1.09-4.20). Our results indicate that active CIN2 surveillance could be implemented for women up to 45 years, after selection according to anatomo-clinical criteria and biomarker status. To improve feasibility, the biomarkers can be used sequentially, taking advantage of the HPV genotyping available in primary screening tests, and eventually refining the selection by using the other biomarkers in selected subgroups.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimates of global, regional, and national incidence of Hodgkin lymphoma attributable to Human Immunodeficiency virus: A population attributable modeling study. 人类免疫缺陷病毒引起的全球、地区和国家霍奇金淋巴瘤发病率的估计：一项人群归因模型研究。

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-08-29 DOI: 10.1002/ijc.70115

Jianhui Zhao, Yixuan Zhang, Kangning Li, Liying Xu, Jingyu Ye, Erxu Xue, Xiangjie Lin, Yan Chen, Limei Yin, Jiayi Chen, Yaojie Wang, Xiaoqin Yao, Xue Li, Zhengwei Wan

{"title":"Estimates of global, regional, and national incidence of Hodgkin lymphoma attributable to Human Immunodeficiency virus: A population attributable modeling study.","authors":"Jianhui Zhao, Yixuan Zhang, Kangning Li, Liying Xu, Jingyu Ye, Erxu Xue, Xiangjie Lin, Yan Chen, Limei Yin, Jiayi Chen, Yaojie Wang, Xiaoqin Yao, Xue Li, Zhengwei Wan","doi":"10.1002/ijc.70115","DOIUrl":"https://doi.org/10.1002/ijc.70115","url":null,"abstract":"Hodgkin lymphoma (HL) is one of the prevalent non-acquired immunodeficiency syndrome (AIDS)-related tumors in people living with human immunodeficiency virus (PLWH). This study investigates the risk of HL among PLWH and the global incidence of HL associated with human immunodeficiency virus (HIV). A meta-analysis was conducted to examine the association between HIV infection and HL, utilizing HIV prevalence data from Joint United Nations Programme on HIV/AIDS and pooled relative risk (RR) to calculate the population attributable fraction. Additionally, the age-standardized incidence rate (ASIR) of HIV-associated HL and the estimated annual percentage change (EAPC) were calculated. The findings indicated that PLWH had an increased risk of HL (pooled RR = 11.51, 95% confidence interval: 8.90, 14.89). Globally, 6.07% of new HL cases in 2019 were attributable to HIV, representing a 2.84-fold increase from 1990. The global ASIR for HIV-associated HL per 100,000 population also increased 2.25-fold from 1990 to 2019. Regionally, 41.13% of incident HL cases were attributed to HIV infection in Eastern and Southern Africa. The most notable upward trend was observed in Eastern Europe and Central Asia (EAPC 20.04%). From 1990 to 2019, 83.58% (112/134) of countries exhibited an increasing trend in HIV-associated HL ASIR, with the majority of countries showing the highest increases located in Eastern Europe, Central Asia, and the Asia-Pacific region. This study highlights the need for targeted HIV prevention policies and interventions to reduce the disease burden of HL. The limited number of studies from low- and middle-income regions, along with heterogeneity across studies, may hinder precise estimations of disease risk and burden.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and temporal trends of depression and anxiety following cancer diagnosis in Japan: Insights from the LIFE study. 日本癌症诊断后抑郁和焦虑的发病率和时间趋势：来自LIFE研究的见解

IF 4.7 2区医学

International Journal of Cancer Pub Date : 2025-08-29 DOI: 10.1002/ijc.70118

Kengo Kawaguchi, Megumi Maeda, Fumiko Murata, Makoto Endo, Yasuharu Nakashima, Haruhisa Fukuda

{"title":"Incidence and temporal trends of depression and anxiety following cancer diagnosis in Japan: Insights from the LIFE study.","authors":"Kengo Kawaguchi, Megumi Maeda, Fumiko Murata, Makoto Endo, Yasuharu Nakashima, Haruhisa Fukuda","doi":"10.1002/ijc.70118","DOIUrl":"https://doi.org/10.1002/ijc.70118","url":null,"abstract":"Depression and anxiety are common among cancer patients and are associated with poorer treatment adherence, quality of life, and survival outcomes. While the prevalence of these conditions has been widely reported, less is known about their incidence and temporal trends. This study aimed to clarify the incidence and temporal patterns of depression and anxiety following cancer diagnosis using claims data from 14 Japanese municipalities. The study cohort comprised 22,863 newly diagnosed cancer patients from April 2018 to March 2021. During a follow-up period of up to 24 months after diagnosis, we identified depression and anxiety using recorded diagnoses in the claims data. We calculated crude incidence rates, and then Poisson regression was used to visualize monthly incidence rates and temporal trends for all patients, as well as according to sex, age, treatment modality, and cancer type. The overall crude incidence rates were 3.36 and 3.11 per 1000 person-months for depression and anxiety, respectively. Depression incidence peaked around the second month following cancer diagnosis, while anxiety incidence peaked in the month of cancer diagnosis. Female sex and chemotherapy were associated with higher incidence rates for depression and anxiety. Pancreatic cancer showed the highest incidence rates for both disorders. These findings provide valuable insights into the burden and timing of mental disorders among cancer patients in Japan and emphasize the need for targeted interventions during high-risk periods.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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